메뉴 건너뛰기




Volumn 33, Issue 9, 2017, Pages 1545-1557

Effect of metformin on clinical, metabolic and endocrine outcomes in women with polycystic ovary syndrome: a meta-analysis of randomized controlled trials

Author keywords

Clinical; endocrine; meta analysis; metabolic; metformin; polycystic ovary syndrome

Indexed keywords

ANDROGEN; CHOLESTEROL; ESTRADIOL; FOLLITROPIN; GLUCOSE; HIGH DENSITY LIPOPROTEIN; INSULIN; LOW DENSITY LIPOPROTEIN; LUTEINIZING HORMONE; METFORMIN; PRASTERONE SULFATE; PROGESTERONE; SEX HORMONE BINDING GLOBULIN; TESTOSTERONE; TRIACYLGLYCEROL; VERY LOW DENSITY LIPOPROTEIN; ANTIDIABETIC AGENT;

EID: 85027699560     PISSN: 03007995     EISSN: 14734877     Source Type: Journal    
DOI: 10.1080/03007995.2017.1279597     Document Type: Review
Times cited : (47)

References (53)
  • 1
    • 15844418279 scopus 로고    scopus 로고
    • Definitions, prevalence and symptoms of polycystic ovaries and polycystic ovary syndrome
    • Hart R, Hickey M, Franks S., Definitions, prevalence and symptoms of polycystic ovaries and polycystic ovary syndrome. Best Pr Res Clin Obs Gynaecol 2004;18:671-83
    • (2004) Best Pr Res Clin Obs Gynaecol , vol.18 , pp. 671-683
    • Hart, R.1    Hickey, M.2    Franks, S.3
  • 2
    • 2942642477 scopus 로고    scopus 로고
    • The prevalence and features of the polycystic ovary syndrome in an unselected population
    • Azziz R, Woods KS, Reyna R, et al. The prevalence and features of the polycystic ovary syndrome in an unselected population. J Clin Endocrinol Metab 2004;89:2745-9
    • (2004) J Clin Endocrinol Metab , vol.89 , pp. 2745-2749
    • Azziz, R.1    Woods, K.S.2    Reyna, R.3
  • 3
    • 79952425938 scopus 로고    scopus 로고
    • PCOS Forum: research in polycystic ovary syndrome today and tomorrow
    • Pasquali R, Stener-Victorin E, Yildiz BO, et al. PCOS Forum:research in polycystic ovary syndrome today and tomorrow. Clin Endocrinol 2011;74:424-33
    • (2011) Clin Endocrinol , vol.74 , pp. 424-433
    • Pasquali, R.1    Stener-Victorin, E.2    Yildiz, B.O.3
  • 4
    • 0032436041 scopus 로고    scopus 로고
    • Polycystic ovary syndrome: symptomatology, pathophysiology, and epidemiology
    • Guzick D, York N., Polycystic ovary syndrome:symptomatology, pathophysiology, and epidemiology. Am J Obs Gynecol 1998;179:89-93
    • (1998) Am J Obs Gynecol , vol.179 , pp. 89-93
    • Guzick, D.1    York, N.2
  • 5
    • 0034874183 scopus 로고    scopus 로고
    • Polycystic ovarian syndrome (PCOS) and insulin resistance
    • Park KH, Kim JY, Ahn CW, et al. Polycystic ovarian syndrome (PCOS) and insulin resistance. Int J Gynaecol Obstet 2001;74:261-7
    • (2001) Int J Gynaecol Obstet , vol.74 , pp. 261-267
    • Park, K.H.1    Kim, J.Y.2    Ahn, C.W.3
  • 6
    • 0344286476 scopus 로고    scopus 로고
    • Prevalence of impaired glucose tolerance and diabetes in women with polycystic ovary syndrome
    • Ehrmann D, Barnes R, Rosenfield R, et al. Prevalence of impaired glucose tolerance and diabetes in women with polycystic ovary syndrome. Diabetes Care 1999;22:141-6
    • (1999) Diabetes Care , vol.22 , pp. 141-146
    • Ehrmann, D.1    Barnes, R.2    Rosenfield, R.3
  • 7
    • 77954870760 scopus 로고    scopus 로고
    • Impaired glucose tolerance, type 2 diabetes and metabolic syndrome in polycystic ovary syndrome: a systematic review and meta-analysis
