Frailty in relation to sedentary behaviours and moderate-vigorous intensity physical activity

Reviews in Clinical Gerontology

Volumn 24, Issue 4, 2014, Pages 239-254

  Blodgett, Joanna ^a   Theou, Olga ^a   Kirkland, Susan ^a,b   Andreou, Pantelis ^a   Rockwood, Kenneth ^b,c  

^a Departments of Community Health and Epidemiology   (Canada)

^b DALHOUSIE UNIVERSITY   (Canada)

^c QUEEN ELIZABETH II HEALTH SCIENCES CENTRE   (Canada)

Author keywords

ageing; frailty; moderate vigorous physical activity; sedentary behavior

Indexed keywords

ACCELEROMETER; ARTICLE; ENERGY EXPENDITURE; FITNESS; FRAILTY; HEALTH STATUS; HUMAN; LIFESTYLE MODIFICATION; PHYSICAL ACTIVITY; SEDENTARY LIFESTYLE;

EID: 85027954820     PISSN: 09592598     EISSN: 14699036     Source Type: Journal    
DOI: 10.1017/S0959259814000124     Document Type: Article

References (185)

1. National Institute on Aging. Global Health and Aging. 2011; 11-7737.
2. Fried LP, Ferrucci L, Darer J, Williamson JD, Anderson G. Untangling the concepts of disability, frailty, and comorbidity: implications for improved targeting and care. J Gerontol A Biol Sci Med Sci 2004; 59: 255-63.
3. Canadian Institute for Health Information. Health Care in Canada, 2011: A Focus on Seniors and Aging. 2011; available at: https://secure.cihi.ca/free-products/HCIC-2011 -seniors-report-en.pdf (accessed 11 March 2013).
4. Booth FW, Chakravarthy MV. Cost and Consequences of Sedentary Living: New Battleground for an Old Enemy. President's Council on Physical Fitness and Sports: Research Digest 2002; 3: 1-8.
5. Ferrucci L, Guralnik JM, Studenski S, Fried LP, Cutler GB Jr, Walston JD et al. Designing randomized, controlled trials aimed at preventing or delaying functional decline and disability in frail, older persons: a consensus report. J Am Geriatr Soc 2004; 52: 625-34.
6. World Health Organization. Preventing chronic diseases: a vital investment. 2005.
7. Rockwood K, Theou O. Should frailty status always be considered when treating the elderly patient? Aging Health 2012; 9: 261-71.
8. Fried LP, Tangen CM, Walston J, Newman AB, Hirsch C, Gottdiener J et al. Frailty in older adults: evidence for a phenotype. J Gerontol A Biol Sci Med Sci 2001; 56: M146-56.
9. Ensrud KE, Ewing SK, Taylor BC, Fink HA, Cawthon PM, Stone KL et al. Comparison of 2 frailty indexes for prediction of falls, disability, fractures, and death in older women. Arch Intern Med 2008; 168: 382-89.
10. Rockwood MR, MacDonald E, Sutton E, Rockwood K, Baron M; Canadian Scleroderma Research Group. Frailty index to measure health status in people with systemic sclerosis. J Rheumatol 2014; 41: 698-705.
11. Zampini JM. CORR Insights(R): Association of a modified frailty index with mortality after femoral neck fracture in patients aged 60 years and older. Clin Orthop Relat Res 2014; 472: 1018-19.
12. Evans SJ, Sayers M, Mitnitski A, Rockwood K. The risk of adverse outcomes in hospitalized older patients in relation to a frailty index based on a comprehensive geriatric assessment. Age Ageing 2014; 43: 127-32.
13. Garcia-Gonzalez JJ, Garcia-Pena C, Franco-Marina F, Gutierrez-Robledo LM. A frailty index to predict the mortality risk in a population of senior Mexican adults. BMC Geriatr 2009; 9: 47-2318-9-47.
14. Levers MJ, Estabrooks CA, Ross Kerr JC. Factors contributing to frailty: literature review. J Advanced Nursing 2006; 56: 282-91.
15. Bauman A, Ainsworth BE, Sallis JF, Hagstromer M, Craig CL, Bull FC et al. The descriptive epidemiology of sitting. A 20-country comparison using the International Physical Activity Questionnaire (IPAQ). Am J Prev Med 2011; 41: 228-35.
16. Katzmarzyk PT, Church TS, Craig CL, Bouchard C. Sitting time and mortality from all causes, cardiovascular disease, and cancer. Med Sci Sports Exerc 2009; 41: 998-1005.
17. Thorp AA, Owen N, Neuhaus M, Dunstan DW. Sedentary behaviors and subsequent health outcomes in adults a systematic review of longitudinal studies, 1996-2011. Am J Prev Med 2011; 41: 207-15.
18. Healy GN, Wijndaele K, Dunstan DW, Shaw JE, Salmon J, Zimmet PZ et al. Objectively measured sedentary time, physical activity, and metabolic risk: the Australian Diabetes, Obesity and Lifestyle Study (AusDiab). Diabetes Care 2008; 31: 369-71.
