-
1
-
-
34848848499
-
Fluorine in pharmaceuticals: Looking beyond intuition
-
Müller, K., Faeh, C. & Diederich, F. Fluorine in pharmaceuticals: looking beyond intuition. Science 317, 1881-1886 (2007).
-
(2007)
Science
, vol.317
, pp. 1881-1886
-
-
Müller, K.1
Faeh, C.2
Diederich, F.3
-
2
-
-
38149070200
-
Fluorine in medicinal chemistry
-
Purser, S., Moore, P. R., Swallow, S. & Gouverneur, V. Fluorine in medicinal chemistry. Chem. Soc. Rev. 37, 320-330 (2008).
-
(2008)
Chem. Soc. Rev
, vol.37
, pp. 320-330
-
-
Purser, S.1
Moore, P.R.2
Swallow, S.3
Gouverneur, V.4
-
3
-
-
49449097238
-
The many roles for fluorine in medicinal chemistry
-
Hagmann, W. K. The many roles for fluorine in medicinal chemistry. J. Med. Chem. 51, 4359-4369 (2008).
-
(2008)
J. Med. Chem
, vol.51
, pp. 4359-4369
-
-
Hagmann, W.K.1
-
4
-
-
84897584974
-
Fluorine in pharmaceutical industry: Fluorine-containing drugs introduced to the market in the last decade (2001-2011)
-
Wang, J. et al. Fluorine in pharmaceutical industry: fluorine-containing drugs introduced to the market in the last decade (2001-2011). Chem. Rev. 114, 2432-2506 (2014).
-
(2014)
Chem. Rev
, vol.114
, pp. 2432-2506
-
-
Wang, J.1
-
5
-
-
79958141712
-
Aromatic trifluoromethylation with metal complexes
-
Tomashenko, O. A. & Grushin, V. V. Aromatic trifluoromethylation with metal complexes. Chem. Rev. 111, 4475-4521 (2011).
-
(2011)
Chem. Rev
, vol.111
, pp. 4475-4521
-
-
Tomashenko, O.A.1
Grushin, V.V.2
-
6
-
-
84882268052
-
Introduction of fluorine and fluorinecontaining functional groups
-
Liang, T., Neumann, C. N. & Ritter, T. Introduction of fluorine and fluorinecontaining functional groups. Angew. Chem. Int. Ed. 52, 8214-8264 (2013).
-
(2013)
Angew. Chem. Int. Ed
, vol.52
, pp. 8214-8264
-
-
Liang, T.1
Neumann, C.N.2
Ritter, T.3
-
7
-
-
84938686233
-
Transition-metal-catalyzed difluoromethylation, difluoromethylenation, and polydifluoromethylenation reactions
-
Chen, B. & Vicic, D. Transition-metal-catalyzed difluoromethylation, difluoromethylenation, and polydifluoromethylenation reactions. Top. Organomet. Chem. 52, 113-142 (2014).
-
(2014)
Top. Organomet. Chem
, vol.52
, pp. 113-142
-
-
Chen, B.1
Vicic, D.2
-
8
-
-
79955419410
-
Synopsis of some recent tactical application of bioisosteres in drug design
-
Meanwell, N. A. Synopsis of some recent tactical application of bioisosteres in drug design. J. Med. Chem. 54, 2529-2591 (2011).
-
(2011)
J. Med. Chem
, vol.54
, pp. 2529-2591
-
-
Meanwell, N.A.1
-
9
-
-
0000646175
-
Hydrogen bond donor properties of the difluoromethyl group
-
Erickson, J. A. & McLoughlin, J. I. Hydrogen bond donor properties of the difluoromethyl group. J. Org. Chem. 60, 1626-1631 (1995).
-
(1995)
J. Org. Chem
, vol.60
, pp. 1626-1631
-
-
Erickson, J.A.1
McLoughlin, J.I.2
-
11
-
-
0006638276
-
Methylene derivatives as intermediates in polar reactions. VIII. Difluoromethylene in the reaction of chlorodifluoromethane with sodium methoxide
-
Hine, J. & Porter, J. J. Methylene derivatives as intermediates in polar reactions. VIII. Difluoromethylene in the reaction of chlorodifluoromethane with sodium methoxide. J. Am. Chem. Soc. 79, 5493-5496 (1957).
