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Volumn 15, Issue 4, 2015, Pages S6-S12

The role of fat and alcohol in acute pancreatitis: A dangerous liaison

Author keywords

Acute pancreatitis; Alcohol; Calcium overload; Carboxylester lipase; Fatty acid ethyl esters; Mitochondrial dysfunction

Indexed keywords

FATTY ACID;

EID: 85027921316     PISSN: 14243903     EISSN: 14243911     Source Type: Journal    
DOI: 10.1016/j.pan.2015.02.009     Document Type: Review
Times cited : (33)

References (65)
  • 1
    • 0027162138 scopus 로고
    • Pancreatitis in Finland between 1970 and 1989
    • Jaakkola, M., Nordback, I., Pancreatitis in Finland between 1970 and 1989. Gut 34 (1993), 1255–1260.
    • (1993) Gut , vol.34 , pp. 1255-1260
    • Jaakkola, M.1    Nordback, I.2
  • 3
    • 3042515253 scopus 로고    scopus 로고
    • Hospital admission for acute pancreatitis in an English population, 1963–98: database study of incidence and mortality
    • Goldacre, M.J., Roberts, S.E., Hospital admission for acute pancreatitis in an English population, 1963–98: database study of incidence and mortality. BMJ 328 (2004), 1466–1469.
    • (2004) BMJ , vol.328 , pp. 1466-1469
    • Goldacre, M.J.1    Roberts, S.E.2
  • 4
    • 68649126081 scopus 로고    scopus 로고
    • Alcohol as a risk factor for pancreatitis. A systematic review and meta-analysis
    • Irving, H.M., Samokhvalov, A.V., Rehm, J., Alcohol as a risk factor for pancreatitis. A systematic review and meta-analysis. JOP 10 (2009), 387–392.
    • (2009) JOP , vol.10 , pp. 387-392
    • Irving, H.M.1    Samokhvalov, A.V.2    Rehm, J.3
  • 5
    • 0036285492 scopus 로고    scopus 로고
    • Animal models in alcoholic pancreatitis–what can we learn?
    • Schneider, A., Whitcomb, D.C., Singer, M.V., Animal models in alcoholic pancreatitis–what can we learn?. Pancreatology 2 (2002), 189–203.
    • (2002) Pancreatology , vol.2 , pp. 189-203
    • Schneider, A.1    Whitcomb, D.C.2    Singer, M.V.3
  • 6
    • 84876788888 scopus 로고    scopus 로고
    • Models of acute and chronic pancreatitis
    • Lerch, M.M., Gorelick, F.S., Models of acute and chronic pancreatitis. Gastroenterology 144 (2013), 1180–1193.
    • (2013) Gastroenterology , vol.144 , pp. 1180-1193
    • Lerch, M.M.1    Gorelick, F.S.2
  • 8
    • 0242286159 scopus 로고    scopus 로고
    • The epidemiology of alcohol-induced pancreatitis
    • Dufour, M.C., Adamson, M.D., The epidemiology of alcohol-induced pancreatitis. Pancreas 27 (2003), 286–290.
    • (2003) Pancreas , vol.27 , pp. 286-290
    • Dufour, M.C.1    Adamson, M.D.2
  • 9
    • 0037209124 scopus 로고    scopus 로고
    • Issues in hyperlipidemic pancreatitis
    • Yadav, D., Pitchumoni, C.S., Issues in hyperlipidemic pancreatitis. J Clin Gastroenterol 36 (2003), 54–62.
    • (2003) J Clin Gastroenterol , vol.36 , pp. 54-62
    • Yadav, D.1    Pitchumoni, C.S.2
  • 10
    • 61649111812 scopus 로고    scopus 로고
    • Enhanced susceptibility to pancreatitis in severe hypertriglyceridaemic lipoprotein lipase-deficient mice and agonist-like function of pancreatic lipase in pancreatic cells
    • Wang, Y., Sternfeld, L., Yang, F., Rodriguez, J.A., Ross, C., Hayden, M.R., et al. Enhanced susceptibility to pancreatitis in severe hypertriglyceridaemic lipoprotein lipase-deficient mice and agonist-like function of pancreatic lipase in pancreatic cells. Gut 58 (2009), 422–430.
