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Volumn 5, Issue 10, 2014, Pages

RAGE is essential for oncogenic KRAS-mediated hypoxic signaling in pancreatic cancer

Author keywords

[No Author keywords available]

Indexed keywords

ADVANCED GLYCATION END PRODUCT RECEPTOR; HYPOXIA INDUCIBLE FACTOR 1ALPHA; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; ADVANCED GLYCOSYLATION END-PRODUCT RECEPTOR; IMMUNOGLOBULIN RECEPTOR; KRAS PROTEIN, HUMAN; KRAS2 PROTEIN, MOUSE; ONCOPROTEIN; PROTEIN P21; RAS PROTEIN;

EID: 84923123479     PISSN: None     EISSN: 20414889     Source Type: Journal    
DOI: 10.1038/cddis.2014.445     Document Type: Article
Times cited : (69)

References (57)
  • 6
    • 84876802642 scopus 로고    scopus 로고
    • Roles for KRAS in pancreatic tumor development and progression
    • di Magliano MP, Logsdon CD. Roles for KRAS in pancreatic tumor development and progression. Gastroenterology 2013; 144: 1220-1229.
    • (2013) Gastroenterology , vol.144 , pp. 1220-1229
    • Di Magliano, M.P.1    Logsdon, C.D.2
  • 8
    • 50149097983 scopus 로고    scopus 로고
    • Hypoxia HIF1 and glucose metabolism in the solid tumour
    • Denko NC. Hypoxia, HIF1 and glucose metabolism in the solid tumour. Nat Rev Cancer 2008; 8: 705-713.
    • (2008) Nat Rev Cancer , vol.8 , pp. 705-713
    • Denko, N.C.1
  • 9
    • 79954582454 scopus 로고    scopus 로고
    • Hypoxia predicts aggressive growth and spontaneous metastasis formation from orthotopically grown primary xenografts of human pancreatic cancer
    • Chang Q, Jurisica I, Do T, Hedley DW. Hypoxia predicts aggressive growth and spontaneous metastasis formation from orthotopically grown primary xenografts of human pancreatic cancer. Cancer Res 2011; 71: 3110-3120.
    • (2011) Cancer Res , vol.71 , pp. 3110-3120
    • Chang, Q.1    Jurisica, I.2    Do, T.3    Hedley, D.W.4
  • 10
    • 66149164442 scopus 로고    scopus 로고
    • Selective killing of hypoxia-inducible factor-1-active cells improves survival in a mouse model of invasive and metastatic pancreatic cancer
    • Kizaka-Kondoh S, Itasaka S, Zeng L, Tanaka S, Zhao T, Takahashi Y et al. Selective killing of hypoxia-inducible factor-1-active cells improves survival in a mouse model of invasive and metastatic pancreatic cancer. Clin Cancer Res 2009; 15: 3433-3441.
    • (2009) Clin Cancer Res , vol.15 , pp. 3433-3441
    • Kizaka-Kondoh, S.1    Itasaka, S.2    Zeng, L.3    Tanaka, S.4    Zhao, T.5    Takahashi, Y.6
  • 11
  • 12
    • 84874614138 scopus 로고    scopus 로고
    • Strengthened glycolysis under hypoxia supports tumor symbiosis and hexosamine biosynthesis in pancreatic adenocarcinoma
    • Guillaumond F, Leca J, Olivares O, Lavaut MN, Vidal N, Berthezene P et al. Strengthened glycolysis under hypoxia supports tumor symbiosis and hexosamine biosynthesis in pancreatic adenocarcinoma. Proc Natl Acad Sci USA 2013; 110: 3919-3924.