19. Healy GN, Dunstan DW, Salmon J, Shaw JE, Zimmet PZ, Owen N. Television time and continuous metabolic risk in physically active adults. Med Sci Sports Exerc 2008; 40: 639-45.
20. Rockwood K. What would make a definition of frailty successful? Age Ageing 2005; 34: 432-34.
21. Xue QL. The frailty syndrome: definition and natural history Clin Geriatr Med 2011; 27: 1-15.
22. Mitnitski AB, Graham JE, Mogilner AJ, Rockwood K. Frailty, fitness and late-life mortality in relation to chronological and biological age. BMC Geriatr 2002; 2: 1.
23. Mitnitski A, Song X, Rockwood K. Assessing biological aging: the origin of deficit accumulation. Biogerontology 2013; 14: 709-17.
24. Howlett SE, Rockwood K. New horizons in frailty: ageing and the deficit-scaling problem. Age Ageing 2013; 42: 416-23.
25. Kirkwood TB. Frailty only occurs with ageing, a stochastic dynamic process of deficit accumulation. Cell 2005; 120: 437-47.
26. Rockwood K, Stadnyk K, MacKnight C, McDowell I, Hebert R, Hogan DB. A brief clinical instrument to classify frailty in elderly people. Lancet 1999; 353: 205-6.
27. Mitnitski A, Song X, Skoog I, Broe GA, Cox JL, Grunfeld E et al. Relative fitness and frailty of elderly men and women in developed countries and their relationship with mortality. J Am Geriatr Soc 2005 Dec; 53: 2184-89.
28. Hogan DB, MacKnight C, Bergman H, Steering Committee, Canadian Initiative on Frailty and Aging. Models, definitions, and criteria of frailty. Aging Clin Exp Res 2003; 15 (suppl): 1-29.
29. Lipsitz LA. Physiological complexity, aging, and the path to frailty. Sci Aging Knowledge Environ 2004; pe16.
30. Rockwood K, Fox RA, Stolee P, Robertson D, Beattie BL. Frailty in elderly people: an evolving concept. CMAJ 1994; 150: 489-95.
31. Wells JL, Seabrook JA, Stolee P, Borrie MJ, Knoefel F. State of the art in geriatric rehabilitation. Part I: review of frailty and comprehensive geriatric assessment. Arch Phys Med Rehabil 2003; 84: 890-97.
32. Bouillon K, Kivimaki M, Hamer M, Sabia S, Fransson EI, Singh-Manoux A et al. Measures of frailty in population-based studies: an overview. BMC Geriatr 2013; 13: 64-2318-13-64.
33. Baitar A, Van Fraeyenhove F, Vandebroek A, De Droogh E, Galdermans D, Mebis J et al. Evaluation of the Groningen Frailty Indicator and the G8 questionnaire as screening tools for frailty in older patients with cancer. J Geriatr Oncol 2013; 4: 32-38.
34. Gobbens RJ, van Assen MA, Luijkx KG, Schols JM. The predictive validity of the Tilburg Frailty Indicator: disability, health care utilization, and quality of life in a population at risk. Gerontologist 2012; 52: 619-31.
35. Rockwood K, Song X, MacKnight C, Bergman H, Hogan DB, McDowell I et al. A global clinical measure of fitness and frailty in elderly people. CMAJ 2005; 173: 489-95.
36. Rolfson DB, Majumdar SR, Tsuyuki RT, Tahir A, Rockwood K. Validity and reliability of the Edmonton Frail Scale. Age Ageing 2006; 35: 526-29.
37. Abellan van Kan G, Rolland YM, Morley JE, Vellas B. Frailty: toward a clinical definition. J Am Med Dir Assoc 2008; 9: 71-72.
38. Rockwood K. Frailty and its definition: a worthy challenge. J Am Geriatr Soc 2005; 53: 1069-70.
39. Gillick M. Pinning down frailty. J Gerontol A Biol Sci Med Sci 2001; 56: M134-35.
40. Walston J, Hadley EC, Ferrucci L, Guralnik JM, Newman AB, Studenski SA et al. Research agenda for frailty in older adults: toward a better understanding of physiology and etiology: summary from the American Geriatrics Society/National Institute on Aging Research Conference on Frailty in Older Adults. J Am Geriatr Soc 2006; 54: 991-1001.
41. Whitson HE, Purser JL, Cohen HJ. Frailty thy name is . . . Phrailty? J Gerontol A Biol Sci Med Sci 2007; 62: 728-30.
42. Rothman MD, Leo-Summers L, Gill TM. Prognostic significance of potential frailty criteria. J Am Geriatr Soc 2008; 56: 2211-16.
43. Clegg A, Young J. The frailty syndrome. Clin Med 2011; 11: 72-75.
44. Theou O, Brothers TD, Mitnitski A, Rockwood K. Operationalization of frailty using eight commonly used scales and comparison of their ability to predict all-cause mortality. J Am Geriatr Soc 2013; 61: 1537-51.
45. Malmstrom TK, Miller DK, Morley JE. A comparison of four frailty models. J Am Geriatr Soc 2014; 62: 721-26.
46. Collerton J, Martin-Ruiz C, Davies K, Hilkens CM, Isaacs J, Kolenda C et al. Frailty and the role of inflammation, immunosenescence and cellular ageing in the very old: cross-sectional findings from the Newcastle 85+ Study. Mech Ageing Dev 2012; 133: 456-66.
