Should frailty status always be considered when treating the elderly patient?

Aging Health

Volumn 8, Issue 3, 2012, Pages 261-271

  Theou, Olga ^a   Rockwood, Kenneth ^b  

^a DALHOUSIE UNIVERSITY   (Canada)

^b Capital District Health Authority   (Canada)

Author keywords

clinical practice; comprehensive geriatric assessment; frailty; geriatric care

Indexed keywords

ADVERSE OUTCOME; AGED; AGING; ELDERLY CARE; EXERCISE INTENSITY; FRAIL ELDERLY; GERIATRIC ASSESSMENT; GERIATRIC REHABILITATION; HEALTH PROGRAM; HUMAN; NEEDS ASSESSMENT; PHYSICAL ACTIVITY; PRESCRIPTION; REVIEW; RISK FACTOR; RISK REDUCTION; SCREENING TEST; SECONDARY PREVENTION; SOCIAL STATUS; SURGICAL RISK; TREATMENT DURATION; TREATMENT INDICATION;

EID: 84862877336     PISSN: 1745509X     EISSN: 17455103     Source Type: Journal    
DOI: 10.2217/ahe.12.8     Document Type: Review

References (106)

1. Clarfield AM. Screening in frail older people: an ounce of prevention or a pound of trouble? J. Am. Geriatr. Soc. 58(10), 2016-2021 (2010).
2. Lindley RI. Drug trials for older people. J. Gerontol. A Biol. Sci. Med. Sci. doi:10.1093/ gerona/glr065 (Epub ahead of print) (2012).
3. Lee DH, Buth KJ, Martin BJ, Yip AM, Hirsch GM. Frail patients are at increased risk for mortality and prolonged institutional care after cardiac surgery. Circulation 121(8), 973-978 (2010).
4. Sternberg SA, Wershof Schwartz A, Karunananthan S, Bergman H, Mark Clarfield A. The identification of frailty: a systematic literature review. J. Am. Geriatr. Soc. 59(11), 2129-2138 (2011).
5. Hennekens CH, Buring JE. Epidemiology in Medicine. Little, Brown and Company, MA, USA (1987).
6. Pijpers E, Ferreiraa I, Stehouwera C, Nieuwenhuijzen Krusemana A. The frailty dilemma: review of the predictive accuracy of major frailty scores. Eur. J. Intern. Med. 23(2), 118-123 (2012).
7. Rockwood K, Song X, Mitnitski A. Changes in relative fitness and frailty across the adult lifespan: evidence from the Canadian National Population Health Survey. CMAJ 183(8), 487-494 (2011).
8. Hamerman D. Toward an understanding of frailty. Ann. Intern. Med. 130(11), 945-950 (1999).
9. Bortz WM 2nd. A conceptual framework of frailty: a review. J. Gerontol. A Biol. Sci. Med. Sci. 57(5), M283-M288 (2002).
10. Fried LP, Tangen CM, Walston J et al. Frailty in older adults: evidence for a phenotype. J. Gerontol. A Biol. Sci. Med. Sci. 56(3), M146-M156 (2001).
11. Fried LP, Walston J. Frailty and failure to thrive. In: Principles of Geriatric Medicine and Gerontology (5th Edition). Hazzard W, Blass J, Halter J (Eds). McGraw-Hill Professional, NY, USA 1487-1502 (2003).
12. Ahmed N, Mandel R, Fain MJ. Frailty: an emerging geriatric syndrome. Am. J. Med. 120(9), 748-753 (2007).
13. Rockwood K, Fox RA, Stolee P, Robertson D, Beattie BL. Frailty in elderly people: an evolving concept. CMAJ 150(4), 489-495 (1994).
14. Abellan van Kan G, Rolland Y, Houles M, Gillette-Guyonnet S, Soto M, Vellas B. The assessment of frailty in older adults. Clin. Geriatr. Med. 26(2), 275-286 (2010).
15. Clegg A, Young J. The frailty syndrome. Clin. Med. 11(1), 72-75 (2011).
16. Mitnitski A, Mogilner A, Rockwood K. Accumulation of deficits as a proxy measure of aging. Scientific World Journal 1, 323-336 (2001).
17. Buchman AS, Boyle PA, Wilson RS, Tang Y, Bennett DA. Frailty is associated with incident Alzheimer's disease and cognitive decline in the elderly. Psychosom. Med. 69(5), 483-489 (2007).
18. Auyeung TW, Lee JS, Kwok T, Woo J. Physical frailty predicts future cognitive decline - a four-year prospective study in 2737 cognitively normal older adults. J. Nutr. Health Aging 15(8), 690-694 (2011).
19. Lee JS, Auyeung TW, Leung J, Kwok T, Leung PC, Woo J. Physical frailty in older adults is associated with metabolic and atherosclerotic risk factors and cognitive impairment independent of muscle mass. J. Nutr. Health Aging 15(10), 857-862 (2011).
