Meta-analysis of the use of glyceryl trinitrate ointment after haemorrhoidectomy as an analgesic and in promoting wound healing

International Journal of Surgery

Volumn 8, Issue 8, 2010, Pages 606-611

  Ratnasingham, K ^a   Uzzaman, M ^b   Andreani, S M ^c   Light, D ^a   Patel, B ^b  

^a UNIVERSITY HOSPITAL OF NORTH TEES   (United Kingdom)

^b BARTS HEALTH NHS TRUST   (United Kingdom)

^c WHIPPS CROSS UNIVERSITY HOSPITAL   (United Kingdom)

Author keywords

Analgesic; GTN; Haemorrhoidectomy; Wound healing

Indexed keywords

ANALGESIC AGENT; GLYCERYL TRINITRATE; WOUND HEALING PROMOTING AGENT;

CLINICAL TRIAL; DRUG USE; HEADACHE; HEMORRHOIDECTOMY; HUMAN; META ANALYSIS; OINTMENT; POSTOPERATIVE PAIN; PRIORITY JOURNAL; REVIEW; SYSTEMATIC REVIEW;

ANALGESICS; HEADACHE; HEMORRHOIDS; HUMANS; NITROGLYCERIN; OINTMENTS; PAIN MEASUREMENT; PAIN, POSTOPERATIVE; WOUND HEALING;

EID: 78649334978     PISSN: 17439191     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ijsu.2010.04.012     Document Type: Review

References (34)

