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Volumn 39, Issue 6, 2017, Pages

MicroRNA-125a-5p plays a role as a tumor suppressor in lung carcinoma cells by directly targeting STAT3

Author keywords

Apoptosis; Lung cancer; Migration; MiR 125a 5p; STAT3

Indexed keywords

3 (4,5 DIMETHYL 2 THIAZOLYL) 2,5 DIPHENYLTETRAZOLIUM BROMIDE; MICRORNA; MICRORNA 125A 5P; STAT3 PROTEIN; UNCLASSIFIED DRUG; 3' UNTRANSLATED REGION; MIRN125 MICRORNA, HUMAN; STAT3 PROTEIN, HUMAN;

EID: 85028504989     PISSN: 10104283     EISSN: 14230380     Source Type: Journal    
DOI: 10.1177/1010428317697579     Document Type: Article
Times cited : (46)

References (51)
  • 1
    • 84959898840 scopus 로고    scopus 로고
    • The emerging role of myeloid-derived suppressor cells in lung diseases
    • Kolahian S, Oz HH, Zhou B, et al. The emerging role of myeloid-derived suppressor cells in lung diseases. Eur Respir J 2016; 47: 967-977.
    • (2016) Eur Respir J , vol.47 , pp. 967-977
    • Kolahian, S.1    Oz, H.H.2    Zhou, B.3
  • 2
    • 84958954442 scopus 로고    scopus 로고
    • Strategies to improve outcomes of patients with EGRF-mutant non-small cell lung cancer: Review of the literature
    • Zhou C and Yao LD. Strategies to improve outcomes of patients with EGRF-mutant non-small cell lung cancer: review of the literature. J Thorac Oncol 2016; 11: 174-186.
    • (2016) J Thorac Oncol , vol.11 , pp. 174-186
    • Zhou, C.1    Yao, L.D.2
  • 3
    • 84979769225 scopus 로고    scopus 로고
    • The role of tumor-infiltrating lymphocytes in development, progression, and prognosis of non-small cell lung cancer
    • Bremnes RM, Busund LT, Kilvaer TL, et al. The role of tumor-infiltrating lymphocytes in development, progression, and prognosis of non-small cell lung cancer. J Thorac Oncol 2016; 11: 789-800.
    • (2016) J Thorac Oncol , vol.11 , pp. 789-800
    • Bremnes, R.M.1    Busund, L.T.2    Kilvaer, T.L.3
  • 5
    • 84969265316 scopus 로고    scopus 로고
    • Neuronal acetylcholine nicotinic receptors as new targets for lung cancer treatment
    • Mucchietto V, Crespi A, Fasoli F, et al. Neuronal acetylcholine nicotinic receptors as new targets for lung cancer treatment. Curr Pharm Des 2016; 22: 2160-2169.
    • (2016) Curr Pharm Des , vol.22 , pp. 2160-2169
    • Mucchietto, V.1    Crespi, A.2    Fasoli, F.3
  • 6
    • 84957658225 scopus 로고    scopus 로고
    • New and emerging developments in extensive-stage small cell lung cancer therapeutics
    • Parikh M, Riess J and Lara PN Jr. New and emerging developments in extensive-stage small cell lung cancer therapeutics. Curr Opin Oncol 2016; 28: 97-103.
    • (2016) Curr Opin Oncol , vol.28 , pp. 97-103
    • Parikh, M.1    Riess, J.2    Lara, P.N.3
  • 7
    • 84973594978 scopus 로고    scopus 로고
    • 18F-FDG PET/ CT: Therapy response assessment interpretation (Hopkins criteria) and survival outcomes in lung cancer patients
    • Sheikhbahaei S, Mena E, Marcus C, et al. 18F-FDG PET/ CT: therapy response assessment interpretation (Hopkins criteria) and survival outcomes in lung cancer patients. J Nucl Med 2016; 57: 855-860.
    • (2016) J Nucl Med , vol.57 , pp. 855-860
    • Sheikhbahaei, S.1    Mena, E.2    Marcus, C.3
  • 8
    • 84957842807 scopus 로고    scopus 로고
    • The impact of genomic profiling for novel cancer therapy—recent progress in non-small cell lung cancer
    • Xie J and Zhang X. The impact of genomic profiling for novel cancer therapy—recent progress in non-small cell lung cancer. J Genet Genomics 2016; 43: 3-10.
