A bioanalytical HPLC method for coumestrol quantification in skin permeation tests followed by UPLC-QTOF/HDMS stability-indicating method for identification of degradation products

Journal of Chromatography B: Analytical Technologies in the Biomedical and Life Sciences

Volumn 1020, Issue , 2016, Pages 43-52

  Bianchi, Sara E ^a   Teixeira, Helder F ^a   Kaiser, Samuel ^a   Ortega, George G ^a   Schneider, Paulo Henrique ^a   Bassani, Valquiria L ^a  

^a FEDERAL UNIVERSITY OF RIO GRANDE DO SUL   (Brazil)

Author keywords

Bioanalytical method; Coumestrol; Skin permeation; Stability indicating method; UPLC QTOF HDMS; Validation

Indexed keywords

ALKALINITY; CHEMICAL ANALYSIS; CHROMATOGRAPHY; DEGRADATION; DRUG PRODUCTS; HYDROGELS; MASS SPECTROMETRY; PLANTS (BOTANY); STABILITY;

BIOANALYTICAL METHODS; COUMESTROL; SKIN PERMEATION; STABILITY INDICATING METHOD; UPLC-QTOF/HDMS; VALIDATION;

LIQUID CHROMATOGRAPHY;

COUMESTROL;

ALKALINITY; ANIMAL CELL; ARTICLE; COMPARATIVE STUDY; CONTROLLED STUDY; DERMIS; DRUG DEGRADATION; DRUG FORMULATION; DRUG STABILITY; DRUG STRUCTURE; EPIDERMIS; HIGH DEFINITION MASS SPECTROMETRY; LIMIT OF QUANTITATION; MASS SPECTROMETRY; NONHUMAN; OXIDATION; PIG; PRIORITY JOURNAL; QUADRUPOLE MASS SPECTROMETRY; SKIN PENETRATION; STRATUM CORNEUM; TIME OF FLIGHT MASS SPECTROMETRY; ULTRA PERFORMANCE LIQUID CHROMATOGRAPHY; ULTRAVIOLET C RADIATION; ANIMAL; CHEMISTRY; EAR; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; LIMIT OF DETECTION; PHYSIOLOGY; PROCEDURES; REPRODUCIBILITY; SKIN ABSORPTION; STATISTICAL MODEL; TANDEM MASS SPECTROMETRY;

ANIMALS; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; COUMESTROL; DRUG STABILITY; EAR; LIMIT OF DETECTION; LINEAR MODELS; REPRODUCIBILITY OF RESULTS; SKIN ABSORPTION; SWINE; TANDEM MASS SPECTROMETRY;

EID: 84962050753     PISSN: 15700232     EISSN: 1873376X     Source Type: Journal    
DOI: 10.1016/j.jchromb.2016.03.012     Document Type: Article

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