    • Moran LJ, Misso ML, Wild RA, Norman RJ., Impaired glucose tolerance, type 2 diabetes and metabolic syndrome in polycystic ovary syndrome:a systematic review and meta-analysis. Hum Reprod Update 2010;16:347-63
    • (2010) Hum Reprod Update , vol.16 , pp. 347-363
    • Moran, L.J.1    Misso, M.L.2    Wild, R.A.3    Norman, R.J.4
  • 8
  • 9
    • 77954082318 scopus 로고    scopus 로고
    • Polycystic ovary syndrome: a complex condition with psychological, reproductive and metabolic manifestations that impacts on health across the lifespan
    • Teede H, Deeks A, Moran L., Polycystic ovary syndrome:a complex condition with psychological, reproductive and metabolic manifestations that impacts on health across the lifespan. BMC Med 2010;8:41-50
    • (2010) BMC Med , vol.8 , pp. 41-50
    • Teede, H.1    Deeks, A.2    Moran, L.3
  • 10
    • 0031456016 scopus 로고    scopus 로고
    • Insulin resistance and the polycystic ovary syndrome: mechanism and implications for pathogenesis
    • Dunaif A., Insulin resistance and the polycystic ovary syndrome:mechanism and implications for pathogenesis. Endocr Rev 1997;18:774-800
    • (1997) Endocr Rev , vol.18 , pp. 774-800
    • Dunaif, A.1
  • 11
    • 4544246158 scopus 로고    scopus 로고
    • Use of fasting blood to assess the prevalence of insulin resistance in women with polycystic ovary syndrome
    • Carmina E, Lobo RA., Use of fasting blood to assess the prevalence of insulin resistance in women with polycystic ovary syndrome. Fertil Steril 2004;82:661-5
    • (2004) Fertil Steril , vol.82 , pp. 661-665
    • Carmina, E.1    Lobo, R.A.2
  • 12
    • 0036283724 scopus 로고    scopus 로고
    • Insulin resistance, polycystic ovary syndrome, and type 2 diabetes mellitus
    • Ovalle F, Azziz R., Insulin resistance, polycystic ovary syndrome, and type 2 diabetes mellitus. Fertil Steril 2002;77:1095-105
    • (2002) Fertil Steril , vol.77 , pp. 1095-1105
    • Ovalle, F.1    Azziz, R.2
  • 14
    • 84857061698 scopus 로고    scopus 로고
    • Neuroendocrine dysfunction in polycystic ovary syndrome
    • Burt Solorzano CM, Beller JP, Abshire MY, et al. Neuroendocrine dysfunction in polycystic ovary syndrome. Steroids 2012;77:332-7
    • (2012) Steroids , vol.77 , pp. 332-337
    • Burt Solorzano, C.M.1    Beller, J.P.2    Abshire, M.Y.3
  • 16
    • 84971440716 scopus 로고    scopus 로고
    • Pharmacologic therapy of type 2 diabetes
    • Wright JJ, Tylee TS., Pharmacologic therapy of type 2 diabetes. Med Clin North Am 2016;100:647-63
    • (2016) Med Clin North Am , vol.100 , pp. 647-663
    • Wright, J.J.1    Tylee, T.S.2
  • 17
    • 0028315971 scopus 로고
    • Metformin therapy in polycystic ovary syndrome reduces hyperinsulinemia, insulin resistance, hyperandrogenemia, and systolic blood pressure, while facilitating normal menses and pregnancy
    • Velazquez EM, Mendoza S, Hamer T, et al. Metformin therapy in polycystic ovary syndrome reduces hyperinsulinemia, insulin resistance, hyperandrogenemia, and systolic blood pressure, while facilitating normal menses and pregnancy. Metabolism 1994;43:647-54
    • (1994) Metabolism , vol.43 , pp. 647-654
    • Velazquez, E.M.1    Mendoza, S.2    Hamer, T.3
  • 18
    • 0034458234 scopus 로고    scopus 로고
    • Metformin effects on clinical features, endocrine and metabolic profiles, and insulin sensitivity in polycystic clinical evaluation
