Glucocorticoid attenuates acute lung injury through induction of type 2 macrophage

Journal of Translational Medicine

Volumn 15, Issue 1, 2017, Pages

  Tu, Guo wei ^a   Shi, Yi ^a   Zheng, Yi jun ^a   Ju, Min jie ^a   He, Hong yu ^a   Ma, Guo guang ^a   Hao, Guang wei ^a   Luo, Zhe ^a  

^a FUDAN UNIVERSITY   (China)

Author keywords

Acute lung injury; Acute respiratory distress syndrome; Glucocorticoid; Macrophage; Methylprednisolone; Regulatory T cell

Indexed keywords

INTERLEUKIN 10; LIPOPOLYSACCHARIDE; METHYLPREDNISOLONE; TRANSCRIPTION FACTOR FOXP3; TRANSFORMING GROWTH FACTOR BETA; CHEMOKINE; GLUCOCORTICOID;

ACUTE LUNG INJURY; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BAGG ALBINO MOUSE; BONE MARROW CELL; CD25+ T LYMPHOCYTE; CD4+ T LYMPHOCYTE; CELL DIFFERENTIATION; CELL ISOLATION; CELL PROLIFERATION ASSAY; CONTROLLED STUDY; DRUG MECHANISM; ENZYME INDUCTION; FLOW CYTOMETRY; IN VITRO STUDY; INFLAMMATION; LUNG MECHANICS; MACROPHAGE; MALE; MOUSE; NONHUMAN; POLARIZATION; PROTEIN EXPRESSION; REGULATORY T LYMPHOCYTE; RESPIRATORY FUNCTION; SINGLE DRUG DOSE; SUPERNATANT; TH17 CELL; TISSUE INJURY; ANIMAL; BIOLOGICAL MODEL; BLOOD GAS ANALYSIS; BRONCHOALVEOLAR LAVAGE FLUID; DRUG EFFECTS; LUNG; METABOLISM; ORGAN SIZE; PATHOLOGY; PATHOPHYSIOLOGY;

ACUTE LUNG INJURY; ANIMALS; BLOOD GAS ANALYSIS; BRONCHOALVEOLAR LAVAGE FLUID; CELL DIFFERENTIATION; CHEMOKINES; GLUCOCORTICOIDS; INFLAMMATION; INTERLEUKIN-10; LUNG; MACROPHAGES; MALE; METHYLPREDNISOLONE; MICE, INBRED BALB C; MODELS, BIOLOGICAL; ORGAN SIZE; T-LYMPHOCYTES, REGULATORY; TRANSFORMING GROWTH FACTOR BETA;

EID: 85028453103     PISSN: None     EISSN: 14795876     Source Type: Journal    
DOI: 10.1186/s12967-017-1284-7     Document Type: Article

References (35)

