-
1
-
-
85010187554
-
A two-layer gene circuit for decoupling cell growth from metabolite production
-
Lo, T. M., Chng, S. H., Teo, W. S., Cho, H. S. & Chang, M. W. A two-layer gene circuit for decoupling cell growth from metabolite production. Cell Syst. 3, 133-143 (2016).
-
(2016)
Cell Syst.
, vol.3
, pp. 133-143
-
-
Lo, T.M.1
Chng, S.H.2
Teo, W.S.3
Cho, H.S.4
Chang, M.W.5
-
2
-
-
80051910411
-
Engineering microbes to sense and eradicate Pseudomonas aeruginosa, a human pathogen
-
Saeidi, N. et al. Engineering microbes to sense and eradicate Pseudomonas aeruginosa, a human pathogen. Mol. Syst. Biol. 7, 521 (2011).
-
(2011)
Mol. Syst. Biol.
, vol.7
, pp. 521
-
-
Saeidi, N.1
-
3
-
-
84897482912
-
Programmable bacteria detect and record an environmental signal in the mammalian gut
-
Kotula, J. W. et al. Programmable bacteria detect and record an environmental signal in the mammalian gut. Proc. Natl Acad. Sci. USA 111, 4838-4843 (2014).
-
(2014)
Proc. Natl Acad. Sci. USA
, vol.111
, pp. 4838-4843
-
-
Kotula, J.W.1
-
4
-
-
84905569769
-
A synthetic multifunctional mammalian pH sensor and CO2 transgene-control device
-
Auslander, D. et al. A synthetic multifunctional mammalian pH sensor and CO2 transgene-control device. Mol. Cell 55, 397-408 (2014).
-
(2014)
Mol. Cell
, vol.55
, pp. 397-408
-
-
Auslander, D.1
-
5
-
-
84984926987
-
Blue light-mediated transcriptional activation and repression of gene expression in bacteria
-
Jayaraman, P. et al. Blue light-mediated transcriptional activation and repression of gene expression in bacteria. Nucleic Acids Res. 44, 6994-7005 (2016).
-
(2016)
Nucleic Acids Res.
, vol.44
, pp. 6994-7005
-
-
Jayaraman, P.1
-
6
-
-
78650896342
-
Multichromatic control of gene expression in Escherichia coli
-
Tabor, J. J., Levskaya, A. & Voigt, C. A. Multichromatic control of gene expression in Escherichia coli. J. Mol. Biol. 405, 315-324 (2011).
-
(2011)
J. Mol. Biol.
, vol.405
, pp. 315-324
-
-
Tabor, J.J.1
Levskaya, A.2
Voigt, C.A.3
-
7
-
-
58549105950
-
Design and signaling mechanism of light-regulated histidine kinases
-
Moglich, A., Ayers, R. A. & Moffat, K. Design and signaling mechanism of light-regulated histidine kinases. J. Mol. Biol. 385, 1433-1444 (2009).
-
(2009)
J. Mol. Biol.
, vol.385
, pp. 1433-1444
-
-
Moglich, A.1
Ayers, R.A.2
Moffat, K.3
-
8
-
-
0036789439
-
A light-switchable gene promoter system
-
Shimizu-Sato, S., Huq, E., Tepperman, J. M. & Quail, P. H. A light-switchable gene promoter system. Nat. Biotechnol. 20, 1041-1044 (2002).
-
(2002)
Nat. Biotechnol.
, vol.20
, pp. 1041-1044
-
-
Shimizu-Sato, S.1
Huq, E.2
Tepperman, J.M.3
Quail, P.H.4
-
9
-
-
67549145283
-
A synthetic genetic edge detection program
-
Tabor, J. J. et al. A synthetic genetic edge detection program. Cell 137, 1272-1281 (2009).
-
(2009)
Cell
, vol.137
, pp. 1272-1281
-
-
Tabor, J.J.1
-
10
-
-
28544442417
-
Synthetic biology: Engineering Escherichia coli to see light
-
Levskaya, A. et al. Synthetic biology: engineering Escherichia coli to see light. Nature 438, 441-442 (2005).
