Splenectomy following MCAO inhibits the TLR4-NF-κB signaling pathway and protects the brain from neurodegeneration in rats

Journal of Neuroimmunology

Volumn 293, Issue , 2016, Pages 105-113

  Belinga, Victor Fabrice ^a,b   Wu, Guan Jin ^a,b   Yan, Fu Ling ^a,b   Limbenga, Erica Audrey ^a,b  

^a MEDICAL SCHOOL OF SOUTHEAST UNIVERSITY   (China)

^b AFFILIATED ZHONGDA HOSPITAL OF SOUTHEAST UNIVERSITY   (China)

Author keywords

Inflammation; Ischemia; Neuroprotection; NF B; Reperfusion; Splenectomy; TLR4

Indexed keywords

IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; TOLL LIKE RECEPTOR 4; TLR4 PROTEIN, RAT;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; BRAIN INFARCTION SIZE; BRAIN REGION; CEREBROVASCULAR ACCIDENT; CONTROLLED STUDY; CORPUS STRIATUM; HIPPOCAMPUS; IMMUNOHISTOCHEMISTRY; IMMUNOPATHOGENESIS; MALE; MIDDLE CEREBRAL ARTERY OCCLUSION; NERVE DEGENERATION; NEUROPROTECTION; NONHUMAN; PARIETAL LOBE; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; SHAM PROCEDURE; SIGNAL TRANSDUCTION; SPLENECTOMY; STATISTICAL SIGNIFICANCE; TUNEL ASSAY; ANALYSIS OF VARIANCE; ANIMAL; BRAIN; BRAIN INFARCTION; COMPLICATION; DISEASE MODEL; INFARCTION, MIDDLE CEREBRAL ARTERY; METABOLISM; NERVOUS SYSTEM DISEASES; NEURODEGENERATIVE DISEASES; NUCLEAR MAGNETIC RESONANCE IMAGING; PATHOLOGY; PHYSIOLOGY; PROCEDURES; SPRAGUE DAWLEY RAT; TIME FACTOR; TREATMENT OUTCOME;

ANALYSIS OF VARIANCE; ANIMALS; BRAIN; BRAIN INFARCTION; DISEASE MODELS, ANIMAL; IN SITU NICK-END LABELING; INFARCTION, MIDDLE CEREBRAL ARTERY; MAGNETIC RESONANCE IMAGING; MALE; NERVOUS SYSTEM DISEASES; NEURODEGENERATIVE DISEASES; NF-KAPPA B; RATS; RATS, SPRAGUE-DAWLEY; SIGNAL TRANSDUCTION; SPLENECTOMY; TIME FACTORS; TOLL-LIKE RECEPTOR 4; TREATMENT OUTCOME;

EID: 84960469337     PISSN: 01655728     EISSN: 18728421     Source Type: Journal    
DOI: 10.1016/j.jneuroim.2016.03.003     Document Type: Article

References (29)