    • (2013) Proc Natl Acad Sci USA , vol.110 , pp. 3919-3924
    • Guillaumond, F.1    Leca, J.2    Olivares, O.3    Lavaut, M.N.4    Vidal, N.5    Berthezene, P.6
  • 13
    • 79954582454 scopus 로고    scopus 로고
    • Hypoxia predicts aggressive growth and spontaneous metastasis formation from orthotopically grown primary xenografts of human pancreatic cancer
    • Chang Q, Jurisica I, Do T, Hedley DW. Hypoxia predicts aggressive growth and spontaneous metastasis formation from orthotopically grown primary xenografts of human pancreatic cancer. Cancer Res 2011; 71: 3110-3120.
    • (2011) Cancer Res , vol.71 , pp. 3110-3120
    • Chang, Q.1    Jurisica, I.2    Do, T.3    Hedley, D.W.4
  • 14
    • 27744605175 scopus 로고    scopus 로고
    • Signal pathway of hypoxia-inducible factor-1alpha phosphorylation and its interaction with von Hippel-Lindau tumor suppressor protein during ischemia in MiaPaCa-2 pancreatic cancer cells
    • Kwon SJ, Song JJ, Lee YJ. Signal pathway of hypoxia-inducible factor-1alpha phosphorylation and its interaction with von Hippel-Lindau tumor suppressor protein during ischemia in MiaPaCa-2 pancreatic cancer cells. Clin Cancer Res 2005; 11: 7607-7613.
    • (2005) Clin Cancer Res , vol.11 , pp. 7607-7613
    • Kwon, S.J.1    Song, J.J.2    Lee, Y.J.3
  • 15
    • 0142166332 scopus 로고    scopus 로고
    • Targeting HIF-1 for cancer therapy
    • Semenza GL. Targeting HIF-1 for cancer therapy. Nat Rev Cancer 2003; 3: 721-732.
    • (2003) Nat Rev Cancer , vol.3 , pp. 721-732
    • Semenza, G.L.1
  • 17
    • 64749107607 scopus 로고    scopus 로고
    • RAGE (Receptor for Advanced Glycation Endproducts), RAGE ligands, and their role in cancer and inflammation
    • Sparvero LJ, Asafu-Adjei D, Kang R, Tang D, Amin N, Im J et al. RAGE (Receptor for Advanced Glycation Endproducts), RAGE ligands, and their role in cancer and inflammation. J Transl Med 2009; 7: 17.
    • (2009) J Transl Med , vol.7 , pp. 17
    • Sparvero, L.J.1    Asafu-Adjei, D.2    Kang, R.3    Tang, D.4    Amin, N.5    Im, J.6
  • 18
    • 84872718513 scopus 로고    scopus 로고
    • The receptor for advanced glycation end products promotes pancreatic carcinogenesis and accumulation of myeloid-derived suppressor cells
    • Vernon PJ, Loux TJ, Schapiro NE, Kang R, Muthuswamy R, Kalinski P et al. The receptor for advanced glycation end products promotes pancreatic carcinogenesis and accumulation of myeloid-derived suppressor cells. J Immunol 2013; 190: 1372-1379.
    • (2013) J Immunol , vol.190 , pp. 1372-1379
    • Vernon, P.J.1    Loux, T.J.2    Schapiro, N.E.3    Kang, R.4    Muthuswamy, R.5    Kalinski, P.6
  • 19
    • 84860813449 scopus 로고    scopus 로고
    • The expression of the receptor for advanced glycation endproducts (RAGE) is permissive for early pancreatic neoplasia
    • Kang R, Loux T, Tang D, Schapiro NE, Vernon P, Livesey KM et al. The expression of the receptor for advanced glycation endproducts (RAGE) is permissive for early pancreatic neoplasia. Proc Natl Acad Sci USA 2012; 109: 7031-7036.
    • (2012) Proc Natl Acad Sci USA , vol.109 , pp. 7031-7036
    • Kang, R.1    Loux, T.2    Tang, D.3    Schapiro, N.E.4    Vernon, P.5    Livesey, K.M.6
  • 20
    • 80052590666 scopus 로고    scopus 로고
    • The Receptor for Advanced Glycation End-products (RAGE) protects pancreatic tumor cells against oxidative injury
    • Kang R, Tang D, Livesey KM, Schapiro NE, Lotze MT, Zeh HJ 3rd. The Receptor for Advanced Glycation End-products (RAGE) protects pancreatic tumor cells against oxidative injury. Antioxid Redox Signal 2011; 15: 2175-2184.