20. Mitnitski A, Fallah N, Rockwood MR, Rockwood K. Transitions in cognitive status in relation to frailty in older adults: a comparison of three frailty measures. J. Nutr. Health Aging 15(10), 863-867 (2011).
21. Lloyd GER. Hippocratic Writings. Penguin, Harmondsworth, London, UK (1978).
22. Gruenewald TL, Seeman TE, Karlamangla AS, Sarkisian CA. Allostatic load and frailty in older adults. J. Am. Geriatr. Soc. 57(9), 1525-1531 (2009).
23. Rockwood K, Rockwood MR, Mitnitski A. Physiological redundancy in older adults in relation to the change with age in the slope of a Frailty Index. J. Am. Geriatr. Soc. 58(2), 318-323 (2010).
24. Mitnitski A, Graham J, Mogilner A, Rockwood K. Frailty, fitness and late-life mortality in relation to chronological and biological age. BMC Geriatr. 2, 1 (2002).
25. Fairhead JF, Rothwell PM. Underinvestigation and undertreatment of carotid disease in elderly patients with transient ischaemic attack and stroke: comparative population based study. BMJ 333(7567), 525-527 (2006).
26. Gaw A. The care gap: underuse of statin therapy in the elderly. Int. J. Clin. Pract. 58(8), 777-785 (2004).
27. Andrew MK, Mitnitski AB, Rockwood K. Social vulnerability, frailty and mortality in elderly people. PLoS ONE 3(5), e2232 (2008).
28. Xue QL, Fried LP, Glass TA, Laffan A, Chaves PH. Life-space constriction, development of frailty, and the competing risk of mortality: the Women's Health and Aging Study I. Am. J. Epidemiol. 167(2), 240-248 (2008).
29. Gu D, Dupre ME, Sautter J, Zhu H, Liu Y, Yi Z. Frailty and mortality among Chinese at advanced ages. J. Gerontol. B Psychol. Sci. Soc. Sci. 64(2), 279-289 (2009).
30. Lang IA, Hubbard RE, Andrew MK, Llewellyn DJ, Melzer D, Rockwood K. Neighborhood deprivation, individual socioeconomic status, and frailty in older adults. J. Am. Geriatr. Soc. 57(10), 1776-1780 (2009).
31. Yang Y, Lee LC. Dynamics and heterogeneity in the process of human frailty and aging: evidence from the U.S. older adult population. J. Gerontol. B Psychol. Sci. Soc. Sci. 65B(2), 246-255 (2010).
32. Ferrucci L, Guralnik JM, Studenski S et al. Designing randomized, controlled trials aimed at preventing or delaying functional decline and disability in frail, older persons: a consensus report. J. Am. Geriatr. Soc. 52, 625-634 (2004).
33. Gill TM, Allore HG, Holford TR, Guo Z. Hospitalization, restricted activity, and the development of disability among older persons. JAMA 292(17), 2115-2124 (2004).
34. Rockwood K, Song X, MacKnight C et al. A global clinical measure of fitness and frailty in elderly people. CMAJ 173(5), 489-495 (2005).
35. Vermeulen J, Neyens JC, van Rossum E, Spreeuwenberg MD, de Witte LP. Predicting ADL disability in community-dwelling elderly people using physical frailty indicators: a systematic review. BMC Geriatr. 11, 33 (2011).
36. Fried LP, Ferrucci L, Darer J, Williamson JD, Anderson G. Untangling the concepts of disability, frailty, and comorbidity: implications for improved targeting and care. J. Gerontol. A Biol. Sci. Med. Sci. 59(3), 255-263 (2004).
37. Bergman H, Béland F, Karunanathan S, Hummel S, Hogan D, Wolfson C. Developing a working framework for understanding frailty. Gérontologie et Société 109, 15-29 (2004).
38. Kulminski AM, Yashin AI, Ukraintseva SV et al. Accumulation of health disorders as a systemic measure of aging: findings from the NLTCS data. Mech. Ageing Dev. 127(11), 840-848 (2006).
39. Theou O, Kloseck M. Tools to identify community-dwelling older adults in different stages of frailty. Phys. Occup. Ther. Geriatr. 26(3), 1-21 (2007).
40. Rolfson DB, Majumdar SR, Tsuyuki RT, Tahir A, Rockwood K. Validity and reliability of the Edmonton Frail Scale. Age Ageing 35(5), 526-529 (2006).
41. Steverink N, Slaets JPJ, Schuurmans H, Van Lis M. Measuring frailty: developing and testing the GFI (Groningen Frailty Indicator). Gerontologist 41(S1), 236 (2001).
