Hydroxychloroquine inhibits CD154 expression in CD4+ T lymphocytes of systemic lupus erythematosus through NFAT, but not STAT5, signaling

Arthritis Research and Therapy

Volumn 19, Issue 1, 2017, Pages

  Wu, Shu Fen ^a   Chang, Chia Bin ^a   Hsu, Jui Mei ^b   Lu, Ming Chi ^b,c   Lai, Ning Sheng ^b,c   Li, Chin ^a   Tung, Chien Hsueh ^a,b  

^a NATIONAL CHUNG CHENG UNIVERSITY   (Taiwan)

^b DALIN TZU CHI HOSPITAL   (Taiwan)

^c TZU CHI UNIVERSITY   (Taiwan)

Author keywords

CD154; Hydroxychloroquine; NFAT; STAT5; Systemic lupus erythematosus

Indexed keywords

CD40 LIGAND; HYDROXYCHLOROQUINE; INTERLEUKIN 15; IONOMYCIN; STAT5 PROTEIN; TRANSCRIPTION FACTOR NFAT; TRANSCRIPTION FACTOR NFATC1; TRANSCRIPTION FACTOR NFATC2; UNCLASSIFIED DRUG; ANTIRHEUMATIC AGENT;

ADULT; ARTICLE; CALCIUM CELL LEVEL; CALCIUM TRANSPORT; CD4+ T LYMPHOCYTE; CLINICAL ARTICLE; COHORT ANALYSIS; CONTROLLED STUDY; DISEASE SEVERITY; DRUG MEGADOSE; ENZYME ACTIVATION; ENZYME INHIBITION; FEMALE; HUMAN; HUMAN CELL; IN VITRO STUDY; MALE; PROTEIN EXPRESSION; PROTEIN PROTEIN INTERACTION; SIGNAL TRANSDUCTION; SLEDAI; SYSTEMIC LUPUS ERYTHEMATOSUS; T LYMPHOCYTE ACTIVATION; ANTAGONISTS AND INHIBITORS; BLOOD; CELL CULTURE; DRUG EFFECTS; JURKAT CELL LINE; METABOLISM; MIDDLE AGED; YOUNG ADULT;

ADULT; ANTIRHEUMATIC AGENTS; CD4-POSITIVE T-LYMPHOCYTES; CD40 LIGAND; CELLS, CULTURED; FEMALE; HUMANS; HYDROXYCHLOROQUINE; JURKAT CELLS; LUPUS ERYTHEMATOSUS, SYSTEMIC; MALE; MIDDLE AGED; NFATC TRANSCRIPTION FACTORS; SIGNAL TRANSDUCTION; STAT5 TRANSCRIPTION FACTOR; YOUNG ADULT;

EID: 85027151500     PISSN: 14786354     EISSN: 14786362     Source Type: Journal    
DOI: 10.1186/s13075-017-1393-y     Document Type: Article

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