    • (2011) Antioxid Redox Signal , vol.15 , pp. 2175-2184
    • Kang, R.1    Tang, D.2    Livesey, K.M.3    Schapiro, N.E.4    Lotze, M.T.5    Zeh, H.J.6
  • 21
    • 77949542302 scopus 로고    scopus 로고
    • The receptor for advanced glycation end products (RAGE) sustains autophagy and limits apoptosis, promoting pancreatic tumor cell survival
    • Kang R, Tang D, Schapiro NE, Livesey KM, Farkas A, Loughran P et al. The receptor for advanced glycation end products (RAGE) sustains autophagy and limits apoptosis, promoting pancreatic tumor cell survival. Cell Death Differ 2010; 17: 666-676.
    • (2010) Cell Death Differ , vol.17 , pp. 666-676
    • Kang, R.1    Tang, D.2    Schapiro, N.E.3    Livesey, K.M.4    Farkas, A.5    Loughran, P.6
  • 22
    • 84893245205 scopus 로고    scopus 로고
    • The HMGB1/RAGE inflammatory pathway promotes pancreatic tumor growth by regulating mitochondrial bioenergetics
    • Kang R, Tang D, Schapiro NE, Loux T, Livesey KM, Billiar TR et al. The HMGB1/RAGE inflammatory pathway promotes pancreatic tumor growth by regulating mitochondrial bioenergetics. Oncogene 2014; 33: 567-577.
    • (2014) Oncogene , vol.33 , pp. 567-577
    • Kang, R.1    Tang, D.2    Schapiro, N.E.3    Loux, T.4    Livesey, K.M.5    Billiar, T.R.6
  • 23
    • 84864883249 scopus 로고    scopus 로고
    • AGER/RAGE-mediated autophagy promotes pancreatic tumorigenesis and bioenergetics through the IL6-pSTAT3 pathway
    • Kang R, Tang D, Lotze MT, Zeh HJ 3rd. AGER/RAGE-mediated autophagy promotes pancreatic tumorigenesis and bioenergetics through the IL6-pSTAT3 pathway. Autophagy 2012; 8: 989-991.
    • (2012) Autophagy , vol.8 , pp. 989-991
    • Kang, R.1    Tang, D.2    Lotze, M.T.3    Zeh, H.J.4
  • 24
    • 79953658179 scopus 로고    scopus 로고
    • RAGE regulates autophagy and apoptosis following oxidative injury
    • Kang R, Tang D, Lotze MT, Zeh HJ 3rd. RAGE regulates autophagy and apoptosis following oxidative injury. Autophagy 2011; 7: 442-444.
    • (2011) Autophagy , vol.7 , pp. 442-444
    • Kang, R.1    Tang, D.2    Lotze, M.T.3    Zeh, H.J.4
  • 25
    • 78650821446 scopus 로고    scopus 로고
    • Apoptosis to autophagy switch triggered by the MHC class III-encoded receptor for advanced glycation endproducts (RAGE)
    • Kang R, Tang D, Loze MT, Zeh HJ. Apoptosis to autophagy switch triggered by the MHC class III-encoded receptor for advanced glycation endproducts (RAGE). Autophagy 2011; 7: 91-93.
    • (2011) Autophagy , vol.7 , pp. 91-93
    • Kang, R.1    Tang, D.2    Loze, M.T.3    Zeh, H.J.4
  • 26
    • 10044236458 scopus 로고    scopus 로고
    • The role of hypoxia inducible factor 1alpha in cobalt chloride induced cell death in mouse embryonic fibroblasts
    • Vengellur A, LaPres JJ. The role of hypoxia inducible factor 1alpha in cobalt chloride induced cell death in mouse embryonic fibroblasts. Toxicol Sci 2004; 82: 638-646.
