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Volumn 10, Issue 1-3, 2017, Pages 57-68

Expression Profiling of the MAP Kinase Phosphatase Family Reveals a Role for DUSP1 in the Glioblastoma Stem Cell Niche

Author keywords

Camptothecin; Dexamethasone; DUSP1; Glioblastoma multiforme; Hypoxia; Mitogen activated protein kinases; Temozolomide; Tumor stem cell

Indexed keywords


EID: 85027717103     PISSN: 18752292     EISSN: 18752284     Source Type: Journal    
DOI: 10.1007/s12307-017-0197-6     Document Type: Article
Times cited : (19)

References (43)
  • 1
    • 33746696738 scopus 로고    scopus 로고
    • 'Pseudopalisading' necrosis in glioblastoma: a familiar morphologic feature that links vascular pathology, hypoxia, and angiogenesis
    • PID: 16783163
    • Rong Y et al (2006) 'Pseudopalisading' necrosis in glioblastoma: a familiar morphologic feature that links vascular pathology, hypoxia, and angiogenesis. J Neuropathol Exp Neurol 65(6):529–539
    • (2006) J Neuropathol Exp Neurol , vol.65 , Issue.6 , pp. 529-539
    • Rong, Y.1
  • 2
    • 81455142965 scopus 로고    scopus 로고
    • The three-layer concentric model of glioblastoma: cancer stem cells, microenvironmental regulation, and therapeutic implications
    • Persano L et al (2011) The three-layer concentric model of glioblastoma: cancer stem cells, microenvironmental regulation, and therapeutic implications. Sci World J 11:1829–1841
    • (2011) Sci World J , vol.11 , pp. 1829-1841
    • Persano, L.1
  • 3
    • 84905917573 scopus 로고    scopus 로고
    • GBM's multifaceted landscape: highlighting regional and microenvironmental heterogeneity
    • PID: 24642524
    • Vartanian A et al (2014) GBM's multifaceted landscape: highlighting regional and microenvironmental heterogeneity. Neuro-Oncology 16(9):1167–1175
    • (2014) Neuro-Oncology , vol.16 , Issue.9 , pp. 1167-1175
    • Vartanian, A.1
  • 4
    • 65749106405 scopus 로고    scopus 로고
    • Hypoxia-inducible factors regulate tumorigenic capacity of glioma stem cells
    • COI: 1:CAS:528:DC%2BD1MXntlegtbo%3D, PID: 19477429
    • Li Z et al (2009) Hypoxia-inducible factors regulate tumorigenic capacity of glioma stem cells. Cancer Cell 15(6):501–513
    • (2009) Cancer Cell , vol.15 , Issue.6 , pp. 501-513
    • Li, Z.1
  • 5
    • 65749106405 scopus 로고    scopus 로고
    • Hypoxia-inducible factors regulate tumorigenic capacity of glioma stem cells
    • In: p
    • Li Z et al. (2009) Hypoxia-inducible factors regulate tumorigenic capacity of glioma stem cells. In: Cancer Cell. Elsevier Ltd. p 501–513
    • (2009) Cancer Cell. Elsevier Ltd , pp. 501-513
    • Li, Z.1
  • 6
    • 84884992791 scopus 로고    scopus 로고
    • Cooperativity between MAPK and PI3K signaling activation is required for glioblastoma pathogenesis
    • COI: 1:CAS:528:DC%2BC3sXhsFegsL%2FP, PID: 23814263
    • Vitucci M et al (2013) Cooperativity between MAPK and PI3K signaling activation is required for glioblastoma pathogenesis. Neuro-Oncology 15(10):1317–1329
    • (2013) Neuro-Oncology , vol.15 , Issue.10 , pp. 1317-1329
    • Vitucci, M.1
  • 7
    • 34248597065 scopus 로고    scopus 로고