47. Ravindrarajah R, Lee DM, Pye SR, Gielen E, Boonen S, Vanderschueren D et al. The ability of three different models of frailty to predict all-cause mortality: results from the European Male Aging Study (EMAS). Arch Gerontol Geriatr 2013; 57: 360-68.
48. Mitnitski AB, Mogilner AJ, Rockwood K. Accumulation of deficits as a proxy measure of aging. Scientific World J 2001; 1: 323-36.
49. De Lepeleire J, Iliffe S, Mann E, Degryse JM. Frailty: an emerging concept for general practice. Br J Gen Pract 2009; 59: e177-82.
50. Searle SD, Mitnitski A, Gahbauer EA, Gill TM, Rockwood K. A standard procedure for creating a frailty index. BMC Geriatr 2008; 8: 24-2318-8-24.
51. Goggins WB, Woo J, Sham A, Ho SC. Frailty index as a measure of biological age in a Chinese population. J Gerontol A Biol Sci Med Sci 2005; 60: 1046-51.
52. Dent E, Chapman I, Howell S, Piantadosi C, Visvanathan R. Frailty and functional decline indices predict poor outcomes in hospitalised older people. Age Ageing 2013 ; 43: 477-84.
53. Harttgen K, Kowal P, Strulik H, Chatterji S, Vollmer S. Patterns of frailty in older adults: comparing results from higher and lower income countries using the Survey of Health, Ageing and Retirement in Europe (SHARE) and the Study on Global AGEing and Adult Health (SAGE). PLoS One 2013; 8: e75847.
54. Adams P, Ghanem T, Stachler R, Hall F, Velanovich V, Rubinfeld I. Frailty as a predictor of morbidity and mortality in inpatient head and neck surgery. JAMA Otolaryngol Head Neck Surg 2013; 139: 783-89.
55. Farhat JS, Velanovich V, Falvo AJ, Horst HM, Swartz A, Patton JH Jr et al. Are the frail destined to fail? Frailty index as predictor of surgical morbidity and mortality in the elderly. J Trauma Acute Care Surg 2012; 72: 1526-30; discussion 1530-31.
56. Rockwood K, Song X, Mitnitski A. Changes in relative fitness and frailty across the adult lifespan: evidence from the Canadian National Population Health Survey. CMAJ 2011; 183: E487-94.
57. Evans SJ, Sayers M, Mitnitski A, Rockwood K. The risk of adverse outcomes in hospitalized older patients in relation to a frailty index based on a comprehensive geriatric assessment. Age Ageing 2014; 43: 127-32.
58. Mitnitski A, Song X, Skoog I, Broe GA, Cox JL, Grunfeld E et al. Relative fitness and frailty of elderly men and women in developed countries and their relationship with mortality. J Am Geriatr Soc 2005; 53: 2184-89.
59. Xue QL. The frailty syndrome: definition and natural history.Clin Geriatr Med 2011; 27: 1-15.
60. de Vries NM, Staal JB, van Ravensberg CD, Hobbelen JS, Olde Rikkert MG, Nijhuis-van der, Sanden MW. Outcome instruments to measure frailty: a systematic review. Ageing Res Rev 2011; 10: 104-14.
61. Rockwood K, Andrew M, Mitnitski A. A comparison of two approaches to measuring frailty in elderly people. J Gerontol A Biol Sci Med Sci 2007; 62: 738-43.
62. Rockwood K, Mitnitski A. Frailty in relation to the accumulation of deficits. J Gerontol A Biol Sci Med Sci 2007; 62: 722-27.
63. Song X, Mitnitski A, Rockwood K. Non-traditional risk factors combine to predict Alzheimer disease and dementia. Neurology 2011; 77: 227-34.
64. Wallace LM, Theou O, Kirkland SA, Rockwood MR, Davidson KW, Shimbo D, Rockwood K. Accumulation of non-traditional risk factors for coronary heart disease is associated with incident coronary heart disease hospitalization and death. PloS One 2014; 9: e90475.
65. Caspersen CJ, Powell KE, Christenson GM. Physical activity, exercise, and physical fitness: definitions and distinctions for health-related research. Public Health Rep 1985; 100: 126-31.
66. Pate RR, O'Neill JR, Lobelo F. The evolving definition of 'sedentary'. Exerc Sport Sci Rev 2008; 36: 173-78.
67. Oga T, Nishimura K, Tsukino M, Sato S, Hajiro T, Ikeda A et al. Health status measured with the CRQ does not predict mortality in COPD. Eur Respir J 2002; 20: 1147-51.
68. Sedentary Behaviour Research Network. Letter to the editor: standardized use of the terms 'sedentary' and 'sedentary behaviours'. Appl Physiol Nutr Metab 2012; 37: 540-42.
69. Tremblay MS, Colley RC, Saunders TJ, Healy GN, Owen N. Physiological and health implications of a sedentary lifestyle. Appl Physiol Nutr Metab 2010; 35: 725-40.
