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Volumn 31, Issue 9, 2017, Pages 1855-1868

Gemtuzumab ozogamicin in acute myeloid leukemia

Author keywords

[No Author keywords available]

Indexed keywords

ABC TRANSPORTER; CALICHEAMICIN; CD33 ANTIGEN; GEMTUZUMAB OZOGAMICIN; AMINOGLYCOSIDE; CD33 PROTEIN, HUMAN; GEMTUZUMAB; MONOCLONAL ANTIBODY;

EID: 85028812279     PISSN: 08876924     EISSN: 14765551     Source Type: Journal    
DOI: 10.1038/leu.2017.187     Document Type: Review
Times cited : (170)

References (128)
  • 1
    • 84880531303 scopus 로고    scopus 로고
    • Antibody-based therapy of acute myeloid leukemia with gemtuzumab ozogamicin
    • Cowan AJ, Laszlo GS, Estey EH, Walter RB. Antibody-based therapy of acute myeloid leukemia with gemtuzumab ozogamicin. Front Biosci (Landmark Ed) 2013; 18: 1311-1334.
    • (2013) Front Biosci (Landmark Ed) , vol.18 , pp. 1311-1334
    • Cowan, A.J.1    Laszlo, G.S.2    Estey, E.H.3    Walter, R.B.4
  • 2
    • 84921786419 scopus 로고    scopus 로고
    • Siglec-mediated regulation of immune cell function in disease
    • Macauley MS, Crocker PR, Paulson JC. Siglec-mediated regulation of immune cell function in disease. Nat Rev Immunol 2014; 14: 653-666.
    • (2014) Nat Rev Immunol , vol.14 , pp. 653-666
    • Macauley, M.S.1    Crocker, P.R.2    Paulson, J.C.3
  • 5
    • 84881503738 scopus 로고    scopus 로고
    • CD33 Alzheimer's risk-Altering polymorphism, CD33 expression, and exon 2 splicing
    • Malik M, Simpson JF, Parikh I, Wilfred BR, Fardo DW, Nelson PT et al. CD33 Alzheimer's risk-Altering polymorphism, CD33 expression, and exon 2 splicing. J Neurosci 2013; 33: 13320-13325.
    • (2013) J Neurosci , vol.33 , pp. 13320-13325
    • Malik, M.1    Simpson, J.F.2    Parikh, I.3    Wilfred, B.R.4    Fardo, D.W.5    Nelson, P.T.6
  • 6
    • 84898770218 scopus 로고    scopus 로고
    • CD33: Increased inclusion of exon 2 implicates the Ig V-set domain in Alzheimer's disease susceptibility
    • Raj T, Ryan KJ, Replogle JM, Chibnik LB, Rosenkrantz L, Tang A et al. CD33: increased inclusion of exon 2 implicates the Ig V-set domain in Alzheimer's disease susceptibility. Hum Mol Genet 2014; 23: 2729-2736.
    • (2014) Hum Mol Genet , vol.23 , pp. 2729-2736
    • Raj, T.1    Ryan, K.J.2    Replogle, J.M.3    Chibnik, L.B.4    Rosenkrantz, L.5    Tang, A.6
  • 8
    • 84978759387 scopus 로고    scopus 로고
    • Expression and functional characterization of CD33 transcript variants in human acute myeloid leukemia
    • Laszlo GS, Harrington KH, Gudgeon CJ, Beddoe ME, Fitzgibbon MP, Ries RE et al. Expression and functional characterization of CD33 transcript variants in human acute myeloid leukemia. Oncotarget 2016; 7: 43281-43294.
    • (2016) Oncotarget , vol.7 , pp. 43281-43294
    • Laszlo, G.S.1    Harrington, K.H.2    Gudgeon, C.J.3    Beddoe, M.E.4    Fitzgibbon, M.P.5    Ries, R.E.6
  • 9
    • 85028755264 scopus 로고    scopus 로고
    • CD33 splicing polymorphism determines gemtuzumab ozogamicin response in de novo AML: Report from randomized phase III Children's Oncology Group trial AAML0531
    • Lamba JK, Chauhan L, Shin M, Loken M, Pollard J, Wang Y-C et al. CD33 splicing polymorphism determines gemtuzumab ozogamicin response in de novo AML: report from randomized phase III Children's Oncology Group trial AAML0531. J Clin Oncol 2017; doi:10.1200/JCO.2016.71.2513.
    • (2017) J Clin Oncol
    • Lamba, J.K.1    Chauhan, L.2    Shin, M.3    Loken, M.4    Pollard, J.5    Wang, Y.-C.6
  • 12
  • 14
    • 84903122676 scopus 로고    scopus 로고
    • The past and future of CD33 as therapeutic target in acute myeloid leukemia
    • Laszlo GS, Estey EH, Walter RB. The past and future of CD33 as therapeutic target in acute myeloid leukemia. Blood Rev 2014; 28: 143-153.
    • (2014) Blood Rev , vol.28 , pp. 143-153
    • Laszlo, G.S.1    Estey, E.H.2    Walter, R.B.3
  • 15
    • 84995370882 scopus 로고    scopus 로고
    • Expression of CD33 is a predictive factor for effect of gemtuzumab ozogamicin at different doses in adult acute myeloid leukaemia
    • Khan N, Hills RK, Virgo P, Couzens S, Clark N, Gilkes A et al. Expression of CD33 is a predictive factor for effect of gemtuzumab ozogamicin at different doses in adult acute myeloid leukaemia. Leukemia 2017; 31: 1059-1068.
    • Leukemia , vol.2017 , Issue.31 , pp. 1059-1068
    • Khan, N.1    Hills, R.K.2    Virgo, P.3    Couzens, S.4    Clark, N.5    Gilkes, A.6
  • 16
    • 84860333177 scopus 로고    scopus 로고
    • Correlation of CD33 expression level with disease characteristics and response to gemtuzumab ozogamicin containing chemotherapy in childhood AML
    • Pollard JA, Alonzo TA, Loken M, Gerbing RB, Ho PA, Bernstein ID et al. Correlation of CD33 expression level with disease characteristics and response to gemtuzumab ozogamicin containing chemotherapy in childhood AML. Blood 2012; 119: 3705-3711.
    • (2012) Blood , vol.119 , pp. 3705-3711
    • Pollard, J.A.1    Alonzo, T.A.2    Loken, M.3    Gerbing, R.B.4    Ho, P.A.5    Bernstein, I.D.6
  • 17
    • 84897019168 scopus 로고    scopus 로고
    • CD33 target validation and sustained depletion of AML blasts in long-Term cultures by the bispecific T-cell-engaging antibody AMG 330
    • Krupka C, Kufer P, Kischel R, Zugmaier G, Bögeholz J, Köhnke T et al. CD33 target validation and sustained depletion of AML blasts in long-Term cultures by the bispecific T-cell-engaging antibody AMG 330. Blood 2014; 123: 356-365.
    • (2014) Blood , vol.123 , pp. 356-365
    • Krupka, C.1    Kufer, P.2    Kischel, R.3    Zugmaier, G.4    Bögeholz, J.5    Köhnke, T.6
  • 18
    • 0024509637 scopus 로고
    • Restricted expression of an early myeloid and monocytic cell surface antigen defined by monoclonal antibody M195
    • Tanimoto M, Scheinberg DA, Cordon-Cardo C, Huie D, Clarkson BD, Old LJ. Restricted expression of an early myeloid and monocytic cell surface antigen defined by monoclonal antibody M195. Leukemia 1989; 3: 339-348.
    • (1989) Leukemia , vol.3 , pp. 339-348
    • Tanimoto, M.1    Scheinberg, D.A.2    Cordon-Cardo, C.3    Huie, D.4    Clarkson, B.D.5    Old, L.J.6
  • 22
    • 84875152775 scopus 로고    scopus 로고
    • Clinical significance of CD33 nonsynonymous single-nucleotide polymorphisms in pediatric patients with acute myeloid leukemia treated with gemtuzumabozogamicin-containing chemotherapy
    • Mortland L, Alonzo TA, Walter RB, Gerbing RB, Mitra AK, Pollard JA et al. Clinical significance of CD33 nonsynonymous single-nucleotide polymorphisms in pediatric patients with acute myeloid leukemia treated with gemtuzumabozogamicin-containing chemotherapy. Clin Cancer Res 2013; 19: 1620-1627.
    • (2013) Clin Cancer Res , vol.19 , pp. 1620-1627
    • Mortland, L.1    Alonzo, T.A.2    Walter, R.B.3    Gerbing, R.B.4    Mitra, A.K.5    Pollard, J.A.6
  • 23
    • 0344336086 scopus 로고    scopus 로고
    • Immunophenotype of adult and childhood acute promyelocytic leukaemia: Correlation with morphology, type of PML gene breakpoint and clinical outcome. A cooperative Italian study on 196 cases
    • Guglielmi C, Martelli MP, Diverio D, Fenu S, Vegna ML, Cantu-Rajnoldi A et al. Immunophenotype of adult and childhood acute promyelocytic leukaemia: correlation with morphology, type of PML gene breakpoint and clinical outcome. A cooperative Italian study on 196 cases. Br J Haematol 1998; 102: 1035-1041.