-
(1957)
J. Am. Chem. Soc
, vol.79
, pp. 5493-5496
-
-
Hine, J.1
Porter, J.J.2
-
12
-
-
0005599532
-
The preparation of aryl difluoromethyl ethers
-
Miller, T. G. & Thanassi, J. W. The preparation of aryl difluoromethyl ethers. J. Org. Chem. 25, 2009-2012 (1960).
-
(1960)
J. Org. Chem
, vol.25
, pp. 2009-2012
-
-
Miller, T.G.1
Thanassi, J.W.2
-
13
-
-
33845560039
-
Fluoroalkanesulfonyl chlorides
-
Moore, G. G. I. Fluoroalkanesulfonyl chlorides. J. Org. Chem. 44, 1708-1711 (1979).
-
(1979)
J. Org. Chem
, vol.44
, pp. 1708-1711
-
-
Moore, G.G.I.1
-
14
-
-
37549004434
-
Difluoromethyltrialkylammonium salts their expeditious synthesis from chlorodifluoromethane and tertiary amines in the presence of concentrated aqueous sodium hydroxide. the catalytic process
-
Nawrot, E. & Jonczyk, A. Difluoromethyltrialkylammonium salts their expeditious synthesis from chlorodifluoromethane and tertiary amines in the presence of concentrated aqueous sodium hydroxide. The catalytic process. J. Org. Chem. 72, 10258-10260 (2007).
-
(2007)
J. Org. Chem
, vol.72
, pp. 10258-10260
-
-
Nawrot, E.1
Jonczyk, A.2
-
15
-
-
0001161350
-
(Diethylphosphinyl) difluoromethyllithium - Preparation and synthetic application
-
Obayashi, M., Ito, E., Matsui, K. & Kondo, K. (Diethylphosphinyl) difluoromethyllithium - preparation and synthetic application. Tetrahedron Lett. 23, 2323-2326 (1982).
-
(1982)
Tetrahedron Lett
, vol.23
, pp. 2323-2326
-
-
Obayashi, M.1
Ito, E.2
Matsui, K.3
Kondo, K.4
-
16
-
-
0004713598
-
Catalytic irreversible inhibition of mammalian ornithine decarboxylase (E.C.4.1.1.17) by substrate and product analogs
-
Metcalf, B. W. et al. Catalytic irreversible inhibition of mammalian ornithine decarboxylase (E.C.4.1.1.17) by substrate and product analogs. J. Am. Chem. Soc. 100, 2551-2553 (1978).
-
(1978)
J. Am. Chem. Soc
, vol.100
, pp. 2551-2553
-
-
Metcalf, B.W.1
-
17
-
-
0002270583
-
Novel synthesis and application of γ-difluoromethylated prop-2-ynylic and allylic alcohols
-
Konno, T. & Kitazume, T. Novel synthesis and application of γ-difluoromethylated prop-2-ynylic and allylic alcohols. Chem. Commun. 19, 2227-2228 (1996).
-
(1996)
Chem. Commun
, vol.19
, pp. 2227-2228
-
-
Konno, T.1
Kitazume, T.2
-
18
-
-
84987351253
-
Application of dialkylaminosulfur trifluorides in the synthesis of fluoroorganic compounds
-
Markovsi, L. N., Pahinnik, V. E. & Kirsanov, A. V. Application of dialkylaminosulfur trifluorides in the synthesis of fluoroorganic compounds. Synthesis 12, 787-789 (1973).
-
(1973)
Synthesis
, vol.12
, pp. 787-789
-
-
Markovsi, L.N.1
Pahinnik, V.E.2
Kirsanov, A.V.3
-
19
-
-
33847800447
-
New fluorinating reagents. Dialkylaminosulfur fluorides
-
Middleton, W. J. New fluorinating reagents. Dialkylaminosulfur fluorides. J. Org. Chem. 40, 574-578 (1975).
-
(1975)
J. Org. Chem
, vol.40
, pp. 574-578
-
-
Middleton, W.J.1
-
20
-
-
80054711853
-
A new method for aromatic difluoromethylation: Copper-catalyzed cross-coupling and decarboxylation sequence from aryl iodides
-
Fujikawa, K., Fujioka, Y., Kobayashi, A. & Amii, H. A new method for aromatic difluoromethylation: copper-catalyzed cross-coupling and decarboxylation sequence from aryl iodides. Org. Lett. 13, 5560-5563 (2011).
