-
1
-
-
84880418200
-
How we treat lower-risk myelodysplastic syndromes
-
Fenaux, P., Ades, L., How we treat lower-risk myelodysplastic syndromes. Blood 121:21 (2013), 4280–4286.
-
(2013)
Blood
, vol.121
, Issue.21
, pp. 4280-4286
-
-
Fenaux, P.1
Ades, L.2
-
2
-
-
3142688226
-
Anemia and its relationship to clinical outcome in heart failure
-
Anand, I., McMurray, J.J.V., Whitmore, J., et al. Anemia and its relationship to clinical outcome in heart failure. Circulation 110:2 (2004), 149–154.
-
(2004)
Circulation
, vol.110
, Issue.2
, pp. 149-154
-
-
Anand, I.1
McMurray, J.J.V.2
Whitmore, J.3
-
3
-
-
70349545970
-
Iron overload and toxicity: The hidden risk of multiple blood transfusions
-
Shander, A., Cappellini, M.D., Goodnough, L.T., Iron overload and toxicity: The hidden risk of multiple blood transfusions. Vox Sanguinis, 2009, 185–197.
-
(2009)
Vox Sanguinis
, pp. 185-197
-
-
Shander, A.1
Cappellini, M.D.2
Goodnough, L.T.3
-
4
-
-
84995948190
-
Recent advances in the treatment of lower-risk non-del(5q) myelodysplastic syndromes (MDS)
-
Almeida, A., Fenaux, P., List, A.F., Raza, A., Platzbecker, U., Santini, V., Recent advances in the treatment of lower-risk non-del(5q) myelodysplastic syndromes (MDS). Leuk Res 52 (2017), 50–57.
-
(2017)
Leuk Res
, vol.52
, pp. 50-57
-
-
Almeida, A.1
Fenaux, P.2
List, A.F.3
Raza, A.4
Platzbecker, U.5
Santini, V.6
-
5
-
-
0028953367
-
Efficacy of erythropoietin in the myelodysplastic syndromes: a meta-analysis of 205 patients from 17 studies
-
Hellström-Lindberg, E., Efficacy of erythropoietin in the myelodysplastic syndromes: a meta-analysis of 205 patients from 17 studies. Br J Haematol 89:1 (1995), 67–71.
-
(1995)
Br J Haematol
, vol.89
, Issue.1
, pp. 67-71
-
-
Hellström-Lindberg, E.1
-
6
-
-
0030958668
-
Response to recombinant human erythropoietin in patients with myelodysplastic syndromes
-
Stasi, R., Brunetti, M., Bussa, S., et al. Response to recombinant human erythropoietin in patients with myelodysplastic syndromes. Clin Cancer Res 3:5 (1997), 733–739.
-
(1997)
Clin Cancer Res
, vol.3
, Issue.5
, pp. 733-739
-
-
Stasi, R.1
Brunetti, M.2
Bussa, S.3
-
7
-
-
0032409909
-
A randomized double-blind placebo-controlled study with subcutaneous recombinant human erythropoietin in patients with low-risk myelodysplastic syndromes
-
Ferrini, P.R., Grossi, A., Vannucchi, A.M., et al. A randomized double-blind placebo-controlled study with subcutaneous recombinant human erythropoietin in patients with low-risk myelodysplastic syndromes. Br J Haematol 103:4 (1998), 1070–1074.
-
(1998)
Br J Haematol
, vol.103
, Issue.4
, pp. 1070-1074
-
-
Ferrini, P.R.1
Grossi, A.2
Vannucchi, A.M.3
-
8
-
-
0036066255
-
Prolonged administration of erythropoietin increases erythroid response rate in myelodysplastic syndromes: a phase ii trial in 281 patients
-
Terpos, E., Mougiou, A., Kouraklis, A., et al. Prolonged administration of erythropoietin increases erythroid response rate in myelodysplastic syndromes: a phase ii trial in 281 patients. Br J Haematol 118:1 (2002), 174–180.
-
(2002)
Br J Haematol
, vol.118
, Issue.1
, pp. 174-180
-
-
Terpos, E.1
Mougiou, A.2
Kouraklis, A.3
-
9
-
-
85020293414
-
Randomized, double-blind, placebo-controlled, multicenter study evaluating epoetin alfa versus placebo in anemic patients with IPSS LOW- INT1 risk MDS
-
Fenaux, P., Santini, V., Spiriti, M.A.A., et al. Randomized, double-blind, placebo-controlled, multicenter study evaluating epoetin alfa versus placebo in anemic patients with IPSS LOW- INT1 risk MDS. Haematologica, 2016, P248.