42. Ensrud KE, Ewing SK, Taylor BC et al. Comparison of 2 Frailty Indexes for prediction of falls, disability, fractures, and death in older women. Arch. Intern. Med. 168(4), 382-389 (2008).
43. Bandeen-Roche K, Xue Q-L, Ferrucci L et al. Phenotype of frailty: characterization in the women's health and aging studies. J. Gerontol. A Biol. Sci. Med. Sci. 61(3), 262-266 (2006).
44. Rockwood K, Andrew M, Mitnitski A. A comparison of two approaches to measuring frailty in elderly people. J. Gerontol. A Biol. Sci. Med. Sci. 62(7), 738-743 (2007).
45. Au A, Puts MT, Fletcher JD, Sourial N, Bergman H. Frailty markers predicting emergency department visits in a community-dwelling sample of vulnerable seniors in Montreal. Can. J. Aging 30(4), 647-655 (2011).
46. Searle SD, Mitnitski A, Gahbauer EA, Gill TM, Rockwood K. A standard procedure for creating a Frailty Index in a cohort study. BMC Geriatr. 8, 24 (2008).
47. Rockwood K, Mitnitski A. Frailty defined by deficit accumulation and geriatric medicine defined by frailty. Clin. Geriatr. Med. 27(1), 17-26 (2011).
48. Rockwood K, Mitnitski A. Limits to deficit accumulation in elderly people. Mech. Ageing Dev. 127, 494-496 (2006).
49. Song X, Mitnitski A, Rockwood K. Nontraditional risk factors combine to predict Alzheimer disease and dementia. Neurology 77(3), 227-234 (2011).
50. Levers M-J, Estabrooks CA, Ross Kerr JC. Factors contributing to frailty: literature review. J. Adv. Nurs. 56(3), 282-291 (2006).
51. Kulminski AM, Ukraintseva SV, Kulminskaya IV, Arbeev KG, Land K, Yashin AI. Cumulative deficits better characterize susceptibility to death in elderly people than phenotypic frailty: lessons from the Cardiovascular Health Study. J. Am. Geriatr. Soc. 56(5), 898-903 (2008).
52. de Vries NM, Staal JB, van Ravensberg CD, Hobbelen JS, Olde Rikkert MG, Nijhuis-van der Sanden MW. Outcome instruments to measure frailty: a systematic review. Ageing Res. Rev. 10(1), 104-114 (2011).
53. Herrmann FR, Osiek A, Michel J-P, Robine JM. Frailty judgment by hospital team members: degree of agreement and survival prediction. J. Am. Geriatr. Soc. 53(5), 916-917 (2005).
54. Roland K, Theou O, Jakobi J, Swan L, Jones G. Exploring frailty: community physical and occupational therapists' perspectives. Phys. Occup. Ther. Geriatr. 29(4), 270-286 (2011).
55. De Lepeleire J, Degryse J, Illiffe S, Mann E, Buntinx F. Family physicians need easy instruments for frailty. Age Ageing 37(4), 484 (2008).
56. Mitnitski A, Song X, Skoog I et al. Relative fitness and frailty of elderly men and women in developed countries and their relationship with mortality. J. Am. Geriatr. Soc. 53, 2184-2189 (2005).
57. Barreto PD, Greig C, Ferrandez AM. Detecting and categorizing frailty status in older adults using a self-report screening instrument. Arch. Gerontol. Geriatr. 54(3), e249-e254 (2012).
58. Metzelthin SF, Daniëls R, van Rossum E, de Witte L, van den Heuvel WJ, Kempen GI. The psychometric properties of three self-report screening instruments for identifying frail older people in the community. BMC Public Health 10, 176 (2010).
59. Heckman GA. Integrated care for the frail elderly. Healthc. Pap. 11, 62-68 (2011).
60. Ashford JW, Borson S, O'Hara R et al. Should older adults be screened for dementia? It is important to screen for evidence of dementia! Alzheimers Dement. 3(2), 75-80 (2007).
61. Wilson JMG, Junger G. [Principles and practice of screening for disease]. Bol. Oficina Sanit. Panam. 65(4), 281-393 (1968).
62. Fairhall N, Langron C, Sherrington C et al. Treating frailty - a practical guide. BMC Med. 9, 83 (2011).
63. Ko FC. The clinical care of frail, older adults. Clin. Geriatr. Med. 27(1), 89-100 (2011).
64. Dasgupta M, Rolfson DB, Stolee P, Borrie MJ, Speechley M. Frailty is associated with postoperative complications in older adults with medical problems. Arch. Gerontol. Geriatr. 48(1), 78-83 (2009).
