메뉴 건너뛰기




Volumn 19, Issue 3, 2016, Pages 171-176

Signal transducer and activator of transcription 3 signaling as a potential target to treat muscle wasting diseases

Author keywords

Muscle stem cells; Muscle wasting; Signal transducer and activator of transcription 3; Skeletal muscle

Indexed keywords

ANTINEOPLASTIC AGENT; ATROGIN 1; AZD 9150; CCAAT ENHANCER BINDING PROTEIN DELTA; DNA METHYLTRANSFERASE 1; HISTONE LYSINE METHYLTRANSFERASE; HYPOXIA INDUCIBLE FACTOR 1ALPHA; INITIATION FACTOR 2ALPHA; INTERLEUKIN 6; IONIS STAT3RX; MITOGEN ACTIVATED PROTEIN KINASE; MUSCLE RING FINGER 1 PROTEIN; N BENZYL 2 CYANO 3 (3,4 DIHYDROXYPHENYL)ACRYLAMIDE; OPB 31121; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN KINASE R; SORAFENIB; STAT3 ALPHA PROTEIN; STAT3 BETA PROTEIN; STAT3 DECOY; STAT3 DELTA PROTEIN; STAT3 GAMMA PROTEIN; STAT3 PROTEIN; SUNITINIB; TRANSCRIPTION FACTOR EZH2; UBIQUITIN; UNCLASSIFIED DRUG; STAT3 PROTEIN, HUMAN;

EID: 84963656297     PISSN: 13631950     EISSN: 14736519     Source Type: Journal    
DOI: 10.1097/MCO.0000000000000273     Document Type: Review
Times cited : (32)

References (41)
  • 2
    • 84882684464 scopus 로고    scopus 로고
    • Tissue-resident mesenchymal stem/progenitor cells in skeletal muscle: Collaborators or saboteurs?
    • Judson RN, Zhang RH, Rossi FM. Tissue-resident mesenchymal stem/progenitor cells in skeletal muscle: collaborators or saboteurs? FEBS J 2013; 280:4100-4108.
    • (2013) FEBS J , vol.280 , pp. 4100-4108
    • Judson, R.N.1    Zhang, R.H.2    Rossi, F.M.3
  • 3
    • 84900014717 scopus 로고    scopus 로고
    • Macrophage plasticity in skeletal muscle repair
    • Rigamonti E, Zordan P, Sciorati C, et al. Macrophage plasticity in skeletal muscle repair. Biomed Res Int 2014; 2014:560629.
    • (2014) Biomed Res Int , vol.2014 , pp. 560629
    • Rigamonti, E.1    Zordan, P.2    Sciorati, C.3
  • 4
    • 84887493598 scopus 로고    scopus 로고
    • NF-kappa B-mediated Pax7 dysregulation in the muscle microenvironment promotes cancer cachexia
    • He WA, Berardi E, Cardillo VM, et al. NF-kappa B-mediated Pax7 dysregulation in the muscle microenvironment promotes cancer cachexia. J Clin Invest 2013; 123:4821-4835.
    • (2013) J Clin Invest , vol.123 , pp. 4821-4835
    • He, W.A.1    Berardi, E.2    Cardillo, V.M.3
  • 5
    • 84949556815 scopus 로고    scopus 로고
    • Dystrophin expression in muscle stem cells regulates their polarity and asymmetric division
    • Dumont NA, Wang YX, von Maltzahn J, et al. Dystrophin expression in muscle stem cells regulates their polarity and asymmetric division. Nat Med 2015; 21:1455-1463.
    • (2015) Nat Med , vol.21 , pp. 1455-1463
    • Dumont, N.A.1    Wang, Y.X.2    Von Maltzahn, J.3
  • 6
    • 84955499816 scopus 로고    scopus 로고
    • Regulation of muscle satellite cell function in tissue homeostasis and aging
    • Sacco A, Puri PL. Regulation of muscle satellite cell function in tissue homeostasis and aging. Cell Stem Cell 2015; 16:585-587.
    • (2015) Cell Stem Cell , vol.16 , pp. 585-587
    • Sacco, A.1    Puri, P.L.2
  • 7
    • 84953872755 scopus 로고    scopus 로고
    • Autophagy maintains stemness by preventing senescence
    • Garcia-Prat L, Martinez-Vicente M, Perdiguero E, et al. Autophagy maintains stemness by preventing senescence. Nature 2016; 529:37-42.
