Gray and White Matter Abnormalities in Treated Human Immunodeficiency Virus Disease and Their Relationship to Cognitive Function

Clinical Infectious Diseases

Volumn 65, Issue 3, 2017, Pages 422-432

  Underwood, Jonathan ^a,f   Cole, James H ^a   Caan, Matthan ^b   De Francesco, Davide ^c   Leech, Robert ^a   Van Zoest, Rosan A ^b   Su, Tanja ^b   Geurtsen, Gert J ^b   Schmand, Ben A ^b   Portegies, Peter ^b   Prins, Maria ^d   Wit, Ferdinand W N M ^b,e   Sabin, Caroline A ^c   Majoie, Charles ^b   Reiss, Peter ^b,e   Winston, Alan ^a   Sharp, David J ^a  

^a IMPERIAL COLLEGE LONDON   (United Kingdom)

^b ACADEMIC MEDICAL CENTER   (Netherlands)

^c UNIVERSITY COLLEGE LONDON   (United Kingdom)

^d DEPARTMENT OF INFECTIOUS DISEASES   (Netherlands)

^e STICHTING HIV MONITORING   (Netherlands)

^f ST MARY S HOSPITAL   (United Kingdom)

Author keywords

cognitive impairment; diffusion tensor imaging; HIV; neuroimaging; voxel based morphometry

Indexed keywords

ADULT; ARTICLE; BRAIN SIZE; COGNITION ASSESSMENT; COGNITIVE DEFECT; CONTROLLED STUDY; DIFFUSION TENSOR IMAGING; FEMALE; FRACTIONAL ANISOTROPY; GRAY MATTER; HUMAN; HUMAN IMMUNODEFICIENCY VIRUS INFECTED PATIENT; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; IMAGE PROCESSING; MAJOR CLINICAL STUDY; MALE; NEUROIMAGING; NEUROPSYCHOLOGICAL TEST; PRIORITY JOURNAL; UNSUPERVISED MACHINE LEARNING; VOXEL BASED MORPHOMETRY; WHITE MATTER; COMPLICATION; DIAGNOSTIC IMAGING; DIFFUSION WEIGHTED IMAGING; MIDDLE AGED; PATHOLOGY;

COGNITIVE DYSFUNCTION; DIFFUSION MAGNETIC RESONANCE IMAGING; FEMALE; GRAY MATTER; HIV INFECTIONS; HUMANS; MALE; MIDDLE AGED; WHITE MATTER;

EID: 85027894596     PISSN: 10584838     EISSN: 15376591     Source Type: Journal    
DOI: 10.1093/cid/cix301     Document Type: Article

References (41)