    • Differential regulation and properties of MAPKs
    • COI: 1:CAS:528:DC%2BD2sXlt1Wkt7o%3D, PID: 17496909
    • Raman M, Chen W, Cobb MH (2007) Differential regulation and properties of MAPKs. Oncogene 26(22):3100–3112
    • (2007) Oncogene , vol.26 , Issue.22 , pp. 3100-3112
    • Raman, M.1    Chen, W.2    Cobb, M.H.3
  • 8
    • 54049141728 scopus 로고    scopus 로고
    • Mitogen-activated protein (MAP) kinase/MAP kinase phosphatase regulation: roles in cell growth, death, and cancer
    • COI: 1:CAS:528:DC%2BD1MXmsVChtrc%3D, PID: 18922965
    • Boutros T, Chevet E, Metrakos P (2008) Mitogen-activated protein (MAP) kinase/MAP kinase phosphatase regulation: roles in cell growth, death, and cancer. Pharmacol Rev 60(3):261–310
    • (2008) Pharmacol Rev , vol.60 , Issue.3 , pp. 261-310
    • Boutros, T.1    Chevet, E.2    Metrakos, P.3
  • 9
    • 77952294428 scopus 로고    scopus 로고
    • Small molecule kinase inhibitors in glioblastoma: a systematic review of clinical studies
    • PID: 20167819
    • De Witt Hamer PC (2010) Small molecule kinase inhibitors in glioblastoma: a systematic review of clinical studies. Neuro-Oncology 12(3):304–316
    • (2010) Neuro-Oncology , vol.12 , Issue.3 , pp. 304-316
    • De Witt Hamer, P.C.1
  • 10
    • 84874087852 scopus 로고    scopus 로고
    • Constitutive expression of MAP kinase phosphatase-1 confers multi-drug resistance in human glioblastoma cells
    • PID: 23091446
    • Yu H et al (2012) Constitutive expression of MAP kinase phosphatase-1 confers multi-drug resistance in human glioblastoma cells. Cancer Res Treat 44(3):195–201
    • (2012) Cancer Res Treat , vol.44 , Issue.3 , pp. 195-201
    • Yu, H.1
  • 11
    • 80052295403 scopus 로고    scopus 로고
    • Dual-specificity phosphatase DUSP6 has tumor-promoting properties in human glioblastomas
    • COI: 1:CAS:528:DC%2BC3MXkslCmur0%3D, PID: 21499306
    • Messina S et al (2011) Dual-specificity phosphatase DUSP6 has tumor-promoting properties in human glioblastomas. Oncogene 30(35):3813–3820
    • (2011) Oncogene , vol.30 , Issue.35 , pp. 3813-3820
    • Messina, S.1
  • 12
    • 76749139471 scopus 로고    scopus 로고
    • Epigenetic downregulation of mitogen-activated protein kinase phosphatase MKP-2 relieves its growth suppressive activity in glioma cells
    • COI: 1:CAS:528:DC%2BC3cXhvFaktrk%3D, PID: 20124482
    • Waha A et al (2010) Epigenetic downregulation of mitogen-activated protein kinase phosphatase MKP-2 relieves its growth suppressive activity in glioma cells. Cancer Res 70(4):1689–1699
    • (2010) Cancer Res , vol.70 , Issue.4 , pp. 1689-1699
    • Waha, A.1
  • 13
    • 33646229108 scopus 로고    scopus 로고
    • ERK regulation upon contact inhibition in fibroblasts
    • COI: 1:CAS:528:DC%2BD28XktVeisr8%3D, PID: 16467968
    • Wayne J et al (2006) ERK regulation upon contact inhibition in fibroblasts. Mol Cell Biochem 286(1–2):181–189
    • (2006) Mol Cell Biochem , vol.286 , Issue.1-2 , pp. 181-189
    • Wayne, J.1
  • 14
    • 4544222907 scopus 로고    scopus 로고
    • Role of MAPK phosphatase-1 (MKP-1) in adipocyte differentiation
    • COI: 1:CAS:528:DC%2BD2cXnsVKrsr4%3D, PID: 15269202
