-
1
-
-
0026565263
-
Evidence for the participation of endogenous activin A/erythroid differentiation factor in the regulation of erythropoiesis
-
Evidence for the participation of endogenous activin A/erythroid differentiation factor in the regulation of erythropoiesis. Shiozaki M, Sakai R, Tabuchi M, Nakamura T, Sugino K, Sugino H, Eto Y PROC NATL ACAD SCI USA 1992 89 5 1553-1556
-
(1992)
Proc. Natl. Acad. Sci. USA
, vol.89
, Issue.5
, pp. 1553-1556
-
-
Shiozaki, M.1
Sakai, R.2
Tabuchi, M.3
Nakamura, T.4
Sugino, K.5
Sugino, H.6
Eto, Y.7
-
2
-
-
0029003377
-
Osteogenic protein-1 binds to activin type II receptors and induces certain activin-like effects
-
Osteogenic protein-1 binds to activin type II receptors and induces certain activin-like effects. Yamashita H, Tendijke P, Huylebroeck D, Sampath TK, Andries M, Smith JC, Heldin CH, Miyazono K J CELL BIOL 1995 130 1 217-226
-
(1995)
J. Cell. Biol.
, vol.130
, Issue.1
, pp. 217-226
-
-
Yamashita, H.1
Tendijke, P.2
Huylebroeck, D.3
Sampath, T.K.4
Andries, M.5
Smith, J.C.6
Heldin, C.H.7
Miyazono, K.8
-
3
-
-
0035837553
-
Effect of parathyroid hormone (1-34) on fractures and bone mineral density in postmenopausal women with osteoporosis
-
Effect of parathyroid hormone (1-34) on fractures and bone mineral density in postmenopausal women with osteoporosis. Neer RM, Arnaud CD, Zanchetta JR, Prince R, Gaich GA, Reginster JY, Hodsman AB, Eriksen EF, Ish-Shalom S, Genant HK, Wang OH et al N ENGL J MED 2001 344 19 1434-1441
-
(2001)
N. Engl. J. Med.
, vol.344
, Issue.19
, pp. 1434-1441
-
-
Neer, R.M.1
Arnaud, C.D.2
Zanchetta, J.R.3
Prince, R.4
Gaich, G.A.5
Reginster, J.Y.6
Hodsman, A.B.7
Eriksen, E.F.8
Ish-Shalom, S.9
Genant, H.K.10
Wang, O.H.11
-
8
-
-
77957738733
-
Treatment with RAP-011 (a soluble activin receptor type IIA) increases bone mineral density in mice with prior bisphosphonate exposure
-
Abs
-
Treatment with RAP-011 (a soluble activin receptor type IIA) increases bone mineral density in mice with prior bisphosphonate exposure. Pearsall RS, Mangini M, Cornwall-Brady M, Monnell T, Marvell T, Haigis B, Kumar R, Underwood KW, Seehra J BONE 2008 42 Suppl 1 Abs 144
-
(2008)
Bone
, vol.42
, Issue.1 SUPPL.
, pp. 144
-
-
Pearsall, R.S.1
Mangini, M.2
Cornwall-Brady, M.3
Monnell, T.4
Marvell, T.5
Haigis, B.6
Kumar, R.7
Underwood, K.W.8
Seehra, J.9
-
9
-
-
77957728832
-
RAP-011, a soluble activin receptor type IIA IgG-Fc-fusion protein, is a novel bone anabolic agent that prevents bone loss in a mouse model of metastatic breast cancer
-
April 15 Abs
-
RAP-011, a soluble activin receptor type IIA IgG-Fc-fusion protein, is a novel bone anabolic agent that prevents bone loss in a mouse model of metastatic breast cancer. Mulivor AW, Cornwall-Brady M, Kumar R, Pearsall AE, Underwood KW, Ucran J, Sherman ML, Seehra J, Pearsall RS AM ASSOC CANCER RES ANN MEET 2008 99 April 15 Abs 4068
-
(2008)
Am. Assoc. Cancer Res. Ann. Meet.
, vol.99
, pp. 4068
-
-
Mulivor, A.W.1
Cornwall-Brady, M.2
Kumar, R.3
Pearsall, A.E.4
Underwood, K.W.5
Ucran, J.6
Sherman, M.L.7
Seehra, J.8
Pearsall, R.S.9
-
10
-
-
44349141964
-
A soluble activin type IIA receptor induces bone formation and improves skeletal integrity
-
• Describes the construction and puriflcation of RAP-011 and the inhibitory potency of the fusion protein against activin A. In vivo studies evaluating the effects of RAP-011 in ovariectomized mice with established bone loss are also presented
-
A soluble activin type IIA receptor induces bone formation and improves skeletal integrity. Pearsall RS, Canalis E, Cornwall-Brady M, Underwood KW, Haigis B, Ucran J, Kumar R, Pobre E, Grinberg A, Werner ED, Glatt V et al PROC NATL ACAD SCI USA 2008 105 19 7082-7087 • Describes the construction and puriflcation of RAP-011 and the inhibitory potency of the fusion protein against activin A. In vivo studies evaluating the effects of RAP-011 in ovariectomized mice with established bone loss are also presented.
