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Gideon, H.P., Phuah, J., Myers, A.J., Bryson, B.D., Rodgers, M.A., Coleman, M.T., Maiello, P., Rutledge, T., Marino, S., Fortune, S.M., et al. Variability in tuberculosis granuloma T cell responses exists, but a balance of pro- and anti-inflammatory cytokines is associated with sterilization. PLoS Pathog, 11, 2015, e1004603.
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39
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Bertolini, T.B., de Souza, A.I., Gembre, A.F., Pineros, A.R., Prado Rde, Q., Silva, J.S., Ramalho, L.N., Bonato, V.L., Genetic background affects the expansion of macrophage subsets in the lungs of Mycobacterium tuberculosis-infected hosts. Immunology 148 (2016), 102–113.
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40
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M2 macrophages or IL-33 treatment attenuate ongoing Mycobacterium tuberculosis infection
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Pineros, A.R., Campos, L.W., Fonseca, D.M., Bertolini, T.B., Gembre, A.F., Prado, R.Q., Alves-Filho, J.C., Ramos, S.G., Russo, M., Bonato, V.L., M2 macrophages or IL-33 treatment attenuate ongoing Mycobacterium tuberculosis infection. Sci Rep, 7, 2017, 41240.
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Pineros, A.R.1
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41
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aprABC: a Mycobacterium tuberculosis complex-specific locus that modulates pH-driven adaptation to the macrophage phagosome
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Abramovitch, R.B., Rohde, K.H., Hsu, F.F., Russell, D.G., aprABC: a Mycobacterium tuberculosis complex-specific locus that modulates pH-driven adaptation to the macrophage phagosome. Mol Microbiol 80 (2011), 678–694.
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42
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Functional genetic diversity among Mycobacterium tuberculosis complex clinical isolates: delineation of conserved core and lineage-specific transcriptomes during intracellular survival
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Homolka, S., Niemann, S., Russell, D.G., Rohde, K.H., Functional genetic diversity among Mycobacterium tuberculosis complex clinical isolates: delineation of conserved core and lineage-specific transcriptomes during intracellular survival. PLoS Pathog, 6, 2010, e1000988.
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Homolka, S.1
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43
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Mycobacterium tuberculosis invasion of macrophages: linking bacterial gene expression to environmental cues
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Rohde, K.H., Abramovitch, R.B., Russell, D.G., Mycobacterium tuberculosis invasion of macrophages: linking bacterial gene expression to environmental cues. Cell Host Microbe 2 (2007), 352–364.
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Rohde, K.H.1
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44
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Linking the transcriptional profiles and the physiological states of Mycobacterium tuberculosis during an extended intracellular infection
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Rohde, K.H., Veiga, D.F., Caldwell, S., Balazsi, G., Russell, D.G., Linking the transcriptional profiles and the physiological states of Mycobacterium tuberculosis during an extended intracellular infection. PLoS Pathog, 8, 2012, e1002769.
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45
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84907584291
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Exploitation of Mycobacterium tuberculosis reporter strains to probe the impact of vaccination at sites of infection
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This study was the first to utilize bacteria fitness reporters to relate bacteria fitness at site of infection with host immune response in naïve and vaccinated experimental infections.
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Sukumar, N., Tan, S., Aldridge, B.B., Russell, D.G., Exploitation of Mycobacterium tuberculosis reporter strains to probe the impact of vaccination at sites of infection. PLoS Pathog, 10, 2014, e1004394 This study was the first to utilize bacteria fitness reporters to relate bacteria fitness at site of infection with host immune response in naïve and vaccinated experimental infections.
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Sukumar, N.1
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46
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Mycobacterium tuberculosis responds to chloride and pH as synergistic cues to the immune status of its host cell
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Tan, S., Sukumar, N., Abramovitch, R.B., Parish, T., Russell, D.G., Mycobacterium tuberculosis responds to chloride and pH as synergistic cues to the immune status of its host cell. PLoS Pathog, 9, 2013, e1003282.
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Tan, S.1
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47
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Immune activation of the host cell induces drug tolerance in Mycobacterium tuberculosis both in vitro and in vivo
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This study demonstrated the functional linkage between the induction of drug tolerance and the immune activation status of the host phagocytes both in vitro and in vivo.
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Liu, Y., Tan, S., Huang, L., Abramovitch, R.B., Rohde, K.H., Zimmerman, M.D., Chen, C., Dartois, V., VanderVen, B.C., Russell, D.G., Immune activation of the host cell induces drug tolerance in Mycobacterium tuberculosis both in vitro and in vivo. J Exp Med 213 (2016), 809–825 This study demonstrated the functional linkage between the induction of drug tolerance and the immune activation status of the host phagocytes both in vitro and in vivo.
