CD44 Interacts with HIF-2α to Modulate the Hypoxic Phenotype of Perinecrotic and Perivascular Glioma Cells

Cell Reports

Volumn 20, Issue 7, 2017, Pages 1641-1653

  Johansson, Elinn ^a   Grassi, Elisa S ^a   Pantazopoulou, Vasiliki ^a   Tong, Bei ^a   Lindgren, David ^a   Berg, Tracy J ^a   Pietras, Elin J ^b   Axelson, Håkan ^a   Pietras, Alexander ^a  

^a LUND UNIVERSITY   (Sweden)

^b UNIVERSITY OF COPENHAGEN   (Denmark)

Author keywords

CD44; glioma; HIF 1 ; HIF 2 ; hypoxia; hypoxic niche; perivascular niche; stem cell niche; stemness

Indexed keywords

HERMES ANTIGEN; HYPOXIA INDUCIBLE FACTOR 1ALPHA; BASIC HELIX LOOP HELIX TRANSCRIPTION FACTOR; CD44 PROTEIN, MOUSE; ENDOTHELIAL PAS DOMAIN-CONTAINING PROTEIN 1; HIF1A PROTEIN, MOUSE; HYALURONIC ACID BINDING PROTEIN; PROTEIN BINDING; SMALL INTERFERING RNA;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BRAIN OXYGEN TENSION; CELL HYPOXIA; CONTROLLED STUDY; DOWN REGULATION; GENE ACTIVATION; GENE EXPRESSION REGULATION; GLIOMA CELL; HUMAN; HUMAN CELL; INTRACELLULAR MEMBRANE; MOUSE; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL; PROTEIN CLEAVAGE; PROTEIN FUNCTION; PROTEIN PROTEIN INTERACTION; PROTEIN SECRETION; PROTEIN STABILITY; PROTEIN TARGETING; SIGNAL TRANSDUCTION; ANIMAL; ANTAGONISTS AND INHIBITORS; BRAIN TUMOR; CANCER STEM CELL; CANCER TRANSPLANTATION; GENETICS; GLIOMA; HYPOXIA; KNOCKOUT MOUSE; METABOLISM; PATHOLOGY; PROTEIN DEGRADATION; STEM CELL NICHE; TUMOR CELL LINE;

ANIMALS; BASIC HELIX-LOOP-HELIX TRANSCRIPTION FACTORS; BRAIN NEOPLASMS; CELL HYPOXIA; CELL LINE, TUMOR; GENE EXPRESSION REGULATION, NEOPLASTIC; GLIOMA; HUMANS; HYALURONAN RECEPTORS; HYPOXIA; HYPOXIA-INDUCIBLE FACTOR 1, ALPHA SUBUNIT; MICE; MICE, KNOCKOUT; NEOPLASM TRANSPLANTATION; NEOPLASTIC STEM CELLS; PHENOTYPE; PROTEIN BINDING; PROTEOLYSIS; RNA, SMALL INTERFERING; SIGNAL TRANSDUCTION; STEM CELL NICHE;

EID: 85027866438     PISSN: None     EISSN: 22111247     Source Type: Journal    
DOI: 10.1016/j.celrep.2017.07.049     Document Type: Article

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