-
(2008)
Proc. Natl. Acad. Sci. USA
, vol.105
, Issue.19
, pp. 7082-7087
-
-
Pearsall, R.S.1
Canalis, E.2
Cornwall-Brady, M.3
Underwood, K.W.4
Haigis, B.5
Ucran, J.6
Kumar, R.7
Pobre, E.8
Grinberg, A.9
Werner, E.D.10
Glatt, V.11
-
11
-
-
0036675220
-
Metastasis to bone: Causes, consequences and therapeutic opportunities
-
Metastasis to bone: Causes, consequences and therapeutic opportunities. Mundy GR NAT REV CANCER 2002 2 8 584-593
-
(2002)
Nat. Rev. Cancer
, vol.2
, Issue.8
, pp. 584-593
-
-
Mundy, G.R.1
-
13
-
-
77957725931
-
-
Celgene Corp: Form 10-K for the year ended 31 December, Celgene Corp FORM 10-K 2009 February 17
-
Celgene Corp: Form 10-K for the year ended 31 December 2008. Celgene Corp FORM 10-K 2009 February 17
-
(2008)
-
-
-
14
-
-
77956497430
-
RAP-011, a soluble activin receptor type IIA murine IgG-Fc fusion protein, is a novel bone anabolic agent that prevents bone loss and skeletal metastases in a mouse model of metastatic breast cancer
-
Abs OC
-
RAP-011, a soluble activin receptor type IIA murine IgG-Fc fusion protein, is a novel bone anabolic agent that prevents bone loss and skeletal metastases in a mouse model of metastatic breast cancer. Mulivor AW, Barbosa D, Kumar R, Pearsall AE, Underwood KW, Ucran JA, Seehra J, Pearsall R BONE 2009 44 Suppl 2 Abs OC 27
-
(2009)
Bone
, vol.44
, Issue.2 SUPPL.
, pp. 27
-
-
Mulivor, A.W.1
Barbosa, D.2
Kumar, R.3
Pearsall, A.E.4
Underwood, K.W.5
Ucran, J.A.6
Seehra, J.7
Pearsall, R.8
-
16
-
-
77956555237
-
ACE-011, a soluble activin receptor type IIA IgG-Fc fusion protein, increases hemoglobin (Hb) and improves bone lesions in multiple myeloma patients receiving myelosuppressive chemotherapy: Preliminary analysis
-
Abs, • Presents preliminary results from a phase IIa clinical trial in patients with stage II/III MM. Sotatercept 0.1, 0.3 and 0.5 mg/kg sc, q4w for 4 months dose-dependently increased hemoglobin levels and 7 of 22 evaluable patients experienced either complete or very good partial responses
-
ACE-011, a soluble activin receptor type IIA IgG-Fc fusion protein, increases hemoglobin (Hb) and improves bone lesions in multiple myeloma patients receiving myelosuppressive chemotherapy: Preliminary analysis. Abdulkadyrov KM, Salogub GN, Khuazheva MK, Woolf R, Haltom E, Borgstein NG, Knight R, Renshaw G, Yang Y, Sherman ML BLOOD 2009 114 22 Abs 749 • Presents preliminary results from a phase IIa clinical trial in patients with stage II/III MM. Sotatercept (0.1, 0.3 and 0.5 mg/kg sc, q4w for 4 months) dose-dependently increased hemoglobin levels and 7 of 22 evaluable patients experienced either complete or very good partial responses.
-
(2009)
Blood
, vol.114
, Issue.22
, pp. 749
-
-
Abdulkadyrov, K.M.1
Salogub, G.N.2
Khuazheva, M.K.3
Woolf, R.4
Haltom, E.5
Borgstein, N.G.6
Knight, R.7
Renshaw, G.8
Yang, Y.9
Sherman, M.L.10
-
17
-
-
77957744147
-
The use of RAP-011, a novel bone anabolic agent, in combination with parathyroid hormone or zoledronic acid using a mouse model of established bone loss
-
Abs
-
The use of RAP-011, a novel bone anabolic agent, in combination with parathyroid hormone or zoledronic acid using a mouse model of established bone loss. Cornwall-Brady M, Mangini M, Barbosa D, Mazzola L, Marvell T, Milling J, Haigis B, Kumar R, Underwood K, Pearsall RS J BONE MINER RES 2007 22 Suppl 1 Abs S394
-
(2007)
J. Bone Miner Res.
, vol.22
, Issue.1 SUPPL.
-
-
Cornwall-Brady, M.1
Mangini, M.2
Barbosa, D.3
Mazzola, L.4
Marvell, T.5
Milling, J.6
Haigis, B.7
Kumar, R.8
Underwood, K.9
Pearsall, R.S.10
-
18
-
-
77957730874
-
RAP-011 (a soluble activin receptor type IIA) increases bone mineral density in combination with prior antiresorptive therapy
-
Abs
-
RAP-011 (a soluble activin receptor type IIA) increases bone mineral density in combination with prior antiresorptive therapy. Mangini M, Comwall-Brady M, Pullen A, Halley K, Monnell T, Milling J, Haigis B, Kumar R, Underwood K, Pearsall RS J BONE MINER RES 2007 22 Suppl 1 Abs W312
-
(2007)
J. Bone Miner Res.
, vol.22
, Issue.1 SUPPL.
-
-
Mangini, M.1
Comwall-Brady, M.2
Pullen, A.3
Halley, K.4
Monnell, T.5
Milling, J.6
Haigis, B.7
Kumar, R.8
Underwood, K.9
Pearsall, R.S.10
-
19
-
-
34548388339
-
Prevention of cachexia-like syndrome development and reduction of tumor progression in inhibin-deficient mice following administration of a chimeric activin receptor type II-murine Fc protein
-
Prevention of cachexia-like syndrome development and reduction of tumor progression in inhibin-deficient mice following administration of a chimeric activin receptor type II-murine Fc protein. Li QL, Kumar R, Underwood K, O'Connor AE, Loveland KL, Seehra JS, Matzuk MM MOL HUM REPROD 2007 13 9 675-683
-
(2007)
Mol. Hum. Reprod.