    • (2004) Toxicol Sci , vol.82 , pp. 638-646
    • Vengellur, A.1    LaPres, J.J.2
  • 27
    • 84862822257 scopus 로고    scopus 로고
    • Up-regulation of hypoxia inducible factor-1alpha by cobalt chloride correlates with proliferation and apoptosis in PC-2 cells
    • Dai ZJ, Gao J, Ma XB, Yan K, Liu XX, Kang HF et al. Up-regulation of hypoxia inducible factor-1alpha by cobalt chloride correlates with proliferation and apoptosis in PC-2 cells. J Exp Clin Cancer Res 2012; 31: 28.
    • (2012) J Exp Clin Cancer Res , vol.31 , pp. 28
    • Dai, Z.J.1    Gao, J.2    Ma, X.B.3    Yan, K.4    Liu, X.X.5    Kang, H.F.6
  • 28
    • 37549011413 scopus 로고    scopus 로고
    • Hypoxia-inducible factor-1 mediates neuronal expression of the receptor for advanced glycation end products following hypoxia/ ischemia
    • Pichiule P, Chavez JC, Schmidt AM, Vannucci SJ. Hypoxia-inducible factor-1 mediates neuronal expression of the receptor for advanced glycation end products following hypoxia/ ischemia. J Biol Chem 2007; 282: 36330-36340.
    • (2007) J Biol Chem , vol.282 , pp. 36330-36340
    • Pichiule, P.1    Chavez, J.C.2    Schmidt, A.M.3    Vannucci, S.J.4
  • 29
    • 79961174606 scopus 로고    scopus 로고
    • Hypoxia-increased RAGE and P2X7R expression regulates tumor cell invasion through phosphorylation of Erk1/2 and Akt and nuclear translocation of NF-{kappa}B
    • Tafani M, Schito L, Pellegrini L, Villanova L, Marfe G, Anwar T et al. Hypoxia-increased RAGE and P2X7R expression regulates tumor cell invasion through phosphorylation of Erk1/2 and Akt and nuclear translocation of NF-{kappa}B. Carcinogenesis 2011; 32: 1167-1175.
    • (2011) Carcinogenesis , vol.32 , pp. 1167-1175
    • Tafani, M.1    Schito, L.2    Pellegrini, L.3    Villanova, L.4    Marfe, G.5    Anwar, T.6
  • 30
    • 0035418621 scopus 로고    scopus 로고
    • Constitutive expression of hypoxia-inducible factor-1alpha renders pancreatic cancer cells resistant to apoptosis induced by hypoxia and nutrient deprivation
    • Akakura N, Kobayashi M, Horiuchi I, Suzuki A, Wang J, Chen J et al. Constitutive expression of hypoxia-inducible factor-1alpha renders pancreatic cancer cells resistant to apoptosis induced by hypoxia and nutrient deprivation. Cancer Res 2001; 61: 6548-6554.
    • (2001) Cancer Res , vol.61 , pp. 6548-6554
    • Akakura, N.1    Kobayashi, M.2    Horiuchi, I.3    Suzuki, A.4    Wang, J.5    Chen, J.6
  • 31
    • 1842583652 scopus 로고    scopus 로고
    • Hypoxia increases resistance of human pancreatic cancer cells to apoptosis induced by gemcitabine
    • Yokoi K, Fidler IJ. Hypoxia increases resistance of human pancreatic cancer cells to apoptosis induced by gemcitabine. Clin Cancer Res 2004; 10: 2299-2306.
    • (2004) Clin Cancer Res , vol.10 , pp. 2299-2306
    • Yokoi, K.1    Fidler, I.J.2
  • 32
    • 4944246547 scopus 로고    scopus 로고
    • The role of hypoxia inducible factor 1 (HIF-1) in hypoxia induced apoptosis
    • Greijer AE, van der Wall E. The role of hypoxia inducible factor 1 (HIF-1) in hypoxia induced apoptosis. J Clin Pathol 2004; 57: 1009-1014.