    • (2016) Nature , vol.529 , pp. 37-42
    • Garcia-Prat, L.1    Martinez-Vicente, M.2    Perdiguero, E.3
  • 8
    • 84872742337 scopus 로고    scopus 로고
    • Interleukin-6/signal transducer and activator of transcription 3 (STAT3) pathway is essential for macrophage infiltration and myoblast proliferation during muscle regeneration
    • Zhang C, Li Y, Wu Y, et al. Interleukin-6/signal transducer and activator of transcription 3 (STAT3) pathway is essential for macrophage infiltration and myoblast proliferation during muscle regeneration. J Biol Chem 2013; 288:1489-1499.
    • (2013) J Biol Chem , vol.288 , pp. 1489-1499
    • Zhang, C.1    Li, Y.2    Wu, Y.3
  • 9
    • 84914097789 scopus 로고    scopus 로고
    • STAT3 signaling controls satellite cell expansion and skeletal muscle repair
    • Tierney MT, Aydogdu T, Sala D, et al. STAT3 signaling controls satellite cell expansion and skeletal muscle repair. Nat Med 2014; 20:1182-1186.
    • (2014) Nat Med , vol.20 , pp. 1182-1186
    • Tierney, M.T.1    Aydogdu, T.2    Sala, D.3
  • 10
    • 84912099331 scopus 로고    scopus 로고
    • Inhibition of JAK-STAT signaling stimulates adult satellite cell function
    • Price FD, von Maltzahn J, Bentzinger CF, et al. Inhibition of JAK-STAT signaling stimulates adult satellite cell function. Nat Med 2014; 20:1174-1181.
    • (2014) Nat Med , vol.20 , pp. 1174-1181
    • Price, F.D.1    Von Maltzahn, J.2    Bentzinger, C.F.3
  • 11
    • 84936889894 scopus 로고    scopus 로고
    • Nilotinib reduces muscle fibrosis in chronic muscle injury by promoting TNF-mediated apoptosis of fibro/adipogenic progenitors
    • Lemos DR, Babaeijandaghi F, Low M, et al. Nilotinib reduces muscle fibrosis in chronic muscle injury by promoting TNF-mediated apoptosis of fibro/adipogenic progenitors. Nat Med 2015; 21:786-794.
    • (2015) Nat Med , vol.21 , pp. 786-794
    • Lemos, D.R.1    Babaeijandaghi, F.2    Low, M.3
  • 12
    • 75949130333 scopus 로고    scopus 로고
    • Mesenchymal progenitors distinct from satellite cells contribute to ectopic fat cell formation in skeletal muscle
    • Uezumi A, Fukada S, Yamamoto N, et al. Mesenchymal progenitors distinct from satellite cells contribute to ectopic fat cell formation in skeletal muscle. Nat Cell Biol 2010; 12:143-152.
    • (2010) Nat Cell Biol , vol.12 , pp. 143-152
    • Uezumi, A.1    Fukada, S.2    Yamamoto, N.3
  • 13
    • 75949096894 scopus 로고    scopus 로고
    • Muscle injury activates resident fibro/adipogenic progenitors that facilitate myogenesis
    • Joe AW, Yi L, Natarajan A, et al. Muscle injury activates resident fibro/adipogenic progenitors that facilitate myogenesis. Nat Cell Biol 2010; 12:153-163.
    • (2010) Nat Cell Biol , vol.12 , pp. 153-163
    • Joe, A.W.1    Yi, L.2    Natarajan, A.3
  • 14
    • 84901045017 scopus 로고    scopus 로고
    • Identification and characterization of PDGFRalpha+ mesenchymal progenitors in human skeletal muscle
    • Uezumi A, Fukada S, Yamamoto N, et al. Identification and characterization of PDGFRalpha+ mesenchymal progenitors in human skeletal muscle. Cell Death Dis 2014; 5:e1186.
    • (2014) Cell Death Dis , vol.5 , pp. e1186
    • Uezumi, A.1    Fukada, S.2    Yamamoto, N.3
  • 15
    • 84954213531 scopus 로고    scopus 로고
    • Interactions between muscle stem cells, mesenchymal-derived cells and immune cells in muscle homeostasis, regeneration and disease
    • Farup J, Madaro L, Puri PL, Mikkelsen UR. Interactions between muscle stem cells, mesenchymal-derived cells and immune cells in muscle homeostasis, regeneration and disease. Cell Death Dis 2015; 6:e1830.