, vol.13
, Issue.9
, pp. 675-683
-
-
Li, Q.L.1
Kumar, R.2
Underwood, K.3
O'Connor, A.E.4
Loveland, K.L.5
Seehra, J.S.6
Matzuk, M.M.7
-
20
-
-
77957738484
-
ACE-011, a soluble activin receptor type IIA fusion protein, increases BMD and improves microarchitecture in cynomolgus monkeys
-
Abs
-
ACE-011, a soluble activin receptor type IIA fusion protein, increases BMD and improves microarchitecture in cynomolgus monkeys. Fajardo RJ, Bouxsein ML, Pearsall AE, Grinberg A, Davies M, Monnell T, Ucran J, Barazza M, Kelly C, Khanzode D, Underwood K et al J BONE MINER RES 2007 22 Suppl 1 Abs 1230
-
(2007)
J. Bone Miner. Res.
, vol.22
, Issue.1 SUPPL.
, pp. 1230
-
-
Fajardo, R.J.1
Bouxsein, M.L.2
Pearsall, A.E.3
Grinberg, A.4
Davies, M.5
Monnell, T.6
Ucran, J.7
Barazza, M.8
Kelly, C.9
Khanzode, D.10
Underwood, K.11
-
21
-
-
67149119056
-
A single dose of ACE-011 is associated with increases in bone formation and decreases in bone resorption markers in healthy, postmenopausal women
-
Abs
-
A single dose of ACE-011 is associated with increases in bone formation and decreases in bone resorption markers in healthy, postmenopausal women. Ruckle J, Jacobs M, Kramer W, Kumar R, Underwood K, Pearsall RS, Pearsall A, Seehra J, Condon C, Sherman ML J BONE MINER RES 2007 22 Suppl 1 Abs 1132
-
(2007)
J. Bone Miner. Res.
, vol.22
, Issue.1 SUPPL.
, pp. 1132
-
-
Ruckle, J.1
Jacobs, M.2
Kramer, W.3
Kumar, R.4
Underwood, K.5
Pearsall, R.S.6
Pearsall, A.7
Seehra, J.8
Condon, C.9
Sherman, M.L.10
-
22
-
-
77957742818
-
Soluble activin receptor type IIA fusion protein, ACE-011, increases bone mass by stimulating bone formation and inhibiting bone resorption in cynomolgus monkeys
-
Abs SU
-
Soluble activin receptor type IIA fusion protein, ACE-011, increases bone mass by stimulating bone formation and inhibiting bone resorption in cynomolgus monkeys. Lotinun S, Fajardo RJ, Pearsall RS, Bouxsein ML, Baron R J BONE MINER RES 2008 23 Suppl Abs SU 376
-
(2008)
J. Bone Miner. Res.
, vol.23
, Issue.SUPPL.
, pp. 376
-
-
Lotinun, S.1
Fajardo, R.J.2
Pearsall, R.S.3
Bouxsein, M.L.4
Baron, R.5
-
23
-
-
77957735812
-
RAP-011, a soluble activin receptor type IIA, stimulates osteoblast differentiation and inhibits osteoclast development
-
Abs
-
RAP-011, a soluble activin receptor type IIA, stimulates osteoblast differentiation and inhibits osteoclast development. Pearsall RS, Werner ED, Kumar R, Davies M, Pobre E, Haigis B, Underwood KW, Seehra J CALCIF TISSUE INT 2008 82 Suppl 1 Abs Mo-P143
-
(2008)
Calcif. Tissue Int.
, vol.82
, Issue.1 SUPPL.
-
-
Pearsall, R.S.1
Werner, E.D.2
Kumar, R.3
Davies, M.4
Pobre, E.5
Haigis, B.6
Underwood, K.W.7
Seehra, J.8
-
24
-
-
77957739505
-
RAP-011, a soluble activin receptor type IIA IgG-Fc-fusion protein, is a novel bone anabolic agent that prevents bone loss and skeletal metastases in a mouse model of metastatic breast cancer
-
Abs
-
RAP-011, a soluble activin receptor type IIA IgG-Fc-fusion protein, is a novel bone anabolic agent that prevents bone loss and skeletal metastases in a mouse model of metastatic breast cancer. Mulivor A, Kumar R, Pearsall A, Underwood K, Ucran J, Sherman M, Seehra J, Pearsall RS CANCER TREAT REV 2008 34 Suppl 1 Abs P51
-
(2008)
Cancer Treat. Rev.
, vol.34
, Issue.1 SUPPL.
-
-
Mulivor, A.1
Kumar, R.2
Pearsall, A.3
Underwood, K.4
Ucran, J.5
Sherman, M.6
Seehra, J.7
Pearsall, R.S.8
-
25
-
-
77957735541
-
RAP-011, a soluble activin receptor type IIA IgG-Fc fusion protein, is a novel bone anabolic agent that prevents bone disease in multiple myeloma
-
Abs
-
RAP-011, a soluble activin receptor type IIA IgG-Fc fusion protein, is a novel bone anabolic agent that prevents bone disease in multiple myeloma. Chantry A, Heath D, Coulton L, Gallagher O, Evans H, Vanderkerken K, Seehra JS, Croucher PI CLIN EXP METASTASIS 2008 25 Suppl 1 Abs P86
-
(2008)
Clin. Exp. Metastasis
, vol.25
, Issue.1 SUPPL.