-
(2005)
Nature
, vol.438
, pp. 441-442
-
-
Levskaya, A.1
-
11
-
-
84941299991
-
De novo design of heat-repressible RNA thermosensors in E. Coli
-
Hoynes-O'Connor, A., Hinman, K., Kirchner, L. & Moon, T. S. De novo design of heat-repressible RNA thermosensors in E. coli. Nucleic Acids Res. 43, 6166-6179 (2015).
-
(2015)
Nucleic Acids Res.
, vol.43
, pp. 6166-6179
-
-
Hoynes-O'Connor, A.1
Hinman, K.2
Kirchner, L.3
Moon, T.S.4
-
12
-
-
56049106809
-
Design of simple synthetic RNA thermometers for temperature-controlled gene expression in Escherichia coli
-
Neupert, J., Karcher, D. & Bock, R. Design of simple synthetic RNA thermometers for temperature-controlled gene expression in Escherichia coli. Nucleic Acids Res. 36, e124 (2008).
-
(2008)
Nucleic Acids Res.
, vol.36
, pp. e124
-
-
Neupert, J.1
Karcher, D.2
Bock, R.3
-
13
-
-
54049135184
-
Generation of synthetic RNA-based thermosensors
-
Waldminghaus, T., Kortmann, J., Gesing, S. & Narberhaus, F. Generation of synthetic RNA-based thermosensors. Biol. Chem. 389, 1319-1326 (2008).
-
(2008)
Biol. Chem.
, vol.389
, pp. 1319-1326
-
-
Waldminghaus, T.1
Kortmann, J.2
Gesing, S.3
Narberhaus, F.4
-
14
-
-
84966359023
-
Intelligent microbial heat-regulating engine (IMHeRE) for improved thermo-robustness and efficiency of bioconversion
-
Jia, H. et al. Intelligent microbial heat-regulating engine (IMHeRE) for improved thermo-robustness and efficiency of bioconversion. ACS Synth. Biol. 5, 312-320 (2016).
-
(2016)
ACS Synth. Biol.
, vol.5
, pp. 312-320
-
-
Jia, H.1
-
15
-
-
84995529465
-
Tunable thermal bioswitches for in vivo control of microbial therapeutics
-
Piraner, D. I., Abedi, M. H., Moser, B. A., Lee-Gosselin, A. & Shapiro, M. G. Tunable thermal bioswitches for in vivo control of microbial therapeutics. Nat. Chem. Biol. 13, 75-80 (2017).
-
(2017)
Nat. Chem. Biol.
, vol.13
, pp. 75-80
-
-
Piraner, D.I.1
Abedi, M.H.2
Moser, B.A.3
Lee-Gosselin, A.4
Shapiro, M.G.5
-
16
-
-
84991225926
-
Engineering of synthetic, stress-responsive yeast promoters
-
Rajkumar, A. S. et al. Engineering of synthetic, stress-responsive yeast promoters. Nucleic Acids Res. 44, e136 (2016).
-
(2016)
Nucleic Acids Res.
, vol.44
, pp. e136
-
-
Rajkumar, A.S.1
-
17
-
-
84899694320
-
Principles of genetic circuit design
-
Brophy, J. A. & Voigt, C. A. Principles of genetic circuit design. Nat. Methods 11, 508-520 (2014).
-
(2014)
Nat. Methods
, vol.11
, pp. 508-520
-
-
Brophy, J.A.1
Voigt, C.A.2
-
18
-
-
8544280704
-
The Era-like GTPase TrmE conditionally activates gadE and glutamate-dependent acid resistance in Escherichia coli
-
Gong, S., Ma, Z. & Foster, J. W. The Era-like GTPase TrmE conditionally activates gadE and glutamate-dependent acid resistance in Escherichia coli. Mol. Microbiol. 54, 948-961 (2004).
-
(2004)
Mol. Microbiol.
, vol.54
, pp. 948-961
-
-
Gong, S.1
Ma, Z.2
Foster, J.W.3
-
19
-
-
0141566454
-
GadE (YhiE) activates glutamate decarboxylase-dependent acid resistance in Escherichia coli K-12
-
Ma, Z. et al. GadE (YhiE) activates glutamate decarboxylase-dependent acid resistance in Escherichia coli K-12. Mol. Microbiol. 49, 1309-1320 (2003).
-
(2003)
Mol. Microbiol.