    • Moghetti P, Castello R, Negri C, et al. Metformin effects on clinical features, endocrine and metabolic profiles, and insulin sensitivity in polycystic clinical evaluation. J Clin Endocrinol Metab 2014;85:139-46
    • J Clin Endocrinol Metab , vol.85 , pp. 139-146
    • Moghetti, P.1    Castello, R.2    Negri, C.3
  • 19
    • 0034880066 scopus 로고    scopus 로고
    • Metformin to restore normal menses in oligo-amenorrheic teenage girls with polycystic ovary syndrome (PCOS)
    • Glueck CJ, Wang P, Fontaine R, et al. Metformin to restore normal menses in oligo-amenorrheic teenage girls with polycystic ovary syndrome (PCOS). J Adolesc Heal 2001;29:160-9
    • (2001) J Adolesc Heal , vol.29 , pp. 160-169
    • Glueck, C.J.1    Wang, P.2    Fontaine, R.3
  • 20
    • 84862202703 scopus 로고    scopus 로고
    • Statin is a reasonable treatment option for patients with polycystic ovary syndrome: a meta-analysis of randomized controlled trials
    • Gao L, Zhao F, Li S., Statin is a reasonable treatment option for patients with polycystic ovary syndrome:a meta-analysis of randomized controlled trials. Exp Clin Endocrinol Diabetes 2012;120:367-75
    • (2012) Exp Clin Endocrinol Diabetes , vol.120 , pp. 367-375
    • Gao, L.1    Zhao, F.2    Li, S.3
  • 21
    • 85031803755 scopus 로고    scopus 로고
    • Insulin-sensitising drugs (metformin, rosiglitazone, pioglitazone, D-chiro-inositol) for women with polycystic ovary syndrome, oligo amenorrhoea and subfertility
    • Tang T, Lord J, Norman R, et al. Insulin-sensitising drugs (metformin, rosiglitazone, pioglitazone, D-chiro-inositol) for women with polycystic ovary syndrome, oligo amenorrhoea and subfertility. Cochrane Database Syst Rev 2012;5:1-160
    • (2012) Cochrane Database Syst Rev , vol.5 , pp. 1-160
    • Tang, T.1    Lord, J.2    Norman, R.3
  • 22
    • 84861162349 scopus 로고    scopus 로고
    • A systematic review and meta-analysis of randomized controlled trials comparing pioglitazone versus metformin in the treatment of polycystic ovary syndrome
    • Du Q, Wang Y-J, Yang S, et al. A systematic review and meta-analysis of randomized controlled trials comparing pioglitazone versus metformin in the treatment of polycystic ovary syndrome. Curr Med Res Opin 2012;28:723-30
    • (2012) Curr Med Res Opin , vol.28 , pp. 723-730
    • Du, Q.1    Wang, Y.-J.2    Yang, S.3
  • 23
    • 84934302881 scopus 로고    scopus 로고
    • Metformin and lifestyle modification in polycystic ovary syndrome: systematic review and meta-analysis
    • Naderpoor N, Shorakae S, De Courten, B, et al. Metformin and lifestyle modification in polycystic ovary syndrome:systematic review and meta-analysis. Hum Reprod Updat 2015;21:1-15
    • (2015) Hum Reprod Updat , vol.21 , pp. 1-15
    • Naderpoor, N.1    Shorakae, S.2    De Courten, B.3
  • 24
    • 84940773516 scopus 로고    scopus 로고
    • Efficacy and safety of metformin or oral contraceptives, or both in polycystic ovary syndrome
    • Choi E, Yang Y., Efficacy and safety of metformin or oral contraceptives, or both in polycystic ovary syndrome. Ther Clin Risk Manag 2015;11:1345-53
    • (2015) Ther Clin Risk Manag , vol.11 , pp. 1345-1353
    • Choi, E.1    Yang, Y.2
  • 25
    • 84870352868 scopus 로고    scopus 로고
    • Metformin versus clomiphene citrate for infertility in non-obese women with polycystic ovary syndrome: a systematic review and meta-analysis
