Topical nifedipine with lidocaine ointment versus active control for pain after hemorrhoidectomy: Results of a multicentre, prospective, randomized, double-blind study

Canadian Journal of Surgery

Volumn 53, Issue 1, 2010, Pages 17-24

  Perrotti, Pasquale ^a   Dominici, Patrizia ^b   Grossi, Enzo ^b   Cerutti, Renata ^b   Antropoli, Carmine ^a  

^a CARDARELLI HOSPITAL   (Italy)

^b San Donato Milanese   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

EID: 75749091819     PISSN: 0008428X     EISSN: 14882310     Source Type: Journal    
DOI: None     Document Type: Article

References (42)

1. Holzheimer RG. Hemorrhoidectomy: indications and risks. Eur J Med Res 2004; 9: 18-36.
2. Nisar PJ, Scholefield JH. Managing haemorrhoids. BMJ 2003; 327: 847-851
3. Goldstein ET, Williamson PR, Larach SW. Subcutaneous morphine pump for postoperative hemorrhoidectomy pain management. Dis Colon Rectum 1993; 36: 439-446
4. Carapeti EA, Kamm MA, McDonald PJ, et al. Double-blind randomised controlled trial of effect of metronidazole on pain after day-case haemorrhoidectomy. Lancet 1998; 351: 169-172
5. 5. Wasvary HJ, Hain J, Mosed-Vogel M, et al. A randomized, prospective, double-blind, placebo-controlled trial of effect of nitroglycerin ointment on pain after hemorrhoidectomy. Dis Colon Rectum 2001; 44: 1069-1073 (Pubitemid 32758258)
6. 6. Hiltunen KM, Matikainen M. Anal manometric findings in symptomatic hemorrhoids. Dis Colon Rectum 1985; 28: 807-809 (Pubitemid 16215670)
7. Arabi Y, Alexander-Williams J, Keighley MR. Anal pressures in hemorrhoids and anal fissure. Am J Surg 1977; 134: 608-610
8. 8. Deutsch AA, Moshkovitz M, Nudelman I, et al. Anal pressure measurements in the study of hemorrhoid etiology and their relation to treatment. Dis Colon Rectum 1987; 30: 855-857 (Pubitemid 17161854)
9. Roe AM, Bartolo DC, Vellacott KD, et al. Submucosal versus ligation excision haemorrhoidectomy: a comparison of anal sensation, anal sphincter manometry and postoperative pain and function. Br J Surg 1987; 74: 948-951
10. 10. Kanellos I, Zacharakis E, Christoforidis E, et al. Usefulness of lateral internal sphincterotomy in reducing postoperative pain after open hemorrhoidectomy. World J Surg 2005; 29: 464-468 (Pubitemid 41125370)
11. Goligher JC, Graham NG, De Dombal FT, et al. The value of stretching of anal sphincters in the relief of pain after haemorrhoidectomy. Br J Surg 1969; 56: 390.
12. 12. Ho YH, Seow-Choen F, Low JY, et al. Randomised controlled trial of trimebutine (anal sphincter relaxant) for pain after haemorrhoidectomy. Br J Surg 1997; 84: 377-379 (Pubitemid 27141720)
13. 13. Davies J, Duffy D, Boyt N, et al. Botulinum toxin (botox) reduces pain after hemorrhoidectomy: results of a double-blind, randomized study. Dis Colon Rectum 2003; 46: 1097-1102 (Pubitemid 36992993)
14. 14. Nicholson TJ, Armstrong D. Topical metronidazole (10 percent) decreases posthemorrhoidectomy pain and improves healing. Dis Colon Rectum 2004; 47: 711-716 (Pubitemid 38585775)
15. Smith SL, Simon R. Viscous lidocaine as a posthemorrhoidectomy analgesic. Dis Colon Rectum 1979; 22: 40-41
16. Shiau JM, Su HP, Chen HS, et al. Use of a topical anesthetic cream (EMLA) to reduce pain after hemorrhoidectomy. Reg Anesth Pain Med 2008; 33: 30-35
17. Shiau JM, Hung KC, Chen HH, et al. Combination of topical EMLA with local injection of lidocaine: superior pain relief after Ferguson hemorrhoidectomy. Clin J Pain 2007; 23: 586-590
18. 18. Colak T, Akca T, Dirlik M, et al. Micronized flavonoids in pain control after hemorrhoidectomy: a prospective randomized controlled study. Surg Today 2003; 33: 828-832 (Pubitemid 37357656)
19. 19. Coskun A, Duzgun SA, Uzunkoy A, et al. Nitroderm TTS band application for pain after hemorrhoidectomy. Dis Colon Rectum 2001; 44: 680-685 (Pubitemid 32428716)
20. Elton C, Sen P, Montgomery AC. Initial study to assess the effects of topical glyceryl trinitrate for pain after haemorrhoidectomy. Int J Surg Investig 2001; 2: 353-357