-
-
Chantry, A.1
Heath, D.2
Coulton, L.3
Gallagher, O.4
Evans, H.5
Vanderkerken, K.6
Seehra, J.S.7
Croucher, P.I.8
-
26
-
-
71649091151
-
ACE-011, a soluble activin receptor type IIa IgG-Fc fusion protein, increases hemoglobin and hematocrit levels in postmenopausal healthy women
-
Abs
-
ACE-011, a soluble activin receptor type IIa IgG-Fc fusion protein, increases hemoglobin and hematocrit levels in postmenopausal healthy women. Kim KT, Borgstein NG, Yang YJ, Haltom E, Mook L, Ababa MD, Reddy SK, Sherman ML BLOOD 2008 112 11 Abs 3866
-
(2008)
Blood
, vol.112
, Issue.11
, pp. 3866
-
-
Kim, K.T.1
Borgstein, N.G.2
Yang, Y.J.3
Haltom, E.4
Mook, L.5
Ababa, M.D.6
Reddy, S.K.7
Sherman, M.L.8
-
27
-
-
65549147617
-
Single-dose, randomized, double-blind, placebo-controlled study of ACE-011 (ActRIIA-IgG1) in postmenopausal women
-
•• Presents data from healthy postmenopausal women demonstrating that sotatercept 1 and 3 mg/kg iv and 0.1 mg/kg sc reduced FSH levels and increased BSALP and PINP levels. Safety and tolerability data are also provided
-
Single-dose, randomized, double-blind, placebo-controlled study of ACE-011 (ActRIIA-IgG1) in postmenopausal women. Ruckle J, Jacobs M, Kramer W, Pearsall AE, Kumar R, Underwood KW, Seehra J, Yang YJ, Condon CH, Sherman ML J BONE MINER RES 2009 24 4 744-752 •• Presents data from healthy postmenopausal women demonstrating that sotatercept (1 and 3 mg/kg iv and 0.1 mg/kg sc) reduced FSH levels and increased BSALP and PINP levels. Safety and tolerability data are also provided.
-
(2009)
J. Bone Miner. Res.
, vol.24
, Issue.4
, pp. 744-752
-
-
Ruckle, J.1
Jacobs, M.2
Kramer, W.3
Pearsall, A.E.4
Kumar, R.5
Underwood, K.W.6
Seehra, J.7
Yang, Y.J.8
Condon, C.H.9
Sherman, M.L.10
-
28
-
-
77957747475
-
RAP-011, a soluble activin receptor type IIA IgG-Fc fusion protein, is a novel bone anabolic agent that prevents bone loss and skeletal metastases in a mouse model of metastatic breast cancer
-
Abs
-
RAP-011, a soluble activin receptor type IIA IgG-Fc fusion protein, is a novel bone anabolic agent that prevents bone loss and skeletal metastases in a mouse model of metastatic breast cancer. Mulivor AW, Barbosa D, Kumar R, Pearsall AE, Underwood KW, Ucran JA, Seehra J, Pearsall RS CANCER RES 2009 69 2 Suppl Abs 1158
-
(2009)
Cancer Res.
, vol.69
, Issue.2 SUPPL.
, pp. 1158
-
-
Mulivor, A.W.1
Barbosa, D.2
Kumar, R.3
Pearsall, A.E.4
Underwood, K.W.5
Ucran, J.A.6
Seehra, J.7
Pearsall, R.S.8
-
29
-
-
77952104854
-
ACE-011, a soluble activin receptor type IIA IgG-Fc fusion protein, decreases follicle stimulating hormone and increases bone-specific alkaline phosphatase, a marker of bone formation, in postmenopausal healthy women
-
Abs
-
ACE-011, a soluble activin receptor type IIA IgG-Fc fusion protein, decreases follicle stimulating hormone and increases bone-specific alkaline phosphatase, a marker of bone formation, in postmenopausal healthy women. Borgstein NG, Yang Y, Condon CH, Haltom E, Sherman ML CANCER RES 2009 69 2 Suppl Abs 1160
-
(2009)
Cancer Res.
, vol.69
, Issue.2 SUPPL.
, pp. 1160
-
-
Borgstein, N.G.1
Yang, Y.2
Condon, C.H.3
Haltom, E.4
Sherman, M.L.5
-
30
-
-
77957744681
-
ACE-011, a soluble activin receptor type IIA IgG-Fc fusion protein, increases BMD within 4 months in postmenopausal healthy women
-
Abs
-
ACE-011, a soluble activin receptor type IIA IgG-Fc fusion protein, increases BMD within 4 months in postmenopausal healthy women. Borgstein NG, Yang Y, Haltom E, Mook L, Bouxsein M, Sherman ML OSTEOPOROSIS INT 2009 20 Suppl 1 Abs P759SA
-
(2009)
Osteoporosis Int.
, vol.20
, Issue.1 SUPPL.