    • (2009) Gut , vol.58 , pp. 422-430
    • Wang, Y.1    Sternfeld, L.2    Yang, F.3    Rodriguez, J.A.4    Ross, C.5    Hayden, M.R.6
  • 12
    • 0034948044 scopus 로고    scopus 로고
    • Characterization of enzymes involved in formation of ethyl esters of long-chain fatty acids in humans
    • Diczfalusy, M.A., Bjorkhem, I., Einarsson, C., Hillebrant, C.G., Alexson, S.E., Characterization of enzymes involved in formation of ethyl esters of long-chain fatty acids in humans. J Lipid Res 42 (2001), 1025–1032.
    • (2001) J Lipid Res , vol.42 , pp. 1025-1032
    • Diczfalusy, M.A.1    Bjorkhem, I.2    Einarsson, C.3    Hillebrant, C.G.4    Alexson, S.E.5
  • 13
    • 0041477164 scopus 로고    scopus 로고
    • Fatty acid ethyl esters: toxic non-oxidative metabolites of ethanol and markers of ethanol intake
    • Best, C.A., Laposata, M., Fatty acid ethyl esters: toxic non-oxidative metabolites of ethanol and markers of ethanol intake. Front Biosci 8 (2003), e202–e217.
    • (2003) Front Biosci , vol.8 , pp. e202-e217
    • Best, C.A.1    Laposata, M.2
  • 14
    • 0031706126 scopus 로고    scopus 로고
    • Fatty acid ethyl esters: ethanol metabolites which mediate ethanol-induced organ damage and serve as markers of ethanol intake
    • Laposata, M., Fatty acid ethyl esters: ethanol metabolites which mediate ethanol-induced organ damage and serve as markers of ethanol intake. Prog Lipid Res 37 (1998), 307–316.
    • (1998) Prog Lipid Res , vol.37 , pp. 307-316
    • Laposata, M.1
  • 15
    • 0025975873 scopus 로고
    • Cdna cloning of carboxyl ester lipase from human pancreas reveals a unique proline-rich repeat unit
    • Reue, K., Zambaux, J., Wong, H., Lee, G., Leete, T.H., Ronk, M., et al. Cdna cloning of carboxyl ester lipase from human pancreas reveals a unique proline-rich repeat unit. J Lipid Res 32 (1991), 267–276.
    • (1991) J Lipid Res , vol.32 , pp. 267-276
    • Reue, K.1    Zambaux, J.2    Wong, H.3    Lee, G.4    Leete, T.H.5    Ronk, M.6
  • 16
    • 0026660088 scopus 로고
    • Genomic organization, sequence analysis, and chromosomal localization of the human carboxyl ester lipase (cel) gene and a cel-like (cell) gene
    • Lidberg, U., Nilsson, J., Stromberg, K., Stenman, G., Sahlin, P., Enerback, S., et al. Genomic organization, sequence analysis, and chromosomal localization of the human carboxyl ester lipase (cel) gene and a cel-like (cell) gene. Genomics 13 (1992), 630–640.
    • (1992) Genomics , vol.13 , pp. 630-640
    • Lidberg, U.1    Nilsson, J.2    Stromberg, K.3    Stenman, G.4    Sahlin, P.5    Enerback, S.6
  • 17
    • 0034667596 scopus 로고    scopus 로고
    • The tissue-specific regulation of the carboxyl ester lipase gene in exocrine pancreas differs significantly between mouse and human
    • Kannius-Janson, M., Lidberg, U., Bjursell, G., Nilsson, J., The tissue-specific regulation of the carboxyl ester lipase gene in exocrine pancreas differs significantly between mouse and human. Biochem J 351:Pt 2 (2000), 367–376.