65. Lee JS, He K, Harbaugh CM et al. Frailty, core muscle size, and mortality in patients undergoing open abdominal aortic aneurysm repair. J. Vasc. Surg. 53(4), 912-917 (2011).
66. Ekerstad N, Swahn E, Janzon M et al. Frailty is independently associated with short-term outcomes for elderly patients with non-ST-Segment Elevation Myocardial Infarction. Circulation 124(22), 2397-2404 (2011).
67. Schuurmans H, Steverink N, Lindenberg S, Frieswijk N, Slaets JP. Old or frail: what tells us more? J. Gerontol. A Biol. Sci. Med. Sci. 59(9), M962-M965 (2004).
68. Theou O, Jones G, Jakobi J, Mitnitski A, Vandervoort A. A comparison of the relationship of 14 performance-based measures with frailty in older women. Appl. Physiol. Nutr. Metab. 36(6), 928-938 (2011).
69. Robinson TN, Eiseman B, Wallace JI. Redefining geriatric preoperative assessment using frailty, disability and co-morbidity. Ann. Surg. 250(3), 449-455 (2009).
70. Brown NA, Zenilman ME. The impact of frailty in the elderly on the outcome of surgery in the aged. Adv. Surg. 44, 229-249 (2010).
71. Makary MA, Segev DI, Pronovost PJ et al. Frailty as a predictor of surgical outcomes in older patients. J. Am. Coll. Surg. 210, 901-908 (2010).
72. Yourman LC, Lee SJ, Schonberg MA, Widera EW, Smith AK. Prognostic indices for older adults: a systematic review. JAMA 307(2), 182-192 (2012).
73. Afilalo J, Karunananthan S, Eisenberg MJ, Alexander KP, Bergman H. Role of frailty in patients with cardiovascular disease. Am. J. Cardiol. 103, 1616-1621 (2009).
74. Singh M, Alexander K, Roger VL et al. Frailty and its potential relevance to cardiovascular care. Mayo Clin. Proc. 83, 1146-1153 (2008).
75. Hastings SN, Purser JL, Johnson KS, Sloane RJ, Whitson HE. Frailty predicts some but not all adverse outcomes in older adults discharged from the emergency department. J. Am. Geriatr. Soc. 56, 1651-1657 (2008).
76. Robinson TN, Wu DS, Stiegmann GV, Moss M. Frailty predicts increased hospital and six-month healthcare cost following colorectal surgery in older adults. Am. J. Surg. 202(5), 511-514 (2011).
77. Pulignano G, Del Sindaco D, Di Lenarda A. Usefulness of frailty profile for targeting older heart failure patients in disease management programs: a cost-effectiveness, pilot study. J. Cardiovasc. Med. (Hagerstown) 11(10), 739-747 (2010).
78. Braithwaite RS, Fiellin D, Justice AC. The payoff time: a flexible framework to help clinicians decide when patients with comorbid disease are not likely to benefit from practice guidelines. Med. Care 47, 610-617 (2009).
79. Mallery LH, Moorhouse P. Respecting frailty. J. Med. Ethics 37, 126-128 (2011).
80. Boockvar KS, Meier DE. Palliative care for frail older adults. "There are things I can't do anymore that I wish I could". JAMA 296(18), 2245-2253 (2006).
81. Rockwood K, Abeysundera MJ, Mitnitski A. How should we grade frailty in nursing home patients? J. Am. Med. Dir. Assoc. 8(9), 595-603 (2007).
82. Rockwood K, Mitnitski A, Song X, Steen B, Skoog I. Long-term risks of death and institutionalization of elderly people in relation to deficit accumulation at age 70. J. Am. Geriatr. Soc. 54(6), 975-979 (2006).
83. De Lepeleire J, Iliffe S, Mann E, Degryse JM. Frailty: an emerging concept for general practice. Br. J. Gen. Pract. 59, e177-e182 (2009).
84. Gill TM, Gahbauer EA, Allore HG, Han L. Transitions between frailty states among community-living older persons. Arch. Intern. Med. 166(4), 418-423 (2006).
85. Hirdes JP. Addressing the health needs of frail elderly people: Ontario's experience with an integrated health information system. Age Ageing 35, 329-331 (2006).
86. Boult C, Green AF, Boult LB, Pacala JT, Snyder C, Leff B. Successful models of comprehensive care for older adults with chronic conditions: evidence for the Institute of Medicine's "retooling for an aging America" report. J. Am. Geriatr. Soc. 57(12), 2328-2337 (2009).