    • (2004) J Clin Pathol , vol.57 , pp. 1009-1014
    • Greijer, A.E.1    Van Der Wall, E.2
  • 33
    • 43649104579 scopus 로고    scopus 로고
    • Mitochondrial autophagy is an HIF-1-dependent adaptive metabolic response to hypoxia
    • Zhang H, Bosch-Marce M, Shimoda LA, Tan YS, Baek JH, Wesley JB et al. Mitochondrial autophagy is an HIF-1-dependent adaptive metabolic response to hypoxia. J Biol Chem 2008; 283: 10892-10903.
    • (2008) J Biol Chem , vol.283 , pp. 10892-10903
    • Zhang, H.1    Bosch-Marce, M.2    Shimoda, L.A.3    Tan, Y.S.4    Baek, J.H.5    Wesley, J.B.6
  • 34
    • 66349121718 scopus 로고    scopus 로고
    • Hypoxia-induced autophagy is mediated through hypoxia-inducible factor induction of BNIP3 and BNIP3L via their BH3 domains
    • Bellot G, Garcia-Medina R, Gounon P, Chiche J, Roux D, Pouyssegur J et al. Hypoxia-induced autophagy is mediated through hypoxia-inducible factor induction of BNIP3 and BNIP3L via their BH3 domains. Mol Cell Biol 2009; 29: 2570-2581.
    • (2009) Mol Cell Biol , vol.29 , pp. 2570-2581
    • Bellot, G.1    Garcia-Medina, R.2    Gounon, P.3    Chiche, J.4    Roux, D.5    Pouyssegur, J.6
  • 35
    • 84862014301 scopus 로고    scopus 로고
    • Autophagy mediates survival of pancreatic tumour-initiating cells in a hypoxic microenvironment
    • Rausch V, Liu L, Apel A, Rettig T, Gladkich J, Labsch S et al. Autophagy mediates survival of pancreatic tumour-initiating cells in a hypoxic microenvironment. J Pathol 2012; 227: 325-335.
    • (2012) J Pathol , vol.227 , pp. 325-335
    • Rausch, V.1    Liu, L.2    Apel, A.3    Rettig, T.4    Gladkich, J.5    Labsch, S.6
  • 38
    • 70350534499 scopus 로고    scopus 로고
    • Oncogenic KRAS and BRAF differentially regulate hypoxia-inducible factor-1alpha and -2alpha in colon cancer
    • Kikuchi H, Pino MS, Zeng M, Shirasawa S, Chung DC. Oncogenic KRAS and BRAF differentially regulate hypoxia-inducible factor-1alpha and -2alpha in colon cancer. Cancer Res 2009; 69: 8499-8506.
    • (2009) Cancer Res , vol.69 , pp. 8499-8506
    • Kikuchi, H.1    Pino, M.S.2    Zeng, M.3    Shirasawa, S.4    Chung, D.C.5
  • 39
    • 0036546501 scopus 로고    scopus 로고
    • NF-kappaB in cancer: From innocent bystander to major culprit
    • Karin M, Cao Y, Greten FR, Li ZW. NF-kappaB in cancer: from innocent bystander to major culprit. Nat Rev Cancer 2002; 2: 301-310.
    • (2002) Nat Rev Cancer , vol.2 , pp. 301-310
    • Karin, M.1    Cao, Y.2    Greten, F.R.3    Li, Z.W.4
  • 40
    • 44849100198 scopus 로고    scopus 로고
    • NF-kappaB links innate immunity to the hypoxic response through transcriptional regulation of HIF-1alpha
    • Rius J, Guma M, Schachtrup C, Akassoglou K, Zinkernagel AS, Nizet V et al. NF-kappaB links innate immunity to the hypoxic response through transcriptional regulation of HIF-1alpha. Nature 2008; 453: 807-811.