    • (1998) Br J Haematol , vol.102 , pp. 1035-1041
    • Guglielmi, C.1    Martelli, M.P.2    Diverio, D.3    Fenu, S.4    Vegna, M.L.5    Cantu-Rajnoldi, A.6
  • 24
    • 0041327727 scopus 로고    scopus 로고
    • Expression of cell-surface antigens in acute promyelocytic leukaemia
    • Paietta E. Expression of cell-surface antigens in acute promyelocytic leukaemia. Best Pract Res Clin Haematol 2003; 16: 369-385.
    • (2003) Best Pract Res Clin Haematol , vol.16 , pp. 369-385
    • Paietta, E.1
  • 25
    • 80053636410 scopus 로고    scopus 로고
    • High CD33 expression levels in acute myeloid leukemia cells carrying the nucleophosmin (NPM1) mutation
    • De Propris MS, Raponi S, Diverio D, Milani ML, Meloni G, Falini B et al. High CD33 expression levels in acute myeloid leukemia cells carrying the nucleophosmin (NPM1) mutation. Haematologica 2011; 96: 1548-1551.
    • (2011) Haematologica , vol.96 , pp. 1548-1551
    • De Propris, M.S.1    Raponi, S.2    Diverio, D.3    Milani, M.L.4    Meloni, G.5    Falini, B.6
  • 26
    • 84903691167 scopus 로고    scopus 로고
    • Distribution and levels of cell surface expression of CD33 and CD123 in acute myeloid leukemia
    • Ehninger A, Kramer M, Röllig C, Thiede C, Bornhäuser M, von Bonin M et al. Distribution and levels of cell surface expression of CD33 and CD123 in acute myeloid leukemia. Blood Cancer J 2014; 4: e218.
    • (2014) Blood Cancer J , vol.4 , pp. e218
    • Ehninger, A.1    Kramer, M.2    Röllig, C.3    Thiede, C.4    Bornhäuser, M.5    Von Bonin, M.6
  • 27
    • 84964294715 scopus 로고    scopus 로고
    • CD33 expression and its association with gemtuzumab ozogamicin response: Results from the randomized phase III Children's Oncology Group trial AAML0531
    • Pollard JA, Loken M, Gerbing RB, Raimondi SC, Hirsch BA, Aplenc R et al. CD33 expression and its association with gemtuzumab ozogamicin response: results from the randomized phase III Children's Oncology Group trial AAML0531. J Clin Oncol 2016; 34: 747-755.
    • (2016) J Clin Oncol , vol.34 , pp. 747-755
    • Pollard, J.A.1    Loken, M.2    Gerbing, R.B.3    Raimondi, S.C.4    Hirsch, B.A.5    Aplenc, R.6
  • 28
    • 85016775310 scopus 로고    scopus 로고
    • The level of blast CD33 expression positively impacts the effect of gemtuzumab ozogamicin in patients with acute myeloid leukemia
    • Olombel G, Guerin E, Guy J, Perrot JY, Dumezy F, de Labarthe A et al. The level of blast CD33 expression positively impacts the effect of gemtuzumab ozogamicin in patients with acute myeloid leukemia. Blood 2016; 127: 2157-2160.
    • (2016) Blood , vol.127 , pp. 2157-2160
    • Olombel, G.1    Guerin, E.2    Guy, J.3    Perrot, J.Y.4    Dumezy, F.5    De Labarthe, A.6
  • 29
    • 84859899567 scopus 로고    scopus 로고
    • Acute myeloid leukemia stem cells and CD33-Targeted immunotherapy
    • Walter RB, Appelbaum FR, Estey EH, Bernstein ID. Acute myeloid leukemia stem cells and CD33-Targeted immunotherapy. Blood 2012; 119: 6198-6208.
    • (2012) Blood , vol.119 , pp. 6198-6208
    • Walter, R.B.1    Appelbaum, F.R.2    Estey, E.H.3    Bernstein, I.D.4
  • 31
    • 0023202032 scopus 로고
    • Clonal development, stem-cell differentiation, and clinical remissions in acute nonlymphocytic leukemia
    • Fialkow PJ, Singer JW, Raskind WH, Adamson JW, Jacobson RJ, Bernstein ID et al. Clonal development, stem-cell differentiation, and clinical remissions in acute nonlymphocytic leukemia. N Engl J Med 1987; 317: 468-473.
    • (1987) N Engl J Med , vol.317 , pp. 468-473
    • Fialkow, P.J.1    Singer, J.W.2    Raskind, W.H.3    Adamson, J.W.4    Jacobson, R.J.5    Bernstein, I.D.6
  • 32
    • 0023228244 scopus 로고
    • Treatment of acute myeloid leukemia cells in vitro with a monoclonal antibody recognizing a myeloid differentiation antigen allows normal progenitor cells to be expressed
    • Bernstein ID, Singer JW, Andrews RG, Keating A, Powell JS, Bjornson BH et al. Treatment of acute myeloid leukemia cells in vitro with a monoclonal antibody recognizing a myeloid differentiation antigen allows normal progenitor cells to be expressed. J Clin Invest 1987; 79: 1153-1159.
    • (1987) J Clin Invest , vol.79 , pp. 1153-1159
    • Bernstein, I.D.1    Singer, J.W.2    Andrews, R.G.3    Keating, A.4    Powell, J.S.5    Bjornson, B.H.6
  • 33
    • 0026546492 scopus 로고
    • Differences in the frequency of normal and clonal precursors of colony-forming cells in chronic myelogenous leukemia and acute myelogenous leukemia
    • Bernstein ID, Singer JW, Smith FO, Andrews RG, Flowers DA, Petersens J et al. Differences in the frequency of normal and clonal precursors of colony-forming cells in chronic myelogenous leukemia and acute myelogenous leukemia. Blood 1992; 79: 1811-1816.
    • (1992) Blood , vol.79 , pp. 1811-1816
    • Bernstein, I.D.1    Singer, J.W.2    Smith, F.O.3    Andrews, R.G.4    Flowers, D.A.5    Petersens, J.6
  • 34
    • 28844456971 scopus 로고    scopus 로고
    • Hematopoietic stem cells express multiple myeloid markers: Implications for the origin and targeted therapy of acute myeloid leukemia
    • Taussig DC, Pearce DJ, Simpson C, Rohatiner AZ, Lister TA, Kelly G et al. Hematopoietic stem cells express multiple myeloid markers: implications for the origin and targeted therapy of acute myeloid leukemia. Blood 2005; 106: 4086-4092.
    • (2005) Blood , vol.106 , pp. 4086-4092
    • Taussig, D.C.1    Pearce, D.J.2    Simpson, C.3    Rohatiner, A.Z.4    Lister, T.A.5    Kelly, G.6
  • 35
    • 23044471884 scopus 로고    scopus 로고
    • Phase III randomized multicenter study of a humanized anti-CD33 monoclonal antibody, lintuzumab, in combination with chemotherapy, versus chemotherapy alone in patients with refractory or first-relapsed acute myeloid leukemia
    • Feldman EJ, Brandwein J, Stone R, Kalaycio M, Moore J, O'Connor J et al. Phase III randomized multicenter study of a humanized anti-CD33 monoclonal antibody, lintuzumab, in combination with chemotherapy, versus chemotherapy alone in patients with refractory or first-relapsed acute myeloid leukemia. J Clin Oncol 2005; 23: 4110-4116.
    • (2005) J Clin Oncol , vol.23 , pp. 4110-4116
    • Feldman, E.J.1    Brandwein, J.2    Stone, R.3    Kalaycio, M.4    Moore, J.5    O'Connor, J.6
  • 36
    • 84872072793 scopus 로고    scopus 로고
    • Randomized phase IIb study of low-dose cytarabine and lintuzumab versus low-dose cytarabine and placebo in older adults with untreated acute myeloid leukemia
    • Sekeres MA, Lancet JE, Wood BL, Grove LE, Sandalic L, Sievers EL et al. Randomized phase IIb study of low-dose cytarabine and lintuzumab versus low-dose cytarabine and placebo in older adults with untreated acute myeloid leukemia. Haematologica 2013; 98: 119-128.
    • (2013) Haematologica , vol.98 , pp. 119-128
    • Sekeres, M.A.1    Lancet, J.E.2    Wood, B.L.3    Grove, L.E.4    Sandalic, L.5    Sievers, E.L.6
  • 37
    • 0036007596 scopus 로고    scopus 로고
    • Gemtuzumab ozogamicin, a potent and selective anti-CD33 antibody-calicheamicin conjugate for treatment of acute myeloid leukemia
    • Hamann PR, Hinman LM, Hollander I, Beyer CF, Lindh D, Holcomb R et al. Gemtuzumab ozogamicin, a potent and selective anti-CD33 antibody-calicheamicin conjugate for treatment of acute myeloid leukemia. Bioconjug Chem 2002; 13: 47-58.
    • (2002) Bioconjug Chem , vol.13 , pp. 47-58
    • Hamann, P.R.1    Hinman, L.M.2    Hollander, I.3    Beyer, C.F.4    Lindh, D.5    Holcomb, R.6
  • 40
    • 0034900174 scopus 로고    scopus 로고
    • Approval summary: Gemtuzumab ozogamicin in relapsed acute myeloid leukemia
    • Bross PF, Beitz J, Chen G, Chen XH, Duffy E, Kieffer L et al. Approval summary: gemtuzumab ozogamicin in relapsed acute myeloid leukemia. Clin Cancer Res 2001; 7: 1490-1496.