-
(2016)
Haematologica
, pp. P248
-
-
Fenaux, P.1
Santini, V.2
Spiriti, M.A.A.3
-
10
-
-
28444489284
-
Darbepoetin alfa for the treatment of anemic patients with low- and intermediate-1-risk myelodysplastic syndromes
-
Stasi, R., Abruzzese, E., Lanzetta, G., Terzoli, E., Amadori, S., Darbepoetin alfa for the treatment of anemic patients with low- and intermediate-1-risk myelodysplastic syndromes. Ann Oncol 16:12 (2005), 1921–1927.
-
(2005)
Ann Oncol
, vol.16
, Issue.12
, pp. 1921-1927
-
-
Stasi, R.1
Abruzzese, E.2
Lanzetta, G.3
Terzoli, E.4
Amadori, S.5
-
11
-
-
33646237362
-
High-dose darbepoetin alpha in the treatment of anaemia of lower risk myelodysplastic syndrome results of a phase II study
-
Mannone, L., Gardin, C., Quarre, M.C., et al. High-dose darbepoetin alpha in the treatment of anaemia of lower risk myelodysplastic syndrome results of a phase II study. Br J Haematol 133:5 (2006), 513–519.
-
(2006)
Br J Haematol
, vol.133
, Issue.5
, pp. 513-519
-
-
Mannone, L.1
Gardin, C.2
Quarre, M.C.3
-
12
-
-
46949086842
-
Phase 2, single-arm trial to evaluate the effectiveness of darbepoetin alfa for correcting anaemia in patients with myelodysplastic syndromes
-
Gabrilove, J., Paquette, R., Lyons, R.M., et al. Phase 2, single-arm trial to evaluate the effectiveness of darbepoetin alfa for correcting anaemia in patients with myelodysplastic syndromes. Br J Haematol 142:3 (2008), 379–393.
-
(2008)
Br J Haematol
, vol.142
, Issue.3
, pp. 379-393
-
-
Gabrilove, J.1
Paquette, R.2
Lyons, R.M.3
-
13
-
-
84987755614
-
Efficacy and safety of darbepoetin alpha in patients with myelodysplastic syndromes: a systematic review and meta-analysis
-
Park, S., Fenaux, P., Greenberg, P., et al. Efficacy and safety of darbepoetin alpha in patients with myelodysplastic syndromes: a systematic review and meta-analysis. Br J Haematol 174:5 (2016), 730–747.
-
(2016)
Br J Haematol
, vol.174
, Issue.5
, pp. 730-747
-
-
Park, S.1
Fenaux, P.2
Greenberg, P.3
-
14
-
-
85028816042
-
A phase 3 randomized placebo-controlled trial of darbepoetin alfa in patients with anemia and lower-risk myelodysplastic syndromes
-
Jun 19 (epub ahead of print)
-
Platzbecker, U., Symeonidis, A., Oliva, E.N., et al. A phase 3 randomized placebo-controlled trial of darbepoetin alfa in patients with anemia and lower-risk myelodysplastic syndromes. Leukemia, 2017 Jun 19 (epub ahead of print).
-
(2017)
Leukemia
-
-
Platzbecker, U.1
Symeonidis, A.2
Oliva, E.N.3
-
15
-
-
84887380862
-
Can the revised IPSS predict response to erythropoietic-stimulating agents in patients with classical IPSS low or intermediate-1 MDS?
-
Santini, V., Schemenau, J., Levis, A., et al. Can the revised IPSS predict response to erythropoietic-stimulating agents in patients with classical IPSS low or intermediate-1 MDS?. Blood 122:13 (2013), 2286–2288.
-
(2013)
Blood
, vol.122
, Issue.13
, pp. 2286-2288
-
-
Santini, V.1
Schemenau, J.2
Levis, A.3
-
16
-
-
85008252451
-
Erythropoiesis-stimulating agents significantly delay the onset of a regular transfusion need in nontransfused patients with lower-risk myelodysplastic syndrome
-
Garelius, H.K., Johnston, W.T., Smith, A.G., et al. Erythropoiesis-stimulating agents significantly delay the onset of a regular transfusion need in nontransfused patients with lower-risk myelodysplastic syndrome. J Intern Med. 281:3 (2017), 284–299.
-
(2017)
J Intern Med.
, vol.281
, Issue.3
, pp. 284-299
-
-
Garelius, H.K.1
Johnston, W.T.2
Smith, A.G.3
-
17
-
-
77957016201
-
Early introduction of ESA in low risk MDS patients may delay the need for RBC transfusion: a retrospective analysis on 112 patients
-
Park, S., Kelaidi, C., Sapena, R., et al. Early introduction of ESA in low risk MDS patients may delay the need for RBC transfusion: a retrospective analysis on 112 patients. Leuk Res 34:11 (2010), 1430–1436.