1. Gibbison B, Lopez-Lopez JA, Higgins JP, Miller T, Angelini GD, Lightman SL, Annane D. Corticosteroids in septic shock: a systematic review and network meta-analysis. Crit Care. 2017;21:78.
2. Ozturk O, Tezcan AH, Adali Y, Yildirim CH, Aksoy O, Yagmurdur H, Bilge A. Effect of ozone and methylprednisolone treatment following crush type sciatic nerve injury. Acta Cir Bras. 2016;31:730-5.
3. Cheng S, Gao W, Xu X, Fan H, Wu Y, Li F, Zhang J, Zhu X, Zhang Y. Methylprednisolone sodium succinate reduces BBB disruption and inflammation in a model mouse of intracranial haemorrhage. Brain Res Bull. 2016;127:226-33.
4. Royse CF, Saager L, Whitlock R, Ou-Young J, Royse A, Vincent J, Devereaux PJ, Kurz A, Awais A, Panjasawatwong K, Sessler DI. Impact of methylprednisolone on postoperative quality of recovery and delirium in the steroids in cardiac surgery trial: a randomized, double-blind, placebo-controlled substudy. Anesthesiology. 2017;126:223-33.
5. Marik PE, Meduri GU, Rocco PR, Annane D. Glucocorticoid treatment in acute lung injury and acute respiratory distress syndrome. Crit Care Clin. 2011;27:589-607.
6. Ware LB, Matthay MA. The acute respiratory distress syndrome. N Engl J Med. 2000;342:1334-49.
7. Yang ZG, Lei XL, Li XL. Early application of low-dose glucocorticoid improves acute respiratory distress syndrome: a meta-analysis of randomized controlled trials. Exp Ther Med. 2017;13:1215-24.
8. Belchamber KBR, Donnelly LE. Macrophage dysfunction in respiratory disease. Results Probl Cell Differ. 2017;62:299-313.
9. D'Alessio FR, Craig JM, Singer BD, Files DC, Mock JR, Garibaldi BT, Fallica J, Tripathi A, Mandke P, Gans JH, et al. Enhanced resolution of experimental ARDS through IL-4-mediated lung macrophage reprogramming. Am J Physiol Lung Cell Mol Physiol. 2016;310:L733-46.
10. Liu G, Yang H. Modulation of macrophage activation and programming in immunity. J Cell Physiol. 2013;228:502-12.
11. Tang L, Zhang H, Wang C, Li H, Zhang Q, Bai J. M2A and M2C macrophage subsets ameliorate inflammation and fibroproliferation in acute lung injury through interleukin 10 pathway. Shock. 2016;48:119-29.
12. Kambara K, Ohashi W, Tomita K, Takashina M, Fujisaka S, Hayashi R, Mori H, Tobe K, Hattori Y. In vivo depletion of CD206+ M2 macrophages exaggerates lung injury in endotoxemic mice. Am J Pathol. 2015;185:162-71.
13. Sun J, Han ZB, Liao W, Yang SG, Yang Z, Yu J, Meng L, Wu R, Han ZC. Intrapulmonary delivery of human umbilical cord mesenchymal stem cells attenuates acute lung injury by expanding CD4+ CD25+ Forkhead Boxp3 (FOXP3)+ regulatory T cells and balancing anti- and pro-inflammatory factors. Cell Physiol Biochem. 2011;27:587-96.
14. Singer BD, Mock JR, Aggarwal NR, Garibaldi BT, Sidhaye VK, Florez MA, Chau E, Gibbs KW, Mandke P, Tripathi A, et al. Regulatory T cell DNA methyltransferase inhibition accelerates resolution of lung inflammation. Am J Respir Cell Mol Biol. 2015;52:641-52.
15. Barros MH, Hauck F, Dreyer JH, Kempkes B, Niedobitek G. Macrophage polarisation: an immunohistochemical approach for identifying M1 and M2 macrophages. PLoS ONE. 2013;8:e80908.
16. Kapur R, Kim M, Aslam R, McVey MJ, Tabuchi A, Luo A, Liu J, Li Y, Shanmugabhavananthan S, Speck ER, et al. T regulatory cells and dendritic cells protect against transfusion-related acute lung injury via IL-10. Blood. 2017;129:2557-69.
17. Li G, Cao Y, Sun Y, Xu R, Zheng Z, Song H. Ultrafine particles in the airway aggravated experimental lung injury through impairment in Treg function. Biochem Biophys Res Commun. 2016;478:494-500.
