Pharmacological and Activated Fibroblast Targeting of Gβγ-GRK2 After Myocardial Ischemia Attenuates Heart Failure Progression

Journal of the American College of Cardiology

Volumn 70, Issue 8, 2017, Pages 958-971

  Travers, Joshua G ^a   Kamal, Fadia A ^a,b   Valiente Alandi, Iñigo ^a   Nieman, Michelle L ^c   Sargent, Michelle A ^a   Lorenz, John N ^c   Molkentin, Jeffery D ^a,d   Blaxall, Burns C ^a  

^a CINCINNATI CHILDREN'S HOSPITAL MEDICAL CENTER   (United States)

^b UNIVERSITY OF ROCHESTER MEDICAL CENTER   (United States)

^c UNIVERSITY OF CINCINNATI COLLEGE OF MEDICINE   (United States)

^d HOWARD HUGHES MEDICAL INSTITUTE   (United States)

Author keywords

cardiac fibroblast; cardioprotection; fibrosis; remodeling

Indexed keywords

CARDIOVASCULAR AGENT; G PROTEIN COUPLED RECEPTOR KINASE 2; GALLEIN; GUANINE NUCLEOTIDE BINDING PROTEIN BETA SUBUNIT; GUANINE NUCLEOTIDE BINDING PROTEIN GAMMA SUBUNIT; UNCLASSIFIED DRUG; ADRBK1 PROTEIN, HUMAN; XANTHENE DERIVATIVE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CELL ACTIVATION; CONTROLLED STUDY; DRUG DOSE TITRATION; DRUG MECHANISM; ENZYME INHIBITION; FIBROBLAST; HEART FAILURE; HEART MUSCLE CONTRACTILITY; HEART MUSCLE FIBROSIS; HEART MUSCLE INJURY; HEART MUSCLE ISCHEMIA; HEART PROTECTION; HEART VENTRICLE REMODELING; IN VITRO STUDY; MOUSE; MUSCLE CELL; MYOFIBROBLAST; NONHUMAN; PRIORITY JOURNAL; PROTEIN PROTEIN INTERACTION; REPERFUSION INJURY; ANIMAL; ANTAGONISTS AND INHIBITORS; CARDIAC MUSCLE; DISEASE COURSE; DISEASE MODEL; DRUG EFFECTS; KNOCKOUT MOUSE; METABOLISM; MYOCARDIAL ISCHEMIA; PATHOLOGY;

ANIMALS; DISEASE MODELS, ANIMAL; DISEASE PROGRESSION; G-PROTEIN-COUPLED RECEPTOR KINASE 2; HEART FAILURE; MICE; MICE, KNOCKOUT; MYOCARDIAL ISCHEMIA; MYOCARDIUM; MYOFIBROBLASTS; VENTRICULAR REMODELING; XANTHENES;

EID: 85026799213     PISSN: 07351097     EISSN: 15583597     Source Type: Journal    
DOI: 10.1016/j.jacc.2017.06.049     Document Type: Article

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