    • (2001) Clin Cancer Res , vol.7 , pp. 1490-1496
    • Bross, P.F.1    Beitz, J.2    Chen, G.3    Chen, X.H.4    Duffy, E.5    Kieffer, L.6
  • 41
    • 1242352458 scopus 로고    scopus 로고
    • Internalization and cell cycle-dependent killing of leukemic cells by gemtuzumab ozogamicin: Rationale for efficacy in CD33-negative malignancies with endocytic capacity
    • Jedema I, Barge RM, van der Velden VH, Nijmeijer BA, van Dongen JJ, Willemze R et al. Internalization and cell cycle-dependent killing of leukemic cells by gemtuzumab ozogamicin: rationale for efficacy in CD33-negative malignancies with endocytic capacity. Leukemia 2004; 18: 316-325.
    • (2004) Leukemia , vol.18 , pp. 316-325
    • Jedema, I.1    Barge, R.M.2    Van Der Velden, V.H.3    Nijmeijer, B.A.4    Van Dongen, J.J.5    Willemze, R.6
  • 43
    • 84929646093 scopus 로고    scopus 로고
    • Novel insights on the DNA interaction of calicheamicin gamma 1 (I)
    • Sissi C, Moro S, Crothers DM. Novel insights on the DNA interaction of calicheamicin gamma(1)(I). Biopolymers 2015; 103: 449-459.
    • (2015) Biopolymers , vol.103 , pp. 449-459
    • Sissi, C.1    Moro, S.2    Crothers, D.M.3
  • 44
    • 84865721487 scopus 로고    scopus 로고
    • Induction of DNA strand breaks is critical to predict the cytotoxicity of gemtuzumab ozogamicin against leukemic cells
    • Yamauchi T, Matsuda Y, Tasaki T, Negoro E, Ikegaya S, Takagi K et al. Induction of DNA strand breaks is critical to predict the cytotoxicity of gemtuzumab ozogamicin against leukemic cells. Cancer Sci 2012; 103: 1722-1729.
    • (2012) Cancer Sci , vol.103 , pp. 1722-1729
    • Yamauchi, T.1    Matsuda, Y.2    Tasaki, T.3    Negoro, E.4    Ikegaya, S.5    Takagi, K.6
  • 45
    • 0025048625 scopus 로고
    • Sensitivity of fibroblasts derived from ataxia-Telangiectasia patients to calicheamicin gamma 1I
    • Sullivan N, Lyne L. Sensitivity of fibroblasts derived from ataxia-Telangiectasia patients to calicheamicin gamma 1I. Mutat Res 1990; 245: 171-175.
    • (1990) Mutat Res , vol.245 , pp. 171-175
    • Sullivan, N.1    Lyne, L.2
  • 46
    • 0034694122 scopus 로고    scopus 로고
    • Differential responses of Chinese hamster mutagen sensitive cell lines to low and high concentrations of calicheamicin and neocarzinostatin
    • van Duijn-Goedhart A, Zdzienicka MZ, Sankaranarayanan K, van Buul PP. Differential responses of Chinese hamster mutagen sensitive cell lines to low and high concentrations of calicheamicin and neocarzinostatin. Mutat Res 2000; 471: 95-105
    • (2000) Mutat Res , vol.471 , pp. 95-105
    • Van Duijn-Goedhart, A.1    Zdzienicka, M.Z.2    Sankaranarayanan, K.3    Van Buul, P.P.4
  • 48
    • 11244280890 scopus 로고    scopus 로고
    • Involvement of poly(ADP-ribose) polymerase-1 and XRCC1/DNA ligase III in an alternative route for DNA double-strand breaks rejoining
    • Audebert M, Salles B, Calsou P. Involvement of poly(ADP-ribose) polymerase-1 and XRCC1/DNA ligase III in an alternative route for DNA double-strand breaks rejoining. J Biol Chem 2004; 279: 55117-55126.
    • (2004) J Biol Chem , vol.279 , pp. 55117-55126
    • Audebert, M.1    Salles, B.2    Calsou, P.3
  • 49
    • 79958109315 scopus 로고    scopus 로고
    • A DNAdependent stress response involving DNA-PK occurs in hypoxic cells and contributes to cellular adaptation to hypoxia
    • Bouquet F, Ousset M, Biard D, Fallone F, Dauvillier S, Frit P et al. A DNAdependent stress response involving DNA-PK occurs in hypoxic cells and contributes to cellular adaptation to hypoxia. J Cell Sci 2011; 124 (Pt 11): 1943-1951.
    • (2011) J Cell Sci , vol.124 , pp. 1943-1951
    • Bouquet, F.1    Ousset, M.2    Biard, D.3    Fallone, F.4    Dauvillier, S.5    Frit, P.6
  • 50
    • 57849144238 scopus 로고    scopus 로고
    • Large interindividual differences in cellular sensitivity to calicheamicin may influence gemtuzumab ozogamicin response in acute myeloid leukemia
    • Goemans BF, Zwaan CM, Vijverberg SJH, Loonen AH, Creutzig U, Hählen K et al. Large interindividual differences in cellular sensitivity to calicheamicin may influence gemtuzumab ozogamicin response in acute myeloid leukemia. Leukemia 2008; 22: 2284-2285.
    • (2008) Leukemia , vol.22 , pp. 2284-2285
    • Goemans, B.F.1    Zwaan, C.M.2    Sjh, V.3    Loonen, A.H.4    Creutzig, U.5    Hählen, K.6
  • 51
    • 34249654627 scopus 로고    scopus 로고
    • The role of gemtuzumab ozogamicin in the treatment of acute myeloid leukemia patients
    • Pagano L, Fianchi L, Caira M, Rutella S, Leone G. The role of gemtuzumab ozogamicin in the treatment of acute myeloid leukemia patients. Oncogene 2007; 26: 3679-3690.
    • (2007) Oncogene , vol.26 , pp. 3679-3690
    • Pagano, L.1    Fianchi, L.2    Caira, M.3    Rutella, S.4    Leone, G.5
  • 52
    • 78651378808 scopus 로고    scopus 로고
    • Gemtuzumab ozogamicin for the treatment of acute promyelocytic leukemia: Mechanisms of action and resistance, safety and efficacy
    • Breccia M, Lo-Coco F. Gemtuzumab ozogamicin for the treatment of acute promyelocytic leukemia: mechanisms of action and resistance, safety and efficacy. Expert Opin Biol Ther 2011; 11: 225-234.
    • (2011) Expert Opin Biol Ther , vol.11 , pp. 225-234
    • Breccia, M.1    Lo-Coco, F.2
  • 53
    • 80052509765 scopus 로고    scopus 로고
    • Gemtuzumab ozogamicin in non-Acute promyelocytic acute myeloid leukemia
    • Hötter ML, Schlenk RF. Gemtuzumab ozogamicin in non-Acute promyelocytic acute myeloid leukemia. Expert Opin Biol Ther 2011; 11: 1369-1380.
    • (2011) Expert Opin Biol Ther , vol.11 , pp. 1369-1380
    • Hötter, M.L.1    Schlenk, R.F.2
  • 54
    • 84879134885 scopus 로고    scopus 로고
    • Efficacy and resistance of gemtuzumab ozogamicin for acute myeloid leukemia
    • Takeshita A. Efficacy and resistance of gemtuzumab ozogamicin for acute myeloid leukemia. Int J Hematol 2013; 97: 703-716.
    • (2013) Int J Hematol , vol.97 , pp. 703-716
    • Takeshita, A.1
  • 55
    • 84903940586 scopus 로고    scopus 로고
    • Gemtuzumab ozogamicin in acute myeloid leukemia revisited
    • Thol F, Schlenk RF. Gemtuzumab ozogamicin in acute myeloid leukemia revisited. Expert Opin Biol Ther 2014; 14: 1185-1195.
    • (2014) Expert Opin Biol Ther , vol.14 , pp. 1185-1195
    • Thol, F.1    Schlenk, R.F.2
  • 56
    • 84887079391 scopus 로고    scopus 로고
    • Gemtuzumab ozogamicin can reduce minimal residual disease in patients with childhood acute myeloid leukemia
    • O'Hear C, Inaba H, Pounds S, Shi L, Dahl G, Bowman WP et al. Gemtuzumab ozogamicin can reduce minimal residual disease in patients with childhood acute myeloid leukemia. Cancer 2013; 119: 4036-4043.
    • (2013) Cancer , vol.119 , pp. 4036-4043
    • O'Hear, C.1    Inaba, H.2    Pounds, S.3    Shi, L.4    Dahl, G.5    Bowman, W.P.6
  • 57
    • 33845526373 scopus 로고    scopus 로고
    • High efficacy and safety profile of fractionated doses of Mylotarg as induction therapy in patients with relapsed acute myeloblastic leukemia: A prospective study of the alfa group
    • Taksin AL, Legrand O, Raffoux E, de Revel T, Thomas X, Contentin N et al. High efficacy and safety profile of fractionated doses of Mylotarg as induction therapy in patients with relapsed acute myeloblastic leukemia: A prospective study of the alfa group. Leukemia 2007; 21: 66-71.
    • (2007) Leukemia , vol.21 , pp. 66-71
    • Taksin, A.L.1    Legrand, O.2    Raffoux, E.3    De Revel, T.4    Thomas, X.5    Contentin, N.6
  • 58
    • 84961671223 scopus 로고    scopus 로고
    • Gemtuzumab ozogamicin versus best supportive care in older patients with newly diagnosed acute myeloid leukemia unsuitable for intensive chemotherapy: Results of the randomized phase III EORTC-GIMEMA AML-19 trial
    • Amadori S, Suciu S, Selleslag D, Aversa F, Gaidano G, Musso M et al. Gemtuzumab ozogamicin versus best supportive care in older patients with newly diagnosed acute myeloid leukemia unsuitable for intensive chemotherapy: results of the randomized phase III EORTC-GIMEMA AML-19 trial. J Clin Oncol 2016; 34: 972-979.
