메뉴 건너뛰기




Volumn 8, Issue 9, 2012, Pages 522-533

New insights into mechanisms of therapeutic effects of antimalarial agents in SLE

Author keywords

[No Author keywords available]

Indexed keywords

ALPHA INTERFERON; ANTIMALARIAL AGENT; CHLOROQUINE; HYDROXYCHLOROQUINE; HYDROXYCHLOROQUINE SULFATE; MATRIX METALLOPROTEINASE; MEPACRINE; PERILIPIN; PLACEBO; STEROID; TOLL LIKE RECEPTOR; TOLL LIKE RECEPTOR 2; TOLL LIKE RECEPTOR 3; TOLL LIKE RECEPTOR 4; TOLL LIKE RECEPTOR 7; TOLL LIKE RECEPTOR 9;

EID: 84866103485     PISSN: 17594790     EISSN: 17594804     Source Type: Journal    
DOI: 10.1038/nrrheum.2012.106     Document Type: Review
Times cited : (184)

References (107)
  • 1
    • 0029951023 scopus 로고    scopus 로고
    • The history of antimalarials
    • Wallace, D. J. The history of antimalarials. Lupus 5 (Suppl. 1), S2-S3 (1996 (Pubitemid 26196733)
    • (1996) Lupus , vol.5 , Issue.SUPPL. 1
    • Wallace, D.J.1
  • 2
    • 78651287426 scopus 로고    scopus 로고
    • DrugBank 3.0: A comprehensive resource for 'omics' research on drugs
    • Knox, C. et al. DrugBank 3.0: A comprehensive resource for 'omics' research on drugs. Nucleic Acids Res. 39, D1035-D1041 (2011
    • (2011) Nucleic Acids Res , vol.39
    • Knox, C.1
  • 3
    • 0028263366 scopus 로고
    • Pharmacokinetics and pharmacodynamics of hydroxychloroquine enantiomers in patients with rheumatoid arthritis receiving multiple doses of racemate
    • DOI 10.1002/chir.530060420
    • Tett, S. E., McLachlan, A. J., Cutler, D. J. & Day, R. O. Pharmacokinetics and pharmacodynamics of hydroxychloroquine enantiomers in patients with rheumatoid arthritis receiving multiple doses of racemate. Chirality 6, 355-359 (1994 (Pubitemid 24215102)
    • (1994) Chirality , vol.6 , Issue.4 , pp. 355-359
    • Tett, S.E.1    McLachlan, A.J.2    Cutler, D.J.3    Day, R.O.4
  • 4
    • 0029951024 scopus 로고    scopus 로고
    • Pharmacokinetics of hydroxychloroquine and chloroquine during treatment of rheumatic diseases
    • Furst, D. E. Pharmacokinetics of hydroxychloroquine and chloroquine during treatment of rheumatic diseases. Lupus 5 (Suppl. 1), S11-S15 (1996 (Pubitemid 26196735)
    • (1996) Lupus , vol.5 , Issue.SUPPL. 1
    • Furst, D.E.1
  • 5
    • 1942516133 scopus 로고
    • Comparison of effects of two antimalarial agents, hydroxychloroquine sulfate and chloroquine phosphate, in patients with rheumatoid arthitis
    • Scherbel, A. L., Schuchter, S. L. & Harrison, J. W. Comparison of effects of two antimalarial agents, hydroxychloroquine sulfate and chloroquine phosphate, in patients with rheumatoid arthitis. Cleve. Clin. Q. 24, 98-104 (1957
    • (1957) Cleve. Clin. Q. , vol.24 , pp. 98-104
    • Scherbel, A.L.1    Schuchter, S.L.2    Harrison, J.W.3
  • 6
    • 0032515813 scopus 로고    scopus 로고
    • Hydroxychloroquine and retinal safety
    • Block, J. A. Hydroxychloroquine and retinal safety. Lancet 351, 771 (1998 (Pubitemid 28112335)
    • (1998) Lancet , vol.351 , Issue.9105 , pp. 771
    • Block, J.A.1
  • 9
    • 0034984947 scopus 로고    scopus 로고
    • Antimalarials - The 'real' advance in lupus
    • DOI 10.1191/096120301678646092
    • Wallace, D. J. Antimalarials - the 'real' advance in lupus. Lupus 10, 385-387 (2001 (Pubitemid 32578610)
    • (2001) Lupus , vol.10 , Issue.6 , pp. 385-387
    • Wallace, D.J.1
  • 10
    • 0027434905 scopus 로고
    • Mechanism of action of hydroxychloroquine as an antirheumatic drug
    • Fox, R. I. Mechanism of action of hydroxychloroquine as an antirheumatic drug. Semin. Arthritis Rheum. 23, 82-91 (1993
    • (1993) Semin. Arthritis Rheum. , vol.23 , pp. 82-91
    • Fox, R.I.1
  • 11
    • 0028302865 scopus 로고
    • The effect of hydroxychloroquine therapy on serum levels of immunoregulatory molecules in patients with systemic lupus erythematosus [6]
    • Wallace, D. J., Linker-Israeli, M., Hyun, S., Klinenberg, J. R. & Stecher, V. The effect of hydroxychloroquine therapy on serum levels of immunoregulatory molecules in patients with systemic lupus erythematosus. J. Rheumatol. 21, 375-376 (1994 (Pubitemid 24078865)
    • (1994) Journal of Rheumatology , vol.21 , Issue.2 , pp. 375-376
