A randomized, prospective, double-blind, placebo-controlled trial of the effect of diltiazem gel on pain after hemorrhoidectomy

World Journal of Surgery

Volumn 37, Issue 10, 2013, Pages 2454-2457

  Sugimoto, Takuya ^a   Tsunoda, Akira ^a   Kano, Nobuyasu ^a   Kashiwagura, Yasuharu ^a   Hirose, Ken Ichi ^a   Sasaki, Tadanori ^a  

^a KAMEDA MEDICAL CENTER   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

CALCIUM CHANNEL BLOCKING AGENT; DILTIAZEM; GEL;

AGED; CONTROLLED STUDY; DOUBLE BLIND PROCEDURE; DRUG ADMINISTRATION; FEMALE; FOLLOW UP; GEL; HEMORRHOIDECTOMY; HEMORRHOIDS; HUMAN; MALE; MIDDLE AGED; PAIN MEASUREMENT; PAIN, POSTOPERATIVE; PROSPECTIVE STUDY; RANDOMIZED CONTROLLED TRIAL; TOPICAL DRUG ADMINISTRATION; TREATMENT OUTCOME; ARTICLE; CONTROLLED CLINICAL TRIAL; HEMORRHOID; PAIN ASSESSMENT; POSTOPERATIVE PAIN;

ADMINISTRATION, TOPICAL; AGED; CALCIUM CHANNEL BLOCKERS; DILTIAZEM; DOUBLE-BLIND METHOD; DRUG ADMINISTRATION SCHEDULE; FEMALE; FOLLOW-UP STUDIES; GELS; HEMORRHOIDECTOMY; HEMORRHOIDS; HUMANS; MALE; MIDDLE AGED; PAIN MEASUREMENT; PAIN, POSTOPERATIVE; PROSPECTIVE STUDIES; TREATMENT OUTCOME;

EID: 84883552070     PISSN: 03642313     EISSN: 14322323     Source Type: Journal    
DOI: 10.1007/s00268-013-2124-4     Document Type: Article

References (17)

1. Loder PB, Kamm MA, Nicholls RJ et al (1994) Haemorrhoids: pathology, pathophysiology and aetiology. Br J Surg 81:946-954
2. Carapeti EA, Kamm MA, McDonald PJ et al (1998) Double-blind randomised controlled trial of effect of metronidazole on pain after day-case haemorrhoidectomy. Lancet 17:169-172
3. Ala S, Saeedi M, Eshghi F et al (2008) Topical metronidazole can reduce pain after surgery and pain on defecation in postoperative hemorrhoidectomy. Dis Colon Rectum 51:235-238
4. Wasvary HJ, Hain J, Mosed-Vogel M et al (2001) Randomized, prospective, double-blind, placebo-controlled trial of effect of nitroglycerin ointment on pain after hemorrhoidectomy. Dis Colon Rectum 44:1069-1073
5. Elton C, Sen P, Montgomery AC (2001) Initial study to assess the effects of topical glyceryl trinitrate for pain after haemorrhoidectomy. Int J Surg Invest 2:353-357
6. Hwang DY, Yoon SG, Kim HS et al (2003) Effect of 0.2 percent glyceryl trinitrate ointment on wound healing after a hemorrhoidectomy: results of a randomized, prospective, double-blind, placebo-controlled trial. Dis Colon Rectum 46:950-954
7. Tan KY, Sng KK, Tay KH et al (2006) Randomized clinical trial of 0.2 per cent glyceryl trinitrate ointment for wound healing and pain reduction after open diathermy haemorrhoidectomy. Br J Surg 93:1464-1468
8. Karanlik H, Akturk R, Camlica H et al (2009) The effect of glyceryl trinitrate ointment on posthemorrhoidectomy pain and wound healing: results of a randomized, double-blind, placebo-controlled study. Dis Colon Rectum 52:280-285
9. Brisinda G, Maria G, Bentivoglio AR et al (1999) A comparison of injections of botulinum toxin and topical nitroglycerin ointment for the treatment of chronic anal fissure. N Engl J Med 341:65-69
10. Patti R, Almasio PL, Muggeo VM et al (2005) Improvement of wound healing after hemorrhoidectomy: a double-blind, randomized study of botulinum toxin injection. Dis Colon Rectum 48:2173-2179
11. Patti R, Almasio PL, Arcara M et al (2006) Botulinum toxin vs. topical glyceryl trinitrate ointment for pain control in patients undergoing hemorrhoidectomy: a randomized trial. Dis Colon Rectum 49:1741-1748
12. Silverman R, Bendick PJ, Wasvary HJ (2005) A randomized, prospective, double-blind, placebo-controlled trial of the effect of a calcium channel blocker ointment on pain after hemorrhoidectomy. Dis Colon Rectum 48:1913-1916
13. Amoli HA, Notash AY, Shahandashti FJ et al (2011) A randomized, prospective, double-blind, placebo-controlled trial of the effect of topical diltiazem on posthaemorrhoidectomy pain. Colorectal Dis 13:328-332
14. Tsunoda A, Sada H, Sugimoto T et al (2011) Randomized controlled trial of bipolar diathermy vs ultrasonic scalpel for closed hemorrhoidectomy. World J Gastrointest Surg 27:147-152
15. Armstrong DN, Ambroze WL, Schertzer ME et al (2001) Harmonic Scalpel vs. electrocautery hemorrhoidectomy: a prospective evaluation. Dis Colon Rectum 44:558-564
16. Knight JS, Birks M, Farouk R (2001) Topical diltiazem ointment in the treatment of chronic anal fissure. Br J Surg 88:553-556
17. Carapeti EA, Kamm MA, Evans BK et al (1999) Topical diltiazem and bethanechol decrease anal sphincter pressure without side effects. Gut 45:719-722