    • (2016) J Clin Oncol , vol.34 , pp. 972-979
    • Amadori, S.1    Suciu, S.2    Selleslag, D.3    Aversa, F.4    Gaidano, G.5    Musso, M.6
  • 59
    • 84873409057 scopus 로고    scopus 로고
    • The addition of gemtuzumab ozogamicin to low-dose Ara-C improves remission rate but does not significantly prolong survival in older patients with acute myeloid leukaemia: Results from the LRF AML14 and NCRI AML16 pick-A-winner comparison
    • Burnett AK, Hills RK, Hunter AE, Milligan D, Kell WJ, Wheatley K et al. The addition of gemtuzumab ozogamicin to low-dose Ara-C improves remission rate but does not significantly prolong survival in older patients with acute myeloid leukaemia: results from the LRF AML14 and NCRI AML16 pick-A-winner comparison. Leukemia 2013; 27: 75-81.
    • (2013) Leukemia , vol.27 , pp. 75-81
    • Burnett, A.K.1    Hills, R.K.2    Hunter, A.E.3    Milligan, D.4    Kell, W.J.5    Wheatley, K.6
  • 60
    • 84937804118 scopus 로고    scopus 로고
    • International phase 3 study of azacitidine vs conventional care regimens in older patients with newly diagnosed AML with 430% blasts
    • Dombret H, Seymour JF, Butrym A, Wierzbowska A, Selleslag D, Jang JH et al. International phase 3 study of azacitidine vs conventional care regimens in older patients with newly diagnosed AML with 430% blasts. Blood 2015; 126: 291-299.
    • (2015) Blood , vol.126 , pp. 291-299
    • Dombret, H.1    Seymour, J.F.2    Butrym, A.3    Wierzbowska, A.4    Selleslag, D.5    Jang, J.H.6
  • 61
    • 33750061003 scopus 로고    scopus 로고
    • Effect of gemtuzumab ozogamicin on acute myeloid leukemia blast cells in vitro, as a single agent and combined with other cytotoxic cells
    • Morris KL, Adams JA, Liu JA. Effect of gemtuzumab ozogamicin on acute myeloid leukemia blast cells in vitro, as a single agent and combined with other cytotoxic cells. Br J Haematol 2006; 135: 509-512.
    • (2006) Br J Haematol , vol.135 , pp. 509-512
    • Morris, K.L.1    Adams, J.A.2    Liu, J.A.3
  • 62
    • 75149163333 scopus 로고    scopus 로고
    • The cytotoxic effects of gemtuzumab ozogamicin (mylotarg) in combination with conventional antileukemic agents by isobologram analysis in vitro
    • Tanaka M, Kano Y, Akutsu M, Tsunoda S, Izumi T, Yazawa Y et al. The cytotoxic effects of gemtuzumab ozogamicin (mylotarg) in combination with conventional antileukemic agents by isobologram analysis in vitro. Anticancer Res 2009; 29: 4589-4596.
    • (2009) Anticancer Res , vol.29 , pp. 4589-4596
    • Tanaka, M.1    Kano, Y.2    Akutsu, M.3    Tsunoda, S.4    Izumi, T.5    Yazawa, Y.6
  • 63
    • 79952020383 scopus 로고    scopus 로고
    • Improved outcome of patients with low-And intermediate-risk cytogenetics acute myeloid leukemia (AML) in first relapse with gemtuzumab and cytarabine versus cytarabine: Results of a retrospective comparative study
    • Prebet T, Etienne A, Devillier R, Romeo E, Charbonnier A, D'Incan E et al. Improved outcome of patients with low-And intermediate-risk cytogenetics acute myeloid leukemia (AML) in first relapse with gemtuzumab and cytarabine versus cytarabine: results of a retrospective comparative study. Cancer 2011; 117: 974-981.
    • (2011) Cancer , vol.117 , pp. 974-981
    • Prebet, T.1    Etienne, A.2    Devillier, R.3    Romeo, E.4    Charbonnier, A.5    D'Incan, E.6
  • 64
    • 84907326228 scopus 로고    scopus 로고
    • Corebinding factor acute myeloid leukemia in first relapse: A retrospective study from the French AML Intergroup
    • Hospital MA, Prebet T, Bertoli S, Thomas X, Tavernier E, Braun T et al. Corebinding factor acute myeloid leukemia in first relapse: A retrospective study from the French AML Intergroup. Blood 2014; 124: 1312-1319.
    • (2014) Blood , vol.124 , pp. 1312-1319
    • Hospital, M.A.1    Prebet, T.2    Bertoli, S.3    Thomas, X.4    Tavernier, E.5    Braun, T.6
  • 65
    • 85020406458 scopus 로고    scopus 로고
    • Impact of salvage regimens on response and overall survival in acute myeloid leukemia with induction failure
    • Wattad M, Weber D, Döhner K, Krauter J, Gaidzik VI, Paschka P et al. Impact of salvage regimens on response and overall survival in acute myeloid leukemia with induction failure. Leukemia 2017; 31: 1306-1313.
    • Leukemia , vol.2017 , Issue.31 , pp. 1306-1313
    • Wattad, M.1    Weber, D.2    Döhner, K.3    Krauter, J.4    Gaidzik, V.I.5    Paschka, P.6
  • 66
    • 79952099282 scopus 로고    scopus 로고
    • Identification of patients with acute myeloblastic leukemia who benefit from the addition of gemtuzumab ozogamicin: Results of the MRC AML15 trial
    • Burnett AK, Hills RK, Milligan D, Kjeldsen L, Kell J, Russell NH et al. Identification of patients with acute myeloblastic leukemia who benefit from the addition of gemtuzumab ozogamicin: results of the MRC AML15 trial. J Clin Oncol 2011; 29: 369-377.
    • (2011) J Clin Oncol , vol.29 , pp. 369-377
    • Burnett, A.K.1    Hills, R.K.2    Milligan, D.3    Kjeldsen, L.4    Kell, J.5    Russell, N.H.6
  • 67
    • 84863522871 scopus 로고    scopus 로고
    • Addition of gemtuzumab ozogamicin to induction chemotherapy improves survival in older patients with acute myeloid leukemia
    • Burnett AK, Russell NH, Hills RK, Kell J, Freeman S, Kjeldsen L et al. Addition of gemtuzumab ozogamicin to induction chemotherapy improves survival in older patients with acute myeloid leukemia. J Clin Oncol 2012; 30: 3924-3931.
    • (2012) J Clin Oncol , vol.30 , pp. 3924-3931
    • Burnett, A.K.1    Russell, N.H.2    Hills, R.K.3    Kell, J.4    Freeman, S.5    Kjeldsen, L.6
  • 68
    • 84859911350 scopus 로고    scopus 로고
    • Effect of gemtuzumab ozogamicin on survival of adult patients with de-novo acute myeloid leukaemia (ALFA-0701): A randomised open-label phase 3 study
    • Castaigne S, Pautas C, Terré C, Raffoux E, Bordessoule D, Bastie JN et al. Effect of gemtuzumab ozogamicin on survival of adult patients with de-novo acute myeloid leukaemia (ALFA-0701): A randomised, open-label, phase 3 study. Lancet 2012; 379: 1508-1516.
    • (2012) Lancet , vol.379 , pp. 1508-1516
    • Castaigne, S.1    Pautas, C.2    Terré, C.3    Raffoux, E.4    Bordessoule, D.5    Bastie, J.N.6
  • 69
    • 84861733011 scopus 로고    scopus 로고
    • Addition of gemtuzumab ozogamycin to chemotherapy improves event-free survival but not overall survival of AML patients with intermediate cytogenetics not eligible for allogeneic transplantation. Results of the GOELAMS AML 2006 IR study [abstract]
    • Delaunay J, Recher C, Pigneux A, Witz F, Vey N, Blanchet O et al. Addition of gemtuzumab ozogamycin to chemotherapy improves event-free survival but not overall survival of AML patients with intermediate cytogenetics not eligible for allogeneic transplantation. Results of the GOELAMS AML 2006 IR study [abstract]. Blood 2011; 118: 37-38.
    • (2011) Blood , vol.118 , pp. 37-38
    • Delaunay, J.1    Recher, C.2    Pigneux, A.3    Witz, F.4    Vey, N.5    Blanchet, O.6
  • 70
    • 84881305790 scopus 로고    scopus 로고
    • A phase 3 study of gemtuzumab ozogamicin during induction and postconsolidation therapy in younger patients with acute myeloid leukemia
    • Petersdorf SH, Kopecky KJ, Slovak M, Willman C, Nevill T, Brandwein J et al. A phase 3 study of gemtuzumab ozogamicin during induction and postconsolidation therapy in younger patients with acute myeloid leukemia. Blood 2013; 121: 4854-4860.