    • Wallace, D.J.1    Linker-Israeli, M.2    Hyun, S.3    Klinenberg, J.R.4    Stecher, V.5
  • 12
    • 33744823535 scopus 로고    scopus 로고
    • Chloroquine treatment influences proinflammatory cytokine levels in systemic lupus erythematosus patients
    • DOI 10.1191/0961203306lu2299oa
    • Wozniacka, A., Lesiak, A., Narbutt, J., McCauliffe, D. P. & Sysa-Jedrzejowska, A. Chloroquine treatment influences proinflammatory cytokine levels in systemic lupus erythematosus patients. Lupus 15, 268-275 (2006 (Pubitemid 43828802)
    • (2006) Lupus , vol.15 , Issue.5 , pp. 268-275
    • Wozniacka, A.1    Lesiak, A.2    Narbutt, J.3    McCauliffe, D.P.4    Sysa-Jedrzejowska, A.5
  • 13
    • 33745634132 scopus 로고    scopus 로고
    • Chloroquine inhibits production of TNF-α, IL1β and IL6 from lipopolysaccharide-stimulated human monocytes/macrophages by different modes
    • Jang, C. H., Choi, J. H., Byun, M. S. & Jue, D. M. Chloroquine inhibits production of TNF-α, IL1β and IL6 from lipopolysaccharide- stimulated human monocytes/macrophages by different modes. Rheumatology (Oxford) 45, 703-710 (2006
    • (2006) Rheumatology (Oxford) , vol.45 , pp. 703-710
    • Jang, C.H.1    Choi, J.H.2    Byun, M.S.3    Jue, D.M.4
  • 14
    • 54249137345 scopus 로고    scopus 로고
    • The influence of antimalarial treatment on IL1β, IL6 and TNF-α mRNA expression on UVB-irradiated skin in systemic lupus erythematosus
    • Wozniacka, A. et al. The influence of antimalarial treatment on IL1β, IL6 and TNF-α mRNA expression on UVB-irradiated skin in systemic lupus erythematosus. Br. J. Dermatol. 159, 1124-1130 (2008
    • (2008) Br. J. Dermatol. , vol.159 , pp. 1124-1130
    • Wozniacka, A.1
  • 16
    • 0019797317 scopus 로고
    • Serum deoxyribonuclease I and clinical activity in systemic lupus erythematosus
    • DOI 10.1007/BF00541153
    • Chitrabamrung, S., Rubin, R. L. & Tan, E. M. Serum deoxyribonuclease I and clinical activity in systemic lupus erythematosus. Rheumatol. Int. 1, 55-60 (1981 (Pubitemid 11038705)
    • (1981) Rheumatology International , vol.1 , Issue.2 , pp. 55-60
    • Chitrabamrung, S.1    Rubin, R.L.2    Tan, E.M.3
  • 17
    • 33750369226 scopus 로고    scopus 로고
    • Toll-like receptors in systemic autoimmune disease
    • DOI 10.1038/nri1957, PII NRI1957
    • Marshak-Rothstein, A. Toll-like receptors in systemic autoimmune disease. Nat. Rev. Immunol. 6, 823-835 (2006 (Pubitemid 44631651)
    • (2006) Nature Reviews Immunology , vol.6 , Issue.11 , pp. 823-835
    • Marshak-Rothstein, A.1
  • 18
    • 77949940198 scopus 로고    scopus 로고
    • Intracellular Toll-like receptors
    • Blasius, A. L. & Beutler, B. Intracellular Toll-like receptors. Immunity 32, 305-315 (2010
    • (2010) Immunity , vol.32 , pp. 305-315
    • Blasius, A.L.1    Beutler, B.2
  • 19
    • 0032950459 scopus 로고    scopus 로고
    • Patients with systemic lupus erythematosus (SLE) have a circulating inducer of interferon-alpha (IFN-α) production acting on leucocytes resembling immature dendritic cells
    • DOI 10.1046/j.1365-2249.1999.00772.x
    • Vallin, H., Blomberg, S., Alm, G. V., Cederblad, B. & Ronnblom, L. Patients with systemic lupus erythematosus (SLE) have a circulating inducer of interferon-α (IFN-α) production acting on leucocytes resembling immature dendritic cells. Clin. Exp. Immunol. 115, 196-202 (1999 (Pubitemid 29030385)
    • (1999) Clinical and Experimental Immunology , vol.115 , Issue.1 , pp. 196-202
    • Vallin, H.1    Blomberg, S.2    Alm, G.V.3    Cederblad, B.4    Ronnblom, L.5
  • 20
    • 0036927108 scopus 로고    scopus 로고
    • The natural interferon-α producing cells in systemic lupus erythematosus
    • DOI 10.1016/S0198-8859(02)00757-7, PII S0198885902007577
    • Ronnblom, L. & Alm, G. V. The natural interferon-α producing cells in systemic lupus erythematosus. Hum. Immunol. 63, 1181-1193 (2002 (Pubitemid 36025993)
    • (2002) Human Immunology , vol.63 , Issue.12 , pp. 1181-1193
    • Ronnblom, L.1    Alm, G.V.2
  • 21
    • 79952476762 scopus 로고    scopus 로고
    • Netting neutrophils are major inducers of type I IFN production in pediatric systemic lupus erythematosus
    • 73ra20.