    • (2000) Biochem J , vol.351 , pp. 367-376
    • Kannius-Janson, M.1    Lidberg, U.2    Bjursell, G.3    Nilsson, J.4
  • 18
    • 0035968445 scopus 로고    scopus 로고
    • Bile salt-dependent lipase: its pathophysiological implications
    • Lombardo, D., Bile salt-dependent lipase: its pathophysiological implications. Biochim Biophys Acta 1533 (2001), 1–28.
    • (2001) Biochim Biophys Acta , vol.1533 , pp. 1-28
    • Lombardo, D.1
  • 20
    • 37749028739 scopus 로고    scopus 로고
    • Ethanol-induced cytotoxicity in rat pancreatic acinar ar42j cells: role of fatty acid ethyl esters
    • Wu, H., Bhopale, K.K., Ansari, G.A., Kaphalia, B.S., Ethanol-induced cytotoxicity in rat pancreatic acinar ar42j cells: role of fatty acid ethyl esters. Alcohol Alcohol 43 (2008), 1–8.
    • (2008) Alcohol Alcohol , vol.43 , pp. 1-8
    • Wu, H.1    Bhopale, K.K.2    Ansari, G.A.3    Kaphalia, B.S.4
  • 21
    • 0035990311 scopus 로고    scopus 로고
    • Pancreatic cholesterol esterase, es-10, and fatty acid ethyl ester synthase iii gene expression are increased in the pancreas and liver but not in the brain or heart with long-term ethanol feeding in rats
    • Pfutzer, R.H., Tadic, S.D., Li, H.S., Thompson, B.S., Zhang, J.Y., Ford, M.E., et al. Pancreatic cholesterol esterase, es-10, and fatty acid ethyl ester synthase iii gene expression are increased in the pancreas and liver but not in the brain or heart with long-term ethanol feeding in rats. Pancreas 25 (2002), 101–106.
    • (2002) Pancreas , vol.25 , pp. 101-106
    • Pfutzer, R.H.1    Tadic, S.D.2    Li, H.S.3    Thompson, B.S.4    Zhang, J.Y.5    Ford, M.E.6
  • 22
    • 0030052919 scopus 로고    scopus 로고
    • Fatty acid ethyl ester synthase, an enzyme for nonoxidative ethanol metabolism, is present in serum after liver and pancreatic injury
    • Aleryani, S., Kabakibi, A., Cluette-Brown, J., Laposata, M., Fatty acid ethyl ester synthase, an enzyme for nonoxidative ethanol metabolism, is present in serum after liver and pancreatic injury. Clin Chem 42 (1996), 24–27.
    • (1996) Clin Chem , vol.42 , pp. 24-27
    • Aleryani, S.1    Kabakibi, A.2    Cluette-Brown, J.3    Laposata, M.4
  • 23
    • 0025909738 scopus 로고
    • Carboxylic ester hydrolase. A sensitive serum marker and indicator of severity of acute pancreatitis
    • Blind, P.J., Buchler, M., Blackberg, L., Andersson, Y., Uhl, W., Beger, H.G., et al. Carboxylic ester hydrolase. A sensitive serum marker and indicator of severity of acute pancreatitis. Int J Pancreatol 8 (1991), 65–73.
    • (1991) Int J Pancreatol , vol.8 , pp. 65-73
    • Blind, P.J.1    Buchler, M.2    Blackberg, L.3    Andersson, Y.4    Uhl, W.5    Beger, H.G.6
  • 24
    • 0024342527 scopus 로고
    • Carboxyl ester lipase in human tissues and in acute pancreatitis
    • Aho, H.J., Sternby, B., Kallajoki, M., Nevalainen, T.J., Carboxyl ester lipase in human tissues and in acute pancreatitis. Int J Pancreatol 5 (1989), 123–134.
    • (1989) Int J Pancreatol , vol.5 , pp. 123-134
    • Aho, H.J.1    Sternby, B.2    Kallajoki, M.3    Nevalainen, T.J.4
  • 25
    • 0022634648 scopus 로고
    • Presence of nonoxidative ethanol metabolism in human organs commonly damaged by ethanol abuse
    • Laposata, E.A., Lange, L.G., Presence of nonoxidative ethanol metabolism in human organs commonly damaged by ethanol abuse. Science 231 (1986), 497–499.