    • Misso ML, Costello MF, Garrubba M, et al. Metformin versus clomiphene citrate for infertility in non-obese women with polycystic ovary syndrome:a systematic review and meta-analysis. Hum Reprod Update 2013;19:2-11
    • (2013) Hum Reprod Update , vol.19 , pp. 2-11
    • Misso, M.L.1    Costello, M.F.2    Garrubba, M.3
  • 26
    • 84906062872 scopus 로고    scopus 로고
    • First-trimester exposure to metformin and risk of birth defectsâ: a systematic review and meta-analysis
    • Cassina M, Dona M, Di, Gianantonio E, et al. First-trimester exposure to metformin and risk of birth defectsâ:a systematic review and meta-analysis. Hum Reprod Updat 2014;20:656-69
    • (2014) Hum Reprod Updat , vol.20 , pp. 656-669
    • Cassina, M.1    Dona, M.2    Gianantonio, D.3
  • 27
    • 84949538131 scopus 로고    scopus 로고
    • Efficacy of metformin on pregnancy complications in women with polycystic ovary syndrome: a meta-analysis
    • Feng L, Lin X, Wan Z, et al. Efficacy of metformin on pregnancy complications in women with polycystic ovary syndrome:a meta-analysis. Gynecol Endocrinol 2015;31:833-9
    • (2015) Gynecol Endocrinol , vol.31 , pp. 833-839
    • Feng, L.1    Lin, X.2    Wan, Z.3
  • 28
    • 84902181405 scopus 로고    scopus 로고
    • Effect of metformin intervention during pregnancy on the gestational diabetes mellitus in women with polycystic ovary syndrome: a systematic review and meta-analysis
    • Zhuo Z, Wang A, Yu H., Effect of metformin intervention during pregnancy on the gestational diabetes mellitus in women with polycystic ovary syndrome:a systematic review and meta-analysis. J Diabetes Res 2014;1-13
    • (2014) J Diabetes Res , pp. 1-13
    • Zhuo, Z.1    Wang, A.2    Yu, H.3
  • 29
    • 0142247208 scopus 로고    scopus 로고
    • Metformin in polycystic ovary syndrome: systematic review and meta-analysis
    • Lord JM, Flight IHK, Norman RJ., Metformin in polycystic ovary syndrome:systematic review and meta-analysis. BMJ 2003;327:951-3
    • (2003) BMJ , vol.327 , pp. 951-953
    • Lord, J.M.1    Flight, I.H.K.2    Norman, R.J.3
  • 30
    • 58049195680 scopus 로고    scopus 로고
    • Insulin sensitizing drugs for weight loss in women of reproductive age who are overweight or obese: systematic review and meta-analysis
    • Nieuwenhuis-Ruifrok AE, Kuchenbecker WKH, Hoek A, et al. Insulin sensitizing drugs for weight loss in women of reproductive age who are overweight or obese:systematic review and meta-analysis. Hum Reprod Update 2009;15:57-68
    • (2009) Hum Reprod Update , vol.15 , pp. 57-68
    • Nieuwenhuis-Ruifrok, A.E.1    Kuchenbecker, W.K.H.2    Hoek, A.3
  • 31
    • 84872011968 scopus 로고    scopus 로고
    • The PRISMA statement for reporting systematic reviews and meta-analyses of studies that evaluate health care interventions: explanation and elaboration
    • Liberati A, Altman D, Tetzlaff J, et al. The PRISMA statement for reporting systematic reviews and meta-analyses of studies that evaluate health care interventions:explanation and elaboration. J Clin Epidemiol 2009;62:e1-34
    • (2009) J Clin Epidemiol , vol.62 , pp. e1-e34
    • Liberati, A.1    Altman, D.2    Tetzlaff, J.3
  • 33
    • 28444469203 scopus 로고    scopus 로고
    • Predictive value of glucose-insulin ratio in PCOS and profile of women who will benefit from metformin therapy: obese, lean, hyper or normoinsulinemic?