    • Garcia-Romo, G. S. et al. Netting neutrophils are major inducers of type I IFN production in pediatric systemic lupus erythematosus. Sci. Transl. Med. 3, 73ra20. (2011
    • Sci. Transl. Med. , vol.3 , pp. 2011
    • Garcia-Romo, G.S.1
  • 22
    • 0023318626 scopus 로고
    • Non-methylated CpG-rich islands at the human α-globin locus: Implications for evolution of the α-globin pseudogene
    • Bird, A. P., Taggart, M. H., Nicholls, R. D. & Higgs, D. R. Non-methylated CpG-rich islands at the human α-globin locus: Implications for evolution of the α-globin pseudogene. Embo J. 6, 999-1004 (1987
    • (1987) Embo J , vol.6 , pp. 999-1004
    • Bird, A.P.1    Taggart, M.H.2    Nicholls, R.D.3    Higgs, D.R.4
  • 23
    • 2442450672 scopus 로고    scopus 로고
    • Direct Evidence that Toll-like Receptor 9 (TLR9) Functionally Binds Plasmid DNA by Specific Cytosine-phosphate-guanine Motif Recognition
    • DOI 10.1074/jbc.M313406200
    • Cornelie, S. et al. Direct evidence that Toll-like receptor 9 (TLR9) functionally binds plasmid DNA by specific cytosine-phosphate-guanine motif recognition. J. Biol. Chem. 279, 15124-15129 (2004 (Pubitemid 38618907)
    • (2004) Journal of Biological Chemistry , vol.279 , Issue.15 , pp. 15124-15129
    • Cornelie, S.1    Hoebeke, J.2    Schacht, A.-M.3    Bertin, B.4    Vicogne, J.5    Capron, M.6    Riveau, G.7
  • 25
    • 0031936182 scopus 로고    scopus 로고
    • Antagonism of immunostimulatory CpG-oligodeoxynucleotides by quinacrine, chloroquine, and structurally related compounds
    • Macfarlane, D. E. & Manzel, L. Antagonism of immunostimulatory CpG-oligodeoxynucleotides by quinacrine, chloroquine, and structurally related compounds. J. Immunol. 160, 1122-1131 (1998 (Pubitemid 28093406)
    • (1998) Journal of Immunology , vol.160 , Issue.3 , pp. 1122-1131
    • Macfarlane, D.E.1    Manzel, L.2
  • 28
    • 57349191215 scopus 로고    scopus 로고
    • The ectodomain of Toll-like receptor 9 is cleaved to generate a functional receptor
    • Ewald, S. E. et al. The ectodomain of Toll-like receptor 9 is cleaved to generate a functional receptor. Nature 456, 658-662 (2008
    • (2008) Nature , vol.456 , pp. 658-662
    • Ewald, S.E.1
  • 29
    • 79955046267 scopus 로고    scopus 로고
    • Mechanism of endosomal TLR inhibition by antimalarial drugs and imidazoquinolines
    • Kuznik, A. et al. Mechanism of endosomal TLR inhibition by antimalarial drugs and imidazoquinolines. J. Immunol. 186, 4794-4804 (2011
    • (2011) J. Immunol. , vol.186 , pp. 4794-4804
    • Kuznik, A.1
  • 30
    • 0025139120 scopus 로고
    • Binding of antibodies to the extractable nuclear antigens SS-A/Ro and SS-B/La is induced on the surface of human keratinocytes by ultraviolet light (UVL): implications for the pathogenesis of photosensitive cutaneous lupus
    • Furukawa, F., Kashihara-Sawami, M., Lyons, M. B. & Norris, D. A. Binding of antibodies to the extractable nuclear antigens SSA/Ro and SSB/La is induced on the surface of human keratinocytes by ultraviolet light (UVL): Implications for the pathogenesis of photosensitive cutaneous lupus. J. Invest. Dermatol. 94, 77-85 (1990 (Pubitemid 20046045)
    • (1990) Journal of Investigative Dermatology , vol.94 , Issue.1 , pp. 77-85
    • Furukawa, F.1    Kashihara-Sawami, M.2    Lyons, M.B.3    Norris, D.A.4
  • 31
    • 0008732528 scopus 로고
    • Absorption of antimalarial drugs in human skin; spectroscopic and chemical analysis in epidermis and corium
    • Shaffer, B., Cahn, M. M. & Levy, E. J. Absorption of antimalarial drugs in human skin; spectroscopic and chemical analysis in epidermis and corium. J. Invest. Dermatol. 30, 341-345 (1958
    • (1958) J. Invest. Dermatol. , vol.30 , pp. 341-345
    • Shaffer, B.1    Cahn, M.M.2    Levy, E.J.3
  • 32
    • 0031920435 scopus 로고    scopus 로고
    • 4-Aminoquinoline antimalarials enhance UV-B induced c-jun transcriptional activation
    • DOI 10.1191/096120398678919912
    • Nguyen, T. Q., Capra, J. D. & Sontheimer, R. D. 4aminoquinoline antimalarials enhance UVB induced cJun transcriptional activation. Lupus 7, 148-153 (1998 (Pubitemid 28190677)
    • (1998) Lupus , vol.7 , Issue.3 , pp. 148-153
    • Nguyen, T.Q.1    Capra, J.D.2    Sontheimer, R.D.3
  • 33
    • 0025131483 scopus 로고
    • Cholesterol-lowering effect of hydroxychloroquine in patients with rheumatic disease: Reversal of deleterious effects of steroids on lipids
    • DOI 10.1016/0002-9343(90)90345-E
    • Wallace, D. J., Metzger, A. L., Stecher, V. J., Turnbull, B. A. & Kern, P. A. Cholesterol-lowering effect of hydroxychloroquine in patients with rheumatic disease: reversal of deleterious effects of steroids on lipids. Am. J. Med. 89, 322-326 (1990 (Pubitemid 20323259)
    • (1990) American Journal of Medicine , vol.89 , Issue.3 , pp. 322-326
    • Wallace, D.J.1    Metzger, A.L.2    Stecher, V.J.3    Turnbull, B.A.4    Kern, P.A.5
  • 34
    • 0016703412 scopus 로고
    • Inhibition of proteolytic degradation of low density lipoprotein in human fibroblasts by chloroquine, concanavalin A, and Triton WR 1339
    • Goldstein, J. L., Brunschede, G. Y. & Brown, M. S. Inhibition of proteolytic degradation of low density lipoprotein in human fibroblasts by chloroquine, concanavalin A, and Triton WR 1339. J. Biol. Chem. 250, 7854-7862 (1975
    • (1975) J. Biol. Chem. , vol.250 , pp. 7854-7862
    • Goldstein, J.L.1    Brunschede, G.Y.2    Brown, M.S.3
  • 35
    • 0030002912 scopus 로고    scopus 로고
    • Cholesterol homeostasis is modulated by amphiphiles at transcriptional and post-transcriptional loci
    • Lange, Y., Duan, H. & Mazzone, T. Cholesterol homeostasis is modulated by amphiphiles at transcriptional and post-transcriptional loci. J. Lipid Res. 37, 534-539 (1996 (Pubitemid 26134359)
    • (1996) Journal of Lipid Research , vol.37 , Issue.3 , pp. 534-539
    • Lange, Y.1    Duan, H.2    Mazzone, T.3
  • 36
    • 77957570091 scopus 로고    scopus 로고
    • A Toll-like receptor 9mediated pathway stimulates perilipin 3 (TIP47) expression and induces lipid accumulation in macrophages
    • Gu, J. Q. et al. A Toll-like receptor 9mediated pathway stimulates perilipin 3 (TIP47) expression and induces lipid accumulation in macrophages. Am. J. Physiol. Endocrinol. Metab. 299, E593-E600 (2010
    • (2010) Am. J. Physiol. Endocrinol. Metab. , vol.299
    • Gu, J.Q.1
  • 37
    • 24144502438 scopus 로고    scopus 로고
    • Paying the price for pathogen protection: Toll receptors in atherogenesis
    • DOI 10.1194/jlr.R400015-JLR200
    • Tobias, P. & Curtiss, L. K. Thematic review series: The immune system and atherogenesis. Paying the price for pathogen protection: Toll receptors in atherogenesis. J. Lipid Res. 46, 404-411 (2005 (Pubitemid 43109775)