    • (2016) J Genet Genomics , vol.43 , pp. 3-10
    • Xie, J.1    Zhang, X.2
  • 10
    • 85027934290 scopus 로고    scopus 로고
    • MiRNA-451 inhibits glioma cell proliferation and invasion by downregulating glucose transporter 1
    • Guo H, Nan Y, Zhen Y, et al. MiRNA-451 inhibits glioma cell proliferation and invasion by downregulating glucose transporter 1. Tumour Biol 2016; 37: 13751-13761.
    • (2016) Tumour Biol , vol.37 , pp. 13751-13761
    • Guo, H.1    Nan, Y.2    Zhen, Y.3
  • 11
    • 84980047650 scopus 로고    scopus 로고
    • Noise-induced multistability in the regulation of cancer by genes and pseudogenes
    • Petrosyan KG and Hu CK. Noise-induced multistability in the regulation of cancer by genes and pseudogenes. J Chem Phys 2016; 145: 045102.
    • (2016) J Chem Phys , vol.145
    • Petrosyan, K.G.1    Hu, C.K.2
  • 12
    • 84979688310 scopus 로고    scopus 로고
    • The role of microRNAs in metabolic interactions between viruses and their hosts
    • Powdrill MH, Desrochers GF, Singaravelu R, et al. The role of microRNAs in metabolic interactions between viruses and their hosts. Curr Opin Virol 2016; 19: 71-76.
    • (2016) Curr Opin Virol , vol.19 , pp. 71-76
    • Powdrill, M.H.1    Desrochers, G.F.2    Singaravelu, R.3
  • 13
    • 84983591881 scopus 로고    scopus 로고
    • Extracellular vesicles carry microRNA-195 to intrahepatic cholangiocarcinoma and improve survival in a rat model
    • Li L, Piontek K, Ishida M, et al. Extracellular vesicles carry microRNA-195 to intrahepatic cholangiocarcinoma and improve survival in a rat model. Hepatology 2016; 65: 501-514.
    • (2016) Hepatology , vol.65 , pp. 501-514
    • Li, L.1    Piontek, K.2    Ishida, M.3
  • 14
    • 84988443547 scopus 로고    scopus 로고
    • The regulation roles of miR-125b, miR-221 and miR-27b in porcine salmonella infection signaling pathway
    • Yao M, Gao W, Yang J, et al. The regulation roles of miR-125b, miR-221 and miR-27b in porcine salmonella infection signaling pathway. Biosci Rep 2016; 36: e00375.
    • (2016) Biosci Rep , vol.36
    • Yao, M.1    Gao, W.2    Yang, J.3
  • 15
    • 84986890507 scopus 로고    scopus 로고
    • MicroRNA-33 regulates the innate immune response via ATP binding cassette transporter-mediated remodeling of membrane microdomains
    • Lai L, Azzam KM, Lin WC, et al. MicroRNA-33 regulates the innate immune response via ATP binding cassette transporter-mediated remodeling of membrane microdomains. J Biol Chem 2016; 291: 19651-19660.
    • (2016) J Biol Chem , vol.291 , pp. 19651-19660
    • Lai, L.1    Azzam, K.M.2    Lin, W.C.3
  • 16
    • 84979944343 scopus 로고    scopus 로고
    • Circulating microRNAs in cancer: Hope or hype?
    • Singh R, Ramasubramanian B, Kanji S, et al. Circulating microRNAs in cancer: hope or hype? Cancer Lett 2016; 381: 113-121.
    • (2016) Cancer Lett , vol.381 , pp. 113-121
    • Singh, R.1    Ramasubramanian, B.2    Kanji, S.3
  • 17
    • 84992428517 scopus 로고    scopus 로고
    • Mir-129-5p is down-regulated and involved in migration and invasion of gastric cancer cells by targeting interleukin-8
    • Jiang Z, Wang H, Li Y, et al. Mir-129-5p is down-regulated and involved in migration and invasion of gastric cancer cells by targeting interleukin-8. Neoplasma 2016; 63: 673-680.