    • Önalan G, Goktolga U, Ceyhan T, et al. Predictive value of glucose-insulin ratio in PCOS and profile of women who will benefit from metformin therapy:obese, lean, hyper or normoinsulinemic? Eur J Obstet Gynecol Reprod Biol 2005;123:204-11
    • (2005) Eur J Obstet Gynecol Reprod Biol , vol.123 , pp. 204-211
    • Önalan, G.1    Goktolga, U.2    Ceyhan, T.3
  • 34
    • 1242306504 scopus 로고    scopus 로고
    • Nonobese women with polycystic ovary syndrome respond better than obese women to treatment with metformin
    • Maciel GAR, Soares JM, Alves Da Motta EL, et al. Nonobese women with polycystic ovary syndrome respond better than obese women to treatment with metformin. Fertil Steril 2004;81:355-60
    • (2004) Fertil Steril , vol.81 , pp. 355-360
    • Maciel, G.A.R.1    Soares, J.M.2    Alves Da Motta, E.L.3
  • 35
    • 5144220551 scopus 로고    scopus 로고
    • Effects of metformin and rosiglitazone, alone and in combination, in nonobese women with polycystic ovary syndrome and normal indices of insulin sensitivity
    • Baillargeon JP, Jakubowicz DJ, Iuorno MJ, et al. Effects of metformin and rosiglitazone, alone and in combination, in nonobese women with polycystic ovary syndrome and normal indices of insulin sensitivity. Fertil Steril 2004;82:893-902
    • (2004) Fertil Steril , vol.82 , pp. 893-902
    • Baillargeon, J.P.1    Jakubowicz, D.J.2    Iuorno, M.J.3
  • 36
    • 84867054907 scopus 로고    scopus 로고
    • The effects of calcitriol on improvement of insulin resistance, ovulation and comparison with metformin therapy in PCOS patients: a randomized placebo-controlled clinical trial
    • Bonakdaran S, Khorasani ZM, Davachi B, Khorasani JM., The effects of calcitriol on improvement of insulin resistance, ovulation and comparison with metformin therapy in PCOS patients:a randomized placebo-controlled clinical trial. Iran J Reprod Med 2012;10:465-72
    • (2012) Iran J Reprod Med , vol.10 , pp. 465-472
    • Bonakdaran, S.1    Khorasani, Z.M.2    Davachi, B.3    Khorasani, J.M.4
  • 37
    • 0038245195 scopus 로고    scopus 로고
    • Clinical, metabolic and endocrine parameters in response to metformin in obese women with polycystic ovary syndrome: a randomized, double-blind and placebo-controlled trial
    • Chou K, Corleta H, Capp E, Spritzer P., Clinical, metabolic and endocrine parameters in response to metformin in obese women with polycystic ovary syndrome:a randomized, double-blind and placebo-controlled trial. Horm Metab Res 2003;35:86-91
    • (2003) Horm Metab Res , vol.35 , pp. 86-91
    • Chou, K.1    Corleta, H.2    Capp, E.3    Spritzer, P.4
  • 38
    • 33644821630 scopus 로고    scopus 로고
    • Early effects of metformin in women with polycystic ovary syndrome: a prospective randomized, double-blind, placebo-controlled trial
    • Eisenhardt S, Schwarzmann N, Henschel V, et al. Early effects of metformin in women with polycystic ovary syndrome:a prospective randomized, double-blind, placebo-controlled trial. J Clin Endocrinol Metab 2006;91:946-52
    • (2006) J Clin Endocrinol Metab , vol.91 , pp. 946-952
    • Eisenhardt, S.1    Schwarzmann, N.2    Henschel, V.3
  • 39
    • 4143112307 scopus 로고    scopus 로고
    • A randomized, 48-week, placebo-controlled trial of intensive lifestyle modification and/or metformin therapy in overweight women with polycystic ovary syndrome: a pilot study