    • (1986) Science , vol.231 , pp. 497-499
    • Laposata, E.A.1    Lange, L.G.2
  • 28
    • 33745133374 scopus 로고    scopus 로고
    • Increased plasma fatty acid ethyl ester levels following inhibition of oxidative metabolism of ethanol by 4-methylpyrazole treatment in human subjects
    • Best, C.A., Sarkola, T., Eriksson, C.J., Cluette-Brown, J.E., Laposata, M., Increased plasma fatty acid ethyl ester levels following inhibition of oxidative metabolism of ethanol by 4-methylpyrazole treatment in human subjects. Alcohol Clin Exp Res 30 (2006), 1126–1131.
    • (2006) Alcohol Clin Exp Res , vol.30 , pp. 1126-1131
    • Best, C.A.1    Sarkola, T.2    Eriksson, C.J.3    Cluette-Brown, J.E.4    Laposata, M.5
  • 31
    • 0020700623 scopus 로고
    • Protein content of precipitates present in pancreatic juice of alcoholic subjects and patients with chronic calcifying pancreatitis
    • Guy, O., Robles-Diaz, G., Adrich, Z., Sahel, J., Sarles, H., Protein content of precipitates present in pancreatic juice of alcoholic subjects and patients with chronic calcifying pancreatitis. Gastroenterology 84 (1983), 102–107.
    • (1983) Gastroenterology , vol.84 , pp. 102-107
    • Guy, O.1    Robles-Diaz, G.2    Adrich, Z.3    Sahel, J.4    Sarles, H.5
  • 32
    • 0029902753 scopus 로고    scopus 로고
    • Acute ethanol administration induces oxidative changes in rat pancreatic tissue
    • Altomare, E., Grattagliano, I., Vendemiale, G., Palmieri, V., Palasciano, G., Acute ethanol administration induces oxidative changes in rat pancreatic tissue. Gut 38 (1996), 742–746.
    • (1996) Gut , vol.38 , pp. 742-746
    • Altomare, E.1    Grattagliano, I.2    Vendemiale, G.3    Palmieri, V.4    Palasciano, G.5
  • 33
    • 0021815912 scopus 로고
    • The pathogenesis of acute pancreatitis. The source and role of oxygen-derived free radicals in three different experimental models
    • Sanfey, H., Bulkley, G.B., Cameron, J.L., The pathogenesis of acute pancreatitis. The source and role of oxygen-derived free radicals in three different experimental models. Ann Surg 201 (1985), 633–639.
    • (1985) Ann Surg , vol.201 , pp. 633-639
    • Sanfey, H.1    Bulkley, G.B.2    Cameron, J.L.3
  • 34
    • 0030040178 scopus 로고    scopus 로고
    • Effect of ethanol on cholecystokinin-stimulated zymogen conversion in pancreatic acinar cells
    • Katz, M., Carangelo, R., Miller, L.J., Gorelick, F., Effect of ethanol on cholecystokinin-stimulated zymogen conversion in pancreatic acinar cells. Am J Physiol 270 (1996), G171–G175.
    • (1996) Am J Physiol , vol.270 , pp. G171-G175
    • Katz, M.1    Carangelo, R.2    Miller, L.J.3    Gorelick, F.4
  • 35
    • 84881491755 scopus 로고    scopus 로고
    • Effects of oxidative alcohol metabolism on the mitochondrial permeability transition pore and necrosis in a mouse model of alcoholic pancreatitis
    • 437–446 e436
    • Shalbueva, N., Mareninova, O.A., Gerloff, A., Yuan, J., Waldron, R.T., Pandol, S.J., et al. Effects of oxidative alcohol metabolism on the mitochondrial permeability transition pore and necrosis in a mouse model of alcoholic pancreatitis. Gastroenterology, 144, 2013 437–446 e436.