-
(2010)
Leuk Res
, vol.34
, Issue.11
, pp. 1430-1436
-
-
Park, S.1
Kelaidi, C.2
Sapena, R.3
-
18
-
-
44449088313
-
Erythropoiesis-stimulating agents in the treatment of anemia in myelodysplastic syndromes: a meta-analysis
-
Moyo, V., Lefebvre, P., Duh, M.S., Yektashenas, B., Mundle, S., Erythropoiesis-stimulating agents in the treatment of anemia in myelodysplastic syndromes: a meta-analysis. Ann Hematol, 2008, 527–536.
-
(2008)
Ann Hematol
, pp. 527-536
-
-
Moyo, V.1
Lefebvre, P.2
Duh, M.S.3
Yektashenas, B.4
Mundle, S.5
-
19
-
-
78149250055
-
p-ERK1/2 is a predictive factor of response to erythropoiesis-stimulating agents in low/int-1 myelodysplastic syndromes
-
Frisan, E., Pawlikowska, P., Pierre-Eugène, C., et al. p-ERK1/2 is a predictive factor of response to erythropoiesis-stimulating agents in low/int-1 myelodysplastic syndromes. Haematologica 95:11 (2010), 1964–1968.
-
(2010)
Haematologica
, vol.95
, Issue.11
, pp. 1964-1968
-
-
Frisan, E.1
Pawlikowska, P.2
Pierre-Eugène, C.3
-
20
-
-
84861777979
-
Distinct signal transduction abnormalities and erythropoietin response in bone marrow hematopoietic cell subpopulations of myelodysplastic syndrome patients
-
Spinelli, E., Caporale, R., Buchi, F., et al. Distinct signal transduction abnormalities and erythropoietin response in bone marrow hematopoietic cell subpopulations of myelodysplastic syndrome patients. Clin Cancer Res 18:11 (2012), 3079–3089.
-
(2012)
Clin Cancer Res
, vol.18
, Issue.11
, pp. 3079-3089
-
-
Spinelli, E.1
Caporale, R.2
Buchi, F.3
-
21
-
-
84977079028
-
Are somatic mutations predictive of response to erythropoiesis stimulating agents in lower risk myelodysplastic syndromes?
-
Kosmider, O., Passet, M., Santini, V., et al. Are somatic mutations predictive of response to erythropoiesis stimulating agents in lower risk myelodysplastic syndromes?. Haematologica 101:7 (2016), e280–e283.
-
(2016)
Haematologica
, vol.101
, Issue.7
, pp. e280-e283
-
-
Kosmider, O.1
Passet, M.2
Santini, V.3
-
22
-
-
49049116574
-
Erythropoietin and granulocyte-colony stimulating factor treatment associated with improved survival in myelodysplastic syndrome
-
Jädersten, M., Dybedal, I., Della Porta, M.G., et al. Erythropoietin and granulocyte-colony stimulating factor treatment associated with improved survival in myelodysplastic syndrome. J Clin Oncol 26 (2008), 3607–3613.
-
(2008)
J Clin Oncol
, vol.26
, pp. 3607-3613
-
-
Jädersten, M.1
Dybedal, I.2
Della Porta, M.G.3
-
23
-
-
38349097652
-
Predictive factors of response and survival in myelodysplastic syndrome treated with erythropoietin and G-CSF: the GFM experience
-
Park, S., Grabar, S., Kelaidi, C., et al. Predictive factors of response and survival in myelodysplastic syndrome treated with erythropoietin and G-CSF: the GFM experience. Blood 111:2 (2008), 574–582.
-
(2008)
Blood
, vol.111
, Issue.2
, pp. 574-582
-
-
Park, S.1
Grabar, S.2
Kelaidi, C.3
-
24
-
-
70350512346
-
Treatment of myelodysplastic syndrome patients with erythropoietin with or without granulocyte colony-stimulating factor: results of a prospective randomized phase 3 trial by the Eastern Cooperative Oncology Group (E1996)
-
Greenberg, P.L., Sun, Z., Miller, K.B., et al. Treatment of myelodysplastic syndrome patients with erythropoietin with or without granulocyte colony-stimulating factor: results of a prospective randomized phase 3 trial by the Eastern Cooperative Oncology Group (E1996). Blood 114:12 (2009), 2393–2400.