    • Sakaue H et al (2004) Role of MAPK phosphatase-1 (MKP-1) in adipocyte differentiation. J Biol Chem 279(38):39951–39957
    • (2004) J Biol Chem , vol.279 , Issue.38 , pp. 39951-39957
    • Sakaue, H.1
  • 15
    • 0033617186 scopus 로고    scopus 로고
    • Mitogen-activated protein kinase phosphatase-1 (MKP-1) expression is induced by low oxygen conditions found in solid tumor microenvironments. A candidate MKP for the inactivation of hypoxia-inducible stress-activated protein kinase/c-Jun N-terminal protein kinase activity
    • COI: 1:CAS:528:DyaK1MXjtFGnsbk%3D, PID: 10212278
    • Laderoute KR et al (1999) Mitogen-activated protein kinase phosphatase-1 (MKP-1) expression is induced by low oxygen conditions found in solid tumor microenvironments. A candidate MKP for the inactivation of hypoxia-inducible stress-activated protein kinase/c-Jun N-terminal protein kinase activity. J Biol Chem 274(18):12890–12897
    • (1999) J Biol Chem , vol.274 , Issue.18 , pp. 12890-12897
    • Laderoute, K.R.1
  • 16
    • 49749083806 scopus 로고    scopus 로고
    • Dexamethasone reduced invasiveness of human malignant glioblastoma cells through a MAPK phosphatase-1 (MKP-1) dependent mechanism
    • COI: 1:CAS:528:DC%2BD1cXhtVens7bK, PID: 18652821
    • Lin YM et al (2008) Dexamethasone reduced invasiveness of human malignant glioblastoma cells through a MAPK phosphatase-1 (MKP-1) dependent mechanism. Eur J Pharmacol 593(1–3):1–9
    • (2008) Eur J Pharmacol , vol.593 , Issue.1-3 , pp. 1-9
    • Lin, Y.M.1
  • 17
    • 85055525227 scopus 로고    scopus 로고
    • Data from REMBRANDT. The Cancer Imaging Archive
    • Scarpace L et al. (2015) Data from REMBRANDT. The Cancer Imaging Archive. Available from: https://doi.org/10.7937/K9/TCIA.2015.588OZUZB
    • (2015) Available from:
    • Scarpace, L.1
  • 18
    • 84906901689 scopus 로고    scopus 로고
    • An RNA-sequencing transcriptome and splicing database of glia, neurons, and vascular cells of the cerebral cortex
    • COI: 1:CAS:528:DC%2BC2cXhs12hs7nI, PID: 25186741
    • Zhang Y et al (2014) An RNA-sequencing transcriptome and splicing database of glia, neurons, and vascular cells of the cerebral cortex. J Neurosci 34(36):11929–11947
    • (2014) J Neurosci , vol.34 , Issue.36 , pp. 11929-11947
    • Zhang, Y.1
  • 19
    • 85040003572 scopus 로고    scopus 로고
    • Available from:, Ivy
    • Ivy (2015) Ivy Glioblastoma Atlas Project Available from: http://glioblastoma.alleninstitute.org/rnaseq
    • (2015) Ivy Glioblastoma Atlas Project
  • 20
    • 84940453600 scopus 로고    scopus 로고
    • Available from
    • NCI (2015) The cancer genome atlas; Available from: https://www.cancer.gov/
    • (2015) The cancer genome atlas
  • 21
    • 4944250781 scopus 로고    scopus 로고
    • Isolation and characterization of tumorigenic, stem-like neural precursors from human glioblastoma
    • COI: 1:CAS:528:DC%2BD2cXotFalsLs%3D, PID: 15466194
    • Galli R et al (2004) Isolation and characterization of tumorigenic, stem-like neural precursors from human glioblastoma. Cancer Res 64(19):7011–7021
    • (2004) Cancer Res , vol.64 , Issue.19 , pp. 7011-7021
    • Galli, R.1
  • 22
