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Volumn 31, Issue 11, 2015, Pages 833-839

Efficacy of metformin on pregnancy complications in women with polycystic ovary syndrome: A meta-analysis

Author keywords

Metformin; miscarriage; polycystic ovary syndrome; pregnancy complications; premature birth

Indexed keywords

METFORMIN; ANTIDIABETIC AGENT;

EID: 84949538131     PISSN: 09513590     EISSN: 14730766     Source Type: Journal    
DOI: 10.3109/09513590.2015.1041906     Document Type: Article
Times cited : (40)

References (45)
  • 2
    • 0029095150 scopus 로고
    • Polycystic ovary syndrome
    • Franks S. Polycystic ovary syndrome. New Engl J Med 1995; 333: 853-61
    • (1995) New Engl J Med , vol.333 , pp. 853-861
    • Franks, S.1
  • 3
    • 0033392905 scopus 로고    scopus 로고
    • Polycystic ovaries and associated clinical and biochemical features in young women
    • Michelmore KF, Balen AH, Dunger DB, Vessey MP. Polycystic ovaries and associated clinical and biochemical features in young women. Clin Endocrinol 1999; 51: 779-86
    • (1999) Clin Endocrinol , vol.51 , pp. 779-786
    • Michelmore, K.F.1    Balen, A.H.2    Dunger, D.B.3    Vessey, M.P.4
  • 4
    • 0033345349 scopus 로고    scopus 로고
    • A survey of the polycystic ovary syndrome in the Greek island of Lesbos: Hormonal and metabolic profile
    • Diamanti-Kandarakis E, Kouli CR, Bergiele AT, et al. A survey of the polycystic ovary syndrome in the Greek island of Lesbos: hormonal and metabolic profile. J Clin Endocrinol Metabol 1999; 84: 4006-11
    • (1999) J Clin Endocrinol Metabol , vol.84 , pp. 4006-4011
    • Diamanti-Kandarakis, E.1    Kouli, C.R.2    Bergiele, A.T.3
  • 5
    • 0034457559 scopus 로고    scopus 로고
    • A prospective study of the prevalence of the polycystic ovary syndrome in unselected Caucasian women from Spain
    • Asuncion M, Calvo RM, San Millan JL, et al. A prospective study of the prevalence of the polycystic ovary syndrome in unselected Caucasian women from Spain. J Clin Endocrinol Metabol 2000; 85: 2434-8
    • (2000) J Clin Endocrinol Metabol , vol.85 , pp. 2434-2438
    • Asuncion, M.1    Calvo, R.M.2    San Millan, J.L.3
  • 6
    • 0031773509 scopus 로고    scopus 로고
    • Prevalence of the polycystic ovary syndrome in unselected black and white women of the southeastern United States: A prospective study
    • Knochenhauer ES, Key TJ, Kahsar-Miller M, et al. Prevalence of the polycystic ovary syndrome in unselected black and white women of the southeastern United States: a prospective study. J Clin Endocrinol Metabol 1998; 83: 3078-82
    • (1998) J Clin Endocrinol Metabol , vol.83 , pp. 3078-3082
    • Knochenhauer, E.S.1    Key, T.J.2    Kahsar-Miller, M.3
  • 7
    • 2942642477 scopus 로고    scopus 로고
    • The prevalence and features of the polycystic ovary syndrome in an unselected population
    • Azziz R, Woods KS, Reyna R, et al. The prevalence and features of the polycystic ovary syndrome in an unselected population. J Clin Endocrinol Metab 2004; 89: 2745-9
    • (2004) J Clin Endocrinol Metab , vol.89 , pp. 2745-2749
    • Azziz, R.1    Woods, K.S.2    Reyna, R.3
  • 8
    • 79953310558 scopus 로고    scopus 로고
    • The prevalence of polycystic ovary syndrome in a community sample of Iranian population: Iranian PCOS prevalence study