21. Chrysos E, Xynos E, Tzovaras G, et al. Effect of nifedipine on rectoanal motility. Dis Colon Rectum 1996; 39: 212-216
22. 22. Antropoli C, Perrotti P, Rubino M, et al. Nifedipine for local use in conservative treatment of anal fissures: preliminary results of a multicenter study. Dis Colon Rectum 1999; 42: 1011-1015 (Pubitemid 29383829)
23. 23. Ezri T, Susmallian S. Topical nifedipine vs. topical glyceryl trinitrate for treatment of chronic anal fissure. Dis Colon Rectum 2003; 46: 805-808 (Pubitemid 36693401)
24. Perrotti P, Antropoli C, Noschese G, et al. Topical nifedipine for conservative treatment of acute hemorrhoidal thrombosis. Colorectal Dis 2000; 2: 18-21.
25. Gough MJ, Lewis A. The conservative treatment of fissure-in-ano. Br J Surg 1983; 70: 175-176
26. 26. Neiger A, Herms E. The symptomatic therapy of hemorrhoids and anal eczema -a report of experiences from proctology practice. Schweiz Rundsch Med Prax 1990; 79: 918-920 (Pubitemid 20270435)
27. 27. Cook TA, Brading AF, Mortensen NJ. Effects of nifedipine on anorectal smooth muscle in vitro. Dis Colon Rectum 1999; 42: 782-787 (Pubitemid 29279431)
28. Cook TA Brading AF, Mortensen NJ. Differences in contractile properties of anorectal smooth muscle and the effects of calcium channel blockade. Br J Surg 1999; 86: 70-75
29. 29. Perrotti P, Bove A, Antropoli C, et al. Topical nifedipine with lidocaine ointment vs. active control for treatment of chronic anal fissure: results of a prospective, randomized, double-blind study. Dis Colon Rectum 2002; 45: 1468-1475 (Pubitemid 35345872)
30. 30. Perrotti P, Antropoli C, Molino D, et al. Conservative treatment of acute thrombosed external hemorrhoids with topical nifedipine. Dis Colon Rectum 2001; 44: 405-409 (Pubitemid 32226331)
31. Perrotti P, Grumetto L, Barbato F, et al. Serum levels and possible haemodynamic effects following anorectal application of an ointment containing nifedipine and lignocaine. A study in healthy volunteers. Clin Drug Investig 2006; 26: 459-467
32. Grossi E, Borghi C, Cerchiari EL, et al. Analogue chromatic continuous scale (ACCS): a new method for pain assessment. Clin Exp Rheumatol 1983; 1: 337-340
33. Asfar SK, Juma TH, Ala-Edeen T. Hemorrhoidectomy and sphincterotomy: a prospective study comparing the effectiveness of anal stretch and sphincterotomy in reducing pain after hemorrhoidectomy. Dis Colon Rectum 1988; 31: 181-185
34. Tranqui P, Trottier DC, Victor JC, et al. Nonsurgical treatment of chronic anal fissure: nitroglycerin and dilatation versus nifedipine and botulinum toxin. Can J Surg 2006; 49: 41-45
35. Hwang do Y, Yoon SG, Kim HS, et al. Effect of 0.2 percent glyceryl trinitrate ointment on wound healing after a hemorrhoidectomy: results of a randomized, prospective, double-blind, placebocontrolled trial. Dis Colon Rectum 2003; 46: 950-954
36. 36. Patti R, Almasio PL, Muggeo VM, et al. Improvement of wound healing after hemorrhoidectomy: a double-blind, randomized study of botulinum toxin injection. Dis Colon Rectum 2005; 48: 2173-2179 (Pubitemid 43074436)
37. Read MG, Read NW, Haynes WG, et al. A prospective study of the effect of haemorrhoidectomy on sphincter function and faecal continence. Br J Surg 1982; 69: 396-398
38. 38. Silverman R, Phillip J, Bendick, et al. A randomized, prospective, double-blind, placebo-controlled trial of the effect of a calcium channel blocker ointment on pain after hemorrhoidectomy. Dis Colon Rectum 2005; 48: 1913-1916 (Pubitemid 41437675)
39. Handfield-Jones SE, Cronin E. Contact sensitivity to lignocaine. Clin Exp Dermatol 1993; 18: 342-343
40. Warshaw EM, Schram SE, Belsito DV, et al. Patch-test reactions to topical anesthetics: retrospective analysis of cross-sectional data, 2001 to 2004. Dermatitis 2008; 19: 81-85
41. 41. Madoff RD, Fleshman JW. American Gastroenterological Association technical review on die diagnosis and treatment of hemorrhoids. Gastroenterology 2004; 126: 1463-1473 (Pubitemid 38552809)
42. Holzheimer RG. Hemorrhoidectomy: indications and risks. Eur J Med Res 2004; 9: 18-36.