, vol.49
, pp. 1309-1320
-
-
Ma, Z.1
-
20
-
-
0035086021
-
Escherichia coli acid resistance: CAMP receptor protein and a 20 bp cis-Acting sequence control pH and stationary phase expression of the gadA and gadBC glutamate decarboxylase genes
-
Castanie-Cornet, M. P. & Foster, J. W. Escherichia coli acid resistance: cAMP receptor protein and a 20 bp cis-Acting sequence control pH and stationary phase expression of the gadA and gadBC glutamate decarboxylase genes. Microbiology 147, 709-715 (2001).
-
(2001)
Microbiology
, vol.147
, pp. 709-715
-
-
Castanie-Cornet, M.P.1
Foster, J.W.2
-
21
-
-
0036843687
-
Escherichia coli gene expression responsive to levels of the response regulator EvgA
-
Masuda, N. & Church, G. M. Escherichia coli gene expression responsive to levels of the response regulator EvgA. J. Bacteriol. 184, 6225-6234 (2002).
-
(2002)
J. Bacteriol.
, vol.184
, pp. 6225-6234
-
-
Masuda, N.1
Church, G.M.2
-
22
-
-
0038349356
-
Regulatory network of acid resistance genes in Escherichia coli
-
Masuda, N. & Church, G. M. Regulatory network of acid resistance genes in Escherichia coli. Mol. Microbiol. 48, 699-712 (2003).
-
(2003)
Mol. Microbiol.
, vol.48
, pp. 699-712
-
-
Masuda, N.1
Church, G.M.2
-
23
-
-
0036889029
-
Gene expression profiling of the pH response in Escherichia coli
-
Tucker, D. L., Tucker, N. & Conway, T. Gene expression profiling of the pH response in Escherichia coli. J. Bacteriol. 184, 6551-6558 (2002).
-
(2002)
J. Bacteriol.
, vol.184
, pp. 6551-6558
-
-
Tucker, D.L.1
Tucker, N.2
Conway, T.3
-
24
-
-
33947182874
-
The HP0165-HP0166 two-component system (ArsRS) regulates acid-induced expression of HP1186 alpha-carbonic anhydrase in Helicobacter pylori by activating the pH-dependent promoter
-
Wen, Y., Feng, J., Scott, D. R., Marcus, E. A. & Sachs, G. The HP0165-HP0166 two-component system (ArsRS) regulates acid-induced expression of HP1186 alpha-carbonic anhydrase in Helicobacter pylori by activating the pH-dependent promoter. J. Bacteriol. 189, 2426-2434 (2007).
-
(2007)
J. Bacteriol.
, vol.189
, pp. 2426-2434
-
-
Wen, Y.1
Feng, J.2
Scott, D.R.3
Marcus, E.A.4
Sachs, G.5
-
25
-
-
17644397319
-
Two acid-inducible promoters from Lactococcus lactis require the cis-Acting ACiD-box and the transcription regulator RcfB
-
Madsen, S. M., Hindre, T., Le Pennec, J. P., Israelsen, H. & Dufour, A. Two acid-inducible promoters from Lactococcus lactis require the cis-Acting ACiD-box and the transcription regulator RcfB. Mol. Microbiol. 56, 735-746 (2005).
-
(2005)
Mol. Microbiol.
, vol.56
, pp. 735-746
-
-
Madsen, S.M.1
Hindre, T.2
Le Pennec, J.P.3
Israelsen, H.4
Dufour, A.5
-
26
-
-
0032825378
-
Identification of the pH-inducible, proton-Translocating F1F0-ATPase (atpBEFHAGDC) operon of Lactobacillus acidophilus by differential display: Gene structure, cloning and characterization
-
Kullen, M. J. & Klaenhammer, T. R. Identification of the pH-inducible, proton-Translocating F1F0-ATPase (atpBEFHAGDC) operon of Lactobacillus acidophilus by differential display: gene structure, cloning and characterization. Mol. Microbiol. 33, 1152-1161 (1999).
-
(1999)
Mol. Microbiol.
, vol.33
, pp. 1152-1161
-
-
Kullen, M.J.1
Klaenhammer, T.R.2
-
27
-
-
72749118512
-
A pH-responsive riboregulator
-
Nechooshtan, G., Elgrably-Weiss, M., Sheaffer, A., Westhof, E. & Altuvia, S. A pH-responsive riboregulator. Genes Dev. 23, 2650-2662 (2009).