    • (2013) Blood , vol.121 , pp. 4854-4860
    • Petersdorf, S.H.1    Kopecky, K.J.2    Slovak, M.3    Willman, C.4    Nevill, T.5    Brandwein, J.6
  • 73
    • 84932615484 scopus 로고    scopus 로고
    • A randomized comparison of daunorubicin 90 mg/m2 vs 60 mg/m2 in AML induction: Results from the UK NCRI AML17 trial in 1206 patients
    • Burnett AK, Russell NH, Hills RK, Kell J, Cavenagh J, Kjeldsen L et al. A randomized comparison of daunorubicin 90 mg/m2 vs 60 mg/m2 in AML induction: results from the UK NCRI AML17 trial in 1206 patients. Blood 2015; 125: 3878-3885.
    • (2015) Blood , vol.125 , pp. 3878-3885
    • Burnett, A.K.1    Russell, N.H.2    Hills, R.K.3    Kell, J.4    Cavenagh, J.5    Kjeldsen, L.6
  • 74
    • 84905560676 scopus 로고    scopus 로고
    • Addition of gemtuzumab ozogamicin to induction chemotherapy in adult patients with acute myeloid leukaemia: A meta-Analysis of individual patient data from randomised controlled trials
    • Hills RK, Castaigne S, Appelbaum FR, Delaunay J, Petersdorf S, Othus M et al. Addition of gemtuzumab ozogamicin to induction chemotherapy in adult patients with acute myeloid leukaemia: A meta-Analysis of individual patient data from randomised controlled trials. Lancet Oncol 2014; 15: 986-996.
    • (2014) Lancet Oncol , vol.15 , pp. 986-996
    • Hills, R.K.1    Castaigne, S.2    Appelbaum, F.R.3    Delaunay, J.4    Petersdorf, S.5    Othus, M.6
  • 75
    • 84971506977 scopus 로고    scopus 로고
    • Defining the dose of gemtuzumab ozogamicin in combination with induction chemotherapy in acute myeloid leukemia: A comparison of 3 mg/m2 with 6 mg/m2 in the NCRI AML17 Trial
    • Burnett A, Cavenagh J, Russell N, Hills R, Kell J, Jones G et al. Defining the dose of gemtuzumab ozogamicin in combination with induction chemotherapy in acute myeloid leukemia: A comparison of 3 mg/m2 with 6 mg/m2 in the NCRI AML17 Trial. Haematologica 2016; 101: 724-731.
    • (2016) Haematologica , vol.101 , pp. 724-731
    • Burnett, A.1    Cavenagh, J.2    Russell, N.3    Hills, R.4    Kell, J.5    Jones, G.6
  • 76
    • 84894352589 scopus 로고    scopus 로고
    • Sequential combination of gemtuzumab ozogamicin and standard chemotherapy in older patients with newly diagnosed acute myeloid leukemia: Results of a randomized phase III trial by the EORTC and GIMEMA consortium (AML-17
    • Amadori S, Suciu S, Stasi R, Salih HR, Selleslag D, Muus P et al. Sequential combination of gemtuzumab ozogamicin and standard chemotherapy in older patients with newly diagnosed acute myeloid leukemia: results of a randomized phase III trial by the EORTC and GIMEMA consortium (AML-17). J Clin Oncol 2013; 31: 4424-4430.
    • (2013) J Clin Oncol , vol.31 , pp. 4424-4430
    • Amadori, S.1    Suciu, S.2    Stasi, R.3    Salih, H.R.4    Selleslag, D.5    Muus, P.6
  • 77
    • 84859502851 scopus 로고    scopus 로고
    • Induction therapy of AML with ara-C plus daunorubicin versus ara-C plus gemtuzumab ozogamicin: A randomized phase II trial in elderly patients
    • Brunnberg U, Mohr M, Noppeney R, Dörk HA, Sauerland MC, Möller-Tidow C et al. Induction therapy of AML with ara-C plus daunorubicin versus ara-C plus gemtuzumab ozogamicin: A randomized phase II trial in elderly patients. Ann Oncol 2012; 23: 990-996.
    • (2012) Ann Oncol , vol.23 , pp. 990-996
    • Brunnberg, U.1    Mohr, M.2    Noppeney, R.3    Dörk, H.A.4    Sauerland, M.C.5    Möller-Tidow, C.6
  • 78
    • 84907192040 scopus 로고    scopus 로고
    • Gemtuzumab ozogamicin in children and adolescents with de novo acute myeloid leukemia improves event-free survival by reducing relapse risk: Results from the randomized phase III Children's Oncology Group trial AAML0531
    • Gamis AS, Alonzo TA, Meshinchi S, Sung L, Gerbing RB, Raimondi SC et al. Gemtuzumab ozogamicin in children and adolescents with de novo acute myeloid leukemia improves event-free survival by reducing relapse risk: results from the randomized phase III Children's Oncology Group trial AAML0531. J Clin Oncol 2014; 32: 3021-3032.
    • (2014) J Clin Oncol , vol.32 , pp. 3021-3032
    • Gamis, A.S.1    Alonzo, T.A.2    Meshinchi, S.3    Sung, L.4    Gerbing, R.B.5    Raimondi, S.C.6
  • 79
    • 84966376848 scopus 로고    scopus 로고
    • Gemtuzumab ozogamicin reduces relapse risk in FLT3/ITD acute myeloid leukemia: A report from the Children's Oncology Group
    • Tarlock K, Alonzo TA, Gerbing RB, Raimondi SC, Hirsch BA, Sung L et al. Gemtuzumab ozogamicin reduces relapse risk in FLT3/ITD acute myeloid leukemia: A report from the Children's Oncology Group. Clin Cancer Res 2016; 22: 1951-1957.
    • (2016) Clin Cancer Res , vol.22 , pp. 1951-1957
    • Tarlock, K.1    Alonzo, T.A.2    Gerbing, R.B.3    Raimondi, S.C.4    Hirsch, B.A.5    Sung, L.6
  • 80
    • 77950992731 scopus 로고    scopus 로고
    • Gemtuzumab ozogamicin as postremission treatment in AML at 60 years of age or more: Results of a multicenter phase 3 study
    • Löwenberg B, Beck J, Graux C, van Putten W, Schouten HC, Verdonck LF et al. Gemtuzumab ozogamicin as postremission treatment in AML at 60 years of age or more: results of a multicenter phase 3 study. Blood 2010; 115: 2586-2591.
    • (2010) Blood , vol.115 , pp. 2586-2591
    • Löwenberg, B.1    Beck, J.2    Graux, C.3    Van Putten, W.4    Schouten, H.C.5    Verdonck, L.F.6
  • 81
    • 79956369016 scopus 로고    scopus 로고
    • Autologous transplantation gives encouraging results for young adults with favorable-risk acute myeloid leukemia, but is not improved with gemtuzumab ozogamicin
    • Fernandez HF, Sun Z, Litzow MR, Luger SM, Paietta EM, Racevskis J et al. Autologous transplantation gives encouraging results for young adults with favorable-risk acute myeloid leukemia, but is not improved with gemtuzumab ozogamicin. Blood 2011; 117: 5306-5313.
    • (2011) Blood , vol.117 , pp. 5306-5313
    • Fernandez, H.F.1    Sun, Z.2    Litzow, M.R.3    Luger, S.M.4    Paietta, E.M.5    Racevskis, J.6
  • 82
    • 84864548693 scopus 로고    scopus 로고
    • Gemtuzumab ozogamicin as postconsolidation therapy does not prevent relapse in children with AML: Results from nopho-AML
    • Hasle H, Abrahamsson J, Forestier E, Ha SY, Heldrup J, Jahnukainen K et al. Gemtuzumab ozogamicin as postconsolidation therapy does not prevent relapse in children with AML: results from NOPHO-AML 2004. Blood 2012; 120: 978-984.
    • (2012) Blood 2004 , vol.120 , pp. 978-984
    • Hasle, H.1    Abrahamsson, J.2    Forestier, E.3    Ha, S.Y.4    Heldrup, J.5    Jahnukainen, K.6
  • 83
    • 80052540027 scopus 로고    scopus 로고
    • Targeted drug delivery by gemtuzumab ozogamicin: Mechanism-based mathematical model for treatment strategy improvement and therapy individualization
    • Jager E, van der Velden VHJ, te Marvelde JG, Walter RB, Agur Z, Vainstein V. Targeted drug delivery by gemtuzumab ozogamicin: mechanism-based mathematical model for treatment strategy improvement and therapy individualization. PLoS One 2011; 6: e24265.
    • (2011) PLoS One , vol.6 , pp. e24265
    • Jager, E.1    Van Der Velden Vhj2    Te Marvelde, J.G.3    Walter, R.B.4    Agur, Z.5    Vainstein, V.6
  • 84
    • 84948978098 scopus 로고    scopus 로고
    • Arsenic trioxide and all-Trans retinoic acid treatment for acute promyelocytic leukaemia in all risk groups (AML17): Results of a randomised, controlled, phase 3 trial
    • Burnett AK, Russell NH, Hills RK, Bowen D, Kell J, Knapper S et al. Arsenic trioxide and all-Trans retinoic acid treatment for acute promyelocytic leukaemia in all risk groups (AML17): results of a randomised, controlled, phase 3 trial. Lancet Oncol 2015; 16: 1295-1305.
