MicroRNA-183-5p Increases with Age in Bone-Derived Extracellular Vesicles, Suppresses Bone Marrow Stromal (Stem) Cell Proliferation, and Induces Stem Cell Senescence

Tissue Engineering - Part A

Volumn 23, Issue 21-22, 2017, Pages 1231-1240

  Davis, Colleen ^a   Dukes, Amy ^a   Drewry, Michelle ^a   Helwa, Inas ^a   Johnson, Maribeth H ^a   Isales, Carlos M ^a   Hill, William D ^a   Liu, Yutao ^a   Shi, Xingming ^a   Fulzele, Sadanand ^a   Hamrick, Mark W ^a  

^a MEDICAL COLLEGE OF GEORGIA   (United States)

Author keywords

bone; exosomes; miRNA; oxidative stress

Indexed keywords

BONE; CELL PROLIFERATION; CELL SIGNALING; CYTOLOGY; ENZYME ACTIVITY; MAMMALS; MOLECULAR BIOLOGY; OXIDATIVE STRESS; STEM CELLS;

BONE MARROW MICROENVIRONMENT; BONE MARROW STROMAL CELLS (BMSCS); CELL-CELL COMMUNICATIONS; EXOSOMES; INTERSTITIAL FLUIDS; MIRNA; MOLECULAR PATHWAYS; OSTEOGENIC DIFFERENTIATION;

RNA;

HEME OXYGENASE 1; MICRORNA; MICRORNA 183 5P; UNCLASSIFIED DRUG; MIRN183 MICRORNA, MOUSE;

AGE; AGED; ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; BONE CELL LINE; BONE MARROW STROMA CELL; CELL AGING; CELL DIFFERENTIATION; CELL ISOLATION; CELL PROLIFERATION; CLUSTER ANALYSIS; CONTROLLED STUDY; ENDOCYTOSIS; EXOSOME; IMMUNOGOLD LABELING; IN VIVO STUDY; INTERSTITIAL FLUID; MALE; MICROENVIRONMENT; MOUSE; NONHUMAN; OXIDATIVE STRESS; PRIORITY JOURNAL; PROTEIN EXPRESSION; AGING; ANIMAL; BONE; BONE DEVELOPMENT; BONE MINERALIZATION; C57BL MOUSE; CYTOLOGY; GENE EXPRESSION PROFILING; GENETIC TRANSFECTION; GENETICS; MESENCHYMAL STROMA CELL; METABOLISM; ULTRASTRUCTURE;

AGING; ANIMALS; BONE AND BONES; CALCIFICATION, PHYSIOLOGIC; CELL DIFFERENTIATION; CELL PROLIFERATION; CELLULAR SENESCENCE; ENDOCYTOSIS; EXTRACELLULAR VESICLES; GENE EXPRESSION PROFILING; HEME OXYGENASE-1; MESENCHYMAL STROMAL CELLS; MICE, INBRED C57BL; MICRORNAS; OSTEOGENESIS; OXIDATIVE STRESS; TRANSFECTION;

EID: 85027516950     PISSN: 19373341     EISSN: 1937335X     Source Type: Journal    
DOI: 10.1089/ten.tea.2016.0525     Document Type: Article

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