    • Hoeger KM, Kochman L, Wixom N, et al. A randomized, 48-week, placebo-controlled trial of intensive lifestyle modification and/or metformin therapy in overweight women with polycystic ovary syndrome:a pilot study. Fertil Steril 2004;82:421-9
    • (2004) Fertil Steril , vol.82 , pp. 421-429
    • Hoeger, K.M.1    Kochman, L.2    Wixom, N.3
  • 40
    • 57349113274 scopus 로고    scopus 로고
    • The impact of metformin, oral contraceptives, and lifestyle modification on polycystic ovary syndrome in obese adolescent women in two randomized, placebo-controlled clinical trials
    • Hoeger K, Davidson K, Kochman L, et al. The impact of metformin, oral contraceptives, and lifestyle modification on polycystic ovary syndrome in obese adolescent women in two randomized, placebo-controlled clinical trials. J Clin Endocrinol Metab 2008;93:4299-306
    • (2008) J Clin Endocrinol Metab , vol.93 , pp. 4299-4306
    • Hoeger, K.1    Davidson, K.2    Kochman, L.3
  • 41
    • 34547783350 scopus 로고    scopus 로고
    • Insulin sensitivity after metformin suspension in normal-weight women with polycystic ovary syndrome
    • Palomba S, Falbo A, Russo T, et al. Insulin sensitivity after metformin suspension in normal-weight women with polycystic ovary syndrome. J Clin Endocrinol Metab 2007;92:3128-35
    • (2007) J Clin Endocrinol Metab , vol.92 , pp. 3128-3135
    • Palomba, S.1    Falbo, A.2    Russo, T.3
  • 42
    • 27644463765 scopus 로고    scopus 로고
    • Effect of metformin on the growth hormone response to growth hormone-releasing hormone in obese women with polycystic ovary syndrome
    • Guido M, Romualdi D, Giuliani M, et al. Effect of metformin on the growth hormone response to growth hormone-releasing hormone in obese women with polycystic ovary syndrome. Fertil Steril 2005;84:1470-6
    • (2005) Fertil Steril , vol.84 , pp. 1470-1476
    • Guido, M.1    Romualdi, D.2    Giuliani, M.3
  • 43
    • 77952557432 scopus 로고    scopus 로고
    • Metformin effects on ovarian ultrasound appearance and steroidogenic function in normal-weight normoinsulinemic women with polycystic ovary syndrome: a randomized double-blind placebo-controlled clinical trial
    • Romualdi D, Giuliani M, Cristello F, et al. Metformin effects on ovarian ultrasound appearance and steroidogenic function in normal-weight normoinsulinemic women with polycystic ovary syndrome:a randomized double-blind placebo-controlled clinical trial. Fertil Steril 2010;93:2303-10
    • (2010) Fertil Steril , vol.93 , pp. 2303-2310
    • Romualdi, D.1    Giuliani, M.2    Cristello, F.3
  • 44
    • 0036677536 scopus 로고    scopus 로고
    • The effect of metformin on hirsutism in polycystic ovary syndrome
    • Kelly CJG, Gordon D., The effect of metformin on hirsutism in polycystic ovary syndrome. Eur J Endocrinol 2002;147:217-21
    • (2002) Eur J Endocrinol , vol.147 , pp. 217-221
    • Kelly, C.J.G.1    Gordon, D.2
  • 45
    • 33745512819 scopus 로고    scopus 로고
    • The effect of metformin on fat distribution and the metabolic syndrome in women with polycystic ovary syndrome–a randomised, double-blind, placebo-controlled trial
    • Lord J, Thomas R, Fox B, Acharya U, Wilkin T. The effect of metformin on fat distribution and the metabolic syndrome in women with polycystic ovary syndrome–a randomised, double-blind, placebo-controlled trial. BJOG 2006;113:817-24
    • (2006) BJOG , vol.113 , pp. 817-824
    • Lord, J.1    Thomas, R.2    Fox, B.3    Acharya, U.4    Wilkin, T.5
  • 46
    • 42949103243 scopus 로고    scopus 로고
