Hydroxychloroquine inhibits calcium signals in T cells: A new mechanism to explain its immunomodulatory properties

Blood

Volumn 95, Issue 11, 2000, Pages 3460-3466

  Goldman, Frederick D ^a   Gilman, Andrew L ^b   Hollenback, Clay ^b   Kato, Roberta M ^b   Premack, Brett A ^b   Rawlings, David J ^b  

^a UNIVERSITY OF IOWA HOSPITALS AND CLINICS   (United States)

^b NONE

Author keywords

[No Author keywords available]

Indexed keywords

CD69 ANTIGEN; HYDROXYCHLOROQUINE; INOSITOL PHOSPHATE; T LYMPHOCYTE RECEPTOR;

ANTIGEN EXPRESSION; ARTICLE; BONE MARROW TRANSPLANTATION; CALCIUM CELL LEVEL; CALCIUM MOBILIZATION; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; CROSS LINKING; DOSE RESPONSE; GRAFT VERSUS HOST REACTION; HUMAN; HUMAN CELL; IMMUNOMODULATION; LEUKEMIA CELL LINE; LYMPHOMA CELL LINE; PRIORITY JOURNAL; SIGNAL TRANSDUCTION; T LYMPHOCYTE;

EID: 0034210661     PISSN: 00064971     EISSN: None     Source Type: Journal    
DOI: 10.1182/blood.v95.11.3460     Document Type: Article

References (41)

