Cerebrospinal fluid and serum cytokine profiles in narcolepsy with cataplexy: A case-control study

Brain, Behavior, and Immunity

Volumn 37, Issue , 2014, Pages 260-266

  Dauvilliers, Yves ^a,b,c,d,f   Jaussent, Isabelle ^c,d,f   Lecendreux, Michel ^b,e,f   Scholz, Sabine ^a,b,f   Bayard, Sophie ^a,b,c,d,f   Cristol, Jean Paul ^d,f,g   Blain, Hubert ^d,f,g   Dupuy, Anne Marie ^c,f,g  

^a GUI DE CHAULIAC HOSPITAL   (France)

^b National Reference Network for Orphan Diseases (Narcolepsy   (France)

^c INSERM   (France)

^d UNIV MONTPELLIER   (France)

^e HÔPITAL ROBERT DEBRÉ   (France)

^f MONTPELLIER UNIVERSITY HOSPITAL   (France)

^g CH Corbeil Essonnes   (France)

Author keywords

Autoimmunity; Cataplexy; Cytokine; Hypocretin; Narcolepsy; Sleep

Indexed keywords

CYTOKINE; EPIDERMAL GROWTH FACTOR; GAMMA INTERFERON; INTERLEUKIN 1BETA; INTERLEUKIN 2; INTERLEUKIN 4; INTERLEUKIN 8; MONOCYTE CHEMOTACTIC PROTEIN 1; OREXIN; TUMOR NECROSIS FACTOR ALPHA; VASCULOTROPIN;

ADOLESCENT; ADULT; AGED; ARTICLE; CATAPLEXY; CEREBROSPINAL FLUID ANALYSIS; CHILD; CONTROLLED STUDY; CYTOKINE RELEASE; DAYTIME SOMNOLENCE; FEMALE; HUMAN; MAJOR CLINICAL STUDY; MALE; MIDDLE AGED; NARCOLEPSY; PRESCHOOL CHILD; PRIORITY JOURNAL; PROTEIN BLOOD LEVEL; SCHOOL CHILD; TH1 TH2 BALANCE; TH2 CELL; YOUNG ADULT;

AUTOIMMUNITY; CATAPLEXY; CYTOKINE; HYPOCRETIN; NARCOLEPSY; SLEEP;

ADOLESCENT; ADULT; AGED; CASE-CONTROL STUDIES; CATAPLEXY; CHILD; CHILD, PRESCHOOL; CYTOKINES; FEMALE; HUMANS; MALE; MIDDLE AGED; NARCOLEPSY; SEVERITY OF ILLNESS INDEX; YOUNG ADULT;

EID: 84896737420     PISSN: 08891591     EISSN: 10902139     Source Type: Journal    
DOI: 10.1016/j.bbi.2013.12.019     Document Type: Article

References (40)