    • (2005) Journal of Lipid Research , vol.46 , Issue.3 , pp. 404-411
    • Tobias, P.1    Curtiss, L.K.2
  • 38
    • 66449096511 scopus 로고    scopus 로고
    • Systematic administration of chloroquine in discoid lupus erythematosus reduces skin lesions via inhibition of angiogenesis
    • Lesiak, A. et al. Systematic administration of chloroquine in discoid lupus erythematosus reduces skin lesions via inhibition of angiogenesis. Clin. Exp. Dermatol. 34, 570-575 (2009
    • (2009) Clin. Exp. Dermatol. , vol.34 , pp. 570-575
    • Lesiak, A.1
  • 40
    • 0036123462 scopus 로고    scopus 로고
    • Hydroxychloroquine reverses platelet activation induced by human IgG antiphospholipid antibodies
    • Espinola, R. G., Pierangeli, S. S., Gharavi, A. E. & Harris, E. N. Hydroxychloroquine reverses platelet activation induced by human IgG antiphospholipid antibodies. Thromb. Haemost. 87, 518-522 (2002 (Pubitemid 34232495)
    • (2002) Thrombosis and Haemostasis , vol.87 , Issue.3 , pp. 518-522
    • Espinola, R.G.1    Pierangeli, S.S.2    Ghara, A.E.3    Harris, E.N.4
  • 41
    • 77950435764 scopus 로고    scopus 로고
    • Hydroxychloroquine protects the annexin A5 anticoagulant shield from disruption by antiphospholipid antibodies: Evidence for a novel effect for an old antimalarial drug
    • Rand, J. H. et al. Hydroxychloroquine protects the annexin A5 anticoagulant shield from disruption by antiphospholipid antibodies: Evidence for a novel effect for an old antimalarial drug. Blood 115, 2292-2299 (2010
    • (2010) Blood , vol.115 , pp. 2292-2299
    • Rand, J.H.1
  • 42
    • 0025847582 scopus 로고
    • Matrix metalloproteinases and their inhibitors in connective tissue remodeling
    • Woessner, J. F. Jr. Matrix metalloproteinases and their inhibitors in connective tissue remodeling. Faseb J. 5, 2145-2154 (1991 (Pubitemid 21905847)
    • (1991) FASEB Journal , vol.5 , Issue.8 , pp. 2145-2154
    • Woessner Jr., J.F.1
  • 43
    • 33644665938 scopus 로고    scopus 로고
    • 2-independent mechanism
    • Stuhlmeier, K. M. & Pollaschek, C. Quinacrine but not chloroquine inhibits PMA induced upregulation of matrix metalloproteinases in leukocytes: quinacrine acts at the transcriptional level through a PLA2-independent mechanism. J. Rheumatol. 33, 472-480 (2006 (Pubitemid 43334567)
    • (2006) Journal of Rheumatology , vol.33 , Issue.3 , pp. 472-480
    • Stuhlmeier, K.M.1    Pollaschek, C.2
  • 44
    • 77951209377 scopus 로고    scopus 로고
    • Effect of chloroquine phosphate treatment on serum MMP9 and TIMP1 levels in patients with systemic lupus erythematosus
    • Lesiak, A. et al. Effect of chloroquine phosphate treatment on serum MMP9 and TIMP1 levels in patients with systemic lupus erythematosus. Lupus 19, 683-688 (2010
    • (2010) Lupus , vol.19 , pp. 683-688
    • Lesiak, A.1
  • 46
    • 0343703427 scopus 로고    scopus 로고
    • The antimalarials quinacrine and chloroquine induce weak lysosomal storage of sulphated glycosaminoglycans in cell culture and in vivo
    • DOI 10.1016/0300-483X(96)03319-7
    • Lullmann-Rauch, R., Pods, R. & von Witzendorff, B. The antimalarials quinacrine and chloroquine induce weak lysosomal storage of sulphated glycosaminoglycans in cell culture and in vivo. Toxicology 110, 27-37 (1996 (Pubitemid 26168361)
    • (1996) Toxicology , vol.110 , Issue.1-3 , pp. 27-37
    • Lullmann-Rauch, R.1    Pods, R.2    Von Witzendorff, B.3
  • 47
    • 33645715993 scopus 로고    scopus 로고
    • The reduction of serum Blymphocyte activating factor levels following quinacrine add-on therapy in systemic lupus erythematosus
    • Toubi, E. et al. The reduction of serum Blymphocyte activating factor levels following quinacrine add-on therapy in systemic lupus erythematosus. Scand. J. Immunol. 63, 299-303 (2006
    • (2006) Scand. J. Immunol. , vol.63 , pp. 299-303
    • Toubi, E.1
  • 48
    • 79955799029 scopus 로고    scopus 로고
    • Beyond DNA binding - A review of the potential mechanisms mediating quinacrine's therapeutic activities in parasitic infections, inflammation, and cancers
    • Ehsanian, R., Van Waes, C. & Feller, S. M. Beyond DNA binding - a review of the potential mechanisms mediating quinacrine's therapeutic activities in parasitic infections, inflammation, and cancers. Cell Commun. Signal. 9, 13 (2011
    • Cell Commun. Signal. , vol.9 , Issue.13 , pp. 2011
    • Ehsanian, R.1    Van Waes, C.2    Feller, S.M.3
  • 49
    • 0026074414 scopus 로고
    • A randomized study of the effect of withdrawing hydroxychloroquine sulfate in systemic lupus erythematosus
    • [No Authors Listed] The Canadian Hydroxychloroquine Study Group
    • [No authors listed] A randomized study of the effect of withdrawing hydroxychloroquine sulfate in systemic lupus erythematosus. The Canadian Hydroxychloroquine Study Group. N. Engl. J. Med. 324, 150-154 (1991
    • (1991) N. Engl. J. Med. , vol.324 , pp. 150-154
  • 50
    • 0036309793 scopus 로고    scopus 로고
    • Protective effect of hydroxychloroquine in systemic lupus erythematosus. Prospective long-term study of an Israeli cohort
    • DOI 10.1191/0961203302lu203ra
    • Molad, Y. et al. Protective effect of hydroxychloroquine in systemic lupus erythematosus. Prospective long-term study of an Israeli cohort. Lupus 11, 356-361 (2002 (Pubitemid 34760633)
    • (2002) Lupus , vol.11 , Issue.6 , pp. 356-361
    • Molad, Y.1    Gorshtein, A.2    Wysenbeek, A.J.3    Guedj, D.4    Majadla, R.5    Weinberger, A.6    Amit-Vazina, M.7
  • 55
    • 77649103505 scopus 로고    scopus 로고
    • Antimalarial treatment may have a time-dependent effect on lupus survival: Data from a multinational Latin American inception cohort
    • Shinjo, S. K. et al. Antimalarial treatment may have a time-dependent effect on lupus survival: Data from a multinational Latin American inception cohort. Arthritis Rheum. 62, 855-862 (2010
    • (2010) Arthritis Rheum. , vol.62 , pp. 855-862
    • Shinjo, S.K.1
  • 56
    • 77649222330 scopus 로고    scopus 로고
    • Possible protective effect of hydroxychloroquine on delaying the occurrence of integument damage in lupus: LXXI, data from a multiethnic cohort
    • Pons-Estel, G. J. et al. Possible protective effect of hydroxychloroquine on delaying the occurrence of integument damage in lupus: LXXI, data from a multiethnic cohort. Arthritis Care Res. (Hoboken) 62, 393-400 (2010
    • (2010) Arthritis Care Res. (Hoboken) , vol.62 , pp. 393-400
    • Pons-Estel, G.J.1
  • 57
    • 0023515407 scopus 로고
    • Does hydroxychloroquine sulfate prevent clot formation in systemic lupus erythematosus?