    • (2015) Lancet Oncol , vol.16 , pp. 1295-1305
    • Burnett, A.K.1    Russell, N.H.2    Hills, R.K.3    Bowen, D.4    Kell, J.5    Knapper, S.6
  • 85
    • 85028844290 scopus 로고    scopus 로고
    • ATRA, arsenic trioxide (ATO), and gemtuzumab ozogamicin (GO) is safe and highly effective in patinets with previously untreated high-risk acute promyelocytic leukemia (APL): Final results of the SWOG/Alliance/ECOG S0535 trial [abstract]
    • Lancet JE, Moseley A, Komrokji RS, Coutre SE, DeAngelo DJ, Tallman MS et al. ATRA, arsenic trioxide (ATO), and gemtuzumab ozogamicin (GO) is safe and highly effective in patinets with previously untreated high-risk acute promyelocytic leukemia (APL): final results of the SWOG/Alliance/ECOG S0535 trial [abstract]. Blood 2016; 128: 896.
    • (2016) Blood , vol.128 , pp. 896
    • Lancet, J.E.1    Moseley, A.2    Komrokji, R.S.3    Coutre, S.E.4    Deangelo, D.J.5    Tallman, M.S.6
  • 86
    • 85015251442 scopus 로고    scopus 로고
    • Long-Term outcome of acute promyelocytic leukemia treated with all-Transretinoic acid, arsenic trioxide, and gemtuzumab
    • Abaza Y, Kantarjian H, Garcia-Manero G, Estey E, Borthakur G, Jabbour E et al. Long-Term outcome of acute promyelocytic leukemia treated with all-Transretinoic acid, arsenic trioxide, and gemtuzumab. Blood 2017; 129: 1275-1283.
    • Blood , vol.2017 , Issue.129 , pp. 1275-1283
    • Abaza, Y.1    Kantarjian, H.2    Garcia-Manero, G.3    Estey, E.4    Borthakur, G.5    Jabbour, E.6
  • 87
    • 23744476933 scopus 로고    scopus 로고
    • Efficacy of gemtuzumab ozogamicin on ATRA-And arsenic-resistant acute promyelocytic leukemia (APL) cells
    • Takeshita A, Shinjo K, Naito K, Matsui H, Sahara N, Shigeno K et al. Efficacy of gemtuzumab ozogamicin on ATRA-And arsenic-resistant acute promyelocytic leukemia (APL) cells. Leukemia 2005; 19: 1306-1311.
    • (2005) Leukemia , vol.19 , pp. 1306-1311
    • Takeshita, A.1    Shinjo, K.2    Naito, K.3    Matsui, H.4    Sahara, N.5    Shigeno, K.6
  • 88
    • 85028883120 scopus 로고    scopus 로고
    • Pfizer Inc (accessed 6 May 2017)
    • Pfizer Inc 2010. Available at http://media.pfizer.com/files/products/mylotarg-hcp-letter.pdf (accessed 6 May 2017).
    • (2010)
  • 89
    • 84879551925 scopus 로고    scopus 로고
    • Differences in drug approval processes of 3 regulatory agencies: A case study of gemtuzumab ozogamicin
    • Tanimoto T, Tsubokura M, Mori J, Pietrek M, Ono S, Kami M. Differences in drug approval processes of 3 regulatory agencies: A case study of gemtuzumab ozogamicin. Invest New Drugs 2013; 31: 473-478.
    • (2013) Invest New Drugs , vol.31 , pp. 473-478
    • Tanimoto, T.1    Tsubokura, M.2    Mori, J.3    Pietrek, M.4    Ono, S.5    Kami, M.6
  • 91
    • 2342572260 scopus 로고    scopus 로고
    • High CD33-Antigen loads in peripheral blood limit the efficacy of gemtuzumab ozogamicin (Mylotarg) treatment in acute myeloid leukemia patients
    • van der Velden VHJ, Boeckx N, Jedema I, te Marvelde JG, Hoogeveen PG, Boogaerts M et al. High CD33-Antigen loads in peripheral blood limit the efficacy of gemtuzumab ozogamicin (Mylotarg) treatment in acute myeloid leukemia patients. Leukemia 2004; 18: 983-988.
    • (2004) Leukemia , vol.18 , pp. 983-988
    • Van Der Velden Vhj1    Boeckx, N.2    Jedema, I.3    Te Marvelde, J.G.4    Hoogeveen, P.G.5    Boogaerts, M.6
  • 92
    • 33845201539 scopus 로고    scopus 로고
    • Analysis of the CD33-related siglec family reveals that Siglec-9 is an endocytic receptor expressed on subsets of acute myeloid leukemia cells and absent from normal hematopoietic progenitors
    • Biedermann B, Gil D, Bowen DT, Crocker PR. Analysis of the CD33-related siglec family reveals that Siglec-9 is an endocytic receptor expressed on subsets of acute myeloid leukemia cells and absent from normal hematopoietic progenitors. Leuk Res 2007; 31: 211-220.
    • (2007) Leuk Res , vol.31 , pp. 211-220
    • Biedermann, B.1    Gil, D.2    Bowen, D.T.3    Crocker, P.R.4
  • 95
    • 84898882005 scopus 로고    scopus 로고
    • Mcl-1 dependence predicts response to vorinostat and gemtuzumab ozogamicin in acute myeloid leukemia
    • Pierceall WE, Lena RJ, Medeiros BC, Blake N, Doykan C, Elashoff M et al. Mcl-1 dependence predicts response to vorinostat and gemtuzumab ozogamicin in acute myeloid leukemia. Leuk Res 2014; 38: 564-568.
    • (2014) Leuk Res , vol.38 , pp. 564-568
    • Pierceall, W.E.1    Lena, R.J.2    Medeiros, B.C.3    Blake, N.4    Doykan, C.5    Elashoff, M.6
  • 96
    • 84872174451 scopus 로고    scopus 로고
    • AKT signaling as a novel factor associated with in vitro resistance of human AML to gemtuzumab ozogamicin
    • Rosen DB, Harrington KH, Cordeiro JA, Leung LY, Putta S, Lacayo N et al. AKT signaling as a novel factor associated with in vitro resistance of human AML to gemtuzumab ozogamicin. PLoS One 2013; 8: e53518.
    • (2013) PLoS One , vol.8 , pp. e53518
    • Rosen, D.B.1    Harrington, K.H.2    Cordeiro, J.A.3    Leung, L.Y.4    Putta, S.5    Lacayo, N.6
  • 97
    • 12844257365 scopus 로고    scopus 로고
    • Influence of CD33 expression levels and ITIM-dependent internalization on gemtuzumab ozogamicin-induced cytotoxicity
    • Walter RB, Raden BW, Kamikura DM, Cooper JA, Bernstein ID. Influence of CD33 expression levels and ITIM-dependent internalization on gemtuzumab ozogamicin-induced cytotoxicity. Blood 2005; 105: 1295-1302.
    • (2005) Blood , vol.105 , pp. 1295-1302
    • Walter, R.B.1    Raden, B.W.2    Kamikura, D.M.3    Cooper, J.A.4    Bernstein, I.D.5
  • 98
    • 34248338806 scopus 로고    scopus 로고
    • CD33 expression and P-glycoprotein-mediated drug efflux inversely correlate and predict clinical outcome in patients with acute myeloid leukemia treated with gemtuzumab ozogamicin monotherapy
    • Walter RB, Gooley TA, van der Velden VH, Loken MR, van Dongen JJ, Flowers DA et al. CD33 expression and P-glycoprotein-mediated drug efflux inversely correlate and predict clinical outcome in patients with acute myeloid leukemia treated with gemtuzumab ozogamicin monotherapy. Blood 2007; 109: 4168-4170.
    • (2007) Blood , vol.109 , pp. 4168-4170
    • Walter, R.B.1    Gooley, T.A.2    Van Der Velden, V.H.3    Loken, M.R.4    Van Dongen, J.J.5    Flowers, D.A.6
  • 100
    • 84977632889 scopus 로고    scopus 로고
    • Recommendations for myeloid-derived suppressor cell nomenclature and characterization standards
    • Bronte V, Brandau S, Chen SH, Colombo MP, Frey AB, Greten TF et al. Recommendations for myeloid-derived suppressor cell nomenclature and characterization standards. Nat Commun 2016; 7: 12150.
    • (2016) Nat Commun , vol.7 , pp. 12150
    • Bronte, V.1    Brandau, S.2    Chen, S.H.3    Colombo, M.P.4    Frey, A.B.5    Greten, T.F.6
  • 101
    • 84962651733 scopus 로고    scopus 로고
    • HFE gene mutation status predicts response to gemtuzumab ozogamicin in AML [abstract]
    • Paubelle E, Marceau A, Zylbersztejn F, Dussiot M, Moura IC, C-L P et al. HFE gene mutation status predicts response to gemtuzumab ozogamicin in AML [abstract]. Blood 2015; 126: 1307.
    • (2015) Blood , vol.126 , pp. 1307
    • Paubelle, E.1    Marceau, A.2    Zylbersztejn, F.3    Dussiot, M.4    Moura, I.C.5
  • 102
    • 77954900623 scopus 로고    scopus 로고
    • Sequence of administration and methylation of SOCS3 may govern response to gemtuzumab ozogamicin in combination with conventional chemotherapy in patients with refractory or relapsed acute myelogenous leukemia (AML)
    • Middeldorf I, Galm O, Osieka R, Jost E, Herman JG, Wilop S. Sequence of administration and methylation of SOCS3 may govern response to gemtuzumab ozogamicin in combination with conventional chemotherapy in patients with refractory or relapsed acute myelogenous leukemia (AML). Am J Hematol 2010; 85: 477-481.