    • 0033619778 scopus 로고    scopus 로고
    • Differential regulation of immediate early gene expression in preadipocyte cells through multiple signaling pathways
    • COI: 1:CAS:528:DyaK1MXnvFaqtb8%3D, PID: 10600478
    • Inuzuka H et al (1999) Differential regulation of immediate early gene expression in preadipocyte cells through multiple signaling pathways. Biochem Biophys Res Commun 265(3):664–668
    • (1999) Biochem Biophys Res Commun , vol.265 , Issue.3 , pp. 664-668
    • Inuzuka, H.1
  • 23
    • 84979754043 scopus 로고    scopus 로고
    • An integrative approach predicted co-expression sub-networks regulating properties of stem cells and differentiation
    • COI: 1:CAS:528:DC%2BC28Xht1Klt7zI, PID: 27475236
    • Sahu M, Mallick B (2016) An integrative approach predicted co-expression sub-networks regulating properties of stem cells and differentiation. Comput Biol Chem 64:250–262
    • (2016) Comput Biol Chem , vol.64 , pp. 250-262
    • Sahu, M.1    Mallick, B.2
  • 24
    • 84959247267 scopus 로고    scopus 로고
    • Differential roles for DUSP family members in epithelial-to-mesenchymal transition and cancer stem cell regulation in breast cancer
    • PID: 26859151
    • Boulding T et al (2016) Differential roles for DUSP family members in epithelial-to-mesenchymal transition and cancer stem cell regulation in breast cancer. PLoS One 11(2):e0148065
    • (2016) PLoS One , vol.11 , Issue.2
    • Boulding, T.1
  • 25
    • 70349296853 scopus 로고    scopus 로고
    • The ABCG2 resistance network of glioblastoma
    • PID: 19713741
    • Bleau AM, Huse JT, Holland EC (2009) The ABCG2 resistance network of glioblastoma. Cell Cycle 8(18):2936–2944
    • (2009) Cell Cycle , vol.8 , Issue.18 , pp. 2936-2944
    • Bleau, A.M.1    Huse, J.T.2    Holland, E.C.3
  • 26
    • 80055015155 scopus 로고    scopus 로고
    • Twisted tango: brain tumor neurovascular interactions
    • COI: 1:CAS:528:DC%2BC3MXhtlOnu7zF, PID: 22030548
    • Hjelmeland AB et al (2011) Twisted tango: brain tumor neurovascular interactions. Nat Neurosci 14(11):1375–1381
    • (2011) Nat Neurosci , vol.14 , Issue.11 , pp. 1375-1381
    • Hjelmeland, A.B.1
  • 27
    • 84986889650 scopus 로고    scopus 로고
    • Cancer stem cell hierarchy in glioblastoma Multiforme
    • PID: 27148537
    • Bradshaw A et al (2016) Cancer stem cell hierarchy in glioblastoma Multiforme. Front Surg 3:21
    • (2016) Front Surg , vol.3 , pp. 21
    • Bradshaw, A.1
  • 28
    • 84904391571 scopus 로고    scopus 로고
    • Activation of sodium-dependent glutamate transporters regulates the morphological aspects of oligodendrocyte maturation via signaling through calcium/calmodulin-dependent kinase IIbeta's actin-binding/−stabilizing domain
    • PID: 24866099
    • Martinez-Lozada Z et al (2014) Activation of sodium-dependent glutamate transporters regulates the morphological aspects of oligodendrocyte maturation via signaling through calcium/calmodulin-dependent kinase IIbeta's actin-binding/−stabilizing domain. Glia 62(9):1543–1558
    • (2014) Glia , vol.62 , Issue.9 , pp. 1543-1558
    • Martinez-Lozada, Z.1
  • 29
    • 62849111110 scopus 로고    scopus 로고