    • (2016) Neoplasma , vol.63 , pp. 673-680
    • Jiang, Z.1    Wang, H.2    Li, Y.3
  • 18
    • 84982685867 scopus 로고    scopus 로고
    • Regulation of cell proliferation and migration by miR-203 via GAS41/ miR-10b axis in human glioblastoma cells
    • Pal D, Mukhopadhyay D, Ramaiah MJ, et al. Regulation of cell proliferation and migration by miR-203 via GAS41/ miR-10b axis in human glioblastoma cells. PLoS ONE 2016; 11: e0159092.
    • (2016) Plos ONE , vol.11
    • Pal, D.1    Mukhopadhyay, D.2    Ramaiah, M.J.3
  • 19
    • 84979583923 scopus 로고    scopus 로고
    • MicroRNA-497 downregulation contributes to cell proliferation, migration, and invasion of estrogen receptor alpha negative breast cancer by targeting estrogen-related receptor alpha
    • Han L, Liu B, Jiang L, et al. MicroRNA-497 downregulation contributes to cell proliferation, migration, and invasion of estrogen receptor alpha negative breast cancer by targeting estrogen-related receptor alpha. Tumour Biol 2016; 37: 13205-13214.
    • (2016) Tumour Biol , vol.37 , pp. 13205-13214
    • Han, L.1    Liu, B.2    Jiang, L.3
  • 20
    • 84978776971 scopus 로고    scopus 로고
    • MicroRNA-194 promotes the growth, migration, and invasion of ovarian carcinoma cells by targeting protein tyrosine phosphatase nonreceptor type 12
    • Liang T, Li L, Cheng Y, et al. MicroRNA-194 promotes the growth, migration, and invasion of ovarian carcinoma cells by targeting protein tyrosine phosphatase nonreceptor type 12. Onco Targets Ther 2016; 9: 4307-4315.
    • (2016) Onco Targets Ther , vol.9 , pp. 4307-4315
    • Liang, T.1    Li, L.2    Cheng, Y.3
  • 21
    • 84979738840 scopus 로고    scopus 로고
    • MiR-613 inhibits proliferation and invasion of breast cancer cell via VEGFA
    • Wu J, Yuan P, Mao Q, et al. MiR-613 inhibits proliferation and invasion of breast cancer cell via VEGFA. Biochem Biophys Res Commun 2016; 478: 274-278.
    • (2016) Biochem Biophys Res Commun , vol.478 , pp. 274-278
    • Wu, J.1    Yuan, P.2    Mao, Q.3
  • 22
    • 33644819964 scopus 로고    scopus 로고
    • Unique micro-RNA molecular profiles in lung cancer diagnosis and prognosis
    • Yanaihara N, Caplen N, Bowman E, et al. Unique micro-RNA molecular profiles in lung cancer diagnosis and prognosis. Cancer Cell 2006; 9: 189-198.
    • (2006) Cancer Cell , vol.9 , pp. 189-198
    • Yanaihara, N.1    Caplen, N.2    Bowman, E.3
  • 23
    • 33144490646 scopus 로고    scopus 로고
    • A microRNA expression signature of human solid tumors defines cancer gene targets
    • Volinia S, Calin GA, Liu CG, et al. A microRNA expression signature of human solid tumors defines cancer gene targets. Proc Natl Acad Sci U S A 2006; 103: 2257-2261.
    • (2006) Proc Natl Acad Sci U S A , vol.103 , pp. 2257-2261
    • Volinia, S.1    Calin, G.A.2    Liu, C.G.3
  • 24
    • 84973408822 scopus 로고    scopus 로고
    • Progress on the relationship between miR-125 family and tumorigenesis
    • Yin H, Sun Y, Wang X, et al. Progress on the relationship between miR-125 family and tumorigenesis. Exp Cell Res 2015; 339: 252-260.
    • (2015) Exp Cell Res , vol.339 , pp. 252-260
    • Yin, H.1    Sun, Y.2    Wang, X.3
  • 25
    • 84872155023 scopus 로고    scopus 로고
    • Diverse functions of miR-125 family in different cell contexts
    • Sun YM, Lin KY and Chen YQ. Diverse functions of miR-125 family in different cell contexts. J Hematol Oncol 2013; 6: 6.