70. Owen N, Sugiyama T, Eakin EE, Gardiner PA, Tremblay MS, Sallis JF. Adults' sedentary behavior determinants and interventions. Am J Prev Med 2011; 41: 189-96.
71. Reilly JJ, Coyle J, Kelly L, Burke G, Grant S, Paton JY. An objective method for measurement of sedentary behavior in 3- to 4-year olds. Obes Res 2003; 11: 1155-58.
72. Biddle SJ, Gorely T, Marshall SJ, Murdey I, Cameron N. Physical activity and sedentary behaviours in youth: issues and controversies. J R Soc Promot Health 2004; 124: 29-33.
73. Pate RR, O'Neill JR, Lobelo F. The evolving definition of 'sedentary'. Exerc Sport Sci Rev 2008; 36: 173-78.
74. Owen N, Healy GN, Matthews CE, Dunstan DW. Too much sitting: the population health science of sedentary behavior. Exerc Sport Sci Rev 2010; 38: 105-13.
75. Lowry R, Wechsler H, Galuska DA, Fulton JE, Kann L. Television viewing and its associations with overweight, sedentary lifestyle, and insufficient consumption of fruits and vegetables among US high school students: differences by race, ethnicity, and gender. J SchHealth 2002; 72: 413-21.
76. Paffenbarger RS Jr, Hyde RT, Wing AL, Hsieh CC. Physical activity, all-cause mortality, and longevity of college alumni. N Engl J Med 1986; 314: 605-13.
77. Blair SN, Cheng Y, Holder JS. Is physical activity or physical fitness more important in defining health benefits? Med Sci Sports Exerc 2001; 33 (suppl): S379-99; discussion S419-20.
78. Robson S. Physical Fitness and Resilience: A Review of Relevant Constructs, Measures, and Links to Well-Being. 2013.
79. American College of Sports Medicine Position Stand. The Recommended Quantity and Quality of Exercise for Developing and Maintaining Cardiorespiratory and Muscular Fitness, and Flexibility in Healthy Adults. Med Sci Sports Exercise 1998; 30: 975-91.
80. Singh MA. Exercise to prevent and treat functional disability. Clin Geriatr Med 2002; 18: 431-62, vi-vii.
81. Simonsick EM, Lafferty ME, Phillips CL, Mendes de Leon CF, Kasl SV, Seeman TE et al. Risk due to inactivity in physically capable older adults.Am J Public Health 1993; 83: 1443-50.
82. Cruz-Jentoft AJ, Baeyens JP, Bauer JM, Boirie Y, Cederholm T, Landi F et al. Sarcopenia: European consensus on definition and diagnosis: Report of the European Working Group on Sarcopenia in Older People. Age Ageing 2010; 39: 412-23.
83. Leveille SG, Guralnik JM, Ferrucci L, Langlois JA. Aging successfully until death in old age: opportunities for increasing active life expectancy. Am J Epidemiol 1999; 149: 654-64.
84. Kortebein P, Ferrando A, Lombeida J, Wolfe R, Evans WJ. Effect of 10 days of bed rest on skeletal muscle in healthy older adults. JAMA 2007; 297: 1772-74.
85. Blair SN, Kohl HW 3rd, Barlow CE, Paffenbarger RS Jr, Gibbons LW, Macera CA. Changes in physical fitness and all-cause mortality. A prospective study of healthy and unhealthy men. JAMA 1995; 273: 1093-98.
86. King AC, Pruitt LA, Phillips W, Oka R, Rodenburg A, Haskell WL. Comparative effects of two physical activity programs on measured and perceived physical functioning and other health-related quality of life outcomes in older adults. J Gerontol A Biol Sci Med Sci 2000; 55: M74-83.
87. Cress ME, Buchner DM, Questad KA, Esselman PC, deLateur BJ, Schwartz RS. Exercise: effects on physical functional performance in independent older adults. J Gerontol A Biol Sci Med Sci 1999; 54: M242-48.
88. Landi F, Russo A, Cesari M, Pahor M, Liperoti R, Danese P et al. Walking one hour or more per day prevented mortality among older persons: results from ilSIRENTE study. Prev Med 2008; 47: 422-26.
89. Weuve J, Kang JH, Manson JE, Breteler MM, Ware JH, Grodstein F. Physical activity, including walking, and cognitive function in older women. JAMA 2004; 292: 1454-61.
90. Podewils LJ, Guallar E, Kuller LH, Fried LP, Lopez OL, Carlson M et al. Physical activity, APOE genotype, and dementia risk: findings from the Cardiovascular Health Cognition Study. Am J Epidemiol 2005; 161: 639-51.
91. Bartholomew JB, Morrison D, Ciccolo JT. Effects of acute exercise on mood and well-being in patients with major depressive disorder. Med Sci Sports Exerc 2005; 37: 2032-37.
92. King AC, Pruitt LA, Phillips W, Oka R, Rodenburg A, Haskell WL. Comparative effects of two physical activity programs on measured and perceived physical functioning and other health-related quality of life outcomes in older adults. J Gerontol A Biol Sci Med Sci 2000; 55: M74-83.