-
(2011)
Org. Lett
, vol.13
, pp. 5560-5563
-
-
Fujikawa, K.1
Fujioka, Y.2
Kobayashi, A.3
Amii, H.4
-
21
-
-
84856243970
-
A new reagent for direct difluoromethylation
-
Fujiwara, Y. et al. A new reagent for direct difluoromethylation. J. Am. Chem. Soc. 134, 1494-1497 (2012).
-
(2012)
J. Am. Chem. Soc
, vol.134
, pp. 1494-1497
-
-
Fujiwara, Y.1
-
22
-
-
84859149180
-
Copper-mediated difluoromethylation of aryl and vinyl iodides
-
Fier, P. S. & Hartwig, J. F. Copper-mediated difluoromethylation of aryl and vinyl iodides. J. Am. Chem. Soc. 134, 5524-5527 (2012).
-
(2012)
J. Am. Chem. Soc
, vol.134
, pp. 5524-5527
-
-
Fier, P.S.1
Hartwig, J.F.2
-
23
-
-
84870015768
-
Copper-mediated difluoromethylation of (hetero)aryl iodides and β-styryl halides with tributyl(difluoromethyl)stannane
-
Prakash, G. K. S. et al. Copper-mediated difluoromethylation of (hetero)aryl iodides and β-styryl halides with tributyl(difluoromethyl)stannane. Angew. Chem. Int. Ed. 51, 12090-12094 (2012).
-
(2012)
Angew. Chem. Int. Ed
, vol.51
, pp. 12090-12094
-
-
Prakash, G.K.S.1
-
24
-
-
84921451326
-
Cooperative dual palladium/silver catalyst for direct difluoromethylation of aryl bromides and iodides
-
Gu, Y., Leng, X. & Shen, Q. Cooperative dual palladium/silver catalyst for direct difluoromethylation of aryl bromides and iodides. Nat. Commun. 5, 5405 (2014).
-
(2014)
Nat. Commun
, vol.5
, pp. 5405
-
-
Gu, Y.1
Leng, X.2
Shen, Q.3
-
25
-
-
84912521156
-
Sandmeyer difluoromethylation of (hetero-)arenediazonium salts
-
Matheis, C., Jouvin, K. & Goossen, L. Sandmeyer difluoromethylation of (hetero-)arenediazonium salts. Org. Lett. 16, 5984-5987 (2014).
-
(2014)
Org. Lett
, vol.16
, pp. 5984-5987
-
-
Matheis, C.1
Jouvin, K.2
Goossen, L.3
-
26
-
-
84953449475
-
Access to difluoromethylated arenes by Pd-catalyzed reaction of arylboronic acids with bromodifluoroacetate
-
Feng, Z., Min, Q.-Q. & Zhang, X. Access to difluoromethylated arenes by Pd-catalyzed reaction of arylboronic acids with bromodifluoroacetate. Org. Lett. 18, 44-47 (2016).
-
(2016)
Org. Lett
, vol.18
, pp. 44-47
-
-
Feng, Z.1
Min, Q.-Q.2
Zhang, X.3
-
27
-
-
84959478355
-
Direct difluoromethylation of aryl halides via base metal catalysis at room temperature
-
Xu, L. & Vicic, D. A. Direct difluoromethylation of aryl halides via base metal catalysis at room temperature. J. Am. Chem. Soc. 138, 2536-2539 (2016).
-
(2016)
J. Am. Chem. Soc
, vol.138
, pp. 2536-2539
-
-
Xu, L.1
Vicic, D.A.2
-
28
-
-
84985905510
-
Pd-catalyzed transfer of difluorocarbene
-
Deng, X.-Y., Lin, J.-H. & Xiao, J.-C. Pd-catalyzed transfer of difluorocarbene. Org. Lett. 18, 4384-4387 (2016).
-
(2016)
Org. Lett
, vol.18
, pp. 4384-4387
-
-
Deng, X.-Y.1
Lin, J.-H.2
Xiao, J.-C.3
-
29
-
-
0006598557
-
Die ersten CF3-substituierten organyl (chlor)silane
-
Ruppert, I., Schlich, K. & Volbach, W. Die ersten CF3-substituierten organyl (chlor)silane. Tetrahedron Lett. 25, 2195-2198 (1984).
