Xyloketal B alleviates cerebral infarction and neurologic deficits in a mouse stroke model by suppressing the ROS/TLR4/NF-ΰ B inflammatory signaling pathway

Acta Pharmacologica Sinica

Volumn 38, Issue 9, 2017, Pages 1236-1247

  Pan, Ni ^a   Lu, Liu Yi ^a   Li, Mei ^b   Wang, Guo Hao ^c   Sun, Fang Yun ^d   Sun, Hong Shuo ^e   Wen, Xue Jun ^f   Cheng, Jian DIng ^a   Chen, Jian Wen ^b   Pang, Ji Yan ^b   Liu, Jie ^a   Guan, Yong Yuan ^a   Zhao, Li Yan ^b   Chen, Wen Liang ^g   Wang, Guan Lei ^a,b  

^a SUN YAT SEN UNIVERSITY   (China)

^b SUN YAT SEN UNIVERSITY   (China)

^c LISHUI UNIVERSITY   (China)

^d XIZANG MINZU UNIVERSITY   (China)

^e UNIVERSITY OF TORONTO   (Canada)

^f Virginia Commonwealth University   (United States)

^g GUANGZHOU MEDICAL UNIVERSITY   (China)

Author keywords

ischemic brain injury; middle cerebral artery occlusion; NF B; ROS; stroke; TLR4; Xyloketal B

Indexed keywords

GAMMA INTERFERON; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INDUCIBLE NITRIC OXIDE SYNTHASE; INTERLEUKIN 1BETA; INTERLEUKIN 6; MANGANESE SUPEROXIDE DISMUTASE; NEUROPROTECTIVE AGENT; NORPHENAZONE; REACTIVE OXYGEN METABOLITE; TOLL LIKE RECEPTOR 4; TUMOR NECROSIS FACTOR; UNCLASSIFIED DRUG; XYLOKETAL B; PYRAN DERIVATIVE; TLR4 PROTEIN, MOUSE;

ADULT; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BLOOD BRAIN BARRIER; BRAIN INFARCTION; BRAIN INFARCTION SIZE; BRAIN ISCHEMIA; BRAIN PERFUSION; BRAIN SLICE; BRAIN TISSUE; CEREBROVASCULAR ACCIDENT; CONTROLLED STUDY; DOPPLER FLOWMETER; DOWN REGULATION; DRUG MECHANISM; ENZYME ACTIVATION; HYPOXIC ISCHEMIC ENCEPHALOPATHY; IMMUNOHISTOCHEMISTRY; LASER FLOWMETER; MALE; MIDDLE CEREBRAL ARTERY OCCLUSION; MOUSE; NEUROLOGIC DISEASE; NEUROPROTECTION; NONHUMAN; PROTEIN EXPRESSION; REAL TIME POLYMERASE CHAIN REACTION; SCORING SYSTEM; SIGNAL TRANSDUCTION; SINGLE DRUG DOSE; STAINING; THERAPEUTIC INDEX; WESTERN BLOTTING; ANIMAL; C57BL MOUSE; CEREBRAL ARTERY DISEASE; CHEMISTRY; DISEASE MODEL; DRUG EFFECT; INFLAMMATION; METABOLISM;

ANIMALS; CEREBRAL INFARCTION; DISEASE MODELS, ANIMAL; INFARCTION, MIDDLE CEREBRAL ARTERY; INFLAMMATION; MALE; MICE; MICE, INBRED C57BL; NF-KAPPA B; PYRANS; REACTIVE OXYGEN SPECIES; SIGNAL TRANSDUCTION; STROKE; TOLL-LIKE RECEPTOR 4;

EID: 85028649655     PISSN: 16714083     EISSN: 17457254     Source Type: Journal    
DOI: 10.1038/aps.2017.22     Document Type: Article

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