1. May MT, Gompels M, Delpech V, et al; UK Collaborative HIV Cohort (UK CHIC) Study. Impact on life expectancy of HIV-1 positive individuals of CD4+ cell count and viral load response to antiretroviral therapy. AIDS 2014; 28:1193-202.
2. Schouten J, Wit FW, Stolte IG, et al; AGEhIV Cohort Study Group. Cross-sectional comparison of the prevalence of age-associated comorbidities and their risk factors between HIV-infected and uninfected individuals: the AGEhIV cohort study. Clin Infect Dis 2014; 59:1787-97.
3. Lescure FX, Omland LH, Engsig FN, et al. Incidence and impact on mortality of severe neurocognitive disorders in persons with and without HIV infection: a Danish nationwide cohort study. Clin Infect Dis 2011; 52:235-43.
4. Hinkin CH, Castellon SA, Durvasula RS, et al. Medication adherence among HIV+ adults: effects of cognitive dysfunction and regimen complexity. Neurology 2002; 59:1944-50.
5. Heaton RK, Franklin DR, Ellis RJ, et al; CHARTER Group; HNRC Group. HIVassociated neurocognitive disorders before and during the era of combination antiretroviral therapy: differences in rates, nature, and predictors. J Neurovirol 2011; 17:3-16.
6. Robertson KR, Smurzynski M, Parsons TD, et al. The prevalence and incidence of neurocognitive impairment in the HAART era. AIDS 2007; 21:1915-21.
7. Public Health England. HIV in the United Kingdom: 2014 report. UK: Public Health England, 2014. Available at https://www.gov.uk/government/uploads/system/uploads/attachment-data/file/401662/2014-PHE-HIV-annual-report-draft-Final-07-01-2015.pdf.
8. Becker JT, Maruca V, Kingsley LA, et al. Factors affecting brain structure in men with HIV disease in the post-HAART era. Neuroradiology 2012; 54:113-21.
9. Towgood KJ, Pitkanen M, Kulasegaram R, et al. Mapping the brain in younger and older asymptomatic HIV-1 men: frontal volume changes in the absence of other cortical or diffusion tensor abnormalities. Cortex 2012; 48:230-41.
10. Chiang MC, Dutton RA, Hayashi KM, et al. 3D pattern of brain atrophy in HIV/AIDS visualized using tensor-based morphometry. Neuroimage 2007; 34:44-60.
11. Thompson PM, Dutton RA, Hayashi KM, et al. Thinning of the cerebral cortex visualized in HIV/AIDS reflects CD4+ T lymphocyte decline. Proc Natl Acad Sci U S A 2005; 102:15647-52.
12. Küper M, Rabe K, Esser S, et al. Structural gray and white matter changes in patients with HIV. J Neurol 2011; 258:1066-75.
13. Ances BM, Ortega M, Vaida F, Heaps J, Paul R. Independent effects of HIV, aging, and HAART on brain volumetric measures. J Acquir Immune Defic Syndr 2012; 59:469-77.
14. Corrêa DG, Zimmermann N, Doring TM, et al. Diffusion tensor MR imaging of white matter integrity in HIV-positive patients with planning deficit. Neuroradiology 2015; 57:475-82.
15. Leite SC, Corrêa DG, Doring TM, et al. Diffusion tensor MRI evaluation of the corona radiata, cingulate gyri, and corpus callosum in HIV patients. J Magn Reson Imaging 2013; 38:1488-93.
16. Nir TM, Jahanshad N, Busovaca E, et al. Mapping white matter integrity in elderly people with HIV. Hum Brain Mapp 2014; 35:975-92.
17. Stebbins GT, Smith CA, Bartt RE, et al. HIV-associated alterations in normal-appearing white matter. J Acquir Immune Defic Syndr 2007; 46:564-73.
18. Stubbe-Drger B, Deppe M, Mohammadi S, et al. Early microstructural white matter changes in patients with HIV: a diffusion tensor imaging study. BMC Neurol 2012; 12:23.
19. Su T, Caan MWA, Wit FWNM, et al; AGEhIV Cohort Study. White matter structure alterations in HIV-1-infected men with sustained suppression of viraemia on treatment. AIDS 2015; 30:311-22.
20. Jernigan TL, Archibald SL, Fennema-Notestine C, et al; CHARTER Group. Clinical factors related to brain structure in HIV: the CHARTER study. J Neurovirol 2011; 17:248-57.
21. Brew BJ. Evidence for a change in AIDS dementia complex in the era of highly active antiretroviral therapy and the possibility of new forms of AIDS dementia complex. AIDS 2004; 18:75.
22. Antinori A, Arendt G, Becker JT, et al. Updated research nosology for HIVassociated neurocognitive disorders. Neurology 2007; 69:1789-99.
23. Carey CL, Woods SP, Gonzalez R, et al; HNRC Group. Predictive validity of global deficit scores in detecting neuropsychological impairment in HIV infection. J Clin Exp Neuropsychol 2004; 26:307-19.
24. Huizenga HM, Smeding H, Grasman RP, Schmand B. Multivariate normative comparisons. Neuropsychologia 2007; 45:2534-42.
25. Ashburner J. A fast diffeomorphic image registration algorithm. NeuroImage 2007; 38:95-113.
26. Wang Y, Gupta A, Liu Z, et al. DTI registration in atlas based fiber analysis of infantile Krabbe disease. Neuroimage 2011; 55:1577-86.
27. Smith SM, Jenkinson M, Johansen-Berg H, et al. Tract-based spatial statistics: voxelwise analysis of multi-subject diffusion data. Neuroimage 2006; 31:1487-505.
28. Winkler AM, Ridgway GR, Webster MA, Smith SM, Nichols TE. Permutation inference for the general linear model. Neuroimage 2014; 92:381-97.
29. Smith SM, Nichols TE. Threshold-free cluster enhancement: addressing problems of smoothing, threshold dependence and localisation in cluster inference. Neuroimage 2009; 44:83-98.
30. Hennig C. Cluster-wise assessment of cluster stability. Comput Stat Data An 2007; 52:258-71.
31. Heaton RK, Clifford DB, Franklin DR Jr, et al; CHARTER Group. HIV-associated neurocognitive disorders persist in the era of potent antiretroviral therapy: CHARTER Study. Neurology 2010; 75:2087-96.
32. McDonnell J, Haddow L, Daskalopoulou M, et al; Cognitive Impairment in People With HIV in the European Region (CIPHER) Study Group. Minimal cognitive impairment in UK HIV-positive men who have sex with men: effect of case definitions and comparison with the general population and HIV-negative men. J Acquir Immune Defic Syndr 2014; 67:120-7.
33. Su T, Schouten J, Geurtsen GJ, et al; AGEhIV Cohort Study Group. Multivariate normative comparison, a novel method for more reliably detecting cognitive impairment in HIV infection. AIDS 2015; 29:547-57.
34. Everall IP, Luthert PJ, Lantos PL. Neuronal number and volume alterations in the neocortex of HIV infected individuals. J Neurol Neurosurg Psychiatry 1993; 56:481-6.
35. Song SK, Sun SW, Ju WK, Lin SJ, Cross AH, Neufeld AH. Diffusion tensor imaging detects and differentiates axon and myelin degeneration in mouse optic nerve after retinal ischemia. Neuroimage 2003; 20:1714-22.
36. Gray F, Lescs MC, Keohane C, et al. Early brain changes in HIV infection: neuropathological study of 11 HIV seropositive, non-AIDS cases. J Neuropathol Exp Neurol 1992; 51:177-85.
37. Brew BJ. Has HIV-associated neurocognitive disorders now transformed into vascular cognitive impairment? AIDS 2016; 30:2379-80.
38. Medina D, DeToledo-Morrell L, Urresta F, et al. White matter changes in mild cognitive impairment and AD: a diffusion tensor imaging study. Neurobiol Aging 2006; 27:663-72.
39. Mussini C, Lorenzini P, Cozzi-Lepri A, et al; Icona Foundation Study Group. CD4/CD8 ratio normalisation and non-AIDS-related events in individuals with HIV who achieve viral load suppression with antiretroviral therapy: an observational cohort study. Lancet HIV 2015; 2:e98-106.
40. Serrano-Villar S, Sainz T, Lee SA, et al. HIV-infected individuals with low CD4/CD8 ratio despite effective antiretroviral therapy exhibit altered T cell subsets, heightened CD8+ T cell activation, and increased risk of non-AIDS morbidity and mortality. PLoS Pathog 2014; 10:e1004078.
41. Granziera C, Daducci A, Simioni S, et al. Micro-structural brain alterations in aviremic HIV+ patients with minor neurocognitive disorders: a multi-contrast study at high field. PLoS One 2013; 8:e72547.