A randomized, prospective, double-blind, placebo-controlled trial of the effect of a calcium channel blocker ointment on pain after hemorrhoidectomy

Diseases of the Colon and Rectum

Volumn 48, Issue 10, 2005, Pages 1913-1916

  Silverman, Ralph ^a,b   Bendick, Phillip J ^a   Wasvary, Harry J ^a  

^a WILLIAM BEAUMONT HOSPITAL   (United States)

^b Southeast Texas Medical Associates   (United States)

Author keywords

Analgesia; Calcium channel blocker; Hemorrhoidectomy

Indexed keywords

CALCIUM CHANNEL BLOCKING AGENT; DILTIAZEM; HYDROCODONE BITARTRATE PLUS PARACETAMOL; NARCOTIC AGENT; NONSTEROID ANTIINFLAMMATORY AGENT; PARACETAMOL; PLACEBO;

ADULT; ANUS; ARTICLE; BLEEDING; CLINICAL ARTICLE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DEFECATION DISORDER; DOUBLE BLIND PROCEDURE; DRUG EFFECT; FEMALE; FOLLOW UP; HEMORRHOIDECTOMY; HUMAN; MALE; MEDICAL RECORD; MICTURITION DISORDER; MORBIDITY; OINTMENT; PAIN ASSESSMENT; POSTOPERATIVE COMPLICATION; POSTOPERATIVE PAIN; POSTOPERATIVE PERIOD; PRESCRIPTION; PROSPECTIVE STUDY; RANDOMIZED CONTROLLED TRIAL; RASH; SCORING SYSTEM; SIDE EFFECT; STATISTICAL SIGNIFICANCE; TREATMENT OUTCOME; VISUAL ANALOG SCALE;

ADMINISTRATION, TOPICAL; ADULT; CALCIUM CHANNEL BLOCKERS; DILTIAZEM; DOUBLE-BLIND METHOD; FEMALE; HEMORRHOIDS; HUMANS; MALE; MIDDLE AGED; OINTMENTS; PAIN MEASUREMENT; PAIN, POSTOPERATIVE; PROSPECTIVE STUDIES; SURGICAL PROCEDURES, OPERATIVE; TREATMENT OUTCOME;

EID: 26444598604     PISSN: 00123706     EISSN: 15300358     Source Type: Journal    
DOI: 10.1007/s10350-005-0135-4     Document Type: Article

References (13)

1. SR Gorfine 1995 Treatment of benign anal disease with topical nitroglycerin Dis Colon Rectum 38 453 6
2. JN Lund JH Scholefield 1997 A randomized, prospective, double-blind, placebo-controlled trial of glyceryl trinitrate ointment in treatment of anal fissure Lancet 349 11 4
3. HJ Wasvary J Hain M Mosed-Vogel P Bendick DC Barkel SN Klein 2001 Randomized, prospective, double-blind, placebo-controlled trial of effect of nitroglycerin ointment on pain after hemorrhoidectomy Dis Colon Rectum 44 1069 73
4. G Brisinda G Maria AR Bentivoglio E Cassetta D Gui A Albanese 1999 A comparison of injections of botulinum toxin and topical nitroglycerin ointment for the treatment of chronic anal fissure N Engl J Med 341 65 9
5. EA Carapeti MA Kamm PJ McDonald RK Phillips 1998 Double-blind randomized controlled trial of effect of metronidazole on pain after day-case haemorrhoidectomy Lancet 351 169 72
6. PB Loder MA Kamm RJ Nicholls RK Phillips 1994 'Reversible chemical sphincterotomy' by local application of glyceryl trinitrate Br J Surg 81 1386 9
7. SR Gorfine 1995 Topical nitroglycerin therapy for anal fissures and ulcers N Engl J Med 333 1156 7
8. JN Lund NC Armitage JH Scholefield 1996 Use of glyceryl trinitrate ointment in the treatment of anal fissure Br J Surg 83 776 7
9. SJ Watson MA Kamm RJ Nicholls RK Phillips 1996 Topical glyceryl trinitrate in the treatment of chronic anal fissure Br J Surg 83 771 5
10. DF Altomare M Rinaldi G Milito 2000 Glyceryl trinitrate for chronic anal fissure-healing or headache: results of a multicenter, randomized, placebo-controlled, double-blind trial Dis Colon Rectum 43 174 9
11. WR Schouten JW Briel MO Boerma JJ Auwerda EB Wilms BH Graatsma 1996 Pathophysiological aspects and clinical outcome of intra-anal application of isosorbide dinitrate in patients with chronic anal fissure Gut 39 465 9
12. T Exri S Susmallian 2003 Topical nifedipine vs. topical glyceryl trinitrate for treatment of chronic anal fissure Dis Colon Rectum 46 805 8
13. HM Kocher M Steward AJ Leather PT Cullen 2002 Randomized clinical trial assessing the side-effects of glyceryl trinitrate and diltiazem hydrochloride in the treatment of chronic anal fissure Br J Surg 89 413 7