-
-
Borgstein, N.G.1
Yang, Y.2
Haltom, E.3
Mook, L.4
Bouxsein, M.5
Sherman, M.L.6
-
31
-
-
72049109947
-
Treatment with a soluble receptor for activin improves bone mass and structure in the axial and appendicular skeleton of female cynomolgus macaques (Macaca fascicularis)
-
• The impact of sotatercept on bone mineral density, compressive mechanical properties and ash content is described, along with the pharmacokinetic profile of the fusion protein in cynomolgus monkeys
-
Treatment with a soluble receptor for activin improves bone mass and structure in the axial and appendicular skeleton of female cynomolgus macaques (Macaca fascicularis). Fajardo RJ, Manoharan RK, Pearsall RS, Davies MV, Marvell T, Monnell TE, Ucran JA, Pearsall AE, Khanzode D, Kumar R, Underwood KW et al BONE 2010 46 1 64-71 • The impact of sotatercept on bone mineral density, compressive mechanical properties and ash content is described, along with the pharmacokinetic profile of the fusion protein in cynomolgus monkeys.
-
(2010)
Bone
, vol.46
, Issue.1
, pp. 64-71
-
-
Fajardo, R.J.1
Manoharan, R.K.2
Pearsall, R.S.3
Davies, M.V.4
Marvell, T.5
Monnell, T.E.6
Ucran, J.A.7
Pearsall, A.E.8
Khanzode, D.9
Kumar, R.10
Underwood, K.W.11
-
32
-
-
77950533566
-
A soluble activin receptor type IIA fusion protein (ACE-011) increases bone mass via a dual anabolic-antiresorptive effect in cynomolgus monkeys
-
• Presents in vivo data demonstrating that sotatercept increased osteoblast surface and number, and promoted bone formation. The tolerability of sotatercept in cynomolgus monkeys and effects on biomarkers of bone formation are also described
-
A soluble activin receptor type IIA fusion protein (ACE-011) increases bone mass via a dual anabolic-antiresorptive effect in cynomolgus monkeys. Lotinun S, Pearsall RS, Davies MV, Marvell TH, Monnell TE, Ucran J, Fajardo RJ, Kumar R, Underwood KW, Seehra J, Bouxsein ML et al BONE 2010 46 4 1082-1088 • Presents in vivo data demonstrating that sotatercept increased osteoblast surface and number, and promoted bone formation. The tolerability of sotatercept in cynomolgus monkeys and effects on biomarkers of bone formation are also described.
-
(2010)
Bone
, vol.46
, Issue.4
, pp. 1082-1088
-
-
Lotinun, S.1
Pearsall, R.S.2
Davies, M.V.3
Marvell, T.H.4
Monnell, T.E.5
Ucran, J.6
Fajardo, R.J.7
Kumar, R.8
Underwood, K.W.9
Seehra, J.10
Bouxsein, M.L.11
-
33
-
-
74949112740
-
Effects of RAP-011, a soluble activin receptor, on multiple myeloma (MM) via targeting the microenvironment
-
April 12 Abs
-
Effects of RAP-011, a soluble activin receptor, on multiple myeloma (MM) via targeting the microenvironment. Vallet S, Mukherjee S, Vaghela N, Hideshima T, Pozzi S, Santo L, Yan H, Cirstea D, Seehra J, Scadden D, Anderson K et al AM ASSOC CANCER RES ANN MEET 2008 99 April 12 Abs 1521
-
(2008)
Am. Assoc. Cancer Res. Ann. Meet.
, vol.99
, pp. 1521
-
-
Vallet, S.1
Mukherjee, S.2
Vaghela, N.3
Hideshima, T.4
Pozzi, S.5
Santo, L.6
Yan, H.7
Cirstea, D.8
Seehra, J.9
Scadden, D.10
Anderson, K.11
-
34
-
-
84873485706
-
RAP-011, a soluble activin receptor type IIA murine IgG-Fc fusion protein, prevents chemotherapy induced anemia
-
Abs
-
RAP-011, a soluble activin receptor type IIA murine IgG-Fc fusion protein, prevents chemotherapy induced anemia. Mulivor AW, Barbosa D, Kumar R, Sherman ML, Seehra J, Pearsall RS BLOOD 2009 114 22 Abs 161
-
(2009)
Blood
, vol.114
, Issue.22
, pp. 161
-
-
Mulivor, A.W.1
Barbosa, D.2
Kumar, R.3
Sherman, M.L.4
Seehra, J.5
Pearsall, R.S.6
-
35
-
-
77957747476
-
Comparison of a soluble activin receptor type IIA (ACTRIIA), PTH and zoledronate, for treatment of established bone loss in OVX mice
-
Abs
-
Comparison of a soluble activin receptor type IIA (ACTRIIA), PTH and zoledronate, for treatment of established bone loss in OVX mice. Rosen E, Canalis E, Stadmeyer L, Cory E, Glatt V, Pearsall RS, Bouxsein ML J BONE MINER RES 2007 22 Suppl 1 Abs 1233
-
(2007)
J. Bone Miner Res.
, vol.22
, Issue.1 SUPPL.
, pp. 1233
-
-
Rosen, E.1
Canalis, E.2
Stadmeyer, L.3
Cory, E.4
Glatt, V.5
Pearsall, R.S.6
Bouxsein, M.L.7
-
36
-
-
77957748419
-
Pharmacological inhibition of signaling through the activin receptor type IIA prevents primary tumor growth and skeletal metastases in mouse models of breast cancer
-
Abs
-
Pharmacological inhibition of signaling through the activin receptor type IIA prevents primary tumor growth and skeletal metastases in mouse models of breast cancer. Mulivor AW, Barbosa D, Kumar R, Underwood KW, Ucran JA, Seehra J, Pearsall RS CANCER RES 2009 69 24 Suppl 3 Abs 5058
-
(2009)
Cancer Res.