18. Tu G, Ju M, Zheng Y, Xu M, Rong R, Zhu D, Zhu T, Luo Z. Early- and late-onset severe pneumonia after renal transplantation. Int J Clin Exp Med. 2015;8:1324-32.
19. Tu GW, Ju MJ, Zheng YJ, Zhu DM, Xu M, Rong RM, Zhu TY, Luo Z. An interdisciplinary approach for renal transplant recipients with severe pneumonia: a single ICU experience. Intensive Care Med. 2014;40:914-5.
20. Tu GW, Ju MJ, Han Y, He HY, Rong RM, Xu M, Xue ZG, Zhu TY, Luo Z. Moderate-dose glucocorticoids as salvage therapy for severe pneumonia in renal transplant recipients: a single-center feasibility study. Ren Fail. 2014;36:202-9.
21. Mosser DM. The many faces of macrophage activation. J Leukoc Biol. 2003;73:209-12.
22. Nelson MP, Christmann BS, Werner JL, Metz AE, Trevor JL, Lowell CA, Steele C. IL-33 and M2a alveolar macrophages promote lung defense against the atypical fungal pathogen Pneumocystis murina. J Immunol. 2011;186:2372-81.
23. Zhou L, Chong MM, Littman DR. Plasticity of CD4+ T cell lineage differentiation. Immunity. 2009;30:646-55.
24. Levings MK, Gregori S, Tresoldi E, Cazzaniga S, Bonini C, Roncarolo MG. Differentiation of Tr1 cells by immature dendritic cells requires IL-10 but not CD25+ CD4+ Tr cells. Blood. 2005;105:1162-9.
25. Loevenich K, Ueffing K, Abel S, Hose M, Matuschewski K, Westendorf AM, Buer J, Hansen W. DC-derived IL-10 modulates pro-inflammatory cytokine production and promotes induction of CD4+ IL-10+ regulatory T cells during Plasmodium yoelii infection. Front Immunol. 2017;8:152.
26. Arpaia N, Green JA, Moltedo B, Arvey A, Hemmers S, Yuan S, Treuting PM, Rudensky AY. A distinct function of regulatory T cells in tissue protection. Cell. 2015;162:1078-89.
27. Kapur R, Kim M, Aslam R, McVey MJ, Tabuchi A, Luo A, Liu J, Li Y, Shanmugabhavananthan S, Speck ER, et al. T regulatory cells and dendritic cells protect against transfusion-related acute lung injury via IL-10. Blood. 2017;129:2557-69.
28. Zhu T, Wang DX, Zhang W, Liao XQ, Guan X, Bo H, Sun JY, Huang NW, He J, Zhang YK, et al. Andrographolide protects against LPS-induced acute lung injury by inactivation of NF-kappaB. PLoS ONE. 2013;8:e56407.
29. Liu S, Feng G, Wang GL, Liu GJ. p38MAPK inhibition attenuates LPS-induced acute lung injury involvement of NF-kappaB pathway. Eur J Pharmacol. 2008;584:159-65.
30. Hou S, Ding H, Lv Q, Yin X, Song J, Landen NX, Fan H. Therapeutic effect of intravenous infusion of perfluorocarbon emulsion on LPS-induced acute lung injury in rats. PLoS ONE. 2014;9:e87826.
31. Stephens RS, Johnston L, Servinsky L, Kim BS, Damarla M. The tyrosine kinase inhibitor imatinib prevents lung injury and death after intravenous LPS in mice. Physiol Rep. 2015;3:e12589.
32. Ghosh S, Wilson MR, Choudhury S, Yamamoto H, Goddard ME, Falusi B, Marczin N, Takata M. Effects of inhaled carbon monoxide on acute lung injury in mice. Am J Physiol Lung Cell Mol Physiol. 2005;288:L1003-9.
33. Wang S, Zhang C, Li J, Niyazi S, Zheng L, Xu M, Rong R, Yang C, Zhu T. Erythropoietin protects against rhabdomyolysis-induced acute kidney injury by modulating macrophage polarization. Cell Death Dis. 2017;8:e2725.
34. Lancelin W, Guerrero-Plata A. Isolation of mouse lung dendritic cells. J Vis Exp. 2011;57:3563.
35. Yang C, Xu Z, Zhao Z, Li L, Zhao T, Peng D, Xu M, Rong R, Long YQ, Zhu T. A novel proteolysis-resistant cyclic helix B peptide ameliorates kidney ischemia reperfusion injury. Biochim Biophys Acta. 2014;1842:2306-17.