    • (2013) Gastroenterology , vol.144
    • Shalbueva, N.1    Mareninova, O.A.2    Gerloff, A.3    Yuan, J.4    Waldron, R.T.5    Pandol, S.J.6
  • 38
    • 0034700135 scopus 로고    scopus 로고
    • Calcium-dependent enzyme activation and vacuole formation in the apical granular region of pancreatic acinar cells
    • Raraty, M., Ward, J., Erdemli, G., Vaillant, C., Neoptolemos, J.P., Sutton, R., et al. Calcium-dependent enzyme activation and vacuole formation in the apical granular region of pancreatic acinar cells. Proc Natl Acad Sci USA 97 (2000), 13126–13131.
    • (2000) Proc Natl Acad Sci USA , vol.97 , pp. 13126-13131
    • Raraty, M.1    Ward, J.2    Erdemli, G.3    Vaillant, C.4    Neoptolemos, J.P.5    Sutton, R.6
  • 39
    • 0033887738 scopus 로고    scopus 로고
    • The role of intracellular calcium signaling in premature protease activation and the onset of pancreatitis
    • Kruger, B., Albrecht, E., Lerch, M.M., The role of intracellular calcium signaling in premature protease activation and the onset of pancreatitis. Am J Pathol 157 (2000), 43–50.
    • (2000) Am J Pathol , vol.157 , pp. 43-50
    • Kruger, B.1    Albrecht, E.2    Lerch, M.M.3
  • 41
    • 0036554826 scopus 로고    scopus 로고
    • Bile acids induce calcium signals in mouse pancreatic acinar cells: implications for bile-induced pancreatic pathology
    • Voronina, S., Longbottom, R., Sutton, R., Petersen, O.H., Tepikin, A., Bile acids induce calcium signals in mouse pancreatic acinar cells: implications for bile-induced pancreatic pathology. J Physiol 540 (2002), 49–55.
    • (2002) J Physiol , vol.540 , pp. 49-55
    • Voronina, S.1    Longbottom, R.2    Sutton, R.3    Petersen, O.H.4    Tepikin, A.5
  • 42
    • 33644872533 scopus 로고    scopus 로고
    • Fatty acid ethyl esters cause pancreatic calcium toxicity via inositol trisphosphate receptors and loss of atp synthesis
    • Criddle, D.N., Murphy, J., Fistetto, G., Barrow, S., Tepikin, A.V., Neoptolemos, J.P., et al. Fatty acid ethyl esters cause pancreatic calcium toxicity via inositol trisphosphate receptors and loss of atp synthesis. Gastroenterology 130 (2006), 781–793.
    • (2006) Gastroenterology , vol.130 , pp. 781-793
    • Criddle, D.N.1    Murphy, J.2    Fistetto, G.3    Barrow, S.4    Tepikin, A.V.5    Neoptolemos, J.P.6
  • 44
    • 0027278594 scopus 로고
    • Fatty acid ethyl esters increase rat pancreatic lysosomal fragility
    • Haber, P.S., Wilson, J.S., Apte, M.V., Pirola, R.C., Fatty acid ethyl esters increase rat pancreatic lysosomal fragility. J Lab Clin Med 121 (1993), 759–764.
    • (1993) J Lab Clin Med , vol.121 , pp. 759-764
    • Haber, P.S.1    Wilson, J.S.2    Apte, M.V.3    Pirola, R.C.4
  • 45
    • 0026343189 scopus 로고
    • The role of acetaldehyde in the pathogenesis of acute alcoholic pancreatitis
    • Nordback, I.H., MacGowan, S., Potter, J.J., Cameron, J.L., The role of acetaldehyde in the pathogenesis of acute alcoholic pancreatitis. Ann Surg 214 (1991), 671–678.
    • (1991) Ann Surg , vol.214 , pp. 671-678
    • Nordback, I.H.1    MacGowan, S.2    Potter, J.J.3    Cameron, J.L.4
  • 47
    • 33845992232 scopus 로고    scopus 로고
    • Menadione-induced reactive oxygen species generation via redox cycling promotes apoptosis of murine pancreatic acinar cells
    • Criddle, D.N., Gillies, S., Baumgartner-Wilson, H.K., Jaffar, M., Chinje, E.C., Passmore, S., et al. Menadione-induced reactive oxygen species generation via redox cycling promotes apoptosis of murine pancreatic acinar cells. J Biol Chem 281 (2006), 40485–40492.