-
(1984)
Tetrahedron Lett
, vol.25
, pp. 2195-2198
-
-
Ruppert, I.1
Schlich, K.2
Volbach, W.3
-
30
-
-
84856544834
-
The unusual reaction of (trifluoromethyl)trimethylsilane with sodium borohydride
-
Tyutyunov, A. A., Boyko, V. E. & Igoumnov, S. M. The unusual reaction of (trifluoromethyl)trimethylsilane with sodium borohydride. Fluorine Notes 74, 1 (2011).
-
(2011)
Fluorine Notes
, vol.74
, pp. 1
-
-
Tyutyunov, A.A.1
Boyko, V.E.2
Igoumnov, S.M.3
-
31
-
-
0038441453
-
Preparation of tri- and difluoromethylsilanes via an unusual magnesium metal-mediated reductive triand difluoromethylation of chlorosilanes using tri- and difluoromethyl sulfides, sulfoxides, and sulfones
-
Prakash, G. K. S., Hu, J. & Olah, G. A. Preparation of tri- and difluoromethylsilanes via an unusual magnesium metal-mediated reductive triand difluoromethylation of chlorosilanes using tri- and difluoromethyl sulfides, sulfoxides, and sulfones. J. Org. Chem. 68, 4457-4463 (2003).
-
(2003)
J. Org. Chem
, vol.68
, pp. 4457-4463
-
-
Prakash, G.K.S.1
Hu, J.2
Olah, G.A.3
-
32
-
-
0000716001
-
Fluorinated carbenes
-
Brahms, D. L. S. & Dailey, W. P. Fluorinated carbenes. Chem. Rev. 96, 1585-1632 (1996).
-
(1996)
Chem. Rev
, vol.96
, pp. 1585-1632
-
-
Brahms, D.L.S.1
Dailey, W.P.2
-
33
-
-
0001401118
-
Transition-metal dihalocarbene complexes
-
Brothers, P. J. & Roper, W. R. Transition-metal dihalocarbene complexes. Chem. Rev. 88, 1293-1326 (1988).
-
(1988)
Chem. Rev
, vol.88
, pp. 1293-1326
-
-
Brothers, P.J.1
Roper, W.R.2
-
34
-
-
84935854440
-
Ruthenium-catalyzed olefin cross-metathesis with tetrafluoroethylene and analogous fluoroolefins
-
Takahira, Y. & Morizawa, Y. Ruthenium-catalyzed olefin cross-metathesis with tetrafluoroethylene and analogous fluoroolefins. J. Am. Chem. Soc. 137, 7031-7034 (2015).
-
(2015)
J. Am. Chem. Soc
, vol.137
, pp. 7031-7034
-
-
Takahira, Y.1
Morizawa, Y.2
-
35
-
-
0035903584
-
Olefin metathesis with 1, 1- difluoroethylene
-
Trnka, T. M., Day, M. W. & Grubbs, R. H. Olefin metathesis with 1, 1- difluoroethylene. Angew. Chem. Int. Ed. 40, 3441-3444 (2001).
-
(2001)
Angew. Chem. Int. Ed
, vol.40
, pp. 3441-3444
-
-
Trnka, T.M.1
Day, M.W.2
Grubbs, R.H.3
-
36
-
-
84953311705
-
D10 nickel difluorocarbenes and their cycloaddition reactions with tetrafluoroethylene
-
Harrison, D. J., Daniels, A. L., Korobkov, I. & Baker, R. T. d10 nickel difluorocarbenes and their cycloaddition reactions with tetrafluoroethylene. Organometallics 34, 5683-5686 (2015).
-
(2015)
Organometallics
, vol.34
, pp. 5683-5686
-
-
Harrison, D.J.1
Daniels, A.L.2
Korobkov, I.3
Baker, R.T.4
-
37
-
-
84857618437
-
CF3-Ph reductive elimination from [(Xantphos)Pd(CF3) (Ph)]
-
Bakhmutov, V. I. et al. CF3-Ph reductive elimination from [(Xantphos)Pd(CF3) (Ph)]. Organometallics 31, 1315-1328 (2012).