    • (2008) Nature , vol.453 , pp. 807-811
    • Rius, J.1    Guma, M.2    Schachtrup, C.3    Akassoglou, K.4    Zinkernagel, A.S.5    Nizet, V.6
  • 41
    • 45349097483 scopus 로고    scopus 로고
    • Regulation of hypoxia-inducible factor-1alpha by NF-kappaB
    • van Uden P, Kenneth NS, Rocha S. Regulation of hypoxia-inducible factor-1alpha by NF-kappaB. Biochem J 2008; 412: 477-484.
    • (2008) Biochem J. , vol.412 , pp. 477-484
    • Van Uden, P.1    Kenneth, N.S.2    Rocha, S.3
  • 42
    • 0034682315 scopus 로고    scopus 로고
    • Blockade of RAGEamphoterin signalling suppresses tumour growth and metastases
    • Taguchi A, Blood DC, del Toro G, Canet A, Lee DC, Qu W et al. Blockade of RAGEamphoterin signalling suppresses tumour growth and metastases. Nature 2000; 405: 354-360.
    • (2000) Nature , vol.405 , pp. 354-360
    • Taguchi, A.1    Blood, D.C.2    Del Toro, G.3    Canet, A.4    Lee, D.C.5    Qu, W.6
  • 45
    • 84855356374 scopus 로고    scopus 로고
    • RAGE gene deletion inhibits the development and progression of ductal neoplasia and prolongs survival in a murine model of pancreatic cancer
    • Discussion 112
    • DiNorcia J, Lee MK, Moroziewicz DN, Winner M, Suman P, Bao F et al. RAGE gene deletion inhibits the development and progression of ductal neoplasia and prolongs survival in a murine model of pancreatic cancer. J Gastrointest Surg 2012; 16: 104-112 discussion 112.
    • (2012) J Gastrointest Surg , vol.16 , pp. 104-112
    • DiNorcia, J.1    Lee, M.K.2    Moroziewicz, D.N.3    Winner, M.4    Suman, P.5    Bao, F.6
  • 46
    • 59449097787 scopus 로고    scopus 로고
    • Expression of receptor for advanced glycation end products (RAGE) is related to prognosis in patients with esophageal squamous cell carcinoma
    • Tateno T, Ueno S, Hiwatashi K, Matsumoto M, Okumura H, Setoyama T et al. Expression of receptor for advanced glycation end products (RAGE) is related to prognosis in patients with esophageal squamous cell carcinoma. Ann Surg Oncol 2009; 16: 440-446.
    • (2009) Ann Surg Oncol , vol.16 , pp. 440-446
    • Tateno, T.1    Ueno, S.2    Hiwatashi, K.3    Matsumoto, M.4    Okumura, H.5    Setoyama, T.6
  • 48
    • 29944431722 scopus 로고    scopus 로고
    • Proliferative stimulus of lung fibroblasts on lung cancer cells is impaired by the receptor for advanced glycation end-products
    • Bartling B, Demling N, Silber RE, Simm A. Proliferative stimulus of lung fibroblasts on lung cancer cells is impaired by the receptor for advanced glycation end-products. Am J Respir Cell Mol Biol 2006; 34: 83-91.
    • (2006) Am J Respir Cell Mol Biol , vol.34 , pp. 83-91
    • Bartling, B.1    Demling, N.2    Silber, R.E.3    Simm, A.4
  • 49
    • 34250186432 scopus 로고    scopus 로고
    • Endogenous secretory receptor for advanced glycation endproducts as a novel prognostic marker in chondrosarcoma
    • Takeuchi A, Yamamoto Y, Tsuneyama K, Cheng C, Yonekura H, Watanabe T et al. Endogenous secretory receptor for advanced glycation endproducts as a novel prognostic marker in chondrosarcoma. Cancer 2007; 109: 2532-2540.