93. Peterson MJ, Giuliani C, Morey MC, Pieper CF, Evenson KR, Mercer V et al. Physical activity as a preventative factor for frailty: the health, aging, and body composition study. J Gerontol A Biol Sci Med Sci 2009; 64: 61-68.
94. Gill TM, Baker DI, Gottschalk M, Peduzzi PN, Allore H, Byers A. A program to prevent functional decline in physically frail, elderly persons who live at home. N Engl J Med 2002; 347: 1068-74.
95. Brown M, Sinacore DR, Ehsani AA, Binder EF, Holloszy JO, Kohrt WM. Low-intensity exercise as a modifier of physical frailty in older adults. Arch Phys Med Rehabil 2000; 81: 960-65.
96. Binder EF, Schechtman KB, Ehsani AA, Steger-May K, Brown M, Sinacore DR et al. Effects of exercise training on frailty in community-dwelling older adults: results of a randomized, controlled trial.J Am Geriatr Soc 2002; 50: 1921-28.
97. LaCroix AZ, Guralnik JM, Berkman LF, Wallace RB, Satterfield S. Maintaining mobility in late life. II. Smoking, alcohol consumption, physical activity, and body mass index. Am J Epidemiol 1993; 137: 858-69.
98. Pahor M, Blair SN, Espeland M, Fielding R, Gill TM, Guralnik JM. Effects of a physical activity intervention on measures of physical performance: results of the Lifestyle Interventions and Independence for Elders Pilot (LIFE-P) study. J Gerontol: Med Sci 2006; 61A: M1157-65.
99. Centers for Disease Control and Prevention (CDC). Physical Activity for Everyone: The Benefits of Physical Activity. 2011; available at: http://www.cdc.gov/physicalactivity/everyone/ health/ (accessed 15 November 2013).
100. Landi F, Russo A, Cesari M, Pahor M, Liperoti R, Danese P et al. Walking one hour or more per day prevented mortality among older persons: results from ilSIRENTE study. Prev Med 2008; 47: 422-26.
101. Carnethon M, Whitsel LP, Franklin BA, Kris-Etherton P, Milani R, Pratt CA et al. Worksite wellness programs for cardiovascular disease prevention: a policy statement from the American Heart Association. Circulation 2009; 120: 1725-41.
102. Tremblay MS, Kho ME, Tricco AC, Duggan M. Process description and evaluation of Canadian Physical Activity Guidelines development. Int J Behav Nutr Phys Act 2010; 7: 42-5868-7-42.
103. Hubbard RE, Fallah N, Searle SD, Mitnitski A, Rockwood K. Impact of exercise in community-dwelling older adults. PLoS One 2009; 4: e6174.
104. Katzmarzyk PT, Mason C. The physical activity transition. J Phys Act Health 2009; 6: 269-80.
105. Healy GN, Wijndaele K, Dunstan DW, Shaw JE, Salmon J, Zimmet PZ et al. Objectively measured sedentary time, physical activity, and metabolic risk: the Australian Diabetes, Obesity and Lifestyle Study (AusDiab). Diabetes Care 2008; 31: 369-71.
106. Brownson RC, Boehmer TK, Luke DA. Declining rates of physical activity in the United States: what are the contributors? Ann Rev Public Health 2005; 26: 421-43.
107. Dunstan DW, Salmon J, Owen N, Armstrong T, Zimmet PZ, Welborn TA et al. Associations of TV viewing and physical activity with the metabolic syndrome in Australian adults. Diabetologia 2005; 48: 2254-61.
108. Jakes RW, Day NE, Khaw KT, Luben R, Oakes S, Welch A et al. Television viewing and low participation in vigorous recreation are independently associated with obesity and markers of cardiovascular disease risk: EPIC-Norfolk population-based study. Eur J Clin Nutr 2003; 57:1089-96.
109. Healy GN, Matthews CE, Dunstan DW, Winkler EA, Owen N. Sedentary time and cardiometabolic biomarkers in US adults: NHANES 2003-2006. Eur Heart J 2011; 32: 590-97.
110. Hu FB, Leitzmann MF, Stampfer MJ, Colditz GA, Willett WC, Rimm EB. Physical activity and television watching in relation to risk for type 2 diabetes mellitus in men. Arch Intern Med 2001 Jun 25;161(12):1542-1548.
111. Hu FB, Li TY, Colditz GA, Willett WC, Manson JE. Television watching and other sedentary behaviors in relation to risk of obesity and type 2 diabetes mellitus in women. JAMA 2003; 289: 1785-91.
112. Howard RA, Freedman DM, Park Y, Hollenbeck A, Schatzkin A, Leitzmann MF. Physical activity, sedentary behavior, and the risk of colon and rectal cancer in the NIH-AARP Diet and Health Study. Cancer Causes Control 2008; 19: 939-53.
113. Gierach GL, Chang SC, Brinton LA, Lacey JV Jr, Hollenbeck AR, Schatzkin A et al. Physical activity, sedentary behavior, and endometrial cancer risk in the NIH-AARP Diet and Health Study. Int J Cancer 2009; 124: 2139-47.