-
(2012)
Organometallics
, vol.31
, pp. 1315-1328
-
-
Bakhmutov, V.I.1
-
38
-
-
0037160365
-
Mild iridium-catalyzed borylation of arenes. High turnover numbers, room temperature reactions, and isolation of a potential intermediate
-
Ishiyama, T. et al. Mild iridium-catalyzed borylation of arenes. High turnover numbers, room temperature reactions, and isolation of a potential intermediate. J. Am. Chem. Soc. 124, 390-391 (2002).
-
(2002)
J. Am. Chem. Soc
, vol.124
, pp. 390-391
-
-
Ishiyama, T.1
-
39
-
-
84855690955
-
Rhodium(I)-catalyzed borylation of nitriles through the cleavage of carbon-cyano bonds
-
Tobisu, M., Kinuta, H., Kita, Y., Rémond, E. & Chatani, N. Rhodium(I)-catalyzed borylation of nitriles through the cleavage of carbon-cyano bonds. J. Am. Chem. Soc. 134, 115-118 (2012).
-
(2012)
J. Am. Chem. Soc
, vol.134
, pp. 115-118
-
-
Tobisu, M.1
Kinuta, H.2
Kita, Y.3
Rémond, E.4
Chatani, N.5
-
40
-
-
84872729735
-
Cobalt fluorocarbene complexes
-
Harrison, D. J., Gorelsky, S. I., Lee, G. M., Korobkov, I. & Baker, R. T. Cobalt fluorocarbene complexes. Organometallics 32, 12-15 (2013).
-
(2013)
Organometallics
, vol.32
, pp. 12-15
-
-
Harrison, D.J.1
Gorelsky, S.I.2
Lee, G.M.3
Korobkov, I.4
Baker, R.T.5
-
41
-
-
33749527055
-
Facile Ar-CF3 bond formation at Pd. Strikingly different outcomes of reductive elimination from [(Ph3P)2Pd(CF3)Ph] and [(Xantphos)Pd(CF3)Ph]
-
Grushin, V. V. & Marshall, W. J. Facile Ar-CF3 bond formation at Pd. Strikingly different outcomes of reductive elimination from [(Ph3P)2Pd(CF3)Ph] and [(Xantphos)Pd(CF3)Ph]. J. Am. Chem. Soc. 128, 12644-12645 (2006).
-
(2006)
J. Am. Chem. Soc
, vol.128
, pp. 12644-12645
-
-
Grushin, V.V.1
Marshall, W.J.2
-
42
-
-
84925294782
-
Trifluoromethylcopper: A useful difluoromethylene transfer reagent: A novel double insertion of difluoromethylene into pentafluorophenylcopper
-
Yang, Z.-Y., Wiemers, D. M. & Burton, D. J. Trifluoromethylcopper: a useful difluoromethylene transfer reagent: a novel double insertion of difluoromethylene into pentafluorophenylcopper. J. Am. Chem. Soc. 114, 4402-4403 (1992).
-
(1992)
J. Am. Chem. Soc
, vol.114
, pp. 4402-4403
-
-
Yang, Z.-Y.1
Wiemers, D.M.2
Burton, D.J.3
-
43
-
-
37049100904
-
Oxidation state control of the reactivity of a transition metal-carbon double bond. Synthesis, X-ray crystal structure, and reactions of the zerovalent difluorocarbene complex [Ru=CF2) (CO) 2(PPh3)2]
-
Clark, G. R., Hoskins, S. V., Jones, T. C. & Roper, W. R. Oxidation state control of the reactivity of a transition metal-carbon double bond. Synthesis, X-ray crystal structure, and reactions of the zerovalent difluorocarbene complex [Ru=CF2) (CO)2(PPh3)2]. J. Chem. Soc. Chem. Commun. 1983, 719-721 (1983).
-
(1983)
J. Chem. Soc. Chem. Commun
, vol.1983
, pp. 719-721
-
-
Clark, G.R.1
Hoskins, S.V.2
Jones, T.C.3
Roper, W.R.4
-
44
-
-
0001595922
-
Synthesis and structural studies of phenyl(iodo)- and methyl (phenyl)palladium(II) complexes of bidentate nitrogen donor ligands
-
Markies, B. A. et al. Synthesis and structural studies of phenyl(iodo)- and methyl (phenyl)palladium(II) complexes of bidentate nitrogen donor ligands. J. Organomet. Chem. 482, 191-199 (1994).
-
(1994)
J. Organomet. Chem
, vol.482
, pp. 191-199
-
-
Markies, B.A.1
|