    • Wallace, D. J. Does hydroxychloroquine sulfate prevent clot formation in systemic lupus erythematosus? Arthritis Rheum. 30, 1435-1436 (1987
    • (1987) Arthritis Rheum , vol.30 , pp. 1435-1436
    • Wallace, D.J.1
  • 60
    • 58849159669 scopus 로고    scopus 로고
    • Risk and protective factors for thrombosis in systemic lupus erythematosus: Results from a large, multi-ethnic cohort
    • Kaiser, R., Cleveland, C. M. & Criswell, L. A. Risk and protective factors for thrombosis in systemic lupus erythematosus: results from a large, multi-ethnic cohort. Ann. Rheum. Dis. 68, 238-241 (2009
    • (2009) Ann. Rheum. Dis. , vol.68 , pp. 238-241
    • Kaiser, R.1    Cleveland, C.M.2    Criswell, L.A.3
  • 61
    • 58349097555 scopus 로고    scopus 로고
    • Risk factors for thrombosis and primary thrombosis prevention in patients with systemic lupus erythematosus with or without antiphospholipid antibodies
    • Tektonidou, M. G., Laskari, K., Panagiotakos, D. B. & Moutsopoulos, H. M. Risk factors for thrombosis and primary thrombosis prevention in patients with systemic lupus erythematosus with or without antiphospholipid antibodies. Arthritis Rheum. 61, 29-36 (2009
    • (2009) Arthritis Rheum , vol.61 , pp. 29-36
    • Tektonidou, M.G.1    Laskari, K.2    Panagiotakos, D.B.3    Moutsopoulos, H.M.4
  • 62
    • 77649142208 scopus 로고    scopus 로고
    • The protective effect of antimalarial drugs on thrombovascular events in systemic lupus erythematosus
    • Jung, H. et al. The protective effect of antimalarial drugs on thrombovascular events in systemic lupus erythematosus. Arthritis Rheum. 62, 863-868 (2010
    • (2010) Arthritis Rheum , vol.62 , pp. 863-868
    • Jung, H.1
  • 63
    • 0028300241 scopus 로고
    • Effect of prednisone and hydroxychloroquine on coronary artery disease risk factors in systemic lupus erythematosus: A longitudinal data analysis
    • DOI 10.1016/0002-9343(94)90151-1
    • Petri, M., Lakatta, C., Magder, L. & Goldman, D. Effect of prednisone and hydroxychloroquine on coronary artery disease risk factors in systemic lupus erythematosus: A longitudinal data analysis. Am. J. Med. 96, 254-259 (1994 (Pubitemid 24099225)
    • (1994) American Journal of Medicine , vol.96 , Issue.3 , pp. 254-259
    • Petri, M.1    Lakatta, C.2    Magder, L.3    Goldman, D.4
  • 64
    • 0031018699 scopus 로고    scopus 로고
    • Hydroxychloroquine effects on lipoprotein profiles (the HELP trial): A double-blind, randomized, placebo-controlled, pilot study in patients with systemic lupus erythematosus
    • Kavanaugh, A., Adams-Huet, B., Jain, R., Denke, M. & McFarlin, J. Hydroxychloroquine effects on lipoprotein profiles (the HELP trial): A double-blind, randomized, placebo-controlled, pilot study in patients with systemic lupus erythematosus. J. Clin. Rheumatol. 3, 3-8 (1997 (Pubitemid 27087947)
    • (1997) Journal of Clinical Rheumatology , vol.3 , Issue.1 , pp. 3-8
    • Kavanaugh, A.1    Adams-Huet, B.2    Jain, R.3    Denke, M.4    McFarlin, J.5
  • 65
    • 0035078958 scopus 로고    scopus 로고
    • Longterm beneficial effect of chloroquine diphosphate on lipoprotein profile in lupus patients with and without steroid therapy
    • Borba, E. F. & Bonfa, E. Longterm beneficial effect of chloroquine diphosphate on lipoprotein profile in lupus patients with and without steroid therapy. J. Rheumatol. 28, 780-785 (2001 (Pubitemid 32246946)
    • (2001) Journal of Rheumatology , vol.28 , Issue.4 , pp. 780-785
    • Borba, E.F.1    Bonfa, E.2
  • 66
    • 0029990745 scopus 로고    scopus 로고
    • Hydroxychloroquine use in the Baltimore Lupus Cohort: Effects on lipids, glucose and thrombosis
    • Petri, M. Hydroxychloroquine use in the Baltimore Lupus Cohort: Effects on lipids, glucose and thrombosis. Lupus 5 (Suppl. 1), S16-S22 (1996 (Pubitemid 26196736)
    • (1996) Lupus , vol.5 , Issue.SUPPL. 1
    • Petri, M.1
  • 67
    • 66749098319 scopus 로고    scopus 로고
    • Protective effect of hydroxychloroquine on renal damage in patients with lupus nephritis: LXV, data from a multiethnic US cohort
    • Pons-Estel, G. J. et al. Protective effect of hydroxychloroquine on renal damage in patients with lupus nephritis: LXV, data from a multiethnic US cohort. Arthritis Rheum. 61, 830-839 (2009
    • (2009) Arthritis Rheum , vol.61 , pp. 830-839
    • Pons-Estel, G.J.1
  • 68
    • 84863820014 scopus 로고    scopus 로고
    • Anti-malarials exert a protective effect while Mestizo patients are at increased risk of developing SLE renal disease: Data from a Latin-American cohort
    • Pons-Estel, G. J. et al. Anti-malarials exert a protective effect while Mestizo patients are at increased risk of developing SLE renal disease: Data from a Latin-American cohort. Rheumatology (Oxford) http://dx.doi.org/10.1093/ rheumatology/ker514.