-
(2009)
Genes Dev.
, vol.23
, pp. 2650-2662
-
-
Nechooshtan, G.1
Elgrably-Weiss, M.2
Sheaffer, A.3
Westhof, E.4
Altuvia, S.5
-
28
-
-
84891776041
-
Changes in transcriptional pausing modify the folding dynamics of the pH-responsive RNA element
-
Nechooshtan, G., Elgrably-Weiss, M. & Altuvia, S. Changes in transcriptional pausing modify the folding dynamics of the pH-responsive RNA element. Nucleic Acids Res. 42, 622-630 (2014).
-
(2014)
Nucleic Acids Res.
, vol.42
, pp. 622-630
-
-
Nechooshtan, G.1
Elgrably-Weiss, M.2
Altuvia, S.3
-
29
-
-
0042121256
-
Mfold web server for nucleic acid folding and hybridization prediction
-
Zuker, M. Mfold web server for nucleic acid folding and hybridization prediction. Nucleic Acids Res. 31, 3406-3415 (2003).
-
(2003)
Nucleic Acids Res.
, vol.31
, pp. 3406-3415
-
-
Zuker, M.1
-
30
-
-
0036330537
-
Noninvasive measurement of bacterial intracellular pH on a single-cell level with green fluorescent protein and fluorescence ratio imaging microscopy
-
Olsen, K. N. et al. Noninvasive measurement of bacterial intracellular pH on a single-cell level with green fluorescent protein and fluorescence ratio imaging microscopy. Appl. Environ. Microbiol. 68, 4145-4147 (2002).
-
(2002)
Appl. Environ. Microbiol.
, vol.68
, pp. 4145-4147
-
-
Olsen, K.N.1
-
31
-
-
84901236471
-
Arginine deiminase in Staphylococcus epidermidis functions to augment biofilm maturation through pH homeostasis
-
Lindgren, J. K. et al. Arginine deiminase in Staphylococcus epidermidis functions to augment biofilm maturation through pH homeostasis. J. Bacteriol. 196, 2277-2289 (2014).
-
(2014)
J. Bacteriol.
, vol.196
, pp. 2277-2289
-
-
Lindgren, J.K.1
-
32
-
-
84866953925
-
Modular control of multiple pathways using engineered orthogonal T7 polymerases
-
Temme, K., Hill, R., Segall-Shapiro, T. H., Moser, F. & Voigt, C. A. Modular control of multiple pathways using engineered orthogonal T7 polymerases. Nucleic Acids Res. 40, 8773-8781 (2012).
-
(2012)
Nucleic Acids Res.
, vol.40
, pp. 8773-8781
-
-
Temme, K.1
Hill, R.2
Segall-Shapiro, T.H.3
Moser, F.4
Voigt, C.A.5
-
33
-
-
0028027513
-
Characterization of a set of T7 RNA polymerase active site mutants
-
Bonner, G., Lafer, E. M. & Sousa, R. Characterization of a set of T7 RNA polymerase active site mutants. J. Biol. Chem. 269, 25120-25128 (1994).
-
(1994)
J. Biol. Chem.
, vol.269
, pp. 25120-25128
-
-
Bonner, G.1
Lafer, E.M.2
Sousa, R.3
-
34
-
-
84925225805
-
Permanent genetic memory with >1-byte capacity
-
Yang, L. et al. Permanent genetic memory with >1-byte capacity. Nat. Methods 11, 1261-1266 (2014).
-
(2014)
Nat. Methods
, vol.11
, pp. 1261-1266
-
-
Yang, L.1
-
35
-
-
84869476328
-
Ribozyme-based insulator parts buffer synthetic circuits from genetic context
-
Lou, C., Stanton, B., Chen, Y. J., Munsky, B. & Voigt, C. A. Ribozyme-based insulator parts buffer synthetic circuits from genetic context. Nat. Biotechnol. 30, 1137-1142 (2012).
-
(2012)
Nat. Biotechnol.
, vol.30
, pp. 1137-1142
-
-
Lou, C.1
Stanton, B.2
Chen, Y.J.3
Munsky, B.4
Voigt, C.A.5
-
36
-
-
79954784829
-
Molecular aspects of bacterial pH sensing and homeostasis
-
Krulwich, T. A., Sachs, G. & Padan, E. Molecular aspects of bacterial pH sensing and homeostasis. Nat. Rev. Microbiol. 9, 330-343 (2011).