-
(2009)
Blood
, vol.114
, Issue.12
, pp. 2393-2400
-
-
Greenberg, P.L.1
Sun, Z.2
Miller, K.B.3
-
25
-
-
60849116699
-
An assessment of erythroid response to epoetin alpha as a single agent versus in combination with granulocyte- or granulocyte-macrophage-colony-stimulating factor in myelodysplastic syndromes using a meta-analysis approach
-
Mundle, S., Lefebvre, P., Vekeman, F., Duh, M.S., Rastogi, R., Moyo, V., An assessment of erythroid response to epoetin alpha as a single agent versus in combination with granulocyte- or granulocyte-macrophage-colony-stimulating factor in myelodysplastic syndromes using a meta-analysis approach. Cancer 115:4 (2009), 706–715.
-
(2009)
Cancer
, vol.115
, Issue.4
, pp. 706-715
-
-
Mundle, S.1
Lefebvre, P.2
Vekeman, F.3
Duh, M.S.4
Rastogi, R.5
Moyo, V.6
-
26
-
-
41949092882
-
Treatment of myelodysplastic syndromes with 5q deletion before the lenalidomide era; the GFM experience with EPO and thalidomide
-
Kelaidi, C., Park, S., Brechignac, S., et al. Treatment of myelodysplastic syndromes with 5q deletion before the lenalidomide era; the GFM experience with EPO and thalidomide. Leuk Res 32:7 (2008), 1049–1053.
-
(2008)
Leuk Res
, vol.32
, Issue.7
, pp. 1049-1053
-
-
Kelaidi, C.1
Park, S.2
Brechignac, S.3
-
27
-
-
80053621748
-
A randomized phase 3 study of lenalidomide versus placebo in RBC transfusion-dependent patients with Low-/Intermediate-1-risk myelodysplastic syndromes with del5q
-
Fenaux, P., Giagounidis, A., Selleslag, D., et al. A randomized phase 3 study of lenalidomide versus placebo in RBC transfusion-dependent patients with Low-/Intermediate-1-risk myelodysplastic syndromes with del5q. Blood 118:14 (2011), 3765–3776.
-
(2011)
Blood
, vol.118
, Issue.14
, pp. 3765-3776
-
-
Fenaux, P.1
Giagounidis, A.2
Selleslag, D.3
-
28
-
-
84878924059
-
Long-term outcome of anemic lower-risk myelodysplastic syndromes without 5q deletion refractory to or relapsing after erythropoiesis-stimulating agents
-
Kelaidi, C., Park, S., Sapena, R., et al. Long-term outcome of anemic lower-risk myelodysplastic syndromes without 5q deletion refractory to or relapsing after erythropoiesis-stimulating agents. Leukemia 27:6 (2013), 1283–1290.
-
(2013)
Leukemia
, vol.27
, Issue.6
, pp. 1283-1290
-
-
Kelaidi, C.1
Park, S.2
Sapena, R.3
-
29
-
-
85026885535
-
Outcome of Lower-Risk Patients With Myelodysplastic Syndromes Without 5q Deletion After Failure of Erythropoiesis-Stimulating Agents
-
Park, S., Hamel, J.F., Toma, A., et al. Outcome of Lower-Risk Patients With Myelodysplastic Syndromes Without 5q Deletion After Failure of Erythropoiesis-Stimulating Agents. J Clin Oncol. 35:14 (2017), 1591–1597.
-
(2017)
J Clin Oncol.
, vol.35
, Issue.14
, pp. 1591-1597
-
-
Park, S.1
Hamel, J.F.2
Toma, A.3
-
30
-
-
84901839639
-
Limited clinical efficacy of azacitidine in transfusion-dependent, growth factor-resistant, low- and Int-1-risk MDS: Results from the nordic NMDSG08A phase II trial
-
Tobiasson, M., Dybedahl, I., Holm, M.S., et al. Limited clinical efficacy of azacitidine in transfusion-dependent, growth factor-resistant, low- and Int-1-risk MDS: Results from the nordic NMDSG08A phase II trial. Blood Cancer J, 4(3), 2014, e189.
-
(2014)
Blood Cancer J
, vol.4
, Issue.3
, pp. e189
-
-
Tobiasson, M.1
Dybedahl, I.2
Holm, M.S.3
-
31
-
-
38049113182
-
Phase 2 study of lenalidomide in transfusion-dependent, low-risk, and intermediate-1-risk myelodysplastic syndromes with karyotypes other than deletion 5q
-
Raza, A., Reeves, J.A., Feldman, E.J., et al. Phase 2 study of lenalidomide in transfusion-dependent, low-risk, and intermediate-1-risk myelodysplastic syndromes with karyotypes other than deletion 5q. Blood 111:1 (2008), 86–93.