    • Neurogenin2 directs granule neuroblast production and amplification while NeuroD1 specifies neuronal fate during hippocampal neurogenesis
    • PID: 19274100
    • Roybon L et al (2009) Neurogenin2 directs granule neuroblast production and amplification while NeuroD1 specifies neuronal fate during hippocampal neurogenesis. PLoS One 4(3):e4779
    • (2009) PLoS One , vol.4 , Issue.3
    • Roybon, L.1
  • 30
    • 33745685904 scopus 로고    scopus 로고
    • Mitogen-activated protein kinase phosphatase 2: a novel transcription target of p53 in apoptosis
    • COI: 1:CAS:528:DC%2BD28XlvVSksr4%3D, PID: 16778175
    • Shen WH et al (2006) Mitogen-activated protein kinase phosphatase 2: a novel transcription target of p53 in apoptosis. Cancer Res 66(12):6033–6039
    • (2006) Cancer Res , vol.66 , Issue.12 , pp. 6033-6039
    • Shen, W.H.1
  • 31
    • 0142039878 scopus 로고    scopus 로고
    • The phosphatase MKP1 is a transcriptional target of p53 involved in cell cycle regulation
    • COI: 1:CAS:528:DC%2BD3sXotFWgtL4%3D, PID: 12890671
    • Li M et al (2003) The phosphatase MKP1 is a transcriptional target of p53 involved in cell cycle regulation. J Biol Chem 278(42):41059–41068
    • (2003) J Biol Chem , vol.278 , Issue.42 , pp. 41059-41068
    • Li, M.1
  • 32
    • 42049106601 scopus 로고    scopus 로고
    • DUSP1 is controlled by p53 during the cellular response to oxidative stress
    • COI: 1:CAS:528:DC%2BD1cXksFKmsL4%3D, PID: 18403641
    • Liu YX et al (2008) DUSP1 is controlled by p53 during the cellular response to oxidative stress. Mol Cancer Res 6(4):624–633
    • (2008) Mol Cancer Res , vol.6 , Issue.4 , pp. 624-633
    • Liu, Y.X.1
  • 33
    • 84856019858 scopus 로고    scopus 로고
    • The DNA damage response and cancer therapy
    • COI: 1:CAS:528:DC%2BC38Xps1GmsQ%3D%3D, PID: 22258607
    • Lord CJ, Ashworth A (2012) The DNA damage response and cancer therapy. Nature 481(7381):287–294
    • (2012) Nature , vol.481 , Issue.7381 , pp. 287-294
    • Lord, C.J.1    Ashworth, A.2
  • 34
    • 0034626988 scopus 로고    scopus 로고
    • Inactivation of the DNA-repair gene MGMT and the clinical response of gliomas to alkylating agents
    • COI: 1:CAS:528:DC%2BD3cXosFOltLg%3D, PID: 11070098
    • Esteller M et al (2000) Inactivation of the DNA-repair gene MGMT and the clinical response of gliomas to alkylating agents. N Engl J Med 343(19):1350–1354
    • (2000) N Engl J Med , vol.343 , Issue.19 , pp. 1350-1354
    • Esteller, M.1
  • 35
    • 20044372154 scopus 로고    scopus 로고
    • MGMT gene silencing and benefit from temozolomide in glioblastoma
    • COI: 1:CAS:528:DC%2BD2MXit1Wktro%3D, PID: 15758010
    • Hegi ME et al (2005) MGMT gene silencing and benefit from temozolomide in glioblastoma. N Engl J Med 352(10):997–1003
    • (2005) N Engl J Med , vol.352 , Issue.10 , pp. 997-1003
    • Hegi, M.E.1
  • 36
    • 84962493544 scopus 로고    scopus 로고
    • Mitogen-dependent regulation of DUSP1 governs ERK and p38 signaling during early 3T3-L1 adipocyte differentiation
    • COI: 1:CAS:528:DC%2BC2MXhvFWqt7bI, PID: 26566083