    • (2015) Cell Death Dis , vol.6 , pp. e1830
    • Farup, J.1    Madaro, L.2    Puri, P.L.3    Mikkelsen, U.R.4
  • 16
    • 84898927430 scopus 로고    scopus 로고
    • HDAC-regulated myomiRs control BAF60 variant exchange and direct the functional phenotype of fibroadipogenic progenitors in dystrophic muscles
    • Saccone V, Consalvi S, Giordani L, et al. HDAC-regulated myomiRs control BAF60 variant exchange and direct the functional phenotype of fibroadipogenic progenitors in dystrophic muscles. Genes Dev 2014; 28:841-857.
    • (2014) Genes Dev , vol.28 , pp. 841-857
    • Saccone, V.1    Consalvi, S.2    Giordani, L.3
  • 17
    • 84950119839 scopus 로고    scopus 로고
    • The impact of sarcopenia and myosteatosis on outcomes of unresectable pancreatic cancer or distal cholangiocarcinoma
    • [Epub ahead of print]
    • Rollins KE, Tewari N, Ackner A, et al. The impact of sarcopenia and myosteatosis on outcomes of unresectable pancreatic cancer or distal cholangiocarcinoma. Clin Nutr 2015; doi: 10.1016/j.clnu.2015.08.005. [Epub ahead of print]
    • (2015) Clin Nutr
    • Rollins, K.E.1    Tewari, N.2    Ackner, A.3
  • 18
    • 84955716294 scopus 로고    scopus 로고
    • Low muscularity and myosteatosis is related to the host systemic inflammatory response in patients undergoing surgery for colorectal cancer
    • Malietzis G, Johns N, Al-Hassi HO, et al. Low muscularity and myosteatosis is related to the host systemic inflammatory response in patients undergoing surgery for colorectal cancer. Ann Surg 2016; 263:320-325.
    • (2016) Ann Surg , vol.263 , pp. 320-325
    • Malietzis, G.1    Johns, N.2    Al-Hassi, H.O.3
  • 19
    • 84943795592 scopus 로고    scopus 로고
    • The role of STAT3 in autophagy
    • You L, Wang Z, Li H, et al. The role of STAT3 in autophagy. Autophagy 2015; 11:729-739.
    • (2015) Autophagy , vol.11 , pp. 729-739
    • You, L.1    Wang, Z.2    Li, H.3
  • 20
    • 84908161000 scopus 로고    scopus 로고
    • Revisiting STAT3 signalling in cancer: New and unexpected biological functions
    • Yu H, Lee H, Herrmann A, et al. Revisiting STAT3 signalling in cancer: new and unexpected biological functions. Nat Rev Cancer 2014; 14:736-746.
    • (2014) Nat Rev Cancer , vol.14 , pp. 736-746
    • Yu, H.1    Lee, H.2    Herrmann, A.3
  • 21
    • 84939137853 scopus 로고    scopus 로고
    • IL10-driven STAT3 signalling in senescent macrophages promotes pathological eye angiogenesis
    • Nakamura R, Sene A, Santeford A, et al. IL10-driven STAT3 signalling in senescent macrophages promotes pathological eye angiogenesis. Nat Commun 2015; 6:7847.
    • (2015) Nat Commun , vol.6 , pp. 7847
    • Nakamura, R.1    Sene, A.2    Santeford, A.3
  • 22
    • 84861215508 scopus 로고    scopus 로고
    • Acetylated STAT3 is crucial for methylation of tumor-suppressor gene promoters and inhibition by resveratrol results in demethylation
    • Lee H, Zhang P, Herrmann A, et al. Acetylated STAT3 is crucial for methylation of tumor-suppressor gene promoters and inhibition by resveratrol results in demethylation. Proc Natl Acad Sci U S A 2012; 109:7765-7769.
    • (2012) Proc Natl Acad Sci U S A , vol.109 , pp. 7765-7769
    • Lee, H.1    Zhang, P.2    Herrmann, A.3
  • 23
    • 84879000598 scopus 로고    scopus 로고
    • Phosphorylation of EZH2 activates STAT3 signaling via STAT3 methylation and promotes tumorigenicity of glioblastoma stem-like cells
    • Kim E, Kim M, Woo DH, et al. Phosphorylation of EZH2 activates STAT3 signaling via STAT3 methylation and promotes tumorigenicity of glioblastoma stem-like cells. Cancer Cell 2013; 23:839-852.