1. Zvaitler NJ. Update in rheumatology: focus on hydroxychloroquine. Am J Med. 1988;75:68.
2. Gilman A, Morris C, Mogul M, et al. Hydroxychloroquine for the treatment of chronic graft-versus-host disease [abstract]. Biol Blood Bone Marrow Transplant. 2000. In press.
3. Lombard-Platlet S, Bertolino P, Deng H, Gerlier D, Rabourdine-Combe C. Inhibition by chloroquine of the class II histocompatibility complex-restricted presentation of endogenous antigens varies according to the cellular origin of the antigen-presenting cells, the nature of the T-cell epitope, and the responding cell. Immunology. 1993; 80:566.
4. Gilman AL, Beams F, Tefft M, Mazumder A. The effect of hydroxychloroquine on alloreactivity and its potential use for graft-versus-host disease. Bone Marrow Transplant. 1996;17:1069.
5. Sperber K, Quraishi H, Kalb TH. Selective regulation of cytokine secretion by hydroxychloroquine: inhibition of interleukin-1-alpha (IL-1-α) and IL-6 in human monocytes and T cells. J Rheumatol. 1993;20:803.
6. Chan AC, Desai DM, Weiss A. The role of protein tyrosine kinases and protein tyrosine phosphatases in T cell antigen receptor signal transduction. Annu Rev Immunol. 1994;12:555.
7. Wardenburg JB, Fu C, Jackman JK, et al. Phosphorylation of SLP-76 by the ZAP-70 protein-tyrosine kinase is required for T-cell receptor function. J Biol Chem. 1996;271:19,641.
8. Nishibe S, Wahl MI, Hernandez-Sotomayor SMT, Tonks NK, Rhee SG. Carpenter G. Increase of the catalytic activity of phospholipase C gamma 1 by tyrosine phosphorylation. Science. 1990;250: 1253.
9. Rao A, Luo C, Hogan PG. Transcription factors of the NFAT family: regulation and function. Annu Rev Immunol. 1997;15:707.
10. Koretzky GA, Picus J, Schultz T, Weiss A. The tyrosine phosphatase CD45 is required for T cell antigen receptor and CD2-mediated activation of a protein tyrosine kinase and interleukin 2 production. Proc Natl Acad Sci U S A. 1991;88:2037.
11. Hara T, Jung L, Bjorndahl J, Fu SM. Human T cell activation, III: rapid induction of a phosphorylated 28 kD/32 kD disulfide-linked early activation antigen (EA-1) by TPA, mitogens, and antigens. J Exp Med. 1986;164:1988.
12. Testi R, Phillips JH, Lanier LL. T cell activation via Leu-23 (CD69). J Immunol. 1989;142:1123.
13. Gardner P. Calcium and T lymphocyte activation. Cell. 1989;59:15.
14. Berridge MJ. Inositol trisphosphate and calcium signalling. Nature. 1993;361:315.
15. Williams NG, Paradis H, Agarwal S, Charest DL, Pelech SL, Roberts TM. Raf-1 and p21v-ras cooperate in the activation of mitogen-activated protein kinase. Proc Natl Acad Sci U S A. 1993;90: 5772.
16. Franklin RA, Tordai A, Patel H, Gardner AM, Johnson GL, Gelfand EW. Ligation of the T cell receptor complex results in activation of the ras/ raf-1/MEK/MAPK cascade in human T lymphocytes. J Clin Invest. 1994;93:2134.
17. Lange-Carter CA, Pleiman CM, Gardner AM, Blumer KJ, Johnson GL. A divergence in the MAP kinase regulatory network defined by MEK kinase and Raf. Science. 1993;260:315.
18. DeVries-Smits AMM, Burgering BMT, Leevers SJ, Marshall CJ, Bos JL. Involvement of p21 ras in activation of extracellular signal-regulated kinase 2. Nature. 1992;357:602.
19. Leevers SJ, Marshall CJ. Activation of extracellular signal-regulated kinase, ERK2, by p21ras oncoprotein. EMBO J. 1992;11:569.
20. Hoth M, Penner R. Depletion of intracellular calcium stores activates a calcium current in mast cells. Nature. 1992;355:353.
21. +)-ATPase inhibitors. J Immunol. 1994;152:5226-5240.
22. Misra UK, Chu CT, Rubenstein DS, Gawdi G, Pizzo SV. α2-Macrogloboin receptor-recognized forms elevate intracellular calcium and cyclic AMP in murine peritoneal macrophages. Biochem J. 1993;291:885.
23. Bootman MD, Berridge MJ. The elemental principles of calcium signaling. Cell. 1995;83:675.
24. Clapham DE. Calcium signaling. Cell. 1995;80: 259.
25. Thastrup O, Dawson AP, Scharff O, et al. Thapsigargin, a novel molecular probe for studying intracellular calcium release and storage. Agents Actions. 1989;27:17.
26. Lytton J, Westlin M, Hanley MR. Thapsigargin inhibits the sarcoplasmic or endoplasmic reticulum Ca-ATPase family of calcium pumps. J Biol Chem. 1991;266:17,067.
27. + endoplasmic reticulum-ATPase inhibitor thagsigargin. Eur J Immunol. 1990;20:2269.
28. Takemura H, Hughes AR, Thastrup O, Putney JW Jr. Activation of calcium entry by the tumor promoter thapsigargin in parotid acinar cells: evidence that an intracellular calcium pool and not an inositol phosphate regulates calcium fluxes at the plasma membrane. J Biol Chem. 1989;264: 12,266.
29. Schultz KR, Bader S, Paquet J, Wei L. Chloroquine treatment affects T-cell priming to minor histocompatibility antigens and graft-versus-host disease. Blood. 1995;86:1.
30. Fox R. Anti-malarial drugs: possible mechanisms of action in autoimmune disease and prospects for drug development. Lupus. 1996;1(suppl):S4.
31. Schultz KR, Nelson D, Bader S. Synergy between lysosomotropic amines and cyclosporin A on human T cell responses to an exogenous protein antigen, tetanus toxoid. Bone Marrow Transplant. 1996;18:625.
32. Landewe RBM, Miltenburg AMM, Breedveld FC, Daha MR, Dijkmans BAC. Cyclosporine and chloroquine synergistically inhibit the interferon-gamma production by CD4 positive and CD8 positive synovial T cell clones derived from a patient with rheumatoid arthritis. J Rheumatol. 1992; 19:1353.
33. Ho SN, Thomas DJ, Timmerman LA, Li X, Francke U, Crabtree GR. NFATc3, a lymphoid-spacific NFATc family member that is calcium-regulated and exhibits distinct DNA binding specificity. J Biol Chem. 1995;270:19,898.
34. Hivroz-Burgaud C, Clipstone NA, Cantrell DA. Signaling requirements for the expression of the transactivating factor NF-AT in human T lymphocytes. Eur J Immunol. 1991;21:2811.
35. + signaling, and reporter gene expression in antigen-specific mouse T cells. J Immunol. 1997;159:1628.
36. + influx: functional synergy between Raf and calcineurin. J Immunol. 1996;157: 5277.
37. Healy JI, Dolmetsch RE, Timmerman LA, et al. Different nuclear signals are activated by the B cell receptor during positive versus negative signaling. Immunity. 1997;6:419.
38. + response amplitude and duration. Nature. 1997;386:855.
39. Misra UK, Gawdi G, Pizzo SV. Chloroquine, quinine and quinidine inhibit calcium release from macrophage intracellular stores by blocking inositol 1,4,5-trisphosphate binding to its receptor. J Cell Biochem. 1997;64:225.
40. Barry SR, Bernal J. Antimalarial drugs inhibit calcium-dependent backward swimming and calcium currents in Paramecium calkinsi. J Comp Physiol [A]. 1993;172:457.
41. +-antagonistic properties of phospholipase A2 inhibitors, mepacrine and chloroquine. Gen Physiol Biophys. 1989;8:113.