-
(2008)
Blood
, vol.111
, Issue.1
, pp. 86-93
-
-
Raza, A.1
Reeves, J.A.2
Feldman, E.J.3
-
32
-
-
13444256401
-
Efficacy of lenalidomide in myelodysplastic syndromes
-
List, A., Kurtin, S., Roe, D.J., et al. Efficacy of lenalidomide in myelodysplastic syndromes. N Engl J Med 352:6 (2005), 549–557.
-
(2005)
N Engl J Med
, vol.352
, Issue.6
, pp. 549-557
-
-
List, A.1
Kurtin, S.2
Roe, D.J.3
-
33
-
-
84867612592
-
Combined treatment with lenalidomide and epoetin alfa in lower-risk patients with myelodysplastic syndrome
-
Komrokji, R.S., Lancet, J.E., Swern, A.S., et al. Combined treatment with lenalidomide and epoetin alfa in lower-risk patients with myelodysplastic syndrome. Blood 120:17 (2012), 3419–3424.
-
(2012)
Blood
, vol.120
, Issue.17
, pp. 3419-3424
-
-
Komrokji, R.S.1
Lancet, J.E.2
Swern, A.S.3
-
34
-
-
84857033689
-
Lenalidomide in lower-risk myelodysplastic syndromes with karyotypes other than deletion 5q and refractory to erythropoiesis-stimulating agents
-
Sibon, D., Cannas, G., Baracco, F., et al. Lenalidomide in lower-risk myelodysplastic syndromes with karyotypes other than deletion 5q and refractory to erythropoiesis-stimulating agents. Br J Haematol 156:5 (2012), 619–625.
-
(2012)
Br J Haematol
, vol.156
, Issue.5
, pp. 619-625
-
-
Sibon, D.1
Cannas, G.2
Baracco, F.3
-
35
-
-
84954348593
-
Lenalidomide with or without erythropoietin in transfusion-dependent erythropoiesis-stimulating agent-refractory lower-risk MDS without 5q deletion
-
Toma, A., Kosmider, O., Chevret, S., et al. Lenalidomide with or without erythropoietin in transfusion-dependent erythropoiesis-stimulating agent-refractory lower-risk MDS without 5q deletion. Leukemia 30:4 (2016), 897–905.
-
(2016)
Leukemia
, vol.30
, Issue.4
, pp. 897-905
-
-
Toma, A.1
Kosmider, O.2
Chevret, S.3
-
36
-
-
0025781542
-
Serum erythropoietin concentrations in patients with myelodysplastic syndromes
-
Aul, C., Arning, M., Runde, V., Schneider, W., Serum erythropoietin concentrations in patients with myelodysplastic syndromes. Leuk Res 15:7 (1991), 571–575.
-
(1991)
Leuk Res
, vol.15
, Issue.7
, pp. 571-575
-
-
Aul, C.1
Arning, M.2
Runde, V.3
Schneider, W.4
-
37
-
-
83455220200
-
From stem cell to red cell: regulation of erythropoiesis at multiple levels by multiple proteins, RNAs, and chromatin modifications
-
Hattangadi, S.M., Wong, P., Zhang, L., Flygare, J., Lodish, H.F., From stem cell to red cell: regulation of erythropoiesis at multiple levels by multiple proteins, RNAs, and chromatin modifications. Blood 118:24 (2011), 6258–6268.
-
(2011)
Blood
, vol.118
, Issue.24
, pp. 6258-6268
-
-
Hattangadi, S.M.1
Wong, P.2
Zhang, L.3
Flygare, J.4
Lodish, H.F.5
-
38
-
-
0036493359
-
In vitro proliferation and differentiation of erythroid progenitors from patients with myelodysplastic syndromes: Evidence for Fas-dependent apoptosis
-
Claessens, Y.E., Bouscary, D., Dupont, J.M., et al. In vitro proliferation and differentiation of erythroid progenitors from patients with myelodysplastic syndromes: Evidence for Fas-dependent apoptosis. Blood 99:5 (2002), 1594–1601.
-
(2002)
Blood
, vol.99
, Issue.5
, pp. 1594-1601
-
-
Claessens, Y.E.1
Bouscary, D.2
Dupont, J.M.3
-
39
-
-
0033824309
-
Transforming growth factor inhibits erythropoiesis by blocking proliferation and accelerating differentiation of erythroid progenitors
-
Zermati, Y., Fichelson, S., Valensi, F., et al. Transforming growth factor inhibits erythropoiesis by blocking proliferation and accelerating differentiation of erythroid progenitors. Exp Hematol 28:8 (2000), 885–894.