    • Rheumatology (Oxford)
    • Pons-Estel, G.J.1
  • 69
    • 73349136001 scopus 로고    scopus 로고
    • Predictors of major infections in systemic lupus erythematosus
    • Ruiz-Irastorza, G. et al. Predictors of major infections in systemic lupus erythematosus. Arthritis Res. Ther. 11, R109 (2009
    • (2009) Arthritis Res. Ther. , vol.11
    • Ruiz-Irastorza, G.1
  • 70
    • 73449120372 scopus 로고    scopus 로고
    • Clinical efficacy and side effects of antimalarials in systemic lupus erythematosus: A systematic review
    • Ruiz-Irastorza, G., Ramos-Casals, M., Brito-Zeron, P. & Khamashta, M. A. Clinical efficacy and side effects of antimalarials in systemic lupus erythematosus: A systematic review. Ann. Rheum. Dis. 69, 20-28 (2010
    • (2010) Ann. Rheum. Dis. , vol.69 , pp. 20-28
    • Ruiz-Irastorza, G.1    Ramos-Casals, M.2    Brito-Zeron, P.3    Khamashta, M.A.4
  • 71
    • 77649209443 scopus 로고    scopus 로고
    • Hydroxychloroquine treatment in a community-based cohort of patients with systemic lupus erythematosus
    • Schmajuk, G., Yazdany, J., Trupin, L. & Yelin, E. Hydroxychloroquine treatment in a community-based cohort of patients with systemic lupus erythematosus. Arthritis Care Res. (Hoboken) 62, 386-392 (2010
    • (2010) Arthritis Care Res. (Hoboken) , vol.62 , pp. 386-392
    • Schmajuk, G.1    Yazdany, J.2    Trupin, L.3    Yelin, E.4
  • 72
    • 0026450808 scopus 로고
    • Treatment of cutaneous lupus erythematosus with acitretin and hydroxychloroquine
    • Ruzicka, T., Sommerburg, C., Goerz, G., Kind, P. & Mensing, H. Treatment of cutaneous lupus erythematosus with acitretin and hydroxychloroquine. Br. J. Dermatol. 127, 513-518 (1992
    • (1992) Br. J. Dermatol. , vol.127 , pp. 513-518
    • Ruzicka, T.1    Sommerburg, C.2    Goerz, G.3    Kind, P.4    Mensing, H.5
  • 73
    • 67049088535 scopus 로고    scopus 로고
    • Treatment of lupus skin involvement with quinacrine and hydroxychloroquine
    • Cavazzana, I. et al. Treatment of lupus skin involvement with quinacrine and hydroxychloroquine. Lupus 18, 735-739 (2009
    • (2009) Lupus , vol.18 , pp. 735-739
    • Cavazzana, I.1
  • 74
    • 81855190663 scopus 로고    scopus 로고
    • Response to antimalarial agents in cutaneous lupus erythematosus: A prospective analysis
    • Chang, A. Y. et al. Response to antimalarial agents in cutaneous lupus erythematosus: A prospective analysis. Arch. Dermatol. 147, 1261-1267 (2011
    • (2011) Arch. Dermatol. , vol.147 , pp. 1261-1267
    • Chang, A.Y.1
  • 75
    • 0031758140 scopus 로고    scopus 로고
    • Smoking interferes with efficacy of antimalarial therapy in cutaneous lupus
    • Rahman, P., Gladman, D. D. & Urowitz, M. B. Smoking interferes with efficacy of antimalarial therapy in cutaneous lupus. J. Rheumatol. 25, 1716-1719 (1998 (Pubitemid 28439264)
    • (1998) Journal of Rheumatology , vol.25 , Issue.9 , pp. 1716-1719
    • Rahman, P.1    Gladman, D.D.2    Urowitz, M.B.3
  • 76
    • 0034081444 scopus 로고    scopus 로고
    • Patients with cutaneous lupus erythematosus who smoke are less responsive to antimalarial treatment
    • Jewell, M. L. & McCauliffe, D. P. Patients with cutaneous lupus erythematosus who smoke are less responsive to antimalarial treatment. J. Am. Acad. Dermatol. 42, 983-987 (2000 (Pubitemid 30368665)
    • (2000) Journal of the American Academy of Dermatology , vol.42 , Issue.6 , pp. 983-987
    • Jewell, M.L.1    McCauliffe, D.E.2
  • 77
    • 62649110780 scopus 로고    scopus 로고
    • Lupus erythematosus tumidus: Response to antimalarial treatment in 36 patients with emphasis on smoking
    • Kreuter, A. et al. Lupus erythematosus tumidus: response to antimalarial treatment in 36 patients with emphasis on smoking. Arch. Dermatol. 145, 244-248 (2009
    • (2009) Arch. Dermatol. , vol.145 , pp. 244-248
    • Kreuter, A.1
  • 80
    • 0033773688 scopus 로고    scopus 로고
    • Balance of matrix metalloprotease 9 and tissue inhibitor of metalloprotease1 from alveolar macrophages in cigarette smokers regulation by interleukin 10
    • Lim, S. et al. Balance of matrix metalloprotease9 and tissue inhibitor of metalloprotease1 from alveolar macrophages in cigarette smokers. Regulation by interleukin10. Am. J. Respir. Crit. Care Med. 162, 1355-1360 (2000
    • (2000) Am. J. Respir. Crit. Care Med. , Issue.162 , pp. 1355-1360
    • Lim, S.1
  • 81
    • 0036570082 scopus 로고    scopus 로고
    • Relation between markers of systemic vascular inflammation and smoking in women
    • DOI 10.1016/S0002-9149(02)02284-1, PII S0002914902022841
    • Bermudez, E. A., Rifai, N., Buring, J. E., Manson, J. E. & Ridker, P. M. Relation between markers of systemic vascular inflammation and smoking in women. Am. J. Cardiol. 89, 1117-1119 (2002 (Pubitemid 34462860)
    • (2002) American Journal of Cardiology , vol.89 , Issue.9 , pp. 1117-1119
    • Bermudez, E.A.1    Rifai, N.2    Buring, J.E.3    Manson, J.E.4    Ridker, P.M.5
  • 82
    • 14344259622 scopus 로고    scopus 로고
    • Influence du tabagisme sur l'efficacité des antipaludéens de synthese (APS) sur les lésions cutanées de sujets atteints de lupus: Évaluation a travers une étude prospective