, vol.69
, Issue.3-24 SUPPL.
, pp. 5058
-
-
Mulivor, A.W.1
Barbosa, D.2
Kumar, R.3
Underwood, K.W.4
Ucran, J.A.5
Seehra, J.6
Pearsall, R.S.7
-
37
-
-
77957727888
-
Inhibiting activin-A signaling stimulates bone formation and prevents cancer induced bone destruction in vivo
-
June 07 DOI: 10.1002/jbmr.142, • The effects of RAP-011 in two different mouse models of MM are presented. RAP-011 had a positive impact on bone loss, tumor burden of the bone and survival time
-
Inhibiting activin-A signaling stimulates bone formation and prevents cancer induced bone destruction in vivo. Chantry AD, Heath D, Mulivor AW, Pearsall S, Baud'huin M, Coulton L, Evans H, Abdul N, Werner ED, Bouxsein ML, Key ML et al J BONE MINER RES 2010 June 07 DOI: 10.1002/jbmr.142 • The effects of RAP-011 in two different mouse models of MM are presented. RAP-011 had a positive impact on bone loss, tumor burden of the bone and survival time.
-
(2010)
J. Bone Miner Res.
-
-
Chantry, A.D.1
Heath, D.2
Mulivor, A.W.3
Pearsall, S.4
Baud'huin, M.5
Coulton, L.6
Evans, H.7
Abdul, N.8
Werner, E.D.9
Bouxsein, M.L.10
Key, M.L.11
-
38
-
-
77957736768
-
Pharmacological inhibition of signaling through the activin receptor type IIA heals osteolytic lesions and prevents anemia following chemotherapy
-
Abs
-
Pharmacological inhibition of signaling through the activin receptor type IIA heals osteolytic lesions and prevents anemia following chemotherapy. Mulivor A, Barbosa D, Kumar R, Pearsall A, Underwood K, Monnell T, Ucran J, Seehra J, Pearsall R J BONE MINER RES 2009 24 Suppl 1 Abs A09003057
-
(2009)
J. Bone Miner Res.
, vol.24
, Issue.1 SUPPL.
-
-
Mulivor, A.1
Barbosa, D.2
Kumar, R.3
Pearsall, A.4
Underwood, K.5
Monnell, T.6
Ucran, J.7
Seehra, J.8
Pearsall, R.9
-
39
-
-
77956509121
-
A soluble activin type II receptor prevents myeloma bone disease
-
Abs
-
A soluble activin type II receptor prevents myeloma bone disease. Chantry A, Heath D, Coulton L, Gallagher O, Evans H, Seehra J, Vanderkerken K, Croucher PI HAEMATOLOGICA 2007 92 6 Suppl 2 Abs PO-319
-
(2007)
Haematologica
, vol.92
, Issue.2-6 SUPPL.
-
-
Chantry, A.1
Heath, D.2
Coulton, L.3
Gallagher, O.4
Evans, H.5
Seehra, J.6
Vanderkerken, K.7
Croucher, P.I.8
-
40
-
-
77957737424
-
A soluble activin type II receptor prevents the development of myeloma bone disease
-
Abs
-
A soluble activin type II receptor prevents the development of myeloma bone disease. Chantry A, Heath D, Coulton L, Evans H, Abdul N, Seehra J, Vanderkerken K, Croucher P CANCER TREAT REV 2008 34 Suppl 1 Abs P3
-
(2008)
Cancer Treat. Rev.
, vol.34
, Issue.1 SUPPL.
-
-
Chantry, A.1
Heath, D.2
Coulton, L.3
Evans, H.4
Abdul, N.5
Seehra, J.6
Vanderkerken, K.7
Croucher, P.8
-
41
-
-
77957737015
-
Treatment with a soluble activin type II receptor reverses bone loss in ovariectomized mice
-
Abs
-
Treatment with a soluble activin type II receptor reverses bone loss in ovariectomized mice. Pearsall RS, Cornwall-Brady M, Lachey J, Glatt V J BONE MINER RES 2006 21 Suppl 1 Abs 1090
-
(2006)
J. Bone Miner Res.
, vol.21
, Issue.1 SUPPL.
, pp. 1090
-
-
Pearsall, R.S.1
Cornwall-Brady, M.2
Lachey, J.3
Glatt, V.4
-
42
-
-
11144236140
-
Reconstitution and analysis of soluble inhibin and activin receptor complexes in a cell-free system
-
Reconstitution and analysis of soluble inhibin and activin receptor complexes in a cell-free system. del Re E, Sidis Y, Fabrizio DA, Lin HY, Schneyer A J BIOL CHEM 2004 279 51 53126-53135
-
(2004)
