The effect of anti-CD40 ligand antibody on B cells in human systemic lupus erythematosus

Arthritis and Rheumatism

Volumn 46, Issue 6, 2002, Pages 1554-1562

  Huang, Weiqing ^a   Sinha, Jayashree ^a   Newman, Jeffrey ^a   Reddy, Bhoompally ^a   Budhai, Lalbachan ^a   Furie, Richard ^b   Vaishnaw, Akshay ^c   Davidson, Anne ^a  

^a ALBERT EINSTEIN COLLEGE OF MEDICINE   (United States)

^b NORTH SHORE UNIVERSITY HOSPITAL   (United States)

^c BIOGEN   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BG 9588; CD27 ANTIGEN; CD40 LIGAND MONOCLONAL ANTIBODY; DNA ANTIBODY; IMMUNOGLOBULIN; IMMUNOGLOBULIN D; IMMUNOGLOBULIN G; IMMUNOGLOBULIN HEAVY CHAIN; MESSENGER RNA;

ADULT; ANTIBODY PRODUCING CELL; ARTICLE; AUTOIMMUNE DISEASE; B LYMPHOCYTE; CLINICAL ARTICLE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DRUG EFFECT; ENZYME LINKED IMMUNOSORBENT ASSAY; EPSTEIN BARR VIRUS; FEMALE; FLOW CYTOMETRY; GENE MUTATION; GENE SEQUENCE; GERM LINE; HUMAN; HUMAN CELL; HUMAN TISSUE; LUPUS ERYTHEMATOSUS NEPHRITIS; LYMPHOCYTE SUBPOPULATION; MALE; MONONUCLEAR CELL; MULTICENTER STUDY; PHENOTYPE; PRIORITY JOURNAL; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SERUM; SOMATIC MUTATION; SYSTEMIC LUPUS ERYTHEMATOSUS; THROMBOSIS; TREATMENT OUTCOME;

ADULT; ANTIBODIES, ANTINUCLEAR; ANTIBODIES, MONOCLONAL; B-LYMPHOCYTES; BIOLOGICAL MARKERS; CD40 LIGAND; CELL LINE, TRANSFORMED; FEMALE; FLOW CYTOMETRY; HERPESVIRUS 4, HUMAN; HUMANS; IMMUNOENZYME TECHNIQUES; IMMUNOGLOBULIN G; LUPUS NEPHRITIS; MALE; MUTATION; RNA, MESSENGER;

EID: 0036272915     PISSN: 00043591     EISSN: None     Source Type: Journal    
DOI: 10.1002/art.10273     Document Type: Article

References (44)

1. Anti-DNA antibodies bind directly to renal antigens and induce kidney dysfunction in the isolated perfused rat kidney
2. The role of somatic mutation in the pathogenic anti-DNA response
3. The central role of the CD40-ligand and CD40 pathway in T-lymphocyte-mediated differentiation of B lymphocytes
4. Costimulatory B7 molecules in the pathogenesis of infectious and autoimmune diseases
5. Triple check for antigen specificity of B cells during germinal centre reactions
6. Germinal centers: Form and function
7. Memory B cells are biased towards terminal differentiation: A strategy that may prevent repertoire freezing
8. Increased expression of CD40 ligand on systemic lupus erythematosus lymphocytes
9. Hyperexpression of CD40 ligand by B and T cells in human lupus and its role in pathogenic autoantibody production
10. Interaction between CD40 and its ligand gp39 in the development of murine lupus nephritis
11. Anti-CD40 ligand antibody treatment of SNF1 mice with established nephritis: Preservation of kidney function
12. Identification of a novel surface protein on activated CD4+ T cells that induces contact-dependent B cell differentiation (help)
13. Pharmacokinetics/dynamics of 5c8, a monoclonal antibody to CD154 (CD40 ligand) suppression of an immune response in monkeys
14. Lupus nephritis: Pathology, pathogenesis, clinical correlations and prognosis
15. An in vitro assay for detection of glomerular binding IgG autoantibodies in patients with systemic lupus erythematosus
16. Rheumatoid factors from the peripheral blood of two patients with rheumatoid arthritis are genetically heterogeneous and somatically mutated
17. Somatic hypermutation of immunoglobulin genes is independent of the Bloom's syndrome DNA helicase
18. Somatic hypermutation of Ig genes in patients with xeroderma pigmentosum (XP-D)
19. Monitoring and interpreting the intrinsic features of somatic hypermutation
20. The 1982 revised criteria for the classification of systemic lupus erythematosus
21. Human immunoglobulin (Ig)M+IgD+ peripheral blood B cells expressing the CD27 cell surface antigen carry somatically mutated variable region genes: CD27 as a general marker for somatically mutated (memory) B cells
22. Cellular origin of human B-cell lymphomas
23. Disturbed peripheral B lymphocyte homeostasis in systemic lupus erythematosus
24. Expression of C3d receptors during human B cell differentiation: Immunofluorescence analysis with the HB-5 monoclonal antibody
25. Identification of early plasma cells in peripheral blood and their clinical significance
26. Cellular interaction in germinal centers: Roles of CD40 ligand and B7-2 in established germinal centers
27. Management of systemic lupus erythematosus
28. A short-course of BG9588 (anti-CD40L antibody) improves serologic activity and decreases hematuria in patients with proliferative lupus glomerulonephritis
29. Quantitation of IgM- and IgG-secreting B cells in the peripheral blood of patients with systemic lupus erythematosus
30. CD27: A memory B-cell marker
31. CD40 and CD154 in cell-mediated immunity
32. Normalization of peripheral B cells following treatment of active SLE patients with humanized anti-CD154 mAb (5c8, BG9588)
33. CTLA4Ig inhibits T cell-dependent B-cell maturation in murine systemic lupus erythematosus
34. Survival of long-lived plasma cells is independent of antigen
35. Lupus-specific antibodies reveal an altered pattern of somatic mutation
36. Enhanced mutational activity and disturbed selection of mutations in V(H) gene rearrangements in a patient with systemic lupus erythematosus
37. The role of CD40-CD40 ligand (CD154) interactions in immunoglobulin light chain repertoire generation and somatic mutation
38. Cutting edge: A role for CD1 in the pathogenesis of lupus in NZB/NZW mice
39. Precursor B cells for autoantibody production in genomically Fas-intact autoimmune disease are not subject to Fas-mediated immune elimination
40. Analysis of CD5 expression on peripheral B cells following treatment of active SLE patients with humanized anti-CD154 mAb (5c8, BG9588)
41. Anti-CD40 ligand antibody treatment prevents the development of lupus-like nephritis in a subset of New Zealand black X New Zealand white mice: Response correlates with the absence of an anti-antibody response
42. Anti-CD40L prevents disease onset but does not induce remission in NZB/NZW F1 mice
43. The clinical course of experimental autoimmune encephalomyelitis and inflammation is controlled by the expression of CD40 within the central nervous system
44. Long-term inhibition of murine lupus by brief simultaneous blockade of the B7/CD28 and CD40/gp39 costimulation pathways