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Liu, Y.1
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48
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The minimal unit of infection: Mycobacterium tuberculosis in the macrophage
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VanderVen, B.C., Huang, L., Rohde, K.H., Russell, D.G., The minimal unit of infection: Mycobacterium tuberculosis in the macrophage. Microbiol Spectr, 2016, 4.
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Microbiol Spectr
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VanderVen, B.C.1
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49
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Mitochondria are the powerhouses of immunity
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Mills, E.L., Kelly, B., O'Neill, L.A.J., Mitochondria are the powerhouses of immunity. Nat Immunol 18 (2017), 488–498.
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Van den Bossche, J., O'Neill, L.A., Menon, D., Macrophage immunometabolism: where are we (going)?. Trends Immunol, 2017.
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Van den Bossche, J.1
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Infection with Mycobacterium tuberculosis induces the Warburg effect in mouse lungs
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Shi, L., Salamon, H., Eugenin, E.A., Pine, R., Cooper, A., Gennaro, M.L., Infection with Mycobacterium tuberculosis induces the Warburg effect in mouse lungs. Sci Rep, 5, 2015, 18176.
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Shi, L.1
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52
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Cutting edge: Mycobacterium tuberculosis induces aerobic glycolysis in human alveolar macrophages that is required for control of intracellular bacillary replication
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Gleeson, L.E., Sheedy, F.J., Palsson-McDermott, E.M., Triglia, D., O'Leary, S.M., O'Sullivan, M.P., O'Neill, L.A., Keane, J., Cutting edge: Mycobacterium tuberculosis induces aerobic glycolysis in human alveolar macrophages that is required for control of intracellular bacillary replication. J Immunol 196 (2016), 2444–2449.
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Gleeson, L.E.1
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53
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Intracellular Mycobacterium tuberculosis exploits host-derived fatty acids to limit metabolic stress
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Lee, W., VanderVen, B.C., Fahey, R.J., Russell, D.G., Intracellular Mycobacterium tuberculosis exploits host-derived fatty acids to limit metabolic stress. J Biol Chem 288 (2013), 6788–6800.
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54
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Foamy macrophages from tuberculous patients’ granulomas constitute a nutrient-rich reservoir for M. tuberculosis persistence
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Peyron, P., Vaubourgeix, J., Poquet, Y., Levillain, F., Botanch, C., Bardou, F., Daffe, M., Emile, J.F., Marchou, B., Cardona, P.J., et al. Foamy macrophages from tuberculous patients’ granulomas constitute a nutrient-rich reservoir for M. tuberculosis persistence. PLoS Pathog, 4, 2008, e1000204.
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Peyron, P.1
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55
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Foamy macrophages and the progression of the human tuberculosis granuloma
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Russell, D.G., Cardona, P.J., Kim, M.J., Allain, S., Altare, F., Foamy macrophages and the progression of the human tuberculosis granuloma. Nat Immunol 10 (2009), 943–948.
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56
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Novel inhibitors of cholesterol degradation in Mycobacterium tuberculosis reveal how the bacterium's metabolism is constrained by the intracellular environment
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This study details completion of a large empirical chemical screen against intracellular Mtb that identified bacterial cholesterol metabolism as critical to intracellular survival and growth. The result highlights the intimate association between host cell immune status and metabolism, and bacterial nutrient acquisition.
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VanderVen, B.C., Fahey, R.J., Lee, W., Liu, Y., Abramovitch, R.B., Memmott, C., Crowe, A.M., Eltis, L.D., Perola, E., Deininger, D.D., et al. Novel inhibitors of cholesterol degradation in Mycobacterium tuberculosis reveal how the bacterium's metabolism is constrained by the intracellular environment. PLoS Pathog, 11, 2015, e1004679 This study details completion of a large empirical chemical screen against intracellular Mtb that identified bacterial cholesterol metabolism as critical to intracellular survival and growth. The result highlights the intimate association between host cell immune status and metabolism, and bacterial nutrient acquisition.
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PLoS Pathog
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VanderVen, B.C.1
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57
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Mechanisms of triglyceride accumulation in activated macrophages
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Feingold, K.R., Shigenaga, J.K., Kazemi, M.R., McDonald, C.M., Patzek, S.M., Cross, A.S., Moser, A., Grunfeld, C., Mechanisms of triglyceride accumulation in activated macrophages. J Leukoc Biol 92 (2012), 829–839.
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Feingold, K.R.1
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Cross, A.S.6
Moser, A.7
Grunfeld, C.8
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