-
(2000)
Exp Hematol
, vol.28
, Issue.8
, pp. 885-894
-
-
Zermati, Y.1
Fichelson, S.2
Valensi, F.3
-
40
-
-
84943567455
-
Cooperative effect of erythropoietin and TGF-β inhibition on erythroid development in human pluripotent stem cells
-
Xie, Y., Bai, H., Liu, Y., Hoyle, D.L., Cheng, T., Wang, Z.Z., Cooperative effect of erythropoietin and TGF-β inhibition on erythroid development in human pluripotent stem cells. J Cell Biochem 116:12 (2015), 2735–2743.
-
(2015)
J Cell Biochem
, vol.116
, Issue.12
, pp. 2735-2743
-
-
Xie, Y.1
Bai, H.2
Liu, Y.3
Hoyle, D.L.4
Cheng, T.5
Wang, Z.Z.6
-
41
-
-
84930933095
-
TGF-β signaling in the control of hematopoietic stem cells
-
Blank, U., Karlsson, S., TGF-β signaling in the control of hematopoietic stem cells. Blood 125:23 (2015), 3542–3550.
-
(2015)
Blood
, vol.125
, Issue.23
, pp. 3542-3550
-
-
Blank, U.1
Karlsson, S.2
-
42
-
-
84898042418
-
Transforming growth factor-β superfamily ligand trap ACE-536 corrects anemia by promoting late-stage erythropoiesis
-
Suragani, R.N.V.S., Cadena, S.M., Cawley, S.M., et al. Transforming growth factor-β superfamily ligand trap ACE-536 corrects anemia by promoting late-stage erythropoiesis. Nat Med 20:4 (2014), 408–414.
-
(2014)
Nat Med
, vol.20
, Issue.4
, pp. 408-414
-
-
Suragani, R.N.V.S.1
Cadena, S.M.2
Cawley, S.M.3
-
43
-
-
54049149411
-
Inhibition of the TGF-β receptor I kinase promotes hematopoiesis in MDS
-
Zhou, L., Nguyen, A.N., Sohal, D., et al. Inhibition of the TGF-β receptor I kinase promotes hematopoiesis in MDS. Blood 112:8 (2008), 3434–3443.
-
(2008)
Blood
, vol.112
, Issue.8
, pp. 3434-3443
-
-
Zhou, L.1
Nguyen, A.N.2
Sohal, D.3
-
44
-
-
84879149544
-
MiR-21 mediates hematopoietic suppression in MDS by activating TGF-β signaling
-
Bhagat, T.D., Zhou, L., Sokol, L., et al. MiR-21 mediates hematopoietic suppression in MDS by activating TGF-β signaling. Blood 121:15 (2013), 2875–2881.
-
(2013)
Blood
, vol.121
, Issue.15
, pp. 2875-2881
-
-
Bhagat, T.D.1
Zhou, L.2
Sokol, L.3
-
45
-
-
79551518231
-
Reduced SMAD7 leads to overactivation of TGF-β signaling in MDS that can be reversed by a specific inhibitor of TGF-β receptor I kinase
-
Zhou, L., McMahon, C., Bhagat, T., et al. Reduced SMAD7 leads to overactivation of TGF-β signaling in MDS that can be reversed by a specific inhibitor of TGF-β receptor I kinase. Cancer Res 71:3 (2011), 955–963.
-
(2011)
Cancer Res
, vol.71
, Issue.3
, pp. 955-963
-
-
Zhou, L.1
McMahon, C.2
Bhagat, T.3
-
46
-
-
77957734208
-
Sotatercept, a soluble activin receptor type 2A IgG-Fc fusion protein for the treatment of anemia and bone loss
-
Raje, N., Vallet, S., Sotatercept, a soluble activin receptor type 2A IgG-Fc fusion protein for the treatment of anemia and bone loss. Curr Opin Mol Ther 12:5 (2010), 586–597.
-
(2010)
Curr Opin Mol Ther
, vol.12
, Issue.5
, pp. 586-597
-
-
Raje, N.1
Vallet, S.2
-
47
-
-
77950533566
-
A soluble activin receptor Type IIA fusion protein (ACE-011) increases bone mass via a dual anabolic-antiresorptive effect in Cynomolgus monkeys
-
Lotinun, S., Pearsall, R.S., Davies, M.V., et al. A soluble activin receptor Type IIA fusion protein (ACE-011) increases bone mass via a dual anabolic-antiresorptive effect in Cynomolgus monkeys. Bone 46:4 (2010), 1082–1088.