    • Tehrani FR, Simbar M, Tohidi M, et al. The prevalence of polycystic ovary syndrome in a community sample of Iranian population: iranian PCOS prevalence study. Reprod Biol Endocrinol 2011; 9: 39
    • (2011) Reprod Biol Endocrinol , vol.9 , pp. 39
    • Tehrani, F.R.1    Simbar, M.2    Tohidi, M.3
  • 9
    • 45949103220 scopus 로고    scopus 로고
    • Prevalence of polycystic ovary syndrome in unselected women from southern China
    • Chen X, Yang D, Mo Y, et al. Prevalence of polycystic ovary syndrome in unselected women from southern China. Eur J Obstetr Gynecol Reprod Biol 2008; 139: 59-64
    • (2008) Eur J Obstetr Gynecol Reprod Biol , vol.139 , pp. 59-64
    • Chen, X.1    Yang, D.2    Mo, Y.3
  • 10
    • 33750201631 scopus 로고    scopus 로고
    • A meta-analysis of pregnancy outcomes in women with polycystic ovary syndrome
    • Boomsma CM, Eijkemans M, Hughes EG, et al. A meta-analysis of pregnancy outcomes in women with polycystic ovary syndrome. Hum Reprod Update 2006; 12: 673-83
    • (2006) Hum Reprod Update , vol.12 , pp. 673-683
    • Boomsma, C.M.1    Eijkemans, M.2    Hughes, E.G.3
  • 11
    • 84879440043 scopus 로고    scopus 로고
    • Obstetric complications in women with polycystic ovary syndrome: A systematic review and meta-analysis
    • Qin JZ, Pang LH, Li MJ, et al. Obstetric complications in women with polycystic ovary syndrome: a systematic review and meta-analysis. Reprod Biol Endocrinol 2013; 11: 56
    • (2013) Reprod Biol Endocrinol , vol.11 , pp. 56
    • Qin, J.Z.1    Pang, L.H.2    Li, M.J.3
  • 12
    • 0142247208 scopus 로고    scopus 로고
    • Metformin in polycystic ovary syndrome: Systematic review and meta-analysis
    • Lord JM, Flight IH, Norman RJ. Metformin in polycystic ovary syndrome: systematic review and meta-analysis. BMJ 2003; 327: 951
    • (2003) BMJ , vol.327 , pp. 951
    • Lord, J.M.1    Flight, I.H.2    Norman, R.J.3
  • 13
    • 70350564452 scopus 로고    scopus 로고
    • Effect of preconceptional metformin on abortion risk in polycystic ovary syndrome: A systematic review and meta-analysis of randomized controlled trials
    • Palomba S, Falbo A, Orio FJ, Zullo F. Effect of preconceptional metformin on abortion risk in polycystic ovary syndrome: a systematic review and meta-analysis of randomized controlled trials. Fertil Steril 2009; 92: 1646-58
    • (2009) Fertil Steril , vol.92 , pp. 1646-1658
    • Palomba, S.1    Falbo, A.2    Orio, F.J.3    Zullo, F.4
  • 14
    • 84878225400 scopus 로고    scopus 로고
    • How metformin acts in PCOS pregnant women: Insights into insulin secretion and peripheral action at each trimester of gestation
    • Romualdi D, De Cicco S, Gagliano D, et al. How metformin acts in PCOS pregnant women: insights into insulin secretion and peripheral action at each trimester of gestation. Diabetes Care 2013; 36: 1477-82
    • (2013) Diabetes Care , vol.36 , pp. 1477-1482
    • Romualdi, D.1    De Cicco, S.2    Gagliano, D.3
  • 15
    • 84862097793 scopus 로고    scopus 로고
    • Pregnancy outcomes and the effect of metformin treatment in women with polycystic ovary syndrome: An overview
    • Ghazeeri GS, Nassar AH, Younes Z, Awwad JT. Pregnancy outcomes and the effect of metformin treatment in women with polycystic ovary syndrome: an overview. Acta Obstet Gynecol Scand 2012; 91: 658-78
    • (2012) Acta Obstet Gynecol Scand , vol.91 , pp. 658-678
    • Ghazeeri, G.S.1    Nassar, A.H.2    Younes, Z.3    Awwad, J.T.4
  • 16
    • 0346186090 scopus 로고    scopus 로고