    • (2006) J Biol Chem , vol.281 , pp. 40485-40492
    • Criddle, D.N.1    Gillies, S.2    Baumgartner-Wilson, H.K.3    Jaffar, M.4    Chinje, E.C.5    Passmore, S.6
  • 48
    • 79958157501 scopus 로고    scopus 로고
    • Reactive oxygen species induced by bile acid induce apoptosis and protect against necrosis in pancreatic acinar cells
    • Booth, D.M., Murphy, J.A., Mukherjee, R., Awais, M., Neoptolemos, J.P., Gerasimenko, O.V., et al. Reactive oxygen species induced by bile acid induce apoptosis and protect against necrosis in pancreatic acinar cells. Gastroenterology 140 (2011), 2116–2125.
    • (2011) Gastroenterology , vol.140 , pp. 2116-2125
    • Booth, D.M.1    Murphy, J.A.2    Mukherjee, R.3    Awais, M.4    Neoptolemos, J.P.5    Gerasimenko, O.V.6
  • 49
    • 0036142305 scopus 로고    scopus 로고
    • Ethanol metabolism and transcription factor activation in pancreatic acinar cells in rats
    • Gukovskaya, A.S., Mouria, M., Gukovsky, I., Reyes, C.N., Kasho, V.N., Faller, L.D., et al. Ethanol metabolism and transcription factor activation in pancreatic acinar cells in rats. Gastroenterology 122 (2002), 106–118.
    • (2002) Gastroenterology , vol.122 , pp. 106-118
    • Gukovskaya, A.S.1    Mouria, M.2    Gukovsky, I.3    Reyes, C.N.4    Kasho, V.N.5    Faller, L.D.6
  • 50
    • 0032808415 scopus 로고    scopus 로고
    • Acetaldehyde prevents nuclear factor-kappa b activation and hepatic inflammation in ethanol-fed rats
    • Lindros, K.O., Jokelainen, K., Nanji, A.A., Acetaldehyde prevents nuclear factor-kappa b activation and hepatic inflammation in ethanol-fed rats. Lab Invest 79 (1999), 799–806.
    • (1999) Lab Invest , vol.79 , pp. 799-806
    • Lindros, K.O.1    Jokelainen, K.2    Nanji, A.A.3
  • 52
    • 80054044447 scopus 로고    scopus 로고
    • Calcium and reactive oxygen species in acute pancreatitis: friend or foe?
    • Booth, D.M., Mukherjee, R., Sutton, R., Criddle, D.N., Calcium and reactive oxygen species in acute pancreatitis: friend or foe?. Antioxid Redox Signal 15 (2011), 2683–2698.
    • (2011) Antioxid Redox Signal , vol.15 , pp. 2683-2698
    • Booth, D.M.1    Mukherjee, R.2    Sutton, R.3    Criddle, D.N.4
  • 53
    • 79958136757 scopus 로고    scopus 로고
    • Organellar dysfunction in the pathogenesis of pancreatitis
    • Gukovsky, I., Pandol, S.J., Gukovskaya, A.S., Organellar dysfunction in the pathogenesis of pancreatitis. Antioxid Redox Signal 15 (2011), 2699–2710.
    • (2011) Antioxid Redox Signal , vol.15 , pp. 2699-2710
    • Gukovsky, I.1    Pandol, S.J.2    Gukovskaya, A.S.3
  • 55
    • 80455129106 scopus 로고    scopus 로고
    • Lipotoxicity causes multisystem organ failure and exacerbates acute pancreatitis in obesity
    • 107ra110
    • Navina, S., Acharya, C., DeLany, J.P., Orlichenko, L.S., Baty, C.J., Shiva, S.S., et al. Lipotoxicity causes multisystem organ failure and exacerbates acute pancreatitis in obesity. Sci Transl Med, 3, 2011 107ra110.