-
(2010)
Bone
, vol.46
, Issue.4
, pp. 1082-1088
-
-
Lotinun, S.1
Pearsall, R.S.2
Davies, M.V.3
-
48
-
-
72049109947
-
Treatment with a soluble receptor for activin improves bone mass and structure in the axial and appendicular skeleton of female cynomolgus macaques (Macaca fascicularis)
-
Fajardo, R.J., Manoharan, R.K., Pearsall, R.S., et al. Treatment with a soluble receptor for activin improves bone mass and structure in the axial and appendicular skeleton of female cynomolgus macaques (Macaca fascicularis). Bone 46:1 (2010), 64–71.
-
(2010)
Bone
, vol.46
, Issue.1
, pp. 64-71
-
-
Fajardo, R.J.1
Manoharan, R.K.2
Pearsall, R.S.3
-
49
-
-
44349141964
-
A soluble activin type IIA receptor induces bone formation and improves skeletal integrity
-
Pearsall, R.S., Canalis, E., Cornwall-Brady, M., et al. A soluble activin type IIA receptor induces bone formation and improves skeletal integrity. Proc Natl Acad Sci U S A 105:19 (2008), 7082–7087.
-
(2008)
Proc Natl Acad Sci U S A
, vol.105
, Issue.19
, pp. 7082-7087
-
-
Pearsall, R.S.1
Canalis, E.2
Cornwall-Brady, M.3
-
50
-
-
84873485706
-
RAP-011, a soluble activin receptor type IIa murine IgG-Fc fusion protein, prevents chemotherapy induced anemia
-
Mulivor, A.W., Barbosa, D., Kumar, R., Sherman, M.L., Seehra, J.S., Pearsall, R.S., RAP-011, a soluble activin receptor type IIa murine IgG-Fc fusion protein, prevents chemotherapy induced anemia. Blood, 114(22), 2009, 161.
-
(2009)
Blood
, vol.114
, Issue.22
, pp. 161
-
-
Mulivor, A.W.1
Barbosa, D.2
Kumar, R.3
Sherman, M.L.4
Seehra, J.S.5
Pearsall, R.S.6
-
51
-
-
84898049056
-
An activin receptor IIA ligand trap corrects ineffective erythropoiesis in β-thalassemia
-
Dussiot, M., Maciel, T.T., Fricot, A., et al. An activin receptor IIA ligand trap corrects ineffective erythropoiesis in β-thalassemia. Nat Med 20:4 (2014), 398–407.
-
(2014)
Nat Med
, vol.20
, Issue.4
, pp. 398-407
-
-
Dussiot, M.1
Maciel, T.T.2
Fricot, A.3
-
52
-
-
84901690058
-
An activin receptor IIA ligand trap promotes erythropoiesis resulting in a rapid induction of red blood cells and haemoglobin
-
Carrancio, S., Markovics, J., Wong, P., et al. An activin receptor IIA ligand trap promotes erythropoiesis resulting in a rapid induction of red blood cells and haemoglobin. Br J Haematol 165:6 (2014), 870–882.
-
(2014)
Br J Haematol
, vol.165
, Issue.6
, pp. 870-882
-
-
Carrancio, S.1
Markovics, J.2
Wong, P.3
-
53
-
-
65549147617
-
Single-dose, randomized, double-blind, placebo-controlled study of ACE-011 (ActRIIA-IgG1) in postmenopausal women
-
Ruckle, J., Jacobs, M., Kramer, W., et al. Single-dose, randomized, double-blind, placebo-controlled study of ACE-011 (ActRIIA-IgG1) in postmenopausal women. J Bone Miner Res 24:4 (2009), 744–752.
-
(2009)
J Bone Miner Res
, vol.24
, Issue.4
, pp. 744-752
-
-
Ruckle, J.1
Jacobs, M.2
Kramer, W.3
-
54
-
-
84892903671
-
Multiple-dose, safety, pharmacokinetic, and pharmacodynamic study of sotatercept (ActRIIA-IgG1), a novel erythropoietic agent, in healthy postmenopausal women
-
Sherman, M.L., Borgstein, N.G., Mook, L., et al. Multiple-dose, safety, pharmacokinetic, and pharmacodynamic study of sotatercept (ActRIIA-IgG1), a novel erythropoietic agent, in healthy postmenopausal women. J Clin Pharmacol 53:11 (2013), 1121–1130.
