Total Synthesis of Aspergillomarasmine A and Related Compounds: A Sulfamidate Approach Enables Exploration of Structure–Activity Relationships

Angewandte Chemie - International Edition

Volumn 55, Issue 42, 2016, Pages 13259-13262

  Albu, Silvia A ^a   Koteva, Kalinka ^b   King, Andrew M ^b   Al Karmi, Salma ^a   Wright, Gerard D ^b   Capretta, Alfredo ^a,b  

^a MCMASTER UNIVERSITY   (Canada)

^b MCMASTER UNIVERSITY   (Canada)

Author keywords

antibiotics; enzymes; inhibitors; lactams; total synthesis

Indexed keywords

AMIDES; ANTIBIOTICS; BIOACTIVITY; CORROSION INHIBITORS; ENZYMES; METABOLITES; SYNTHESIS (CHEMICAL);

IN-VITRO; LACTAMASES; LACTAMS; RELATED COMPOUNDS; SECONDARY METABOLITES; STRUCTURE ACTIVITY RELATIONSHIPS; TOTAL SYNTHESIS;

ENZYME ACTIVITY;

AMIDE; ANTIINFECTIVE AGENT; ASPARTIC ACID; ASPERGILLOMARASMINE A; BETA LACTAMASE; BETA-LACTAMASE NDM-1; ENZYME INHIBITOR;

ACINETOBACTER; ANALOGS AND DERIVATIVES; CHEMICAL STRUCTURE; CHEMISTRY; DOSE RESPONSE; DRUG EFFECT; ENTEROBACTERIACEAE; ENZYMOLOGY; METABOLISM; MICROBIAL SENSITIVITY TEST; PSEUDOMONAS; STRUCTURE ACTIVITY RELATION; SYNTHESIS;

ACINETOBACTER; AMIDES; ANTI-BACTERIAL AGENTS; ASPARTIC ACID; BETA-LACTAMASES; DOSE-RESPONSE RELATIONSHIP, DRUG; ENTEROBACTERIACEAE; ENZYME INHIBITORS; MICROBIAL SENSITIVITY TESTS; MOLECULAR STRUCTURE; PSEUDOMONAS; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 84992093037     PISSN: 14337851     EISSN: 15213773     Source Type: Journal    
DOI: 10.1002/anie.201606657     Document Type: Article

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