    • (2013) J Hematol Oncol , vol.6 , pp. 6
    • Sun, Y.M.1    Lin, K.Y.2    Chen, Y.Q.3
  • 26
    • 33847738628 scopus 로고    scopus 로고
    • Coordinate suppression of ERBB2 and ERBB3 by enforced expression of micro-RNA miR-125a or miR-125b
    • Scott GK, Goga A, Bhaumik D, et al. Coordinate suppression of ERBB2 and ERBB3 by enforced expression of micro-RNA miR-125a or miR-125b. J Biol Chem 2007; 282: 1479-1486.
    • (2007) J Biol Chem , vol.282 , pp. 1479-1486
    • Scott, G.K.1    Goga, A.2    Bhaumik, D.3
  • 27
    • 77950584927 scopus 로고    scopus 로고
    • MicroRNA-125a represses cell growth by targeting HuR in breast cancer
    • Guo X, Wu Y and Hartley RS. MicroRNA-125a represses cell growth by targeting HuR in breast cancer. RNA Biol 2009; 6: 575-583.
    • (2009) RNA Biol , vol.6 , pp. 575-583
    • Guo, X.1    Wu, Y.2    Hartley, R.S.3
  • 28
    • 80051748503 scopus 로고    scopus 로고
    • Transcriptomic studies of the airway field of injury associated with smokingrelated lung disease
    • Gower AC, Steiling K, Brothers JF 2nd, et al. Transcriptomic studies of the airway field of injury associated with smokingrelated lung disease. Proc Am Thorac Soc 2011; 8: 173-179.
    • (2011) Proc am Thorac Soc , vol.8 , pp. 173-179
    • Gower, A.C.1    Steiling, K.2    Brothers, J.F.3
  • 29
    • 80051732155 scopus 로고    scopus 로고
    • Advances in proteomic strategies toward the early detection of lung cancer
    • Hassanein M, Rahman JS, Chaurand P, et al. Advances in proteomic strategies toward the early detection of lung cancer. Proc Am Thorac Soc 2011; 8: 183-188.
    • (2011) Proc am Thorac Soc , vol.8 , pp. 183-188
    • Hassanein, M.1    Rahman, J.S.2    Chaurand, P.3
  • 30
    • 79958820786 scopus 로고    scopus 로고
    • Lung cancer and its association with chronic obstructive pulmonary disease: Update on nexus of epigenetics
    • Sundar IK, Mullapudi N, Yao H, et al. Lung cancer and its association with chronic obstructive pulmonary disease: update on nexus of epigenetics. Curr Opin Pulm Med 2011; 17: 279-285.
    • (2011) Curr Opin Pulm Med , vol.17 , pp. 279-285
    • Sundar, I.K.1    Mullapudi, N.2    Yao, H.3
  • 31
    • 85008658879 scopus 로고    scopus 로고
    • MicroRNAs in nonsmall cell lung cancer and idiopathic pulmonary fibrosis
    • Mizuno K, Mataki H, Seki N, et al. MicroRNAs in nonsmall cell lung cancer and idiopathic pulmonary fibrosis. J Hum Genet 2017; 62: 57-65.
    • (2017) J Hum Genet , vol.62 , pp. 57-65
    • Mizuno, K.1    Mataki, H.2    Seki, N.3
  • 32
    • 84981523344 scopus 로고    scopus 로고
    • Integrated genomic analysis of recurrence-associated small non-coding RNAs in oesophageal cancer
    • Jang HJ, Lee HS, Burt BM, et al. Integrated genomic analysis of recurrence-associated small non-coding RNAs in oesophageal cancer. Gut 2016; 66: 215-225.
    • (2016) Gut , vol.66 , pp. 215-225
    • Jang, H.J.1    Lee, H.S.2    Burt, B.M.3
  • 33
    • 84983504728 scopus 로고    scopus 로고
    • MiRSEA: Discovering the pathways regulated by dysfunctional microRNAs
    • Han J, Liu S, Zhang Y, et al. MiRSEA: discovering the pathways regulated by dysfunctional microRNAs. Oncotarget 2016; 7: 55012-55025.
    • (2016) Oncotarget , vol.7 , pp. 55012-55025
    • Han, J.1    Liu, S.2    Zhang, Y.3
  • 34
    • 84871419294 scopus 로고    scopus 로고
    • Thermodynamic control of small RNA-mediated gene silencing
    • Ui-Tei K, Nishi K, Takahashi T, et al. Thermodynamic control of small RNA-mediated gene silencing. Front Genet 2012; 3: 101.