-
(2013)
J Clin Pharmacol
, vol.53
, Issue.11
, pp. 1121-1130
-
-
Sherman, M.L.1
Borgstein, N.G.2
Mook, L.3
-
55
-
-
84901692001
-
Sotatercept in patients with osteolytic lesions of multiple myeloma
-
Abdulkadyrov, K.M., Salogub, G.N., Khuazheva, N.K., et al. Sotatercept in patients with osteolytic lesions of multiple myeloma. Br J Haematol 165:6 (2014), 814–823.
-
(2014)
Br J Haematol
, vol.165
, Issue.6
, pp. 814-823
-
-
Abdulkadyrov, K.M.1
Salogub, G.N.2
Khuazheva, N.K.3
-
56
-
-
84873505981
-
Stromal cell-mediated inhibition of erythropoiesis can be attenuated by Sotatercept (ACE-011), an activin receptor type II ligand trap
-
e17
-
Iancu-Rubin, C., Mosoyan, G., Wang, J., Kraus, T., Sung, V., Hoffman, R., Stromal cell-mediated inhibition of erythropoiesis can be attenuated by Sotatercept (ACE-011), an activin receptor type II ligand trap. Exp Hematol 41:2 (2013), 155–166 e17.
-
(2013)
Exp Hematol
, vol.41
, Issue.2
, pp. 155-166
-
-
Iancu-Rubin, C.1
Mosoyan, G.2
Wang, J.3
Kraus, T.4
Sung, V.5
Hoffman, R.6
-
57
-
-
84969310541
-
An open-label, phase 2, dose-finding study of sotatercept (ACE-011) in patients with low or intermediate-1 (int-1) myelodysplastic syndromes (MDS) or non-proliferative chronic myelomonocytic leukemia (CMML) and anemia requiring transfusion
-
Komrokji, R.S., Garcia-Manero, G., Ades, L., et al. An open-label, phase 2, dose-finding study of sotatercept (ACE-011) in patients with low or intermediate-1 (int-1) myelodysplastic syndromes (MDS) or non-proliferative chronic myelomonocytic leukemia (CMML) and anemia requiring transfusion. Blood, 124(21), 2014, 3251.
-
(2014)
Blood
, vol.124
, Issue.21
, pp. 3251
-
-
Komrokji, R.S.1
Garcia-Manero, G.2
Ades, L.3
-
58
-
-
84902829071
-
A phase 1 study of ACE-536, a regulator of erythroid differentiation, in healthy volunteers
-
Attie, K.M., Allison, M.J., Mcclure, T., et al. A phase 1 study of ACE-536, a regulator of erythroid differentiation, in healthy volunteers. Am J Hematol 89:7 (2014), 766–770.
-
(2014)
Am J Hematol
, vol.89
, Issue.7
, pp. 766-770
-
-
Attie, K.M.1
Allison, M.J.2
Mcclure, T.3
-
59
-
-
85022148244
-
Luspatercept increases hemoglobin and reduces transfusion burden in patients with low-intermediate risk myelodysplastic syndromes (MDS): long-term results from phase 2 PACE-MDS study
-
Platzbecker, U., Germing, U., Götze, K., et al. Luspatercept increases hemoglobin and reduces transfusion burden in patients with low-intermediate risk myelodysplastic syndromes (MDS): long-term results from phase 2 PACE-MDS study. Blood, 128(22), 2016, 3168.
-
(2016)
Blood
, vol.128
, Issue.22
, pp. 3168
-
-
Platzbecker, U.1
Germing, U.2
Götze, K.3
-
60
-
-
84992463049
-
Luspatercept (ACE-536) reduces disease burden, including anemia, iron overload, and leg ulcers, in adults with beta-thalassemia: results from a phase 2 study
-
Piga, A., Perrotta, S., Gamberini, M.R., et al. Luspatercept (ACE-536) reduces disease burden, including anemia, iron overload, and leg ulcers, in adults with beta-thalassemia: results from a phase 2 study. Blood, 126(23), 2015, 752.
-
(2015)
Blood
, vol.126
, Issue.23
, pp. 752
-
-
Piga, A.1
Perrotta, S.2
Gamberini, M.R.3
-
61
-
-
85007240697
-
Activin receptor II ligand traps and their therapeutic potential in myelodysplastic syndromes with ring sideroblasts
-
Mies, A., Hermine, O., Platzbecker, U., Activin receptor II ligand traps and their therapeutic potential in myelodysplastic syndromes with ring sideroblasts. Curr Hematol Malig Rep 11:6 (2016), 416–424.
-
(2016)
Curr Hematol Malig Rep
, vol.11
, Issue.6
, pp. 416-424
-
-
Mies, A.1
Hermine, O.2
Platzbecker, U.3
|