J. Biol. Chem.
, vol.279
, Issue.51
, pp. 53126-53135
-
-
Del Re, E.1
Sidis, Y.2
Fabrizio, D.A.3
Lin, H.Y.4
Schneyer, A.5
-
43
-
-
35648944164
-
BMP-3 and BMP-6 structures illuminate the nature of binding specificity with receptors
-
BMP-3 and BMP-6 structures illuminate the nature of binding specificity with receptors. Allendorph GP, Isaacs MJ, Kawakami Y, Izpisua Belmonte JC, Choe S BIOCHEMISTRY 2007 46 43 12238-12247
-
(2007)
Biochemistry
, vol.46
, Issue.43
, pp. 12238-12247
-
-
Allendorph, G.P.1
Isaacs, M.J.2
Kawakami, Y.3
Belmonte, J.C.I.4
Choe, S.5
-
44
-
-
0028929863
-
Functional analysis of activins during mammalian development
-
Functional analysis of activins during mammalian development. Matzuk MM, Kumar TR, Vassalli A, Bickenbach JR, Roop DR, Jaenisch R, Bradley A NATURE 1995 374 6520 354-356
-
(1995)
Nature
, vol.374
, Issue.6520
, pp. 354-356
-
-
Matzuk, M.M.1
Kumar, T.R.2
Vassalli, A.3
Bickenbach, J.R.4
Roop, D.R.5
Jaenisch, R.6
Bradley, A.7
-
46
-
-
34548508972
-
The activin A-follistatin system: Potent regulator of human extracellular matrix mineralization
-
The activin A-follistatin system: Potent regulator of human extracellular matrix mineralization. Eijken M, Swagemakers S, Koedam M, Steenbergen C, Derkx P, Uitterlinden AG, van der Spek PJ, Visser JA, de Jong FH, Pols HAP, van Leeuwen JP FASEB J 2007 21 11 2949-2960
-
(2007)
Faseb J.
, vol.21
, Issue.11
, pp. 2949-2960
-
-
Eijken, M.1
Swagemakers, S.2
Koedam, M.3
Steenbergen, C.4
Derkx, P.5
Uitterlinden, A.G.6
Van Der Spek, P.J.7
Visser, J.A.8
De Jong, F.H.9
Pols, H.A.P.10
Van Leeuwen, J.P.11
-
47
-
-
0036144102
-
Inhibin suppresses and activin stimulates osteoblastogenesis and osteoclastogenesis in murine bone marrow cultures
-
Inhibin suppresses and activin stimulates osteoblastogenesis and osteoclastogenesis in murine bone marrow cultures. Gaddy-Kurten D, Coker JK, Abe E, Jilka RL, Manolagas SC ENDOCRINOLOGY 2002 143 1 74-83
-
(2002)
Endocrinology
, vol.143
, Issue.1
, pp. 74-83
-
-
Gaddy-Kurten, D.1
Coker, J.K.2
Abe, E.3
Jilka, R.L.4
Manolagas, S.C.5
-
48
-
-
0033231930
-
Inhibitory effects of activin-A on osteoblast differentiation during cultures of fetal rat calvarial cells
-
Inhibitory effects of activin-A on osteoblast differentiation during cultures of fetal rat calvarial cells. Ikenoue T, Jingushi S, Urabe K, Okazaki K, Iwamoto Y J CELL BIOCHEM 1999 75 2 206-214
-
(1999)
J. Cell Biochem.
, vol.75
, Issue.2
, pp. 206-214
-
-
Ikenoue, T.1
Jingushi, S.2
Urabe, K.3
Okazaki, K.4
Iwamoto, Y.5
-
49
-
-
0033016747
-
Local administration of activin promotes fracture healing in the rat fibula fracture model
-
Local administration of activin promotes fracture healing in the rat fibula fracture model. Sakai R, Miwa K, Eto Y BONE 1999 25 2 191-196
-
(1999)
Bone
, vol.25
, Issue.2
, pp. 191-196
-
-
Sakai, R.1
Miwa, K.2
Eto, Y.3
-
50
-
-
0034080583
-
Activin increases bone mass and mechanical strength of lumbar vertebrae in aged ovariectomized rats
-
Activin increases bone mass and mechanical strength of lumbar vertebrae in aged ovariectomized rats. Sakai R, Fujita S, Horie T, Ohyama T, Miwa K, Maki T, Okimoto N, Nakamura T, Eto Y BONE 2000 27 1 91-96
-
(2000)
Bone
, vol.27
, Issue.1
, pp. 91-96
-
-
Sakai, R.1
Fujita, S.2
Horie, T.3
Ohyama, T.4
Miwa, K.5
Maki, T.6
Okimoto, N.7
Nakamura, T.8
Eto, Y.9
-
51
-
-
33947370286
-
Inhibin A is an endocrine stimulator of bone mass and strength
-
Inhibin A is an endocrine stimulator of bone mass and strength. Perrien DS, Akel NS, Edwards PK, Carver AA, Bendre MS, Swain FL, Skinner RA, Hogue WR, Nicks KM, Pierson TM, Suva LJ et al ENDOCRINOLOGY 2007 148 4 1654-1665
-
(2007)
Endocrinology
, vol.148
, Issue.4
, pp. 1654-1665
-
-
Perrien, D.S.1
Akel, N.S.2
Edwards, P.K.3
Carver, A.A.4
Bendre, M.S.5
Swain, F.L.6
Skinner, R.A.7
Hogue, W.R.8
Nicks, K.M.9
Pierson, T.M.10
Suva, L.J.11
-
52
-
-
35048875471
-
Pathologic fractures correlate with reduced survival in patients with malignant bone disease
-
Pathologic fractures correlate with reduced survival in patients with malignant bone disease. Saad F, Lipton A, Cook R, Chen YM, Smith M, Coleman R CANCER 2007 110 8 1860-1867
-
(2007)
Cancer
, vol.110
, Issue.8
, pp. 1860-1867
-
-
Saad, F.1
Lipton, A.2
Cook, R.3
Chen, Y.M.4
Smith, M.5
Coleman, R.6
-
53
-
-
0025009869
-
Bone metastasis from gynecologic carcinomas: A clinicopathologic study
-
Bone metastasis from gynecologic carcinomas: A clinicopathologic study. Abdul-Karim FW, Kida M, Wentz WB, Carter JR, Sorensen K, Macfee M, Zika J, Makley JT GYNECOL ONCOL 1990 39 2 108-114
-
(1990)
Gynecol. Oncol.
