Tumor infiltrating lymphocytes differ in invasive micropapillary carcinoma and medullary carcinoma of breast

Modern Pathology

Volumn 21, Issue 9, 2008, Pages 1101-1107

  Guo, Xiaojing ^a   Fan, Yu ^a   Lang, Ronggang ^a   Gu, Feng ^a   Chen, Ling ^a   Cui, Lifang ^a   Pringle, Gordon A ^b   Zhang, Xinmin ^b   Fu, Li ^a  

^a TIANJIN MEDICAL UNIVERSITY   (China)

^b TEMPLE UNIVERSITY HOSPITAL   (United States)

Author keywords

Breast; Invasive micropapillary carcinoma; Laser scanning confocal microscope; Medullary carcinoma; Tumor infiltrating lymphocytes

Indexed keywords

FAS ANTIGEN; FAS LIGAND; GRANZYME B; PERFORIN;

ADULT; AGED; ANTIGEN EXPRESSION; ARTICLE; BREAST CARCINOMA; CANCER INFILTRATION; CD8+ T LYMPHOCYTE; CLINICAL ARTICLE; COMPARATIVE STUDY; FEMALE; HUMAN; HUMAN TISSUE; IMMUNE RESPONSE; IMMUNOHISTOCHEMISTRY; INVASIVE MICROPAPILLARY CARCINOMA; LYMPH NODE METASTASIS; MEDULLARY CARCINOMA; PAPILLARY CARCINOMA; PRIORITY JOURNAL; PROGNOSIS; PROTEIN EXPRESSION; TUMOR ASSOCIATED LEUKOCYTE;

ADULT; AGED; BREAST NEOPLASMS; CARCINOMA, MEDULLARY; CARCINOMA, PAPILLARY; CD8-POSITIVE T-LYMPHOCYTES; FAS LIGAND PROTEIN; FEMALE; HUMANS; IMMUNOENZYME TECHNIQUES; LYMPH NODES; LYMPHOCYTES, TUMOR-INFILTRATING; MIDDLE AGED; NEOPLASM INVASIVENESS; T-LYMPHOCYTES, CYTOTOXIC; TUMOR MARKERS, BIOLOGICAL;

EID: 50249085361     PISSN: 08933952     EISSN: 15300285     Source Type: Journal    
DOI: 10.1038/modpathol.2008.72     Document Type: Article

References (24)

1. Tsuta K, Ishii G, Kim E, et al. Primary lung adenocarcinoma with massive lymphocyte infiltration. Am J Clin Pathol 2005;123:547-552.
2. Canna K, McArdle PA, McMillan DC, et al. The relationship between tumour T-lymphocyte infiltration, the systemic inflammatory response and survival in patients undergoing curative resection for colorectal cancer. Br J Cancer 2005;92:651-654.
3. Tavassoli FA, Devilee P. WHO Classification of Tumours. Pathology & Genetics, Tumours of the Breast and Female Genital Organs. IARC Press: Lyon, 2003, 28-29.
4. Guo X, Chen L, Lang R, et al. Invasive micropapillary carcinoma of the breast Association of pathologic features with lymph node metastasis. Am J Clin Pathol 2006;126:740-746.
5. Zekioglu O, Erhan Y, Ciris M, et al. Invasive micropapillary carcinoma of the breast: high incidence of lymph node metastasis with extranodal extension and its immunohistochemical profile compared with invasive ductal carcinoma. Histopathology 2004;44:18-23.
6. Vincent-Salomon A, Gruel N, Lucchesi C, et al. Identification of typical medullary breast carcinoma as a genomic sub-group of basal-like carcinomas, a heterogeneous new molecular entity. Breast Cancer Res 2007;9:R24.
7. Rapin V, Contesso G, Mouriesse H, et al. Medullary breast carcinoma. A reevaluation of 95 cases of breast cancer with inflammatory stroma. Cancer 1998;61:2503-2510.
8. Wargotz ES, Silverberg SG. Medullary carcinoma of the breast: a clinicopathologic study with appraisal of current diagnostic criteria. Hum Pathol 1988;19:1340-1346.
9. Ridolfi RL, Rosen PP, Port A, et al. Medullary carcinoma of the breast: a clinicopathologic study with 10-year follow-up. Cancer 1997;40:1365-1385.
10. Coronella JA, Spier C, Welch M, et al. Antigen-driven oligoclonal expansion of tumor-infiltrating B cells in infiltrating ductal carcinoma of the breast. J Immunol 2002;169:1829-1836.
11. Nzula S, Going JJ, Stott DI. Antigen driven clonal proliferation, somatic hypermutation, and selection of B lymphocytes infiltrating human ductal breast carcinomas. Cancer Res 2003;63:3275-3280.
12. Clemente CG, Mihm Jr MC, Bufalino R, et al. Prognostic value of tumor infiltrating lymphocytes in the vertical growth phase of primary cutaneous melanoma. Cancer 1996;77:1303-1310.
13. Gajewski TF. Identifying and overcoming immune resistance mechanisms in the melanoma tumor microenvironment. Clin Cancer Res 2006;12:2326s-2330s.
14. Inokuma M, dela Rosa C, Schmitt C, et al. Functional T cell responses to tumor antigens in breast cancer patients have a distinct phenotype and cytokine signature. J Immunol 2007;179:2627-2633.
15. Leong PP, Mohammad R, Ibrahim N, et al. Phenotyping of lymphocytes expressing regulatory and effector markers in infiltrating ductal carcinoma of the breast. Immunol Lett 2006;102:229-236.
16. Ben-Hur H, Cohen O, Schneider D, et al. The role of lymphocytes and macrophages in human breast tumorigenesis: an immunohistochemical and morphometric study. Anticancer Res 2002;22:1231-1238.
17. Wong PY, Staren ED, Tereshkova N, et al. Functional analysis of tumor-infiltrating leukocytes in breast cancer patients. J Surg Res 1998;76:95-103.
18. Yakirevich E, Izhak OB, Rennert G, et al. Cytotoxic phenotype of tumor infiltrating lymphocytes in medullary carcinoma of the breast. Mod Pathol 1999;12:1050-1056.
19. Tamiolakis D, Simopoulos C, Cheva A, et al. Immunophenotypic profile of tumor infiltrating lymphocytes in medullary carcinoma of the breast. Eur J Gynaecol Oncol 2002;23:433-436.
20. Kuroda H, Tamaru J, Sakamoto G, et al. Immunophenotype of lymphocytic infiltration in medullary carcinoma of the breast. Virchows Arch 2005;446:10-14.
21. Schaider H, Oka M, Bogenrieder T, et al. Differential response of primary and metastatic melanomas to neutrophils attracted by IL-8. Int J Cancer 2003;103:335-343.
22. Shamamian P, Schwartz JD, Pocock BJ, et al. Activation of progelatinase A (MMP-2) by neutrophil elastase, cathepsin G, and proteinase-3: a role for inflammatory cells in tumor invasion and angiogenesis. J Cell Physiol 2001;189:197-206.
23. Scapini P, Nesi L, Morini M, et al. Generation of biologically active angiostatin kringle 1-3 by activated human neutrophils. J Immunol 2002;168:5798-5804.
24. Lin EY, Pollard JW. Role of infiltrated leucocytes in tumour growth and spread. Br J Cancer 2004;90:2053-2058.