87. Rubenstein LZ, Stuck AE, Siu AL, Wieland D. Impacts of geriatric evaluation and management programs on defined outcomes: overview of the evidence. J. Am. Geriatr. Soc. 39(9 Pt 2), S8-S16 (1991).
88. Stuck AE, Iliffe S. Comprehensive geriatric assessment for older adults. BMJ 343, d6799 (2011).
89. Aminzadeh F, Dalziel WB, Molnar FJ. Targeting frail older adults for outpatient comprehensive geriatric assessment and management services: an overview of concepts and criteria. Rev. Clin. Gerontol. 12, 82-92 (2002).
90. Ellis G, Whitehead MA, Robinson D, O'Neill D, Langhorne P. Comprehensive geriatric assessment for older adults admitted to hospital: meta-analysis of randomised controlled trials. BMJ 343, d6553 (2011).
91. Lihavainen K, Sipilä S, Rantanen T, Kauppinen M, Sulkava R, Hartikainen S. Effects of comprehensive geriatric assessment and targeted intervention on mobility in persons aged 75 years and over: a randomized controlled trial. Clin. Rehabil. 26(4), 314-326 (2012).
92. Epstein AM, Hall JA, Fretwell M et al. Consultative geriatric assessment for ambulatory patients. A randomized trial in a health maintenance organization. JAMA 263(4), 538-544 (1990).
93. Faber MJ, Bosscher RJ, Chin A Paw MJ, van Wieringen PC. Effects of exercise programs on falls and mobility in frail and pre-frail older adults: a multicenter randomized controlled trial. Arch. Phys. Med. Rehabil. 87(7), 885-896 (2006).
94. Kinney JM. Nutritional frailty, sarcopenia and falls in the elderly. Curr. Opin. Clin. Nutr. Metab. Care 7(1), 15-20 (2004).
95. Markle-Reid M, Browne G, Gafni A. Nurse-led health promotion interventions improve quality of life in frail older home care clients: lessons learned from three randomized trials in Ontario, Canada. J. Eval. Clin. Pract. doi:10.1111/j.1365-2753.2011.01782.x (2012) (Epub ahead of print).
96. Gill TM, Baker DI, Gottschalk M Peduzzi PN, Allore H, Byers A. A program to prevent functional decline in physically frail, elderly persons who live at home. N. Engl. J. Med. 347(14), 1068-1074 (2002).
97. Daniels R, van Rossum E, Metzelthin S et al. A disability prevention programme for community-dwelling frail older persons. Clin. Rehabil. 25(11), 963-974 (2011).
98. Daniels R, van Rossum E, de Witte L, Kempen GI, van den Heuvel W. Interventions to prevent disability in frail community-dwelling elderly: a systematic review. BMC Health Serv. Res. 8, 278 (2008).
99. Chodzko-Zajko WJ, Proctor DN, Fiatarone Singh MA et al. American College of Sports Medicine position stand. Exercise and physical activity for older adults. Med. Sci. Sports Exerc. 41(7), 1510-1530 (2009).
100. Tremblay MS, Warburton DE, Janssen I et al. New Canadian physical activity guidelines. Appl. Physiol. Nutr. Metab. 36(1), 36-46 (2011).
101. Chin A Paw MJ, van Uffelen JG, Riphagen I, van Mechelen W. The functional effects of physical exercise training in frail older people: a systematic review. Sports Med. 38(9), 781-793 (2008).
102. Theou O, Stathokostas L, Roland K et al. The effectiveness of exercise interventions for the management of frailty: a systematic Review. J. Aging Res. 569194 (2011).
103. Clegg A, Barber S, Young J, Forster A, Iliffe S. The Home-based Older People's Exercise (HOPE) trial: study protocol for a randomised controlled trial. Trials 12, 143 (2011).
104. Warburton DE, Nicol C, Bredin SS. Health benefits of physical activity: the evidence. CMAJ 174, 801-809 (2006).
105. Paterson DH, Jones GR, Rice CL. Ageing and physical activity: evidence to develop exercise recommendations for older adults. Can. J. Public Health 98(S2), S69-S108 (2007).
106. Hubbard RE, Fallah N, Searle SD, Mitnitski A, Rockwood K. Impact of exercise in community-dwelling older adults. PloS ONE 4(7), e6174 (2009).