114. Friberg E, Mantzoros CS, Wolk A. Physical activity and risk of endometrial cancer: a population-based prospective cohort study. Cancer Epidemiol Biomarkers Prev 2006; 15: 2136-40.
115. Sanchez-Villegas A, Ara I, Guillen-Grima F, Bes-Rastrollo M, Varo-Cenarruzabeitia JJ, Martinez-Gonzalez MA. Physical activity, sedentary index, and mental disorders in the SUN cohort study. Med Sci Sports Exerc 2008; 40: 827-34.
116. Camhi SM, Sisson SB, Johnson WD, Katzmarzyk PT, Tudor-Locke C. Accelerometer-determined moderate intensity lifestyle activity and cardiometabolic health. Prev Med 2011; 52: 358-60.
117. Healy GN, Dunstan DW, Salmon J, Cerin E, Shaw JE, Zimmet PZ et al. Objectively measured light-intensity physical activity is independently associated with 2-h plasma glucose. Diabetes Care 2007; 30: 1384-89.
118. Kim Y, Wilkens LR, Park SY, Goodman MT, Monroe KR, Kolonel LN. Association between various sedentary behaviours and all-cause, cardiovascular disease and cancer mortality: the Multiethnic Cohort Study.Int J Epidemiol 2013; 42: 1040-56.
119. Matthews CE, Chen KY, Freedson PS, Buchowski MS, Beech BM, Pate RR et al. Amount of time spent in sedentary behaviors in the United States, 2003-2004. Am J Epidemiol 2008; 167: 875-81.
120. Gennuso KP, Gangnon RE, Matthews CE, Thraen-Borowski KM, Colbert LH. Sedentary behavior, physical activity, and markers of health in older adults. Med Sci Sports Exerc 2013; 45: 1493-1500.
121. Dogra S, Stathokostas L. Sedentary behavior and physical activity are independent predictors of successful aging in middle-aged and older adults. J Aging Res 2012; 190654.
122. Theou O, Jones GR, Vandervoort AA, Jakobi JM. Daily muscle activity and quiescence in non-frail, pre-frail, and frail older women. Exp Gerontol 2010; 45: 909-17.
123. Paterson DH, Jones GR, Rice CL. Aging and physical activity data on which to base recommendations for exercise in older adults. Appl Physiol Nutr Metab 2007; 32 suppl 2F: S75-171.
124. Gill TM, Gahbauer EA, Allore HG, Han L. Transitions between frailty states among community-living older persons. Arch Intern Med 2006; 166: 418-23.
125. Chin A, Paw MJ, de Jong N, Schouten EG, van Staveren WA, Kok FJ. Physical exercise or micronutrient supplementation for the wellbeing of the frail elderly? A randomised controlled trial. Br J Sports Med 2002; 36: 126-31.
126. American College of Sports Medicine Position Stand. Exercise and physical activity for older adults. Med Sci Sports Exerc 1998; 30: 992-1008.
127. Prince SA, Adamo KB, Hamel ME, Hardt J, Connor Gorber S, Tremblay M. A comparison of direct versus self-report measures for assessing physical activity in adults: a systematic review. Int J Behav Nutr Phys Act 2008; 5: 56-5868-5-56.
128. Adams SA, Matthews CE, Ebbeling CB, Moore CG, Cunningham JE, Fulton J et al. The effect of social desirability and social approval on self-reports of physical activity. Am J Epidemiol 2005; 161: 389-98.
129. Sallis JF, Saelens BE. Assessment of physical activity by self-report: status, limitations, and future directions. Res Q Exerc Sport 2000; 71 (suppl): S1-14.
130. Centers for Disease Control and Prevention (CDC). Prevalence of regular physical activity among adults - United States, 2001 and 2005. MMWR Morb Mortal Wkly Rep 2007; 56: 1209-12.
131. Basu S, McKee M, Galea G, Stuckler D. Relationship of soft drink consumption to global overweight, obesity, and diabetes: a cross-national analysis of 75 countries. Am J Public Health 2013; 103: 2071-77.
132. International Health, Racquet & Sports Club Association. The 2013 IHRSA Global Report. 2013.
133. Stamatakis E, Ekelund U, Wareham NJ. Temporal trends in physical activity in England: the Health Survey for England 1991 to 2004. Prev Med 2007; 45: 416-23.
134. Sobolski JC, Kolesar JJ, Kornitzer MD, De Backer GG, Mikes Z, Dramaix MM et al. Physical fitness does not reflect physical activity patterns in middle-aged workers. Med Sci Sports Exerc 1988; 20: 6-13.
135. Lanningham-Foster L, Nysse LJ, Levine JA. Labor saved, calories lost: the energetic impact of domestic labor-saving devices.Obes Res 2003; 11: 1178-81.
136. Great Britain Parliament House of Commons Health Committee. Obesity - Volume 1 - HCP 23-I, Third Report of session 2003-2004. Report, together with formal minutes. 2004.
137. James WP. The fundamental drivers of the obesity epidemic. Obes Rev 2008; 9 (suppl 1): 6-13.
138. Tremblay MS, Colley RC, Saunders TJ, Healy GN, Owen N. Physiological and health implications of a sedentary lifestyle. Appl Physiol Nutr Metab 2010; 35: 725-40.