    • (2013) Cancer Cell , vol.23 , pp. 839-852
    • Kim, E.1    Kim, M.2    Woo, D.H.3
  • 24
  • 25
    • 3843088508 scopus 로고    scopus 로고
    • Proteolytic conversion of STAT3alpha to STAT3gamma in human neutrophils: Role of granule-derived serine proteases
    • Kato T, Sakamoto E, Kutsuna H, et al. Proteolytic conversion of STAT3alpha to STAT3gamma in human neutrophils: role of granule-derived serine proteases. J Biol Chem 2004; 279:31076-31080.
    • (2004) J Biol Chem , vol.279 , pp. 31076-31080
    • Kato, T.1    Sakamoto, E.2    Kutsuna, H.3
  • 26
    • 67649988989 scopus 로고    scopus 로고
    • Mitochondrial STAT3 supports Ras-dependent oncogenic transformation
    • Gough DJ, Corlett A, Schlessinger K, et al. Mitochondrial STAT3 supports Ras-dependent oncogenic transformation. Science 2009; 324:1713-1716.
    • (2009) Science , vol.324 , pp. 1713-1716
    • Gough, D.J.1    Corlett, A.2    Schlessinger, K.3
  • 27
    • 59849101586 scopus 로고    scopus 로고
    • Function of mitochondrial Stat3 in cellular respiration
    • Wegrzyn J, Potla R, Chwae YJ, et al. Function of mitochondrial Stat3 in cellular respiration. Science 2009; 323:793-797.
    • (2009) Science , vol.323 , pp. 793-797
    • Wegrzyn, J.1    Potla, R.2    Chwae, Y.J.3
  • 28
    • 84906284023 scopus 로고    scopus 로고
    • STAT3 and metabolism: How many ways to use a single molecule?
    • Demaria M, Camporeale A, Poli V. STAT3 and metabolism: how many ways to use a single molecule? Int J Cancer 2014; 135:1997-2003.
    • (2014) Int J Cancer , vol.135 , pp. 1997-2003
    • Demaria, M.1    Camporeale, A.2    Poli, V.3
  • 29
    • 84924857323 scopus 로고    scopus 로고
    • The NAD(+)-dependent SIRT1 deacetylase translates a metabolic switch into regulatory epigenetics in skeletal muscle stem cells
    • Ryall JG, Dell'Orso S, Derfoul A, et al. The NAD(+)-dependent SIRT1 deacetylase translates a metabolic switch into regulatory epigenetics in skeletal muscle stem cells. Cell Stem Cell 2015; 16:171-183.
    • (2015) Cell Stem Cell , vol.16 , pp. 171-183
    • Ryall, J.G.1    Dell'Orso, S.2    Derfoul, A.3
  • 30
    • 84937959927 scopus 로고    scopus 로고
    • STAT3 regulated ARF expression suppresses prostate cancer metastasis
    • Pencik J, Schlederer M, Gruber W, et al. STAT3 regulated ARF expression suppresses prostate cancer metastasis. Nat Commun 2015; 6:7736.
    • (2015) Nat Commun , vol.6 , pp. 7736
    • Pencik, J.1    Schlederer, M.2    Gruber, W.3
  • 31
    • 84949195979 scopus 로고    scopus 로고
    • Functional and morphological improvement of dystrophic muscle by interleukin 6 receptor blockade
    • Pelosi L, Berardinelli MG, De Pasquale L, et al. Functional and morphological improvement of dystrophic muscle by interleukin 6 receptor blockade. EBio-Medicine 2015; 2:285-293.
    • (2015) EBio-Medicine , vol.2 , pp. 285-293
    • Pelosi, L.1    Berardinelli, M.G.2    De Pasquale, L.3
  • 32
    • 84883485261 scopus 로고    scopus 로고
    • Stat3 activation links a C/EBPdelta to myostatin pathway to stimulate loss of muscle mass
    • Zhang L, Pan J, Dong Y, et al. Stat3 activation links a C/EBPdelta to myostatin pathway to stimulate loss of muscle mass. Cell Metab 2013; 18:368-379.