    • Ferguson BS et al (2016) Mitogen-dependent regulation of DUSP1 governs ERK and p38 signaling during early 3T3-L1 adipocyte differentiation. J Cell Physiol 231(7):1562–1574
    • (2016) J Cell Physiol , vol.231 , Issue.7 , pp. 1562-1574
    • Ferguson, B.S.1
  • 37
    • 84922069609 scopus 로고    scopus 로고
    • Metabolic circuits in neural stem cells
    • COI: 1:CAS:528:DC%2BC2cXhtFyhu7%2FF, PID: 25037158
    • Kim DY, Rhee I, Paik J (2014) Metabolic circuits in neural stem cells. Cell Mol Life Sci 71(21):4221–4241
    • (2014) Cell Mol Life Sci , vol.71 , Issue.21 , pp. 4221-4241
    • Kim, D.Y.1    Rhee, I.2    Paik, J.3
  • 38
    • 33749415047 scopus 로고    scopus 로고
    • Role of ERK 1/2 signaling in neuronal differentiation of cultured embryonic stem cells
    • COI: 1:CAS:528:DC%2BD28Xht1ems7jE
    • Li Z, Theus MH, Wei L (2006) Role of ERK 1/2 signaling in neuronal differentiation of cultured embryonic stem cells. Develop Growth Differ 48(8):513–523
    • (2006) Develop Growth Differ , vol.48 , Issue.8 , pp. 513-523
    • Li, Z.1    Theus, M.H.2    Wei, L.3
  • 39
    • 33745353794 scopus 로고    scopus 로고
    • Mice lacking MAP kinase phosphatase-1 have enhanced MAP kinase activity and resistance to diet-induced obesity
    • COI: 1:CAS:528:DC%2BD28XmvFyhsr4%3D, PID: 16814733
    • Wu JJ et al (2006) Mice lacking MAP kinase phosphatase-1 have enhanced MAP kinase activity and resistance to diet-induced obesity. Cell Metab 4(1):61–73
    • (2006) Cell Metab , vol.4 , Issue.1 , pp. 61-73
    • Wu, J.J.1
  • 40
    • 32244436592 scopus 로고    scopus 로고
    • p53 suppresses the self-renewal of adult neural stem cells
    • COI: 1:CAS:528:DC%2BD28XhsFamsrk%3D, PID: 16368933
    • Meletis K et al (2006) p53 suppresses the self-renewal of adult neural stem cells. Development 133(2):363–369
    • (2006) Development , vol.133 , Issue.2 , pp. 363-369
    • Meletis, K.1
  • 41
    • 54549108740 scopus 로고    scopus 로고
    • Comprehensive genomic characterization defines human glioblastoma genes and core pathways
    • Cancer Genome Atlas Research, N (2008) Comprehensive genomic characterization defines human glioblastoma genes and core pathways. Nature 455(7216):1061–1068
    • (2008) Nature , vol.455 , Issue.7216 , pp. 1061-1068
  • 42
    • 0035168692 scopus 로고    scopus 로고
    • Transcriptional induction of MKP-1 in response to stress is associated with histone H3 phosphorylation-acetylation
    • COI: 1:CAS:528:DC%2BD3MXotl2gur8%3D, PID: 11689710
    • Li J et al (2001) Transcriptional induction of MKP-1 in response to stress is associated with histone H3 phosphorylation-acetylation. Mol Cell Biol 21(23):8213–8224
    • (2001) Mol Cell Biol , vol.21 , Issue.23 , pp. 8213-8224
    • Li, J.1
  • 43
    • 0038832564 scopus 로고    scopus 로고
    • Reduced MAP kinase phosphatase-1 degradation after p42/p44MAPK-dependent phosphorylation
    • COI: 1:CAS:528:DC%2BD3cXntlaq, PID: 10617468
    • Brondello J (1999) Reduced MAP kinase phosphatase-1 degradation after p42/p44MAPK-dependent phosphorylation. Science 286(5449):2514–2517
    • (1999) Science , vol.286 , Issue.5449 , pp. 2514-2517
    • Brondello, J.1


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