    • (2012) Front Genet , vol.3 , pp. 101
    • Ui-Tei, K.1    Nishi, K.2    Takahashi, T.3
  • 35
    • 84859969412 scopus 로고    scopus 로고
    • Functional parameters of Dicer-independent microRNA biogenesis
    • Yang JS, Maurin T and Lai EC. Functional parameters of Dicer-independent microRNA biogenesis. RNA 2012; 18: 945-957.
    • (2012) RNA , vol.18 , pp. 945-957
    • Yang, J.S.1    Maurin, T.2    Lai, E.C.3
  • 36
    • 84863425849 scopus 로고    scopus 로고
    • Small RNAs have a large impact: Circulating microRNAs as biomarkers for human diseases
    • Weiland M, Gao XH, Zhou L, et al. Small RNAs have a large impact: circulating microRNAs as biomarkers for human diseases. RNA Biol 2012; 9: 850-859.
    • (2012) RNA Biol , vol.9 , pp. 850-859
    • Weiland, M.1    Gao, X.H.2    Zhou, L.3
  • 37
    • 84863092406 scopus 로고    scopus 로고
    • Interrelationship between microsatellite instability and microRNA in gastrointestinal cancer
    • Yamamoto H, Adachi Y, Taniguchi H, et al. Interrelationship between microsatellite instability and microRNA in gastrointestinal cancer. World J Gastroenterol 2012; 18: 2745-2755.
    • (2012) World J Gastroenterol , vol.18 , pp. 2745-2755
    • Yamamoto, H.1    Adachi, Y.2    Taniguchi, H.3
  • 38
    • 84865327159 scopus 로고    scopus 로고
    • MicroRNA regulation of cell viability and drug sensitivity in lung cancer
    • Du L and Pertsemlidis A. MicroRNA regulation of cell viability and drug sensitivity in lung cancer. Expert Opin Biol Ther 2012; 12: 1221-1239.
    • (2012) Expert Opin Biol Ther , vol.12 , pp. 1221-1239
    • Du, L.1    Pertsemlidis, A.2
  • 39
    • 84964977879 scopus 로고    scopus 로고
    • Mir-125a regulates ovarian cancer proliferation and invasion by repressing GALNT14 expression
    • Yang J, Li G and Zhang K. Mir-125a regulates ovarian cancer proliferation and invasion by repressing GALNT14 expression. Biomed Pharmacother 2016; 80: 381-387.
    • (2016) Biomed Pharmacother , vol.80 , pp. 381-387
    • Yang, J.1    Li, G.2    Zhang, K.3
  • 40
    • 84973917372 scopus 로고    scopus 로고
    • The complex STATes of astrocyte reactivity: How are they controlled by the JAK-STAT3 pathway?
    • Ceyzeriat K, Abjean L, Carrillo-de Sauvage MA, et al. The complex STATes of astrocyte reactivity: how are they controlled by the JAK-STAT3 pathway? Neuroscience 2016; 330: 205-218.
    • (2016) Neuroscience , vol.330 , pp. 205-218
    • Ceyzeriat, K.1    Abjean, L.2    Carrillo-De Sauvage, M.A.3
  • 42
    • 84982847721 scopus 로고    scopus 로고
    • Targeted inhibition of STATs and IRFs as a potential treatment strategy in cardiovascular disease
    • Szelag M, Piaszyk-Borychowska A, Plens-Galaska M, et al. Targeted inhibition of STATs and IRFs as a potential treatment strategy in cardiovascular disease. Oncotarget 2016; 7: 48788-48812.
    • (2016) Oncotarget , vol.7 , pp. 48788-48812
    • Szelag, M.1    Piaszyk-Borychowska, A.2    Plens-Galaska, M.3
  • 43
    • 84963656297 scopus 로고    scopus 로고
    • Signal transducer and activator of transcription 3 signaling as a potential target to treat muscle wasting diseases
    • Sala D and Sacco A. Signal transducer and activator of transcription 3 signaling as a potential target to treat muscle wasting diseases. Curr Opin Clin Nutr Metab Care 2016; 19: 171-176.