    • (2013) Cell Metab , vol.18 , pp. 368-379
    • Zhang, L.1    Pan, J.2    Dong, Y.3
  • 33
    • 84928380951 scopus 로고    scopus 로고
    • Inhibition of Stat3 activation suppresses caspase-3 and the ubiquitin-proteasome system, leading to preservation of muscle mass in cancer cachexia
    • Silva KA, Dong J, Dong Y, et al. Inhibition of Stat3 activation suppresses caspase-3 and the ubiquitin-proteasome system, leading to preservation of muscle mass in cancer cachexia. J Biol Chem 2015; 290:11177-11187.
    • (2015) J Biol Chem , vol.290 , pp. 11177-11187
    • Silva, K.A.1    Dong, J.2    Dong, Y.3
  • 34
    • 84903462699 scopus 로고    scopus 로고
    • Pancreatic cancer-induced cachexia is Jak2-dependent in mice
    • Gilabert M, Calvo E, Airoldi A, et al. Pancreatic cancer-induced cachexia is Jak2-dependent in mice. J Cell Physiol 2014; 229:1437-1443.
    • (2014) J Cell Physiol , vol.229 , pp. 1437-1443
    • Gilabert, M.1    Calvo, E.2    Airoldi, A.3
  • 35
    • 84923289520 scopus 로고    scopus 로고
    • Sunitinib prevents cachexia and prolongs survival of mice bearing renal cancer by restraining STAT3 and MuRF-1 activation in muscle
    • Pretto F, Ghilardi C, Moschetta M, et al. Sunitinib prevents cachexia and prolongs survival of mice bearing renal cancer by restraining STAT3 and MuRF-1 activation in muscle. Oncotarget 2015; 6:3043-3054.
    • (2015) Oncotarget , vol.6 , pp. 3043-3054
    • Pretto, F.1    Ghilardi, C.2    Moschetta, M.3
  • 36
    • 84861706956 scopus 로고    scopus 로고
    • Mouse skeletal muscle fiber-typespecific macroautophagy and muscle wasting are regulated by a Fyn/STAT3/Vps34 signaling pathway
    • Yamada E, Bastie CC, Koga H, et al. Mouse skeletal muscle fiber-typespecific macroautophagy and muscle wasting are regulated by a Fyn/STAT3/Vps34 signaling pathway. Cell Rep 2012; 1:557-569.
    • (2012) Cell Rep , vol.1 , pp. 557-569
    • Yamada, E.1    Bastie, C.C.2    Koga, H.3
  • 37
    • 84880924081 scopus 로고    scopus 로고
    • IL-6 induction of TLR-4 gene expression via STAT3 has an effect on insulin resistance in human skeletal muscle
    • Kim TH, Choi SE, Ha ES, et al. IL-6 induction of TLR-4 gene expression via STAT3 has an effect on insulin resistance in human skeletal muscle. Acta Diabetol 2013; 50:189-200.
    • (2013) Acta Diabetol , vol.50 , pp. 189-200
    • Kim, T.H.1    Choi, S.E.2    Ha, E.S.3
  • 38
    • 84873049766 scopus 로고    scopus 로고
    • Constitutive STAT3 phosphorylation contributes to skeletal muscle insulin resistance in type 2 diabetes
    • Mashili F, Chibalin AV, Krook A, Zierath JR. Constitutive STAT3 phosphorylation contributes to skeletal muscle insulin resistance in type 2 diabetes. Diabetes 2013; 62:457-465.
    • (2013) Diabetes , vol.62 , pp. 457-465
    • Mashili, F.1    Chibalin, A.V.2    Krook, A.3    Zierath, J.R.4
  • 39
    • 84937738853 scopus 로고    scopus 로고
    • Knockout of STAT3 in skeletal muscle does not prevent high-fat diet-induced insulin resistance
    • White AT, LaBarge SA, McCurdy CE, Schenk S. Knockout of STAT3 in skeletal muscle does not prevent high-fat diet-induced insulin resistance. Mol Metab 2015; 4:569-575.
    • (2015) Mol Metab , vol.4 , pp. 569-575
    • White, A.T.1    LaBarge, S.A.2    McCurdy, C.E.3    Schenk, S.4
  • 41
    • 84942372445 scopus 로고    scopus 로고
    • Differential control of muscle mass in type 1 and type 2 diabetes mellitus
    • Sala D, Zorzano A. Differential control of muscle mass in type 1 and type 2 diabetes mellitus. Cell Mol Life Sci 2015; 72:3803-3817.
    • (2015) Cell Mol Life Sci , vol.72 , pp. 3803-3817
    • Sala, D.1    Zorzano, A.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.