    • Revised 2003 consensus on diagnostic criteria and long-term health risks related to polycystic ovary syndrome (PCOS)
    • Rotterdam ESHRE/ASRM-Sponsored PCOS Consensus Workshop Group
    • Rotterdam ESHRE/ASRM-Sponsored PCOS Consensus Workshop Group. Revised 2003 consensus on diagnostic criteria and long-term health risks related to polycystic ovary syndrome (PCOS). Hum Reprod (Oxford, England) 2004; 19: 41-7
    • (2004) Hum Reprod (Oxford, England) , vol.19 , pp. 41-47
  • 17
    • 0346725827 scopus 로고    scopus 로고
    • Revised 2003 consensus on diagnostic criteria and long-term health risks related to polycystic ovary syndrome
    • The Rotterdam ESHRE/ASRM-Sponsored PCOS Consensus Workshop Group
    • The Rotterdam ESHRE/ASRM-Sponsored PCOS Consensus Workshop Group. Revised 2003 consensus on diagnostic criteria and long-term health risks related to polycystic ovary syndrome. Fertil Steril 2004; 81: 19-25
    • (2004) Fertil Steril , vol.81 , pp. 19-25
  • 18
    • 33645408556 scopus 로고    scopus 로고
    • Pregnancy outcome in infertile patients with polycystic ovary syndrome who were treated with metformin
    • Thatcher SS, Jackson EM. Pregnancy outcome in infertile patients with polycystic ovary syndrome who were treated with metformin. Fertil Steril 2006; 85: 1002-9
    • (2006) Fertil Steril , vol.85 , pp. 1002-1009
    • Thatcher, S.S.1    Jackson, E.M.2
  • 19
    • 0036009794 scopus 로고    scopus 로고
    • Pregnancies following use of metformin for ovulation induction in patients with polycystic ovary syndrome
    • Heard MJ, Pierce A, Carson SA, Buster JE. Pregnancies following use of metformin for ovulation induction in patients with polycystic ovary syndrome. Fertil Steril 2002; 77: 669-73
    • (2002) Fertil Steril , vol.77 , pp. 669-673
    • Heard, M.J.1    Pierce, A.2    Carson, S.A.3    Buster, J.E.4
  • 20
    • 84964301525 scopus 로고    scopus 로고
    • Outcome of second pregnancies when the first pregnancies were supported by metformin in patients of PCOS
    • Daya S, Pierson R, Gunby J, eds.
    • Malik S, Katoch K, Allahbadia G. Outcome of second pregnancies when the first pregnancies were supported by metformin in patients of PCOS. In: Daya S, Pierson R, Gunby J, eds. International congress series;; 2004: 46-9
    • (2004) International Congress Series , pp. 46-49
    • Malik, S.1    Katoch, K.2    Allahbadia, G.3
  • 21
    • 77952998731 scopus 로고    scopus 로고
    • Effect of metformin on miscarriage in pregnant patients with polycystic ovary syndrome
    • Sohrabvand F, Shariat M, Haghollahi F, Bagheri B. Effect of metformin on miscarriage in pregnant patients with polycystic ovary syndrome. West Indian Med J 2009; 58: 433-6
    • (2009) West Indian Med J , vol.58 , pp. 433-436
    • Sohrabvand, F.1    Shariat, M.2    Haghollahi, F.3    Bagheri, B.4
  • 22
    • 84860761407 scopus 로고    scopus 로고
    • Metformin improves pregnancy and live-birth rates in women with polycystic ovary syndrome (PCOS): A multicenter, double-blind, placebo-controlled randomized trial
    • Morin-Papunen L, Rantala AS, Unkila-Kallio L, et al. Metformin improves pregnancy and live-birth rates in women with polycystic ovary syndrome (PCOS): a multicenter, double-blind, placebo-controlled randomized trial. J Clin Endocrinol Metab 2012; 97: 1492-500
    • (2012) J Clin Endocrinol Metab , vol.97 , pp. 1492-1500
    • Morin-Papunen, L.1    Rantala, A.S.2    Unkila-Kallio, L.3