    • (2010) Am J Hematol , vol.85 , pp. 477-481
    • Middeldorf, I.1    Galm, O.2    Osieka, R.3    Jost, E.4    Herman, J.G.5    Wilop, S.6
  • 103
    • 0033179095 scopus 로고    scopus 로고
    • Frequency and clinical significance of the expression of the multidrug resistance proteins MDR1/P-glycoprotein MRP1, and LRP in acute myeloid leukemia: A Southwest Oncology Group Study
    • Leith CP, Kopecky KJ, Chen IM, Eijdems L, Slovak ML, McConnell TS et al. Frequency and clinical significance of the expression of the multidrug resistance proteins MDR1/P-glycoprotein, MRP1, and LRP in acute myeloid leukemia: A Southwest Oncology Group Study. Blood 1999; 94: 1086-1099.
    • (1999) Blood , vol.94 , pp. 1086-1099
    • Leith, C.P.1    Kopecky, K.J.2    Chen, I.M.3    Eijdems, L.4    Slovak, M.L.5    McConnell, T.S.6
  • 104
    • 0033179207 scopus 로고    scopus 로고
    • Simultaneous activity of MRP1 and Pgp is correlated with in vitro resistance to daunorubicin and with in vivo resistance in adult acute myeloid leukemia
    • Legrand O, Simonin G, Beauchamp-Nicoud A, Zittoun R, Marie JP. Simultaneous activity of MRP1 and Pgp is correlated with in vitro resistance to daunorubicin and with in vivo resistance in adult acute myeloid leukemia. Blood 1999; 94: 1046-1056.
    • (1999) Blood , vol.94 , pp. 1046-1056
    • Legrand, O.1    Simonin, G.2    Beauchamp-Nicoud, A.3    Zittoun, R.4    Marie, J.P.5
  • 105
    • 0842307005 scopus 로고    scopus 로고
    • P-glycoprotein and multidrug resistance associated protein-1 activity in 132 acute myeloid leukemias according to FAB subtypes and cytogenetics risk groups
    • Legrand O, Zompi S, Perrot JY, Faussat AM, Benderra Z, Chaoui D et al. P-glycoprotein and multidrug resistance associated protein-1 activity in 132 acute myeloid leukemias according to FAB subtypes and cytogenetics risk groups. Haematologica 2004; 89: 34-41.
    • (2004) Haematologica , vol.89 , pp. 34-41
    • Legrand, O.1    Zompi, S.2    Perrot, J.Y.3    Faussat, A.M.4    Benderra, Z.5    Chaoui, D.6
  • 106
    • 37249024134 scopus 로고    scopus 로고
    • Sequential influences of leukemia-specific and genetic factors on p-glycoprotein expression in blasts from 817 patients entered into the National Cancer Research Network acute myeloid leukemia 14 and 15 trials
    • Seedhouse CH, Grundy M, White P, Li Y, Fisher J, Yakunina D et al. Sequential influences of leukemia-specific and genetic factors on p-glycoprotein expression in blasts from 817 patients entered into the National Cancer Research Network acute myeloid leukemia 14 and 15 trials. Clin Cancer Res 2007; 13: 7059-7066.
    • (2007) Clin Cancer Res , vol.13 , pp. 7059-7066
    • Seedhouse, C.H.1    Grundy, M.2    White, P.3    Li, Y.4    Fisher, J.5    Yakunina, D.6
  • 107
    • 25144485908 scopus 로고    scopus 로고
    • Final report of the efficacy and safety of gemtuzumab ozogamicin (Mylotarg) in patients with CD33-positive acute myeloid leukemia in first recurrence
    • Larson RA, Sievers EL, Stadtmauer EA, Löwenberg B, Estey EH, Dombret H et al. Final report of the efficacy and safety of gemtuzumab ozogamicin (Mylotarg) in patients with CD33-positive acute myeloid leukemia in first recurrence. Cancer 2005; 104: 1442-1452.
    • (2005) Cancer , vol.104 , pp. 1442-1452
    • Larson, R.A.1    Sievers, E.L.2    Stadtmauer, E.A.3    Löwenberg, B.4    Estey, E.H.5    Dombret, H.6
  • 108
    • 51649119906 scopus 로고    scopus 로고
    • Impaired CD163-mediated hemoglobin-scavenging and severe toxic symptoms in patients treated with gemtuzumab ozogamicin
    • Maniecki MB, Hasle H, Friis-Hansen L, Lausen B, Nielsen OJ, Bendix K et al. Impaired CD163-mediated hemoglobin-scavenging and severe toxic symptoms in patients treated with gemtuzumab ozogamicin. Blood 2008; 112: 1510-1514.
    • (2008) Blood , vol.112 , pp. 1510-1514
    • Maniecki, M.B.1    Hasle, H.2    Friis-Hansen, L.3    Lausen, B.4    Nielsen, O.J.5    Bendix, K.6
  • 109
    • 34147197520 scopus 로고    scopus 로고
    • Gemtuzumab ozogamicin-Associated sinusoidal obstructive syndrome (SOS): An overview from the research on adverse drug events and reports (RADAR) project
    • McKoy JM, Angelotta C, Bennett CL, Tallman MS, Wadleigh M, Evens AM et al. Gemtuzumab ozogamicin-Associated sinusoidal obstructive syndrome (SOS): An overview from the research on adverse drug events and reports (RADAR) project. Leuk Res 2007; 31: 599-604.
    • (2007) Leuk Res , vol.31 , pp. 599-604
    • McKoy, J.M.1    Angelotta, C.2    Bennett, C.L.3    Tallman, M.S.4    Wadleigh, M.5    Evens, A.M.6
  • 110
    • 84891676551 scopus 로고    scopus 로고
    • Incidence of sinusoidal obstruction syndrome following Mylotarg (gemtuzumab ozogamicin): A prospective observational study of 482 patients in routine clinical practice
    • Tallman MS, McDonald GB, DeLeve LD, Baer MR, Cook MN, Graepel GJ et al. Incidence of sinusoidal obstruction syndrome following Mylotarg (gemtuzumab ozogamicin): A prospective observational study of 482 patients in routine clinical practice. Int J Hematol 2013; 97: 456-464.
    • (2013) Int J Hematol , vol.97 , pp. 456-464
    • Tallman, M.S.1    McDonald, G.B.2    Deleve, L.D.3    Baer, M.R.4    Cook, M.N.5    Graepel, G.J.6
  • 111
    • 84961626164 scopus 로고    scopus 로고
    • Evaluation of gemtuzumab ozogamycin associated sinusoidal obstructive syndrome: Findings from an academic pharmacovigilance program review and a pharmaceutical sponsored registry
    • Magwood-Golston JS, Kessler S, Bennett CL. Evaluation of gemtuzumab ozogamycin associated sinusoidal obstructive syndrome: findings from an academic pharmacovigilance program review and a pharmaceutical sponsored registry. Leuk Res 2016; 44: 61-64.
    • (2016) Leuk Res , vol.44 , pp. 61-64
    • Magwood-Golston, J.S.1    Kessler, S.2    Bennett, C.L.3
  • 112
    • 85028301283 scopus 로고    scopus 로고
    • Sinusoidal obstruction syndrome following CD33-Targeted therapy in acute myeloid leukemia
    • Godwin CD, McDonald GB, Walter RB. Sinusoidal obstruction syndrome following CD33-Targeted therapy in acute myeloid leukemia. Blood 2017; 129: 2330-2332.
    • Blood , vol.2017 , Issue.129 , pp. 2330-2332
    • Godwin, C.D.1    McDonald, G.B.2    Walter, R.B.3
  • 113
    • 85009806794 scopus 로고    scopus 로고
    • Risk of sinusoidal obstruction syndrome in allogeneic stem cell transplantation after prior gemtuzumab ozogamicin treatment: A retrospective study from the Acute Leukemia Working Party of the EBMT
    • Battipaglia G, Labopin M, Candoni A, Fanin R, El Cheikh J, Blaise D et al. Risk of sinusoidal obstruction syndrome in allogeneic stem cell transplantation after prior gemtuzumab ozogamicin treatment: A retrospective study from the Acute Leukemia Working Party of the EBMT. Bone Marrow Transplant 2017; 52: 592-599.
    • Bone Marrow Transplant , vol.2017 , Issue.52 , pp. 592-599
    • Battipaglia, G.1    Labopin, M.2    Candoni, A.3    Fanin, R.4    El Cheikh, J.5    Blaise, D.6
  • 114
    • 0042442407 scopus 로고    scopus 로고
    • Prior gemtuzumab ozogamicin exposure significantly increases the risk of veno-occlusive disease in patients who undergo myeloablative allogeneic stem cell transplantation
    • Wadleigh M, Richardson PG, Zahrieh D, Lee SJ, Cutler C, Ho V et al. Prior gemtuzumab ozogamicin exposure significantly increases the risk of veno-occlusive disease in patients who undergo myeloablative allogeneic stem cell transplantation. Blood 2003; 102: 1578-1582.
    • (2003) Blood , vol.102 , pp. 1578-1582
    • Wadleigh, M.1    Richardson, P.G.2    Zahrieh, D.3    Lee, S.J.4    Cutler, C.5    Ho, V.6
  • 115
    • 41049106764 scopus 로고    scopus 로고
    • Determination of pharmacokinetic values of calicheamicin-Antibody conjugates in mice by plasmon resonance analysis of small (5 μl) blood samples
    • Boghaert ER, Khandke KM, Sridharan L, Dougher M, Dijoseph JF, Kunz A et al. Determination of pharmacokinetic values of calicheamicin-Antibody conjugates in mice by plasmon resonance analysis of small (5 μL) blood samples. Cancer Chemother Pharmacol 2008; 61: 1027-1035.
