Hyperoxia provokes a time- and dose-dependent inflammatory response in mechanically ventilated mice, irrespective of tidal volumes

Intensive Care Medicine Experimental

Volumn 5, Issue 1, 2017, Pages

  Helmerhorst, Hendrik J F ^a,b   Schouten, Laura R A ^b   Wagenaar, Gerry T M ^a   Juffermans, Nicole P ^b   Roelofs, Joris J T H ^b   Schultz, Marcus J ^b   de Jonge, Evert ^a   van Westerloo, David J ^a  

^a LEIDEN UNIVERSITY MEDICAL CENTER   (Netherlands)

^b ACADEMIC MEDICAL CENTER   (Netherlands)

Author keywords

Hyperoxia; Inflammation; Mechanical ventilation; mice; Oxygen toxicity; VILI

Indexed keywords

CXCL3 CHEMOKINE; GAMMA INTERFERON; INTERLEUKIN 10; INTERLEUKIN 1BETA; INTERLEUKIN 6; MONOCYTE CHEMOTACTIC PROTEIN 1; PROTEIN; TUMOR NECROSIS FACTOR;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTERIAL BLOOD; ARTERIAL CARBON DIOXIDE TENSION; ARTICLE; ARTIFICIAL VENTILATION; BLOOD GAS ANALYSIS; BODY WEIGHT; BRONCHOALVEOLAR LAVAGE FLUID; CONTROLLED STUDY; ENZYME LINKED IMMUNOSORBENT ASSAY; HIGH MOBILITY GROUP BOX DOMAIN; HISTOPATHOLOGY; HYPEROXIA; INFLAMMATION; LUNG INJURY; MALE; MOUSE; NEUTROPHIL; NONHUMAN; PRIORITY JOURNAL; SCORING SYSTEM; SYSTOLIC BLOOD PRESSURE; TIDAL VOLUME; UPREGULATION;

EID: 85028061390     PISSN: None     EISSN: 2197425X     Source Type: Journal    
DOI: 10.1186/s40635-017-0142-5     Document Type: Article

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