1. Ajmo C.T., Vernon D.O.L., Collier L., et al. The spleen contributes to stroke-induced neurodegeneration. J. Neurosci. Res. 2008, 86(10):2227-2234.
2. Barth Albert M.I., Mody Istvan Changes in hippocampal neuronal activity during and after unilateral selective hippocampal ischemia in vivo. J. Neurosci. 2011, 31(3):851-860. (19 January).
3. Chu Weihua, Li Mei, Li Fei, et al. Immediate splenectomy down-regulates the MAPKYNF-JB signaling pathway in rat brain after severe traumatic brain injury. J. Trauma Acute Care Surg. 2013, 74(6).
4. Dotson Abby L., et al. Splenectomy reduces infarct volume and neuroinflammation in Male but not female mice in experimental stroke. J. Neuroimmunol. 2015, 0:289-298.
5. Fan H., Li L., Zhang X. Oxymatrine down regulates TLR4, TLR2, MyD88, and NF-κB and protects rat brains against focal ischemia. Mediat. Inflamm. 2009, 704-706.
6. Fluri Felix, Schuhmann Michael K., Kleinschnitz Christoph Animal models of ischemic stroke and their application in clinical research. Drug Des. Devel. Ther. 2015, 9:3445-3454.
7. Hanke Mark L., Kielian Tammy Toll-like receptors in health and disease in the brain: mechanisms and therapeutic potential. Clin. Sci. (Lond.) 1979) 2011, 121(9):367-387.
8. Harari O.A., Liao J.K. NF-κB and innate immunity in ischemic stroke. Ann. N. Y. Acad. Sci. 2010, 1207:32-40.
9. Harari, Olivier A., and James K. Liao. NF-κB and innate immunity in ischemic stroke. Ann. N. Y. Acad. Sci. 1207 (2010): 32-40. (PMC. Web. 5 Feb.) 2016.
10. Iadecola Costantino, Anrather Josef The immunology of stroke: from mechanisms to translation. Nat. Med. 2011, 17(7):796-808.
11. Inose Y., Kato Y., Kitagawa K., Uchiyama S., Shibata N. Activated Microglia in Ischemic Stroke Penumbra Up-regulate MCP-1 and CCR2 Expression in Response to Lysophosphatidylcholine Derived from Adjacent Neurons and Astrocytes 2015, Vol. 35(2):186-187. (Feb).
12. Jin, Rong et al. Simvastatin attenuates stroke-induced splenic atrophy and lung susceptibility to spontaneous bacterial infection in mice. Stroke 44.4 (2013): 1135-1143. (PMC. Web. 5 Feb.) 2016.
13. Kilic U., Kilic E., Matter C.M., et al. TLR-4 deficiency protects against focal cerebral ischemia and axotomy-induced neurodegeneration. Neurobiol. Dis. 2008, 31(1):33-40.
14. Koizumi J., Yoshida Y., Nakazawa T., et al. Experimental studies of ischemic brain edema, I: a new experimental model of cerebral embolism in rats in which recirculation can be introduced in the ischemic area. Jpn. J. Stroke 1986, 8(1):1-8.
15. Lenihan Colin R., Taylor Cormac T. The impact of hypoxia on cell death pathways. Biochem. Soc. Trans. 2013, 41:657-663.
16. Levy D.E., Brierley J.B., Silverman D.G., Plum F. Brief hypoxia-ischemia initially damages cerebral neurons. Arch. Neurol. 1975, 32(7):450-456.
17. Liu W., Tang Y., Feng J. Cross talk between activation of microglia and astrocytes in pathological conditions in the central nervous system. Life 2011, 89(5-6):141-146.
18. Longa E.Z., Weinstein P.R., Carlson S., et al. Reversible middle cerebral artery occlusion without craniectomy in rats. Stroke 1989, 20(1):84-91.
19. Offner H., Subramanian S., Parker S.M., et al. Experimental stroke induces massive, rapid activation of the peripheral immune system. J. Cereb. Blood Flow Metab. 2006, 26(5):654-665.
20. Ostrowski R., Schulte R., Nie Y., Ling T., Lee T., Manaenko A., Gridley D., Zhang J. Acute splenic irradiation reduces brain injury in the rat focal ischemic stroke model. Transl. Stroke Res. 2012, 3:473-481.
21. Pennypacker KR, Offner H. The role of the spleen in ischemic stroke.J. Cereb. Blood Flow Metab. 2015 (Feb);35(2):186-7.
22. Seifert HA, Leonardo CC, Hall AA, Rowe DD, Collier LA, Benkovic SA, Willing AE, Pennypacker KR. The spleen contributes to stroke induced neurodegeneration through interferon gamma signaling. Metab. Brain Dis. 2012 (Jun);27(2):131-41.
23. Seifert Hilary A., Collier Lisa A., et al. Pro-inflammatory interferon gamma signaling is directly associated with stroke induced neurodegeneration. J. NeuroImmune Pharmacol. 2014, 9(5):679-689. (December).
24. Shichita T., Ago T., Kamouchi M., et al. Novel therapeutic strategies targeting innate immune responses and early inflammation after stroke. J. Neurochem. 2012, 123(s2):29-38.
25. Shih Ruey-Horng, Wang Chen-Yu, Yang Chuen-Mao NF-kappaB signaling pathways in neurological inflammation: a mini review. Front. Mol. Neurosci. 2015, 8:77.
26. Sørensen J.C., Mattsson B., Andreasen A., Johansson B.B. Rapid disappearance of zinc positive terminals in focal brain ischemia. Brain Res. 1998, 812(1-2):265-269.
27. Wang Jianming, et al. Adoptive transfer of immune subsets prior to MCAO does not exacerbate stroke outcome in splenectomized mice. J. Syst. Integr. Neurosci. 2015, 1(1):20-28.
28. Zhang Bing-jun, Men Xue-jiao, et al. Splenectomy protects experimental rats from cerebral damage after stroke due to anti-inflammatory effects. Chin. Med. J. 2013, 126:12.
29. Zwagerman N., Plumlee C., Guthikonda M. Toll-like receptor-4 and cytokine cascade in stroke after exercise. Neurol. Res. 2010, 32(2):123-126.