-
(2011)
Nat. Rev. Microbiol.
, vol.9
, pp. 330-343
-
-
Krulwich, T.A.1
Sachs, G.2
Padan, E.3
-
37
-
-
34047264809
-
Life in acid: PH homeostasis in acidophiles
-
Baker-Austin, C. & Dopson, M. Life in acid: pH homeostasis in acidophiles. Trends Microbiol. 15, 165-171 (2007).
-
(2007)
Trends Microbiol.
, vol.15
, pp. 165-171
-
-
Baker-Austin, C.1
Dopson, M.2
-
38
-
-
9444285788
-
Escherichia coli acid resistance: Tales of an amateur acidophile
-
Foster, J. W. Escherichia coli acid resistance: Tales of an amateur acidophile. Nat. Rev. Microbiol. 2, 898-907 (2004).
-
(2004)
Nat. Rev. Microbiol.
, vol.2
, pp. 898-907
-
-
Foster, J.W.1
-
39
-
-
72949121897
-
Sensors and regulators of intracellular pH
-
Casey, J. R., Grinstein, S. & Orlowski, J. Sensors and regulators of intracellular pH. Nat. Rev. Mol. Cell Biol. 11, 50-61 (2010).
-
(2010)
Nat. Rev. Mol. Cell Biol.
, vol.11
, pp. 50-61
-
-
Casey, J.R.1
Grinstein, S.2
Orlowski, J.3
-
40
-
-
2542479729
-
Lactic acid tolerance determined by measurement of intracellular pH of single cells of Candida krusei and Saccharomyces cerevisiae isolated from fermented maize dough
-
Halm, M., Hornbaek, T., Arneborg, N., Sefa-Dedeh, S. & Jespersen, L. Lactic acid tolerance determined by measurement of intracellular pH of single cells of Candida krusei and Saccharomyces cerevisiae isolated from fermented maize dough. Int. J. Food Microbiol. 94, 97-103 (2004).
-
(2004)
Int. J. Food Microbiol.
, vol.94
, pp. 97-103
-
-
Halm, M.1
Hornbaek, T.2
Arneborg, N.3
Sefa-Dedeh, S.4
Jespersen, L.5
-
41
-
-
33747367729
-
Improvement of lactic acid production in Saccharomyces cerevisiae by cell sorting for high intracellular pH
-
Valli, M. et al. Improvement of lactic acid production in Saccharomyces cerevisiae by cell sorting for high intracellular pH. Appl. Environ. Microbiol. 72, 5492-5499 (2006).
-
(2006)
Appl. Environ. Microbiol.
, vol.72
, pp. 5492-5499
-
-
Valli, M.1
-
42
-
-
84856275260
-
A combined physiological and proteomic approach to reveal lactic-Acid-induced alterations in Lactobacillus casei Zhang and its mutant with enhanced lactic acid tolerance
-
Wu, C. et al. A combined physiological and proteomic approach to reveal lactic-Acid-induced alterations in Lactobacillus casei Zhang and its mutant with enhanced lactic acid tolerance. Appl. Microbiol. Biotechnol. 93, 707-722 (2012).
-
(2012)
Appl. Microbiol. Biotechnol.
, vol.93
, pp. 707-722
-
-
Wu, C.1
-
43
-
-
84886022252
-
Programming adaptive control to evolve increased metabolite production
-
Chou, H. H. & Keasling, J. D. Programming adaptive control to evolve increased metabolite production. Nat. Commun. 4, 2595 (2013).
-
(2013)
Nat. Commun.
, vol.4
, pp. 2595
-
-
Chou, H.H.1
Keasling, J.D.2
-
44
-
-
0022798983
-
Structure and function of dnaQ and mutD mutators of Escherichia coli
-
Takano, K., Nakabeppu, Y., Maki, H., Horiuchi, T. & Sekiguchi, M. Structure and function of dnaQ and mutD mutators of Escherichia coli. Mol. Gen. Genet. 205, 9-13 (1986).
-
(1986)
Mol. Gen. Genet.
