Effect of Glyceryl Trinitrate Ointment on Pain Control after Hemorrhoidectomy: A Meta-analysis of Randomized Controlled Trials

World Journal of Surgery

Volumn 40, Issue 1, 2016, Pages 215-224

  Liu, Jen Wei ^a   Lin, Chao Chun ^b   Kiu, Kee Thai ^b   Wang, Chun Yu ^a   Tam, Ka Wai ^b,c  

^a SHIN KONG WU HO SU MEMORIAL HOSPITAL   (Taiwan)

^b TAIPEI MEDICAL UNIVERSITY   (Taiwan)

^c TAIPEI MEDICAL UNIVERSITY   (Taiwan)

Author keywords

[No Author keywords available]

Indexed keywords

ANALGESIC AGENT; GLYCERYL TRINITRATE; OINTMENT;

ADVERSE EFFECTS; ANALGESIA; CHEMICALLY INDUCED; DRUG EFFECTS; HEADACHE; HEMORRHOIDECTOMY; HEMORRHOIDS; HUMAN; META ANALYSIS; OINTMENT; PAIN MEASUREMENT; PAIN, POSTOPERATIVE; PROCEDURES; RANDOMIZED CONTROLLED TRIAL (TOPIC); WOUND HEALING;

ANALGESICS, NON-NARCOTIC; HEADACHE; HEMORRHOIDECTOMY; HEMORRHOIDS; HUMANS; NITROGLYCERIN; OINTMENTS; PAIN MANAGEMENT; PAIN MEASUREMENT; PAIN, POSTOPERATIVE; RANDOMIZED CONTROLLED TRIALS AS TOPIC; WOUND HEALING;

EID: 85028280920     PISSN: 03642313     EISSN: 14322323     Source Type: Journal    
DOI: 10.1007/s00268-015-3344-6     Document Type: Article

References (34)