  • 23
    • 80053282262 scopus 로고    scopus 로고
    • The role of continuing metformin therapy during pregnancy in the reduction of gestational diabetes and improving pregnancy outcomes in women with polycystic ovary syndrome
    • Abd El Hameed AA, Shreif HE, Mowafy HE. The role of continuing metformin therapy during pregnancy in the reduction of gestational diabetes and improving pregnancy outcomes in women with polycystic ovary syndrome. Middle East Fertil Soc J 2011; 16: 204-8
    • (2011) Middle East Fertil Soc J , vol.16 , pp. 204-208
    • Abd El Hameed, A.A.1    Shreif, H.E.2    Mowafy, H.E.3
  • 24
    • 78650059171 scopus 로고    scopus 로고
    • Metformin versus placebo from first trimester to delivery in polycystic ovary syndrome: A randomized, controlled multicenter study
    • Vanky E, Stridsklev S, Heimstad R, et al. Metformin versus placebo from first trimester to delivery in polycystic ovary syndrome: a randomized, controlled multicenter study. J Clin Endocrinol Metab 2010; 95: E448-55
    • (2010) J Clin Endocrinol Metab , vol.95 , pp. E448-E455
    • Vanky, E.1    Stridsklev, S.2    Heimstad, R.3
  • 25
    • 4344651482 scopus 로고    scopus 로고
    • Metformin reduces pregnancy complications without affecting androgen levels in pregnant polycystic ovary syndrome women: Results of a randomized study
    • Vanky E, Salvesen KA, Heimstad R, et al. Metformin reduces pregnancy complications without affecting androgen levels in pregnant polycystic ovary syndrome women: results of a randomized study. Hum Reprod 2004; 19: 1734-40
    • (2004) Hum Reprod , vol.19 , pp. 1734-1740
    • Vanky, E.1    Salvesen, K.A.2    Heimstad, R.3
  • 26
    • 33845607644 scopus 로고    scopus 로고
    • Metformin reduces abortion in pregnant women with polycystic ovary syndrome
    • Khattab S, Mohsen IA, Foutouh IA, et al. Metformin reduces abortion in pregnant women with polycystic ovary syndrome. Gynecol Endocrinol 2006; 22: 680-4
    • (2006) Gynecol Endocrinol , vol.22 , pp. 680-684
    • Khattab, S.1    Mohsen, I.A.2    Foutouh, I.A.3
  • 27
    • 80053902515 scopus 로고    scopus 로고
    • Can metformin reduce the incidence of gestational diabetes mellitus in pregnant women with polycystic ovary syndrome? Prospective cohort study
    • Khattab S, Mohsen IA, Aboul FI, et al. Can metformin reduce the incidence of gestational diabetes mellitus in pregnant women with polycystic ovary syndrome? Prospective cohort study. Gynecol Endocrinol 2011; 27: 789-93
    • (2011) Gynecol Endocrinol , vol.27 , pp. 789-793
    • Khattab, S.1    Mohsen, I.A.2    Aboul, F.I.3
  • 28
    • 63149092470 scopus 로고    scopus 로고
    • Prevention of gestational diabetes mellitus by continuing metformin therapy throughout pregnancy in women with polycystic ovary syndrome
    • Begum MR, Khanam NN, Quadir E, et al. Prevention of gestational diabetes mellitus by continuing metformin therapy throughout pregnancy in women with polycystic ovary syndrome. J Obstet Gynaecol Res 2009; 35: 282-6
    • (2009) J Obstet Gynaecol Res , vol.35 , pp. 282-286
    • Begum, M.R.1    Khanam, N.N.2    Quadir, E.3
  • 29
    • 0037098199 scopus 로고    scopus 로고
    • Quantifying heterogeneity in a meta-analysis
    • Higgins J, Thompson SG. Quantifying heterogeneity in a meta-analysis. Stat Med 2002; 21: 1539-58
    • (2002) Stat Med , vol.21 , pp. 1539-1558
    • Higgins, J.1    Thompson, S.G.2