    • (2011) Sci Transl Med , vol.3
    • Navina, S.1    Acharya, C.2    DeLany, J.P.3    Orlichenko, L.S.4    Baty, C.J.5    Shiva, S.S.6
  • 56
    • 0020573718 scopus 로고
    • Mitochondrial dysfunction induced by fatty acid ethyl esters, myocardial metabolites of ethanol
    • Lange, L.G., Sobel, B.E., Mitochondrial dysfunction induced by fatty acid ethyl esters, myocardial metabolites of ethanol. J Clin Invest 72 (1983), 724–731.
    • (1983) J Clin Invest , vol.72 , pp. 724-731
    • Lange, L.G.1    Sobel, B.E.2
  • 57
    • 0028268118 scopus 로고
    • Fatty acid binding site of the mitochondrial uncoupling protein. Demonstration of its existence by epr spectroscopy of 5-doxyl-stearic acid
    • Jezek, P., Freisleben, H.J., Fatty acid binding site of the mitochondrial uncoupling protein. Demonstration of its existence by epr spectroscopy of 5-doxyl-stearic acid. FEBS Lett 343 (1994), 22–26.
    • (1994) FEBS Lett , vol.343 , pp. 22-26
    • Jezek, P.1    Freisleben, H.J.2
  • 59
    • 84872202281 scopus 로고    scopus 로고
    • Central role of mitochondrial injury in the pathogenesis of acute pancreatitis
    • Maleth, J., Rakonczay, Z. Jr., Venglovecz, V., Dolman, N.J., Hegyi, P., Central role of mitochondrial injury in the pathogenesis of acute pancreatitis. Acta Physiol Oxf 207 (2013), 226–235.
    • (2013) Acta Physiol Oxf , vol.207 , pp. 226-235
    • Maleth, J.1    Rakonczay, Z.2    Venglovecz, V.3    Dolman, N.J.4    Hegyi, P.5
  • 60
    • 84896738968 scopus 로고    scopus 로고
    • Ethanol and its non-oxidative metabolites profoundly inhibit cftr function in pancreatic epithelial cells which is prevented by atp supplementation
    • Judak, L., Hegyi, P., Rakonczay, Z. Jr., Maleth, J., Gray, M.A., Venglovecz, V., Ethanol and its non-oxidative metabolites profoundly inhibit cftr function in pancreatic epithelial cells which is prevented by atp supplementation. Pflugers Arch 466 (2014), 549–562.
    • (2014) Pflugers Arch , vol.466 , pp. 549-562
    • Judak, L.1    Hegyi, P.2    Rakonczay, Z.3    Maleth, J.4    Gray, M.A.5    Venglovecz, V.6
  • 62
    • 85090962208 scopus 로고    scopus 로고
    • Tro40303 reduces mitochondrial injury in response to fatty acid ethyl esters and ameliorates alcoholic pancreatitis
    • 1370–1370
    • Javed, M.A., Wen, L., Awais, M., Bordet, T., Michaud, M., Schaller, S., et al. Tro40303 reduces mitochondrial injury in response to fatty acid ethyl esters and ameliorates alcoholic pancreatitis. Pancreas, 43, 2014 1370–1370.
    • (2014) Pancreas , vol.43
    • Javed, M.A.1    Wen, L.2    Awais, M.3    Bordet, T.4    Michaud, M.5    Schaller, S.6
  • 63
    • 85090970493 scopus 로고    scopus 로고
    • Alisporivir (deb025) prevents necrosis in and decreases the severity of experimental pancreatitis
    • 1335–1335
    • Mukherjee, R., Huang, W., Tepikin, A.V., Gukovskaya, A., Criddle, D.N., Sutton, R., Alisporivir (deb025) prevents necrosis in and decreases the severity of experimental pancreatitis. Pancreas, 39, 2010 1335–1335.
    • (2010) Pancreas , vol.39
    • Mukherjee, R.1    Huang, W.2    Tepikin, A.V.3    Gukovskaya, A.4    Criddle, D.N.5    Sutton, R.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.