    • DOI 10.1016/j.revmed.2004.07.005
    • Lardet, D. et al. Effect of smoking on the effectiveness of antimalarial drugs for cutaneous lesions of patients with lupus: Assessment in a prospective study [French]. Rev. Med. Interne 25, 786-791 (2004 (Pubitemid 40292251)
    • (2004) Revue de Medecine Interne , vol.25 , Issue.11 , pp. 786-791
    • Lardet, D.1    Martin, S.2    Truchetet, F.3    Cuny, J.F.4    Virion, J.M.5    Schmutz, J.L.6
  • 83
    • 80052869325 scopus 로고    scopus 로고
    • Clinical and pharmacogenetic influences on response to hydroxychloroquine in discoid lupus erythematosus: A retrospective cohort study
    • Wahie, S. et al. Clinical and pharmacogenetic influences on response to hydroxychloroquine in discoid lupus erythematosus: A retrospective cohort study. J. Invest. Dermatol. 131, 1981-1986 (2011
    • (2011) J. Invest. Dermatol. , vol.131 , pp. 1981-1986
    • Wahie, S.1
  • 84
    • 72449173514 scopus 로고    scopus 로고
    • Cigarette smoking and cutaneous damage in systemic lupus erythematosus
    • Turchin, I., Bernatsky, S., Clarke, A. E., St-Pierre, Y. & Pineau, C. A. Cigarette smoking and cutaneous damage in systemic lupus erythematosus. J. Rheumatol. 36, 2691-2693 (2009
    • (2009) J. Rheumatol. , vol.36 , pp. 2691-2693
    • Turchin, I.1    Bernatsky, S.2    Clarke, A.E.3    St-Pierre, Y.4    Pineau, C.A.5
  • 85
    • 62649117248 scopus 로고    scopus 로고
    • Cross-sectional analysis of a collaborative Web-based database for lupus erythematosus-associated skin lesions: Prospective enrollment of 114 patients
    • Moghadam-Kia, S. et al. Cross-sectional analysis of a collaborative Web-based database for lupus erythematosus-associated skin lesions: prospective enrollment of 114 patients. Arch. Dermatol. 145, 255-260 (2009
    • (2009) Arch. Dermatol. , vol.145 , pp. 255-260
    • Moghadam-Kia, S.1
  • 86
    • 84858723226 scopus 로고    scopus 로고
    • Impact of smoking in cutaneous lupus erythematosus
    • Piette, E. W. et al. Impact of smoking in cutaneous lupus erythematosus. Arch. Dermatol. 148, 317-322 (2012
    • (2012) Arch. Dermatol. , vol.148 , pp. 317-322
    • Piette, E.W.1
  • 87
    • 0023820822 scopus 로고
    • Antimalarial drugs and pregnancy
    • Parke, A. Antimalarial drugs and pregnancy. Am. J. Med. 85, 30-33 (1988
    • (1988) Am. J. Med. , vol.85 , pp. 30-33
    • Parke, A.1
  • 88
    • 0029825260 scopus 로고    scopus 로고
    • Hydroxychloroquine in pregnant patients with systemic lupus erythematosus
    • Parke, A. & West, B. Hydroxychloroquine in pregnant patients with systemic lupus erythematosus. J. Rheumatol. 23, 1715-1718 (1996 (Pubitemid 26342440)
    • (1996) Journal of Rheumatology , vol.23 , Issue.10 , pp. 1715-1718
    • Parke, A.1    West, B.2
  • 91
    • 77957278745 scopus 로고    scopus 로고
    • Evaluation of the risk of anti-SSA/Ro-SSB/La antibody-associated cardiac manifestations of neonatal lupus in fetuses of mothers with systemic lupus erythematosus exposed to hydroxychloroquine
    • Izmirly, P. M. et al. Evaluation of the risk of anti-SSA/Ro-SSB/La antibody-associated cardiac manifestations of neonatal lupus in fetuses of mothers with systemic lupus erythematosus exposed to hydroxychloroquine. Ann. Rheum. Dis. 69, 1827-1830 (2010
    • (2010) Ann. Rheum. Dis. , vol.69 , pp. 1827-1830
    • Izmirly, P.M.1
  • 93
    • 13844296727 scopus 로고    scopus 로고
    • Safety of hydroxychloroquine in pregnant patients with connective tissue diseases. Review of the literature
    • DOI 10.1016/j.autrev.2004.11.009
    • Costedoat-Chalumeau, N., Amoura, Z., Huong, D. L., Lechat, P. & Piette, J. C. Safety of hydroxychloroquine in pregnant patients with connective tissue diseases. Review of the literature. Autoimmun. Rev. 4, 111-115 (2005 (Pubitemid 40255619)
    • (2005) Autoimmunity Reviews , vol.4 , Issue.2 , pp. 111-115
    • Costedoat-Chalumeau, N.1    Amoura, Z.2    Huong, D.L.T.3    Lechat, P.4    Piette, J.-C.5
  • 94
    • 0004199537 scopus 로고    scopus 로고
    • (eds Wallace, D. J. & Hahn, B. H.) Lippincott Williams & Wilkins, Philadelphia
    • Wallace, D. J. in Dubois Lupus Erythematosus 7th edn (eds Wallace, D. J. & Hahn, B. H.) 1152-1176 (Lippincott Williams & Wilkins, Philadelphia, 2007
    • (2007) Dubois Lupus Erythematosus 7th edn , pp. 1152-1176
    • Wallace, D.J.1
  • 96
    • 79551548116 scopus 로고    scopus 로고
    • Revised recommendations on screening for chloroquine and hydroxychloroquine retinopathy
    • Marmor, M. F., Kellner, U., Lai, T. Y., Lyons, J. S. & Mieler, W. F. Revised recommendations on screening for chloroquine and hydroxychloroquine retinopathy. Ophthalmology 118, 415-422 (2011
    • (2011) Ophthalmology , vol.118 , pp. 415-422
    • Marmor, M.F.1    Kellner, U.2    Lai, T.Y.3    Lyons, J.S.4    Mieler, W.F.5
  • 97
    • 84873014815 scopus 로고    scopus 로고
    • Revisiting antimalarials in systemic lupus erythematosus: Developments of translational clinical interest
    • in press
    • Venuturupalli, S. R., Gudsoorkar, V. S. & Wallace, D. J. Revisiting antimalarials in systemic lupus erythematosus: Developments of translational clinical interest. J. Rheumatol. (in press
    • J. Rheumatol.