  • 30
    • 73649108585 scopus 로고    scopus 로고
    • Meta-analyst: Software for meta-analysis of binary, continuous and diagnostic data
    • Wallace BC, Schmid CH, Lau J, Trikalinos TA. Meta-analyst: software for meta-analysis of binary, continuous and diagnostic data. BMC Med Res Methodol 2009; 9: 80
    • (2009) BMC Med Res Methodol , vol.9 , pp. 80
    • Wallace, B.C.1    Schmid, C.H.2    Lau, J.3    Trikalinos, T.A.4
  • 31
    • 0028659004 scopus 로고
    • Operating characteristics of a rank correlation test for publication bias
    • Begg CB, Mazumdar M. Operating characteristics of a rank correlation test for publication bias. Biometrics 1994; 50: 1088-101
    • (1994) Biometrics , vol.50 , pp. 1088-1101
    • Begg, C.B.1    Mazumdar, M.2
  • 32
    • 0035168622 scopus 로고    scopus 로고
    • Continuing metformin throughout pregnancy in women with polycystic ovary syndrome appears to safely reduce first-trimester spontaneous abortion: A pilot study
    • Glueck CJ, Phillips H, Cameron D, et al. Continuing metformin throughout pregnancy in women with polycystic ovary syndrome appears to safely reduce first-trimester spontaneous abortion: a pilot study. Fertil Steril 2001; 75: 46-52
    • (2001) Fertil Steril , vol.75 , pp. 46-52
    • Glueck, C.J.1    Phillips, H.2    Cameron, D.3
  • 33
    • 0036171653 scopus 로고    scopus 로고
    • Effects of metformin on early pregnancy loss in the polycystic ovary syndrome
    • Jakubowicz DJ, Iuorno MJ, Jakubowicz S, et al. Effects of metformin on early pregnancy loss in the polycystic ovary syndrome. J Clin Endocrinol Metab 2002; 87: 524-9
    • (2002) J Clin Endocrinol Metab , vol.87 , pp. 524-529
    • Jakubowicz, D.J.1    Iuorno, M.J.2    Jakubowicz, S.3
  • 34
    • 0035168622 scopus 로고    scopus 로고
    • Continuing metformin throughout pregnancy in women with polycystic ovary syndrome appears to safely reduce first-trimester spontaneous abortion: A pilot study
    • Glueck CJ, Phillips H, Cameron D, et al. Continuing metformin throughout pregnancy in women with polycystic ovary syndrome appears to safely reduce first-trimester spontaneous abortion: a pilot study. Fertil Steril 2001; 75: 46-52
    • (2001) Fertil Steril , vol.75 , pp. 46-52
    • Glueck, C.J.1    Phillips, H.2    Cameron, D.3
  • 35
    • 0036851165 scopus 로고    scopus 로고
    • Pregnancy outcomes among women with polycystic ovary syndrome treated with metformin
    • Glueck CJ, Wang P, Goldenberg N, Sieve-Smith L. Pregnancy outcomes among women with polycystic ovary syndrome treated with metformin. Hum Reprod 2002; 17: 2858-64
    • (2002) Hum Reprod , vol.17 , pp. 2858-2864
    • Glueck, C.J.1    Wang, P.2    Goldenberg, N.3    Sieve-Smith, L.4
  • 36
    • 79958813551 scopus 로고    scopus 로고
    • The administration of metformin during pregnancy reduces polycystic ovary syndrome related gestational complications
    • De Leo V, Musacchio MC, Piomboni P, et al. The administration of metformin during pregnancy reduces polycystic ovary syndrome related gestational complications. Eur J Obstet Gynecol Reprod Biol 2011; 157: 63-6
    • (2011) Eur J Obstet Gynecol Reprod Biol , vol.157 , pp. 63-66
    • De Leo, V.1    Musacchio, M.C.2    Piomboni, P.3
  • 37
    • 52049089236 scopus 로고    scopus 로고
    • Does continuous use of metformin throughout pregnancy improve pregnancy outcomes in women with polycystic ovarian syndrome?