    • Efficacy of metformin in obese and non-obese women with polycystic ovary syndrome: a randomized, double-blinded, placebo-controlled cross-over trial
    • Trolle B, Flyvbjerg A, Kesmodel U, Lauszus FF., Efficacy of metformin in obese and non-obese women with polycystic ovary syndrome:a randomized, double-blinded, placebo-controlled cross-over trial. Hum Reprod 2007;22:2967-73
    • (2007) Hum Reprod , vol.22 , pp. 2967-2973
    • Trolle, B.1    Flyvbjerg, A.2    Kesmodel, U.3    Lauszus, F.F.4
  • 47
    • 78049235991 scopus 로고    scopus 로고
    • Adiponectin levels in women with polycystic ovary syndrome: impact of metformin treatment in a randomized controlled study
    • Trolle B, Lauszus F, Frystyk J, et al. Adiponectin levels in women with polycystic ovary syndrome:impact of metformin treatment in a randomized controlled study. Fertil Steril 2010;94:2234-8
    • (2010) Fertil Steril , vol.94 , pp. 2234-2238
    • Trolle, B.1    Lauszus, F.2    Frystyk, J.3
  • 48
    • 0037229222 scopus 로고    scopus 로고
    • A systematic review of the reproductive system effects of metformin in patients with polycystic ovary syndrome
    • Costello MF, Eden JA., A systematic review of the reproductive system effects of metformin in patients with polycystic ovary syndrome. Fertil Steril 2003;79:1-13
    • (2003) Fertil Steril , vol.79 , pp. 1-13
    • Costello, M.F.1    Eden, J.A.2
  • 49
    • 33646120750 scopus 로고    scopus 로고
    • Metformin in polycystic ovary syndrome: systematic review
    • Lord JM, Flight IHK, Norman RJ., Metformin in polycystic ovary syndrome:systematic review. Br Med J 2003;327:1-6
    • (2003) Br Med J , vol.327 , pp. 1-6
    • Lord, J.M.1    Flight, I.H.K.2    Norman, R.J.3
  • 51
    • 70349287732 scopus 로고    scopus 로고
    • Metformin does not improve the reproductive or metabolic profile in women with polycystic ovary syndrome (PCOS). Reprod
    • Aubuchon M, Lieman H, Stein D, et al. Metformin does not improve the reproductive or metabolic profile in women with polycystic ovary syndrome (PCOS). Reprod Sci 2009;16:938-46
    • (2009) Sci , vol.16 , pp. 938-946
    • Aubuchon, M.1    Lieman, H.2    Stein, D.3
  • 52
    • 76149144326 scopus 로고    scopus 로고
    • Metformin Reduces Arterial Stiffness and Improves Endothelial Function in Young Women with polycystic ovary syndrome: a randomized, placebo-controlled, crossover trial
    • Agarwal N, Rice SPL, Bolusani H, Luzio SD, Dunseath G, Ludgate M, et al. Metformin Reduces Arterial Stiffness and Improves Endothelial Function in Young Women with polycystic ovary syndrome:a randomized, placebo-controlled, crossover trial. J Clin Endocrinol Metab 2015;95:722-30
    • (2015) J Clin Endocrinol Metab , vol.95 , pp. 722-730
    • Agarwal, N.1    Rice, S.P.L.2    Bolusani, H.3    Luzio, S.D.4    Dunseath, G.5    Ludgate, M.6
  • 53
    • 0036170744 scopus 로고    scopus 로고
    • Ovarian function and metabolic factors in women with oligomenorrhea treated with metformin in a randomized double blind placebo-controlled trial
    • Fleming R, Wallace AM, Greer IA, Sattar NHZE., Ovarian function and metabolic factors in women with oligomenorrhea treated with metformin in a randomized double blind placebo-controlled trial. J Clin Endocrinol Metab 2002;87:569
    • (2002) J Clin Endocrinol Metab , vol.87 , pp. 569
    • Fleming, R.1    Wallace, A.M.2    Greer, I.A.3    Sattar, N.H.Z.E.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.