139. Hamilton MT, Healy GN, Dunstan DW, Zderic TW, Owen N. Too little exercise and too much sitting: inactivity physiology and the need for new recommendations on sedentary behavior. Curr Cardiovasc Risk Rep 2008; 2: 292-98.
140. Dunstan DW, Salmon J, Healy GN, Shaw JE, Jolley D, Zimmet PZ et al. Association of television viewing with fasting and 2-h postchallenge plasma glucose levels in adults without diagnosed diabetes. Diabetes Care 2007 Mar; 30: 516-22.
141. Barwais FA, Cuddihy T, Washington T, Tomson ML, Brymer E. Development and validation of a new self-report instrument for measuring sedentary behaviors and light-intensity physical activity in adults. J Phys Act Health 2013 (epub ahead of print 19 Aug).
142. Rosenberg DE, Norman GJ, Wagner N, Patrick K, Calfas KJ, Sallis JF. Reliability and validity of the Sedentary Behavior Questionnaire (SBQ) for adults. J Phys Act Health 2010; 7: 697-705.
143. Henson J, Yates T, Biddle SJ, Edwardson CL, Khunti K, Wilmot EG et al. Associations of objectively measured sedentary behaviour and physical activity with markers of cardiometabolic health. Diabetologia 2013; 56: 1012-20.
144. Ford ES, Kohl HW 3rd, Mokdad AH, Ajani UA. Sedentary behavior, physical activity, and the metabolic syndrome among US adults. Obes Res 2005; 13: 608-14.
145. Howard RA, Freedman DM, Park Y, Hollenbeck A, Schatzkin A, Leitzmann MF. Physical activity, sedentary behavior, and the risk of colon and rectal cancer in the NIH-AARP Diet and Health Study. Cancer Causes Control 2008; 19: 939-53.
146. Friberg E, Mantzoros CS, Wolk A. Physical activity and risk of endometrial cancer: a population-based prospective cohort study. Cancer Epidemiol Biomarkers Prev 2006; 15: 2136-40.
147. US Department of Labor. American Time Use Survey - 2012 Results. 2013; Available at: http://www.bls.gov/news.release/pdf/atus.pdf (accessed 20 November 2013).
148. Biddle SJ. Sedentary behavior. Am J Prev Med 2007; 33: 502-4.
149. Klesges RC, Eck LH, Mellon MW, Fulliton W, Somes GW, Hanson CL. The accuracy of self-reports of physical activity. Med Sci Sports Exerc 1990; 22: 690-97.
150. Schuna JM Jr, Johnson WD, Tudor-Locke C. Adult self-reported and objectively monitored physical activity and sedentary behavior: NHANES 2005-2006. Int J Behav Nutr Phys Act 2013; 10: 126-5868-10-126.
151. Evenson KR, Buchner DM, Morland KB. Objective measurement of physical activity and sedentary behaviour among US adults aged 60 years or older. Prev Chronic Dis 2012; 9 (E26).
152. Tucker JM, Welk GJ, Beyler NK. Physical activity in US: adults compliance with the Physical Activity Guidelines for Americans.Am J Prev Med 2011; 40: 454-61.
153. Adams SA, Matthews CE, Ebbeling CB, Moore CG, Cunningham JE, Fulton J et al. The effect of social desirability and social approval on self-reports of physical activity. Am J Epidemiol 2005; 161: 389-98.
154. Klesges LM, Baranowski T, Beech B, Cullen K, Murray DM, Rochon J et al. Social desirability bias in self-reported dietary, physical activity and weight concerns measures in 8- to 10-year-old African-American girls: results from the Girls Health Enrichment Multisite Studies (GEMS). Prev Med 2004; 38 (suppl): S78-87.
155. Booth ML, Owen N, Bauman A, Gore CJ. Relationship between a 14-day recall measure of leisure-time physical activity and a submaximal test of physical work capacity in a population sample of Australian adults. Res Q Exerc Sport 1996; 67: 221-27.
156. Buchowski MS, Townsend KM, Chen KY, Acra SA, Sun M. Energy expenditure determined by self-reported physical activity is related to body fatness. Obes Res 1999; 7: 23-33.
157. Rowlands AV. Accelerometer assessment of physical activity in children: an update. Pediatr Exerc Sci 2007; 19: 252-66.
158. Corder K, Brage S, Ekelund U. Accelerometers and pedometers: methodology and clinical application. Curr Opin Clin Nutr Metab Care 2007; 10: 597-603.
159. Ward DS, Evenson KR, Vaughn A, Rodgers AB, Troiano RP. Accelerometer use in physical activity: best practices and research recommendations. Med Sci Sports Exerc 2005 Nov; 37(suppl): S582-88.
160. Oliver M, Schofield GM, Kilt GS. Physical activity in pre-schoolers: understanding prevalence and measurement issues. Sports Med 2007; 32: 1045-70.
161. Trost SG. State of the art reviews: measurement of physical activity in children and adolescents. Am J Lifestyle Med 2007; 1: 299-314.