1. Johanson J.F., Sonnenberg A. The prevalence of hemorrhoids and chronic constipation. An epidemiologic study. Gastroenterology 1990 Feb, 98(2):380-386.
2. Burch J., Epstein D., Sari A.B., Weatherly H., Jayne D., Fox D., et al. Stapled haemorrhoidopexy for the treatment of haemorrhoids: a systematic review. Colorectal Dis 2009 Mar, 11(3):233-243. discussion 43.
3. Dal Monte P.P., Tagariello C., Sarago M., Giordano P., Shafi A., Cudazzo E., et al. Transanal haemorrhoidal dearterialisation: nonexcisional surgery for the treatment of haemorrhoidal disease. Tech Coloproctol 2007 Dec, 11(4):333-338. discussion 8-9.
4. Giordano P., Overton J., Madeddu F., Zaman S., Gravante G. Transanal hemorrhoidal dearterialization: a systematic review. Dis Colon Rectum 2009 Sep, 52(9):1665-1671.
5. Miles A.J., Dunkley A.J. Day case haemorrhoidectomy. Colorectal Dis 2007 Jul, 9(6):532-535.
6. Racalbuto A., Aliotta I., Corsaro G., Lanteri R., Di Cataldo A., Licata A. Hemorrhoidal stapler prolapsectomy vs. Milligan-Morgan hemorrhoidectomy: a long-term randomized trial. Int J Colorectal Dis 2004 May, 19(3):239-244.
7. Ye F., Feng Y.X., Lin J.J. A ropivacaine-lidocaine combination for caudal blockade in haemorrhoidectomy. J Int Med Res 2007 May-Jun, 35(3):307-313.
8. Al-Mulhim A.S., Ali A.M., Al-Masuod N., Alwahidi A. Post hemorrhoidectomy pain. A randomized controlled trial. Saudi Med J 2006 Oct, 27(10):1538-1541.
9. Carapeti E.A., Kamm M.A., McDonald P.J., Phillips R.K. Double-blind randomised controlled trial of effect of metronidazole on pain after day-case haemorrhoidectomy. Lancet 1998 Jan 17, 351(9097):169-172.
10. Ala S., Saeedi M., Eshghi F., Mirzabeygi P. Topical metronidazole can reduce pain after surgery and pain on defecation in postoperative hemorrhoidectomy. Dis Colon Rectum 2008 Feb, 51(2):235-238.
11. Nicholson T.J., Armstrong D. Topical metronidazole (10 percent) decreases posthemorrhoidectomy pain and improves healing. Dis Colon Rectum 2004 May, 47(5):711-716.
12. Rattan S., Chakder S. Role of nitric oxide as a mediator of internal anal sphincter relaxation. Am J Physiol 1992 Jan, 262(1 Pt 1):G107-G112.
13. Guillemot F., Leroi H., Lone Y.C., Rousseau C.G., Lamblin M.D., Cortot A. Action of in situ nitroglycerin on upper anal canal pressure of patients with terminal constipation. A pilot study. Dis Colon Rectum 1993 Apr, 36(4):372-376.
14. Loder P.B., Kamm M.A., Nicholls R.J., Phillips R.K. 'Reversible chemical sphincterotomy' by local application of glyceryl trinitrate. Br J Surg 1994 Sep, 81(9):1386-1389.
15. Kua K.B., Kocher H.M., Kelkar A., Patel A.G. Effect of topical glyceryl trinitrate on anodermal blood flow in patients with chronic anal fissures. ANZ J Surg 2001 Sep, 71(9):548-550.
16. Altomare D.F., Rinaldi M., Milito G., Arcana F., Spinelli F., Nardelli N., et al. Glyceryl trinitrate for chronic anal fissure-healing or headache? Results of a multicenter, randomized, placebo-controled, double-blind trial. Dis Colon Rectum 2000 Feb, 43(2):174-179. discussion 9-81.
17. Jonas M., Barrett D.A., Shaw P.N., Scholefield J.H. Systemic levels of glyceryl trinitrate following topical application to the anoderm do not correlate with the measured reduction in anal pressure. Br J Surg 2001 Dec, 88(12):1613-1616.
18. Moher D., Cook D.J., Jadad A.R., Tugwell P., Moher M., Jones A., et al. Assessing the quality of reports of randomised trials: implications for the conduct of meta-analyses. Health Technol Assess 1999, 3(12):1-98. i-iv.
19. Karanlik H., Akturk R., Camlica H., Asoglu O. The effect of glyceryl trinitrate ointment on posthemorrhoidectomy pain and wound healing: results of a randomized, double-blind, placebo-controlled study. Dis Colon Rectum 2009 Feb, 52(2):280-285.
20. Hwang D.Y., Yoon S.G., Kim H.S., Lee J.K., Kim K.Y. Effect of 0.2 percent glyceryl trinitrate ointment on wound healing after a hemorrhoidectomy: results of a randomized, prospective, double-blind, placebo-controlled trial. Dis Colon Rectum 2003 Jul, 46(7):950-954.
21. Wasvary H.J., Hain J., Mosed-Vogel M., Bendick P., Barkel D.C., Klein S.N. Randomized, prospective, double-blind, placebo-controlled trial of effect of nitroglycerin ointment on pain after hemorrhoidectomy. Dis Colon Rectum 2001 Aug, 44(8):1069-1073.
22. Patti R., Arcara M., Padronaggio D., Bonventre S., Angileri M., Salerno R., et al. [Efficacy of topical use of 0.2% glyceryl trinitrate in reducing post-haemorrhoidectomy pain and improving wound healing]. Chir Ital 2005 Jan-Feb, 57(1):77-85.
23. Tan K.Y., Sng K.K., Tay K.H., Lai J.H., Eu K.W. Randomized clinical trial of 0.2 per cent glyceryl trinitrate ointment for wound healing and pain reduction after open diathermy haemorrhoidectomy. Br J Surg 2006 Dec, 93(12):1464-1468.
24. Chauhan A., Thomas S., Bishnoi P.K., Hadke N.S. Randomized controlled trial to assess the role of raised anal pressures in the pathogenesis of symptomatic early hemorrhoids. Dig Surg 2007, 24(1):28-32.
25. Patti R., Almasio P.L., Arcara M., Sparacello M., Termine S., Bonventre S., et al. Long-term manometric study of anal sphincter function after hemorrhoidectomy. Int J Colorectal Dis 2007 Mar, 22(3):253-257.
26. Amorotti C., Mosca D., Trenti C., Pintaudi U. [Usefulness of lateral internal sphincterotomy combined with hemorrhoidectomy by the Milligan-Morgan's technique: results of a prospective randomized trial]. Chir Ital 2003 Nov-Dec, 55(6):879-886.
27. Kanellos I., Zacharakis E., Christoforidis E., Angelopoulos S., Kanellos D., Pramateftakis M.G., et al. Usefulness of lateral internal sphincterotomy in reducing postoperative pain after open hemorrhoidectomy. World J Surg 2005 Apr, 29(4):464-468.
28. Khubchandani I.T. Internal sphincterotomy with hemorrhoidectomy does not relieve pain: a prospective, randomized study. Dis Colon Rectum 2002 Nov, 45(11):1452-1457.
29. Coskun A., Duzgun S.A., Uzunkoy A., Bozer M., Aslan O., Canbeyli B. Nitroderm TTS band application for pain after hemorrhoidectomy. Dis Colon Rectum 2001 May, 44(5):680-685.
30. Di Vita G., Patti R., Arcara M., Petrone R., Davi V., Leo P. A painless treatment for patients undergoing Milligan-Morgan haemorrhoidectomy. Ann Ital Chir 2004 Jul-Aug, 75(4):471-474. discussion 4-5.
31. Carapeti E.A., Kamm M.A., McDonald P.J., Chadwick S.J., Melville D., Phillips R.K. Randomised controlled trial shows that glyceryl trinitrate heals anal fissures, higher doses are not more effective, and there is a high recurrence rate. Gut 1999 May, 44(5):727-730.
32. Lund J.N., Scholefield J.H. A randomised, prospective, double-blind, placebo-controlled trial of glyceryl trinitrate ointment in treatment of anal fissure. Lancet 1997 Jan 4, 349(9044):11-14.
33. Lund J.N., Scholefield J.H. Glyceryl trinitrate is an effective treatment for anal fissure. Dis Colon Rectum 1997 Apr, 40(4):468-470.
34. Balfour L., Stojkovic S.G., Botterill I.D., Burke D.A., Finan P.J., Sagar P.M. A randomized, double-blind trial of the effect of metronidazole on pain after closed hemorrhoidectomy. Dis Colon Rectum 2002 Sep, 45(9):1186-1190. discussion 90-91.