1. MacRae HM, McLeod RS (1995) Comparison of hemorrhoidal treatment modalities: a meta-analysis. Dis Colon Rectum 38:687-694
2. Burch J, Epstein D, Sari AB et al (2009) Stapled haemorrhoidopexy for the treatment of haemorrhoids: a systematic review. Colorectal Dis 11:233-243; discussion 243
3. Cheetham MJ, Mortensen NJ, Nystrom PO, Kamm MA, Phillips RK (2000) Persistent pain and faecal urgency after stapled haemorrhoidectomy. Lancet 356:730-733
4. Ganio E, Altomare DF, Gabrielli F, Milito G, Canuti S (2001) Prospective randomized multicentre trial comparing stapled with open haemorrhoidectomy. Br J Surg 88:669-674
5. Goldstein ET, Williamson PR, Larach SW (1993) Subcutaneous morphine pump for postoperative hemorrhoidectomy pain management. Dis Colon Rectum 36:439-446
6. Schouten WR, Briel JW, Auwerda JJ, Boerma MO (1996) Anal fissure: new concepts in pathogenesis and treatment. Scand J Gastroenterol Suppl 218:78-81
7. Kua KB, Kocher HM, Kelkar A, Patel AG (2001) Effect of topical glyceryl trinitrate on anodermal blood flow in patients with chronic anal fissures. ANZ J Surg 71:548-550
8. Poh A, Tan KY, Seow-Choen F (2010) Innovations in chronic anal fissure treatment: a systematic review. World J Gastrointest Surg 2:231-241
9. Utzig MJ, Kroesen AJ, Buhr HJ (2003) Concepts in pathogenesis and treatment of chronic anal fissure - a review of the literature. Am J Gastroenterol 98:968-974
10. Di Vita G, Patti R, Arcara M, Petrone R, Davì V, Leo P (2004) A painless treatment for patients undergoing Milligan-Morgan haemorrhoidectomy. Ann Ital Chir 75:471-474
11. Elton C, Sen P, Montgomery AC (2001) Initial study to assess the effects of topical glyceryl trinitrate for pain after haemorrhoidectomy. Int J Surg Investig 2:353-357
12. Ratnasingham K, Uzzaman M, Andreani SM, Light D, Patel B (2010) Meta-analysis of the use of glyceryl trinitrate ointment after haemorrhoidectomy as an analgesic and in promoting wound healing. Int J Surg 8:606-611
13. Siddiqui MR, Daulatzai N (2011) Re: meta-analysis of the use of glyceryl trinitrate ointment after haemorrhoidectomy as an analgesic and in promoting wound healing. Int J Surg 9:272
14. Cross T, Bartlett L, Mushaya C, Ashour M, Ho YH (2012) Glyceryl trinitrate ointment did not reduce pain after stapled hemorrhoidectomy: a randomized controlled trial. Int Surg 97:112-119
15. Franceschilli L, D'Ugo S, de Luca E et al (2013) Role of 0.4% glyceryl trinitrate ointment after haemorrhoidectomy: results of a prospective randomised study. Int J Colorectal Dis 28:365-369
16. Higgins JPT, Green S. Cochrane Handbook for Systematic Reviews of Interventions Version 5.1.0 [updated March 2011]. The Cochrane Collaboration. www.cochrane-handbook.org
17. Liberati A, Altman DG, Tetzlaff J et al (2009) The PRISMA statement for reporting systematic reviews and meta-analyses of studies that evaluate health care interventions: explanation and elaboration. J Clin Epidemiol 62:e1-e34
18. DerSimonian R, Laird N (1986) Meta-analysis in clinical trials. Control Clin Trials 7:177-188
19. Hwang DY, Yoon SG, Kim HS, Lee JK, Kim KY (2003) Effect of 0.2 percent glyceryl trinitrate ointment on wound healing after ahemorrhoidectomy: results of a randomized, prospective, double-blind, placebo-controlled trial. Dis Colon Rectum 46:950-954
20. Karanlik H, Akturk R, Camlica H, Asoglu O (2009) The effect of glyceryl trinitrate ointment on posthemorrhoidectomy pain and wound healing: results of a randomized, double-blind, placebo-controlled study. Dis Colon Rectum 52:280-285
21. Mari FS, Nigri G, Dall'Oglio A et al (2013) Topical glyceryl trinitrate ointment for pain related to anal hypertonia after stapled hemorrhoidopexy: a randomized controlled trial. Dis Colon Rectum 56:768-773
22. Patti R, Arcara M, Padronaggio D et al (2005) Efficacy of topical use of 0.2% glyceryl trinitrate in reducing post-haemorrhoidectomy pain and improving wound healing. Chir Ital 57:77-85
23. Patti R, Almasio PL, Arcara M et al (2006) Botulinum toxin vs. topical glyceryl trinitrate ointment for pain control in patients undergoing hemorrhoidectomy: a randomized trial. Dis Colon Rectum 49:1741-1748
24. Tan KY, Sng KK, Tay KH, Lai JH, Eu KW (2006) Randomized clinical trial of 0.2 per cent glyceryl trinitrate ointment for wound healing and pain reduction after open diathermy haemorrhoidectomy. Br J Surg 93:1464-1468
25. Wasvary HJ, Hain J, Mosed-Vogel M, Bendick P, Barkel DC, Klein SN (2001) Randomized, prospective, double-blind, placebo-controlled trial of effect of nitroglycerin ointment on pain after hemorrhoidectomy. Dis Colon Rectum 44:1069-1073
26. Khan K, Waqas A, Akmal M, Mahmood S, Iqbal A (2014) Efficacy of combination of 0.2% GTN and lignocaine ointments in wound healing and pain relief after Milligan Morgan hemorrhoidectomy - a comparison with lignocaine and 0.2% GTN ointments separately. Int J Surg 12:329-333
27. Lund JN, Scholefield JH (1997) A randomised, prospective, double-blind, placebo-controlled trial of glyceryl trinitrate ointment in treatment of anal fissure. Lancet 349:11-14
28. Kennedy ML, Sowter S, Nguyen H, Lubowski DZ (1999) Glyceryl trinitrate ointment for the treatment of chronic anal fissure: results of a placebo-controlled trial and long-term follow-up. Dis Colon Rectum 42:1000-1006
29. Altomare DF, Rinaldi M, Milito G et al (2000) Glyceryl trinitrate for chronic anal fissure-healing or headache? Results of a multicenter, randomized, placebo-controled, double-blind trial. Dis Colon Rectum 43:174-179; discussion 179-181
30. Nelson R (2004) A systematic review of medical therapy for anal fissure. Dis Colon Rectum 47:422-431
31. Nelson RL, Thomas K, Morgan J, Jones A (2012) Non surgical therapy for anal fissure. Cochrane Database Syst Rev 15(2):CD003431
32. Perrotti P, Dominici P, Grossi E, Cerutti R, Antropoli C (2010) Topical nifedipine with lidocaine ointment versus active control for pain after hemorrhoidectomy: results of a multicentre, prospective, randomized, double-blind study. Can J Surg 53:17-24
33. Silverman R, Bendick PJ, Wasvary HJ (2005) A randomized, prospective, double-blind, placebo-controlled trial of the effect of a calcium channel blocker ointment on pain after hemorrhoidectomy. Dis Colon Rectum 48:1913-1916
34. Sugimoto T, Tsunoda A, Kano N, Kashiwagura Y, Hirose K, Sasaki T (2013) A randomized, prospective, double-blind, placebo-controlled trial of the effect of diltiazem gel on pain after hemorrhoidectomy. World J Surg 37:2454-2457. doi: 10.1007/s00268-013-2124-