    • Venuturupalli, S.R.1    Gudsoorkar, V.S.2    Wallace, D.J.3
  • 98
    • 78649363138 scopus 로고    scopus 로고
    • Advances in drug therapy for systemic lupus erythematosus
    • Wallace, D. J. Advances in drug therapy for systemic lupus erythematosus. BMC Med. 8, 77 (2010
    • (2010) BMC Med , vol.8 , pp. 77
    • Wallace, D.J.1
  • 99
    • 0036207633 scopus 로고    scopus 로고
    • Antimalarials in cutaneous lupus erythematosus: Mechanisms of therapeutic benefit
    • DOI 10.1191/0961203302lu147rr
    • Wozniacka, A., Carter, A. & McCauliffe, D. P. Antimalarials in cutaneous lupus erythematosus: mechanisms of therapeutic benefit. Lupus 11, 71-81 (2002 (Pubitemid 34259436)
    • (2002) Lupus , vol.11 , Issue.2 , pp. 71-81
    • Wozniacka, A.1    Carter, A.2    McCauliffe, D.P.3
  • 100
    • 34948862550 scopus 로고    scopus 로고
    • Cytokine polymorphisms influence treatment outcomes in SLE patients treated with antimalarial drugs
    • Lopez, P., Gomez, J., Mozo, L., Gutierrez, C. & Suarez, A. Cytokine polymorphisms influence treatment outcomes in SLE patients treated with antimalarial drugs. Arthritis Res. Ther. 8, R42 (2006
    • (2006) Arthritis Res. Ther. , vol.8
    • Lopez, P.1    Gomez, J.2    Mozo, L.3    Gutierrez, C.4    Suarez, A.5
  • 101
    • 62149105940 scopus 로고    scopus 로고
    • Safety and efficacy of quinacrine in human prion disease (PRION1 study): A patient-preference trial
    • Collinge, J. et al. Safety and efficacy of quinacrine in human prion disease (PRION1 study): A patient-preference trial. Lancet Neurol. 8, 334-344 (2009
    • (2009) Lancet Neurol. , vol.8 , pp. 334-344
    • Collinge, J.1
  • 102
    • 75149144542 scopus 로고    scopus 로고
    • New hopes from old drugs: Revisiting DNA-binding small molecules as anticancer agents
    • Gurova, K. New hopes from old drugs: revisiting DNA-binding small molecules as anticancer agents. Future Oncol. 5, 1685-1704 (2009
    • (2009) Future Oncol , vol.5 , pp. 1685-1704
    • Gurova, K.1
  • 103
    • 0019904124 scopus 로고
    • Tissue and blood concentrations of chloroquine following chronic administration in the rat
    • Adelusi, S. A. & Salako, L. A. Tissue and blood concentrations of chloroquine following chronic administration in the rat. J. Pharm. Pharmacol. 34, 733-735 (1982 (Pubitemid 12005630)
    • (1982) Journal of Pharmacy and Pharmacology , vol.34 , Issue.11 , pp. 733-735
    • Adelusi, S.A.1    Salako, L.A.2
  • 104
    • 32444451688 scopus 로고    scopus 로고
    • The type I interferon system in systemic lupus erythematosus
    • DOI 10.1002/art.21571
    • Ronnblom, L., Eloranta, M. L. & Alm, G. V. The type I interferon system in systemic lupus erythematosus. Arthritis Rheum. 54, 408-420 (2006 (Pubitemid 43228615)
    • (2006) Arthritis and Rheumatism , vol.54 , Issue.2 , pp. 408-420
    • Ronnblom, L.1    Eloranta, M.-L.2    Alm, G.V.3
  • 105
    • 9344260280 scopus 로고    scopus 로고
    • Interferon-α stimulates production of interleukin10 in activated CD4+ T cells and monocytes
    • Aman, M. J. et al. Interferon-α stimulates production of interleukin 10 in activated CD4+ T cells and monocytes. Blood 87, 4731-4736 (1996
    • (1996) Blood , vol.87 , pp. 4731-4736
    • Aman, M.J.1
  • 106
    • 79953161285 scopus 로고    scopus 로고
    • The type I interferon system in the development of lupus
    • Ronnblom, L., Alm, G. V. & Eloranta, M. L. The type I interferon system in the development of lupus. Semin. Immunol. 23, 113-121 (2011
    • (2011) Semin. Immunol. , vol.23 , pp. 113-112
    • Ronnblom, L.1    Alm, G.V.2    Eloranta, M.L.3
  • 107
    • 79960392810 scopus 로고    scopus 로고
    • Netting neutrophils induce endothelial damage, infiltrate tissues, and expose immunostimulatory molecules in systemic lupus erythematosus
    • Villanueva, E. et al. Netting neutrophils induce endothelial damage, infiltrate tissues, and expose immunostimulatory molecules in systemic lupus erythematosus. J. Immunol. 187, 538-552 (2011
    • (2011) J. Immunol. , vol.187 , pp. 538-552
    • Villanueva, E.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.