    • Nawaz FH, Khalid R, Naru T, Rizvi J. Does continuous use of metformin throughout pregnancy improve pregnancy outcomes in women with polycystic ovarian syndrome? J Obstet Gynaecol Res 2008; 34: 832-7
    • (2008) J Obstet Gynaecol Res , vol.34 , pp. 832-837
    • Nawaz, F.H.1    Khalid, R.2    Naru, T.3    Rizvi, J.4
  • 38
    • 3843127654 scopus 로고    scopus 로고
    • Metformin, pre-eclampsia, and pregnancy outcomes in women with polycystic ovary syndrome
    • Glueck CJ, Bornovali S, Pranikoff J, et al. Metformin, pre-eclampsia, and pregnancy outcomes in women with polycystic ovary syndrome. Diabet Med 2004; 21: 829-36
    • (2004) Diabet Med , vol.21 , pp. 829-836
    • Glueck, C.J.1    Bornovali, S.2    Pranikoff, J.3
  • 39
    • 84855786637 scopus 로고    scopus 로고
    • Neonatal morbidity and mortality results in preterm premature rupture of membranes
    • Gezer A, Yalçiner EP, Güralp O, et al. Neonatal morbidity and mortality results in preterm premature rupture of membranes. Turk Pediatri Arsivi-Turkish Arch Pediatr 2011; 46: 296-301
    • (2011) Turk Pediatri Arsivi-Turkish Arch Pediatr , vol.46 , pp. 296-301
    • Gezer, A.1    Yalçiner, E.P.2    Güralp, O.3
  • 40
    • 84883731758 scopus 로고    scopus 로고
    • Premature delivery and the millennium development goal
    • Nour NM. Premature delivery and the millennium development goal. Rev Obstetr Gynecol 2012; 5: 100-5
    • (2012) Rev Obstetr Gynecol , vol.5 , pp. 100-105
    • Nour, N.M.1
  • 43
    • 33747733559 scopus 로고    scopus 로고
    • Neonatal outcome in polycystic ovarian syndrome patients treated with metformin during pregnancy
    • Kovo M, Weissman A, Gur D, et al. Neonatal outcome in polycystic ovarian syndrome patients treated with metformin during pregnancy. J Matern Fetal Neonatal Med 2006; 19: 415-19
    • (2006) J Matern Fetal Neonatal Med , vol.19 , pp. 415-419
    • Kovo, M.1    Weissman, A.2    Gur, D.3
  • 44
    • 58149104062 scopus 로고    scopus 로고
    • Continuation of metformin in the first trimester of women with polycystic ovarian syndrome is not associated with increased perinatal morbidity
    • Bolton S, Cleary B, Walsh J, et al. Continuation of metformin in the first trimester of women with polycystic ovarian syndrome is not associated with increased perinatal morbidity. Eur J Pediatr 2009; 168: 203-6
    • (2009) Eur J Pediatr , vol.168 , pp. 203-206
    • Bolton, S.1    Cleary, B.2    Walsh, J.3
  • 45
    • 72149097638 scopus 로고    scopus 로고
    • Continuation of metformin reduces early pregnancy loss in obese Pakistani women with polycystic ovarian syndrome
    • Nawaz FH, Rizvi J. Continuation of metformin reduces early pregnancy loss in obese Pakistani women with polycystic ovarian syndrome. Gynecol Obstet Invest 2010; 69: 184-9
    • (2010) Gynecol Obstet Invest , vol.69 , pp. 184-189
    • Nawaz, F.H.1    Rizvi, J.2


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