1. Aran A., Lin L., Nevsimalova S., et al. Elevated antistreptococcal antibodies in patients with recent narcolepsy onset. Sleep 2009, 32:979-983.
2. Bender R., Lange S. Adjusting for multiple testing - when and how?. J. Clin. Epidemiol. 2001, 54:343-349.
3. Blain H., Jaussent A., Béziat S., et al. Low serum IL-6 is associated with high 6-minute walking performance in asymptomatic women aged 20-70 years. Exp. Gerontol. 2012, 47:143-148.
4. Cvetkovic-Lopes V., Bayer L., Dorsaz S., et al. Elevated Tribbles homolog 2-specific antibody levels in narcolepsy patients. J. Clin. Invest. 2010, 120:713-719.
5. Dargent-Molina P., Favier F., Grandjean H., et al. Fall-related factors and risk of hip fracture: the EPIDOS prospective study. Lancet 1996, 348:145-149.
6. Dauvilliers Y., Montplaisir J., Molinari N., et al. Age at onset of narcolepsy in two large populations of patients in France and Quebec. Neurology 2001, 57:2029-2033.
7. Dauvilliers Y., Arnulf I., Mignot E. Narcolepsy with cataplexy. Lancet 2007, 369:499-511.
8. Dauvilliers Y., Abril B., Mas E., Michel F., Tafti M. Normalization of hypocretin-1 in narcolepsy after intravenous immunoglobulin treatment. Neurology 2009, 73:1333-1334.
9. Dauvilliers Y., Delallée N., Jaussent I., et al. Normal cerebrospinal fluid histamine and tele-methylhistamine levels in hypersomnia conditions. Sleep 2012, 35:1359-1366.
10. Dauvilliers Y., Arnulf I., Lecendreux M., et al. Increased risk of narcolepsy in children and adults after pandemic H1N1 vaccination in France. Brain 2013, 136:2486-2496.
11. Dupuy A.M., Lehmann S., Cristol J.P. Protein biochip systems for the clinical laboratory. Clin. Chem. Lab. Med. 2005, 43:1291-1302.
12. Faraco J., Lin L., Kornum B.R., et al. ImmunoChip study implicates antigen presentation to T cells in narcolepsy. PLoS Genet. 2013, 9:e1003270.
13. Fitzgerald S.P., Lamont J.V., McConnell R.I., et al. Development of a high-throughput automated analyzer using biochip array technology. Clin. Chem. 2005, 51:1165-1176.
14. Fontana A., Gast H., Reith W., Recher M., Birchler T., Bassetti C.L. Narcolepsy: autoimmunity, effector T cell activation due to infection, or T cell independent, major histocompatibility complex class II induced neuronal loss?. Brain 2010, 133:1300-1311.
15. Haack M., Hinze-Selch D., Fenzel T., et al. Plasma levels of cytokines and soluble cytokine receptors in psychiatric patients upon hospital admission: effects of confounding factors and diagnosis. J. Psychiatr. Res. 1999, 33:407-418.
16. Hallmayer J., Faraco J., Lin L., et al. Narcolepsy is strongly associated with the T-cell receptor alpha locus. Nat. Genet. 2009, 41:708-711.
17. Han F., Lin L., Warby S.C., et al. Narcolepsy onset is seasonal and increased following the 2009 H1N1 pandemic in China. Ann. Neurol. 2011, 70:410-417.
18. Hanada T., Yoshimura A. Regulation of cytokine signaling and inflammation. Cytokine Growth Factor Rev. 2002, 13:413-421.
19. Himmerich H., Beitinger P.A., Fulda S., et al. Plasma levels of tumor necrosis factor alpha and soluble tumor necrosis factor receptors in patients with narcolepsy. Arch. Intern. Med. 2006, 166:1739-1743.
20. Hinze-Selch D., Wetter T.C., Zhang Y., et al. In vivo and in vitro immune variables in patients with narcolepsy and HLA-DR2 matched controls. Neurology 2008, 50:1149-1152.
21. Hor H., Kutalik Z., Dauvilliers Y., et al. Genome-wide association study identifies new HLA class II haplotypes strongly protective against narcolepsy. Nat. Genet. 2010, 42:786-789.
22. Johns M.W. A new method for measuring daytime sleepiness: the Epworth sleepiness scale. Sleep 1991, 14:540-545.
23. Kornum B.R., Kawashima M., Faraco J., et al. Common variants in P2RY11 are associated with narcolepsy. Nat. Genet. 2011, 43:66-71.
24. Kornum B.R., Faraco J., Mignot E. Narcolepsy with hypocretin/orexin deficiency, infections and autoimmunity of the brain. Curr. Opin. Neurobiol. 2011, 21:897-903.
25. Li S., Yu M., Li H., Zhang H., Jiang Y. IL-17 and IL-22 in cerebrospinal fluid and plasma are elevated in Guillain-Barré syndrome. Mediators Inflamm. 2012, 260:473.
26. Maier B., Laurer H.L., Rose S., Buurman W.A., Marzi I. Physiological levels of pro- and anti-inflammatory mediators in cerebrospinal fluid and plasma: a normative study. J. Neurotrauma. 2005, 22:822-835.
27. Mignot E., Lin L., Rogers W., et al. Complex HLA-DR and -DQ interactions confer risk of narcolepsy-cataplexy in three ethnic groups. Am. J. Hum. Genet. 2011, 68:686-699.
28. Okun M.L., Giese S., Lin L., Einen M., Mignot E., Coussons-Read M.E. Exploring the cytokine and endocrine involvement in narcolepsy. Brain Behav. Immun. 2004, 18:326-332.
29. Oswald I.P., Gazzinelli R.T., Sher A., James S.L. IL-10 synergizes with IL-4 and transforming growth factor-beta to inhibit macrophage cytotoxic activity. J. Immunol. 1992, 148:3578-3582.
30. Overeem S., Verschuuren J.J., Fronczek R., et al. Immunohistochemical screening for autoantibodies against lateral hypothalamic neurons in human narcolepsy. J. Neuroimmunol. 2006, 174:187-191.
31. Overeem S., Black J.L., Lammers G.J. Narcolepsy: immunological aspects. Sleep Med. Rev. 2008, 12:95-107.
32. Partinen M., Saarenpää-Heikkilä O., Ilveskoski I., et al. Increased incidence and clinical picture of childhood narcolepsy following the 2009 H1N1 pandemic vaccination campaign in Finland. PLoS One 2012, 7:e33723.
33. Peyron C., Faraco J., Rogers W., et al. A mutation in a case of early onset narcolepsy and a generalized absence of hypocretin peptides in human narcoleptic brains. Nat. Med. 2000, 6:991-997.
34. Rothman K.J. No adjustments are needed for multiple comparisons. Epidemiology 1990, 1:43-46.
35. Sakaguchi S., Yamaguchi T., Nomura T., Ono M. Regulatory T Cells and immune tolerance. Cell 2008, 133:775-787.
36. Sokol C.L., Barton G.M., Farr A.G., Medzhitov R. A mechanism for the initiation of allergen-induced T helper type 2 responses. Nat. Immunol. 2008, 9:310-318.
37. Street N.E., Mosmeann T.R. Functional diversity of T lymphocytes due to secretion of different cytokine patterns. FASEB J. 1991, 5:171-177.
38. Terres G., Coffman R.L. The role of IL-4 and IL-10 cytokines in controlling an anti-tumor response in vivo. Int. Immunol. 1998, 10:823-832.
39. The International Classification of Sleep Disorders 2nd Edition: Diagnostic and Coding Manual 2005, American Academy of Sleep Medicine, Westchester, IL.
40. Vgontzas A.N., Papanicolaou D.A., Bixler E.O., Kales A., Tyson K., Chrousos G.P. Elevation of plasma cytokines in disorders of excessive daytime sleepiness: role of sleep disturbance and obesity. J. Clin. Endocrinol. Metab. 1997, 82:1313-1316.