    • (2008) Cancer Chemother Pharmacol , vol.61 , pp. 1027-1035
    • Boghaert, E.R.1    Khandke, K.M.2    Sridharan, L.3    Dougher, M.4    Dijoseph, J.F.5    Kunz, A.6
  • 117
    • 85016983894 scopus 로고    scopus 로고
    • Liver microvascular injury and thrombocytopenia of antibody-calicheamicin conjugates in cynomolgus monkeys-mechanism and monitoring
    • Guffroy M, Falahatpisheh H, Biddle K, Kreeger J, Obert L, Walters K et al. Liver microvascular injury and thrombocytopenia of antibody-calicheamicin conjugates in cynomolgus monkeys-mechanism and monitoring. Clin Cancer Res 2017; 23: 1760-1770.
    • (2017) Clin Cancer Res , vol.23 , pp. 1760-1770
    • Guffroy, M.1    Falahatpisheh, H.2    Biddle, K.3    Kreeger, J.4    Obert, L.5    Walters, K.6
  • 118
    • 84862162222 scopus 로고    scopus 로고
    • Phase i studies of AVE9633, an anti-CD33 antibody-maytansinoid conjugate, in adult patients with relapsed/refractory acute myeloid leukemia
    • Lapusan S, Vidriales MB, Thomas X, de Botton S, Vekhoff A, Tang R et al. Phase I studies of AVE9633, an anti-CD33 antibody-maytansinoid conjugate, in adult patients with relapsed/refractory acute myeloid leukemia. Invest New Drugs 2012; 30: 1121-1131.
    • (2012) Invest New Drugs , vol.30 , pp. 1121-1131
    • Lapusan, S.1    Vidriales, M.B.2    Thomas, X.3    De Botton, S.4    Vekhoff, A.5    Tang, R.6
  • 119
    • 84875233141 scopus 로고    scopus 로고
    • Phase 1 study of an anti-CD33 immunotoxin, humanized monoclonal antibody M195 conjugated to recombinant gelonin (HUM-195/rGEL), in patients with advanced myeloid malignancies
    • Borthakur G, Rosenblum MG, Talpaz M, Daver N, Ravandi F, Faderl S et al. Phase 1 study of an anti-CD33 immunotoxin, humanized monoclonal antibody M195 conjugated to recombinant gelonin (HUM-195/rGEL), in patients with advanced myeloid malignancies. Haematologica 2013; 98: 217-221.
    • (2013) Haematologica , vol.98 , pp. 217-221
    • Borthakur, G.1    Rosenblum, M.G.2    Talpaz, M.3    Daver, N.4    Ravandi, F.5    Faderl, S.6
  • 120
    • 84886825064 scopus 로고    scopus 로고
    • SGNCD33A: A novel CD33-Targeting antibody-drug conjugate using a pyrrolobenzodiazepine dimer is active in models of drug-resistant AML
    • Kung Sutherland MS, Walter RB, Jeffrey SC, Burke PJ, Yu C, Kostner H et al. SGNCD33A: A novel CD33-Targeting antibody-drug conjugate using a pyrrolobenzodiazepine dimer is active in models of drug-resistant AML. Blood 2013; 122: 1455-1463.
    • (2013) Blood , vol.122 , pp. 1455-1463
    • Kung Sutherland, M.S.1    Walter, R.B.2    Jeffrey, S.C.3    Burke, P.J.4    Yu, C.5    Kostner, H.6
  • 121
    • 84962725190 scopus 로고    scopus 로고
    • IMGN779, a CD33-Targeted antibody-drug conjugate (ADC) with a novel DNA-Alkylating effector molecule, induces DNA damage, cell cycle arrest, and apoptosis in AML cells [abstract]
    • Watkins KM, Walker R, Fishkin N, Audette C, Kovtun Y, Romanelli A. IMGN779, a CD33-Targeted antibody-drug conjugate (ADC) with a novel DNA-Alkylating effector molecule, induces DNA damage, cell cycle arrest, and apoptosis in AML cells [abstract]. Blood 2015; 126: 1366.
    • (2015) Blood , vol.126 , pp. 1366
    • Watkins, K.M.1    Walker, R.2    Fishkin, N.3    Audette, C.4    Kovtun, Y.5    Romanelli, A.6
  • 122
    • 84962677073 scopus 로고    scopus 로고
    • A phase 1 trial of SGN-CD33A as monotherapy in patients with CD33-positive acute myeloid leukemia (AML) [abstract]
    • Stein AS, Walter RB, Erba HP, Fathi AT, Advani AS, Lancet JE et al. A phase 1 trial of SGN-CD33A as monotherapy in patients with CD33-positive acute myeloid leukemia (AML) [abstract]. Blood 2015; 126: 324.
    • (2015) Blood , vol.126 , pp. 324
    • Stein, A.S.1    Walter, R.B.2    Erba, H.P.3    Fathi, A.T.4    Advani, A.S.5    Lancet, J.E.6
  • 123
    • 85013878431 scopus 로고    scopus 로고
    • Vadastuximab talirine monotherapy in older patients with treatment naïve CD33-positive acute myeloid leukemia (AML) [abstract]
    • Bixby DL, Stein AS, Fathi AT, Kovacsovics TJ, Levy MY, Erba HP et al. Vadastuximab talirine monotherapy in older patients with treatment naïve CD33-positive acute myeloid leukemia (AML) [abstract]. Blood 2016; 128: 590.
    • (2016) Blood , vol.128 , pp. 590
    • Bixby, D.L.1    Stein, A.S.2    Fathi, A.T.3    Kovacsovics, T.J.4    Levy, M.Y.5    Erba, H.P.6
  • 124
    • 85015693101 scopus 로고    scopus 로고
    • A phase 1b study of vadastuximab talirine as maintenance and in combination with standard consolidation for patients with acute myeloid leukemia (AML) [abstract]
    • Yang J, Ravandi F, Advani AS, Vasu S, Walter RB, Faderl S et al. A phase 1b study of vadastuximab talirine as maintenance and in combination with standard consolidation for patients with acute myeloid leukemia (AML) [abstract]. Blood 2016; 128: 340.
    • (2016) Blood , vol.128 , pp. 340
    • Yang, J.1    Ravandi, F.2    Advani, A.S.3    Vasu, S.4    Walter, R.B.5    Faderl, S.6
  • 125
    • 85014839941 scopus 로고    scopus 로고
    • Vadastuximab talirine plus hypomethylating agents: A well-Tolerated regimen with high remission rate in frontline older patients with acute myeloid leukemia (AML) [abstract]
    • Fathi AT, Erba HP, Lancet JE, Stein EM, Ravandi F, Faderl S et al. Vadastuximab talirine plus hypomethylating agents: A well-Tolerated regimen with high remission rate in frontline older patients with acute myeloid leukemia (AML) [abstract]. Blood 2016; 128: 591.
    • (2016) Blood , vol.128 , pp. 591
    • Fathi, A.T.1    Erba, H.P.2    Lancet, J.E.3    Stein, E.M.4    Ravandi, F.5    Faderl, S.6
  • 126
    • 84897018823 scopus 로고    scopus 로고
    • Cellular determinants for preclinical activity of a novel CD33/CD3 bispecific T-cell engager (BiTE) antibody, AMG 330, against human AML
    • Laszlo GS, Gudgeon CJ, Harrington KH, Dell'Aringa J, Newhall KJ, Means GD et al. Cellular determinants for preclinical activity of a novel CD33/CD3 bispecific T-cell engager (BiTE) antibody, AMG 330, against human AML. Blood 2014; 123: 554-561.
    • (2014) Blood , vol.123 , pp. 554-561
    • Laszlo, G.S.1    Gudgeon, C.J.2    Harrington, K.H.3    Dell'Aringa, J.4    Newhall, K.J.5    Means, G.D.6
  • 127
    • 85006325284 scopus 로고    scopus 로고
    • Characterization of CD33/CD3 tetravalent bispecific tandem diabodies (TandAbs) for the treatment of acute myeloid leukemia
    • Reusch U, Harrington KH, Gudgeon CJ, Fucek I, Ellwanger K, Weichel M et al. Characterization of CD33/CD3 tetravalent bispecific tandem diabodies (TandAbs) for the treatment of acute myeloid leukemia. Clin Cancer Res 2016; 22: 5829-5838.
    • (2016) Clin Cancer Res , vol.22 , pp. 5829-5838
    • Reusch, U.1    Harrington, K.H.2    Gudgeon, C.J.3    Fucek, I.4    Ellwanger, K.5    Weichel, M.6
  • 128
    • 84938976564 scopus 로고    scopus 로고
    • CD33-specific chimeric antigen receptor T cells exhibit potent preclinical activity against human acute myeloid leukemia
    • Kenderian SS, Ruella M, Shestova O, Klichinsky M, Aikawa V, Morrissette JJ et al. CD33-specific chimeric antigen receptor T cells exhibit potent preclinical activity against human acute myeloid leukemia. Leukemia 2015; 29: 1637-1647.
    • (2015) Leukemia , vol.29 , pp. 1637-1647
    • Kenderian, S.S.1    Ruella, M.2    Shestova, O.3    Klichinsky, M.4    Aikawa, V.5    Morrissette, J.J.6


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