, vol.205
, pp. 9-13
-
-
Takano, K.1
Nakabeppu, Y.2
Maki, H.3
Horiuchi, T.4
Sekiguchi, M.5
-
45
-
-
0023042506
-
DNA sequence and coding properties of mutD(dnaQ) a dominant Escherichia coli mutator gene
-
Cox, E. C. & Horner, D. L. DNA sequence and coding properties of mutD(dnaQ) a dominant Escherichia coli mutator gene. J. Mol. Biol. 190, 113-117 (1986).
-
(1986)
J. Mol. Biol.
, vol.190
, pp. 113-117
-
-
Cox, E.C.1
Horner, D.L.2
-
46
-
-
68949161807
-
Programming cells by multiplex genome engineering and accelerated evolution
-
Wang, H. et al. Programming cells by multiplex genome engineering and accelerated evolution. Nature 460, 894-898 (2009).
-
(2009)
Nature
, vol.460
, pp. 894-898
-
-
Wang, H.1
-
47
-
-
84874608929
-
RNA-guided editing of bacterial genomes using CRISPR-Cas systems
-
Jiang, W., Bikard, D., Cox, D., Zhang, F. & Marraffini, L. A. RNA-guided editing of bacterial genomes using CRISPR-Cas systems. Nat. Biotech. 31, 233-239 (2013).
-
(2013)
Nat. Biotech.
, vol.31
, pp. 233-239
-
-
Jiang, W.1
Bikard, D.2
Cox, D.3
Zhang, F.4
Marraffini, L.A.5
-
48
-
-
26944440137
-
Organic acid toxicity, tolerance, and production in Escherichia coli biorefining applications
-
Warnecke, T. & Gill, R. T. Organic acid toxicity, tolerance, and production in Escherichia coli biorefining applications. Microb. Cell Fact. 4, 25 (2005).
-
(2005)
Microb. Cell Fact.
, vol.4
, pp. 25
-
-
Warnecke, T.1
Gill, R.T.2
-
49
-
-
38349093902
-
Microbial production of organic acids: Expanding the markets
-
Sauer, M., Porro, D., Mattanovich, D. & Branduardi, P. Microbial production of organic acids: expanding the markets. Trends Biotechnol. 26, 100-108 (2008).
-
(2008)
Trends Biotechnol.
, vol.26
, pp. 100-108
-
-
Sauer, M.1
Porro, D.2
Mattanovich, D.3
Branduardi, P.4
-
50
-
-
84992075174
-
In vivo continuous evolution of genes and pathways in yeast
-
Crook, N. et al. In vivo continuous evolution of genes and pathways in yeast. Nat. Commun. 7, 13051 (2016).
-
(2016)
Nat. Commun.
, vol.7
, pp. 13051
-
-
Crook, N.1
-
51
-
-
79961109150
-
BLAST Ring Image Generator (BRIG): Simple prokaryote genome comparisons
-
Alikhan, N. F., Petty, N. K., Ben Zakour, N. L. & Beatson, S. A. BLAST Ring Image Generator (BRIG): simple prokaryote genome comparisons. BMC Genomics 12, 402 (2011).
-
(2011)
BMC Genomics
, vol.12
, pp. 402
-
-
Alikhan, N.F.1
Petty, N.K.2
Ben Zakour, N.L.3
Beatson, S.A.4
-
52
-
-
42049083342
-
A practical guide to measuring mutation rates in antibiotic resistance
-
Pope, C. F., O'Sullivan, D. M., McHugh, T. D. & Gillespie, S. H. A practical guide to measuring mutation rates in antibiotic resistance. Antimicrob. Agents Chemother. 52, 1209-1214 (2008).
-
(2008)
Antimicrob. Agents Chemother.
, vol.52
, pp. 1209-1214
-
-
Pope, C.F.1
O'Sullivan, D.M.2
McHugh, T.D.3
Gillespie, S.H.4
-
53
-
-
66349117823
-
Fluctuation analysis CalculatOR: A web tool for the determination of mutation rate using Luria-Delbruck fluctuation analysis
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Hall, B. M., Ma, C. X., Liang, P. & Singh, K. K. Fluctuation analysis CalculatOR: A web tool for the determination of mutation rate using Luria-Delbruck fluctuation analysis. Bioinformatics 25, 1564-1565 (2009).
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(2009)
Bioinformatics
, vol.25
, pp. 1564-1565
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Hall, B.M.1
Ma, C.X.2
Liang, P.3
Singh, K.K.4
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