    • (2016) Curr Opin Clin Nutr Metab Care , vol.19 , pp. 171-176
    • Sala, D.1    Sacco, A.2
  • 44
    • 84961147160 scopus 로고    scopus 로고
    • STAT3 in the systemic inflammation of cancer cachexia
    • Zimmers TA, Fishel ML and Bonetto A. STAT3 in the systemic inflammation of cancer cachexia. Semin Cell Dev Biol 2016; 54: 28-41.
    • (2016) Semin Cell Dev Biol , vol.54 , pp. 28-41
    • Zimmers, T.A.1    Fishel, M.L.2    Bonetto, A.3
  • 45
    • 84957849045 scopus 로고    scopus 로고
    • The emerging role of signal transducer and activator of transcription 3 in cerebral ischemic and hemorrhagic stroke
    • Liang Z, Wu G, Fan C, et al. The emerging role of signal transducer and activator of transcription 3 in cerebral ischemic and hemorrhagic stroke. Prog Neurobiol 2016; 137: 1-16.
    • (2016) Prog Neurobiol , vol.137 , pp. 1-16
    • Liang, Z.1    Wu, G.2    Fan, C.3
  • 46
    • 84959347264 scopus 로고    scopus 로고
    • Strategies and approaches of targeting STAT3 for cancer treatment
    • Furtek SL, Backos DS, Matheson CJ, et al. Strategies and approaches of targeting STAT3 for cancer treatment. ACS Chem Biol 2016; 11: 308-318.
    • (2016) ACS Chem Biol , vol.11 , pp. 308-318
    • Furtek, S.L.1    Backos, D.S.2    Matheson, C.J.3
  • 47
    • 84979587660 scopus 로고    scopus 로고
    • Embryonic stem cell preconditioned microenvironment suppresses tumorigenic properties in breast cancer
    • He N, Feng G, Li Y, et al. Embryonic stem cell preconditioned microenvironment suppresses tumorigenic properties in breast cancer. Stem Cell Res Ther 2016; 7: 95.
    • (2016) Stem Cell Res Ther , vol.7 , pp. 95
    • He, N.1    Feng, G.2    Li, Y.3
  • 48
    • 84979738414 scopus 로고    scopus 로고
    • Autocrine activity of BDNF induced by the STAT3 signaling pathway causes prolonged TrkB activation and promotes human non-small-cell lung cancer proliferation
    • Chen B, Liang Y, He Z, et al. Autocrine activity of BDNF induced by the STAT3 signaling pathway causes prolonged TrkB activation and promotes human non-small-cell lung cancer proliferation. Sci Rep 2016; 6: 30404.
    • (2016) Sci Rep , vol.6 , pp. 30404
    • Chen, B.1    Liang, Y.2    He, Z.3
  • 49
    • 84982840954 scopus 로고    scopus 로고
    • WSTF promotes proliferation and invasion of lung cancer cells by inducing EMT via PI3K/Akt and IL-6/STAT3 signaling pathways
    • Meng J, Zhang XT, Liu XL, et al. WSTF promotes proliferation and invasion of lung cancer cells by inducing EMT via PI3K/Akt and IL-6/STAT3 signaling pathways. Cell Signal 2016; 28: 1673-1682.
    • (2016) Cell Signal , vol.28 , pp. 1673-1682
    • Meng, J.1    Zhang, X.T.2    Liu, X.L.3
  • 50
    • 84975048874 scopus 로고    scopus 로고
    • Suspension survival mediated by PP2A-STAT3-Col XVII determines tumour initiation and metastasis in cancer stem cells
    • Liu CC, Lin SP, Hsu HS, et al. Suspension survival mediated by PP2A-STAT3-Col XVII determines tumour initiation and metastasis in cancer stem cells. Nat Commun 2016; 7: 11798.
    • (2016) Nat Commun , vol.7 , pp. 11798
    • Liu, C.C.1    Lin, S.P.2    Hsu, H.S.3
  • 51
    • 85028525770 scopus 로고    scopus 로고
    • Unexpected oncosuppressive role for STAT3 in KRAS-induced lung tumorigenesis
    • Grabner B, Moll HP and Casanova E. Unexpected oncosuppressive role for STAT3 in KRAS-induced lung tumorigenesis. Mol Cell Oncol 2016; 3: e1036199.
    • (2016) Mol Cell Oncol , vol.3
    • Grabner, B.1    Moll, H.P.2    Casanova, E.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.