162. Mathie MJ, Coster AC, Lovell NH, Celler BG. Accelerometry: providing an integrated, practical method for long-term, ambulatory monitoring of human movement. Physiol Meas 2004; 25: R1-20.
163. Bouten CV, Verboeket-van de, Venne WP, Westerterp KR, Verduin M, Janssen JD. Daily physical activity assessment: comparison between movement registration and doubly labeled water. J Appl Physiol 1985; 81: 1019-26.
164. Meijer EP, Goris AH, Wouters L, Westerterp KR. Physical inactivity as a determinant of the physical activity level in the elderly. Int J Obes Relat Metab Disord 2001; 25: 935-39.
165. Kochersberger G, McConnell E, Kuchibhatla MN, Pieper C. The reliability, validity, and stability of a measure of physical activity in the elderly. Arch Phys Med Rehabil 1996; 77: 793-95.
166. Hansson GA, Asterland P, Holmer NG, Skerfving S. Validity and reliability of triaxial accelerometers for inclinometry in posture analysis. Med Biol Eng Comput 2001; 39: 405-13.
167. Gardner AW, Poehlman ET. Assessment of free-living daily physical activity in older claudicants: validation against the doubly labeled water technique. J Gerontol A Biol Sci Med Sci 1998; 53: M275-80.
168. Exercise and Physical Activity Resource Center. Doubly-labeled water. Exercise and Physical Activity Resource Center; 2014; Available at: http://www.ucsdeparc.org/index.php?option= com-content&view=article&id=100&Itemid=82 (accessed 10 March 2014).
169. Steele BG, Holt L, Belza B, Ferris S, Lakshminaryan S, Buchner DM. Quantitating physical activity in COPD using a triaxial accelerometer. Chest 2000; 117: 1359-67.
170. Ng AV, Kent-Braun JA. Quantitation of lower physical activity in persons with multiple sclerosis. Med Sci Sports Exerc 1997; 29: 517-23.
171. Fehling PC, Smith DL, Warner SE, Dalsky GP. Comparison of accelerometers with oxygen consumption in older adults during exercise. Med Sci Sports Exerc 1999; 31: 171-75.
172. Bussmann JB, Hartgerink I, van der Woude LH, Stam HJ. Measuring physical strain during ambulation with accelerometry. Med Sci Sports Exerc 2000; 32: 1462-71.
173. Rosenberger ME, Haskell WL, Albinali F, Mota S, Nawyn J, Intille S. Estimating activity and sedentary behaviour from an accelerometer on the hip or wrist. Med Sci Sports Exerc 2013; 45: 964-75.
174. Cleland I, Kikhia B, Nugent C, Boytsov A, Hallberg J, Synnes K et al. Optimal placement of accelerometers for the detection of everyday activities. Sensors (Basel) 2013; 13: 9183-200.
175. Matthews CE, Ainsworth BE, Thompson RW, Bassett DR Jr. Sources of variance in daily physical activity levels as measured by an accelerometer. Med Sci Sports Exerc 2002; 34: 1376-81.
176. Hart TL, Swartz AM, Cashin SE, Strath SJ. How many days of monitoring predict physical activity and sedentary behaviour in older adults? Int J Behav Nutr Phys Act 2011; 8: 62-5868-8-62.
177. de Jong N, Chin A, Paw MJ, de Groot LC, Hiddink GJ, van Staveren WA. Dietary supplements and physical exercise affecting bone and body composition in frail elderly persons. Am J Public Health 2000; 90: 947-54.
178. Schulte JN, Yarasheski KE. Effects of resistance training on the rate of muscle protein synthesis in frail elderly people. Int J Sport Nutr Exerc Metab 2001; 11 (suppl): S111-18.
179. Villareal DT, Steger-May K, Schechtman KB. Effects of exercise training on bone mineral density in frail order women and men: a randomized controlled trial. Age Ageing 2004; 33: 309-12.
180. Boshuizen HC, Stemmerik L, Westhoff MH, Hopman-Rock M. The effects of physical therapists' guidance on improvement in a strength-training program for the frail elderly. J Aging Phys Act 2005; 13: 5-22.
181. Fiatarone MA, O'Neill EF, Ryan ND, Clements KM, Solares GR, Nelson ME et al. Exercise training and nutritional supplementation for physical frailty in very elderly people. N Engl J Med 1994; 330: 1769-775.
182. Timonen L, Rantanen T, Ryynanen OP, Taimela S, Timonen TE, Sulkava R. A randomized controlled trial of rehabilitation after hospitalization in frail older women: effects on strength, balance and mobility. Scand J Med Sci Sports 2002; 12:186-92.
183. Mulrow CD, Gerety MB, Kanten D, Cornell JE, DeNino LA, Chiodo L et al. A randomized trial of physical rehabilitation for very frail nursing home residents. JAMA 1994; 271: 519-24.
184. Seynnes O, Fiatarone Singh MA, Hue O, Pras P, Legros P, Bernard PL. Physiological and functional responses to low-moderate versus high-intensity progressive resistance training in frail elders. J Gerontol A Biol Sci Med Sci 2004; 59: 503-9.
185. Asher RA. The dangers of going to bed. Br Med J 1947; 2: 967.