    • (2007) Cancer , vol.109 , pp. 2532-2540
    • Takeuchi, A.1    Yamamoto, Y.2    Tsuneyama, K.3    Cheng, C.4    Yonekura, H.5    Watanabe, T.6
  • 50
    • 34548859509 scopus 로고    scopus 로고
    • RAGE expression in rhabdomyosarcoma cells results in myogenic differentiation and reduced proliferation, migration, invasiveness, and tumor growth
    • Riuzzi F, Sorci G, Donato R. RAGE expression in rhabdomyosarcoma cells results in myogenic differentiation and reduced proliferation, migration, invasiveness, and tumor growth. Am J Pathol 2007; 171: 947-961.
    • (2007) Am J Pathol , vol.171 , pp. 947-961
    • Riuzzi, F.1    Sorci, G.2    Donato, R.3
  • 51
    • 78149341677 scopus 로고    scopus 로고
    • Oncogenic KRAS modulates mitochondrial metabolism in human colon cancer cells by inducing HIF-1alpha and HIF-2alpha target genes
    • Chun SY, Johnson C, Washburn JG, Cruz-Correa MR, Dang DT, Dang LH. Oncogenic KRAS modulates mitochondrial metabolism in human colon cancer cells by inducing HIF-1alpha and HIF-2alpha target genes. Mol Cancer 2010; 9: 293.
    • (2010) Mol Cancer , vol.9 , pp. 293
    • Chun, S.Y.1    Johnson, C.2    Washburn, J.G.3    Cruz-Correa, M.R.4    Dang, D.T.5    Dang, L.H.6
  • 52
    • 84861526009 scopus 로고    scopus 로고
    • Deconvoluting the context-dependent role for autophagy in cancer
    • White E. Deconvoluting the context-dependent role for autophagy in cancer. Nat Rev Cancer 2012; 12: 401-410.
    • (2012) Nat Rev Cancer , vol.12 , pp. 401-410
    • White, E.1
  • 53
    • 84872692539 scopus 로고    scopus 로고
    • Autophagy in pancreatic cancer pathogenesis and treatment
    • Kang R, Tang D. Autophagy in pancreatic cancer pathogenesis and treatment. Am J Cancer Res 2012; 2: 383-396.
    • (2012) Am J Cancer Res , vol.2 , pp. 383-396
    • Kang, R.1    Tang, D.2
  • 55
    • 84890432985 scopus 로고    scopus 로고
    • P53 status determines the role of autophagy in pancreatic tumour development
    • Rosenfeldt MT, O'Prey J, Morton JP, Nixon C, MacKay G, Mrowinska A et al. p53 status determines the role of autophagy in pancreatic tumour development. Nature 2013; 504: 296-300.
    • (2013) Nature , vol.504 , pp. 296-300
    • Rosenfeldt, M.T.1    O'Prey, J.2    Morton, J.P.3    Nixon, C.4    MacKay, G.5    Mrowinska, A.6
  • 56
    • 84905499163 scopus 로고    scopus 로고
    • Autophagy is critical for pancreatic tumor growth and progression in tumors with p53 alterations
    • Yang A, Rajeshkumar NV, Wang X, Yabuuchi S, Alexander BM, Chu GC et al. Autophagy is critical for pancreatic tumor growth and progression in tumors with p53 alterations. Cancer Discov 2014; 4: 905-913.
    • (2014) Cancer Discov , vol.4 , pp. 905-913
    • Yang, A.1    Rajeshkumar, N.V.2    Wang, X.3    Yabuuchi, S.4    Alexander, B.M.5    Chu, G.C.6
  • 57
    • 2942756123 scopus 로고    scopus 로고
    • Receptor for advanced glycation end products (RAGE) regulates sepsis but not the adaptive immune response
    • Liliensiek B, Weigand MA, Bierhaus A, Nicklas W, Kasper M, Hofer S et al. Receptor for advanced glycation end products (RAGE) regulates sepsis but not the adaptive immune response. J Clin Invest 2004; 113: 1641-1650.
    • (2004) J Clin Invest , vol.113 , pp. 1641-1650
    • Liliensiek, B.1    Weigand, M.A.2    Bierhaus, A.3    Nicklas, W.4    Kasper, M.5    Hofer, S.6


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