, vol.39
, Issue.2
, pp. 108-114
-
-
Abdul-Karim, F.W.1
Kida, M.2
Wentz, W.B.3
Carter, J.R.4
Sorensen, K.5
Macfee, M.6
Zika, J.7
Makley, J.T.8
-
54
-
-
0030749321
-
Skeletal complications of malignancy
-
Skeletal complications of malignancy. Coleman RE CANCER 1997 80 8 Suppl 1588-1594
-
(1997)
Cancer
, vol.80
, Issue.8 SUPPL.
, pp. 1588-1594
-
-
Coleman, R.E.1
-
55
-
-
0034691162
-
Parathyroid hormone-related protein induces spontaneous osteoclast formation via a paracrine cascade
-
Parathyroid hormone-related protein induces spontaneous osteoclast formation via a paracrine cascade. Nakchbandi IA, Weir EE, Insogna KL, Philbrick WM, Broadus AE PROC NATL ACAD SCI USA 2000 97 13 7296-7300
-
(2000)
Proc. Natl. Acad. Sci. USA
, vol.97
, Issue.13
, pp. 7296-7300
-
-
Nakchbandi, I.A.1
Weir, E.E.2
Insogna, K.L.3
Philbrick, W.M.4
Broadus, A.E.5
-
56
-
-
0034861109
-
Breast cancer increases osteoclastogenesis by secreting M-CSF and upregulating RANKL in stromal cells
-
Breast cancer increases osteoclastogenesis by secreting M-CSF and upregulating RANKL in stromal cells. Mancino AT, Klimberg VS, Yamamoto M, Manolagas SC, Abe E J SURG RES 2001 100 1 18-24
-
(2001)
J. Surg. Res.
, vol.100
, Issue.1
, pp. 18-24
-
-
Mancino, A.T.1
Klimberg, V.S.2
Yamamoto, M.3
Manolagas, S.C.4
Abe, E.5
-
57
-
-
23744498205
-
Myeloma cells block RUNX2/CBFA1 activity in human bone marrow osteoblast progenitors and inhibit osteoblast formation and differentiation
-
Myeloma cells block RUNX2/CBFA1 activity in human bone marrow osteoblast progenitors and inhibit osteoblast formation and differentiation. Giuliani N, Colla S, Morandi F, Lazzaretti M, Sala R, Bonomini S, Grano M, Colucci S, Svaldi M, Rizzoli V BLOOD 2005 106 7 2472-2483
-
(2005)
Blood
, vol.106
, Issue.7
, pp. 2472-2483
-
-
Giuliani, N.1
Colla, S.2
Morandi, F.3
Lazzaretti, M.4
Sala, R.5
Bonomini, S.6
Grano, M.7
Colucci, S.8
Svaldi, M.9
Rizzoli, V.10
-
58
-
-
14944371405
-
IL-1 mediates TNF-induced osteoclastogenesis
-
IL-1 mediates TNF-induced osteoclastogenesis. Wei S, Kitaura H, Zhou P, Ross FP, Teitelbaum SL J CLIN INVEST 2005 115 2 282-290
-
(2005)
J. Clin. Invest.
, vol.115
, Issue.2
, pp. 282-290
-
-
Wei, S.1
Kitaura, H.2
Zhou, P.3
Ross, F.P.4
Teitelbaum, S.L.5
-
59
-
-
34248545487
-
Monocyte chemotactic protein-1 mediates prostate cancer-induced bone resorption
-
Monocyte chemotactic protein-1 mediates prostate cancer-induced bone resorption. Lu Y, Cai Z, Xiao GZ, Keller ET, Mizokami A, Yao Z, Roodman GD, Zhang J CANCER RES 2007 67 8 3646-3653
-
(2007)
Cancer. Res.
, vol.67
, Issue.8
, pp. 3646-3653
-
-
Lu, Y.1
Cai, Z.2
Xiao, G.Z.3
Keller, E.T.4
Mizokami, A.5
Yao, Z.6
Roodman, G.D.7
Zhang, J.8
-
60
-
-
56149084790
-
Osteoclasts are active in bone forming metastases of prostate cancer patients
-
Osteoclasts are active in bone forming metastases of prostate cancer patients. Roato I, D'Amelio P, Gorassini E, Grimaldi A, Bonello L, Fiori C, Delsedime L, Tizzani A, De Libero A, Isaia G, Ferracini R PLOS ONE 2008 3 11 e3627
-
(2008)
Plos. One
, vol.3
, Issue.11
-
-
Roato, I.1
D'Amelio, P.2
Gorassini, E.3
Grimaldi, A.4
Bonello, L.5
Fiori, C.6
Delsedime, L.7
Tizzani, A.8
De Libero, A.9
Isaia, G.10
Ferracini, R.11
-
61
-
-
0346363760
-
The role of the Wnt-signaling antagonist DKK1 in the development of osteolytic lesions in multiple myeloma
-
The role of the Wnt-signaling antagonist DKK1 in the development of osteolytic lesions in multiple myeloma. Tian E, Zhan FH, Walker R, Rasmussen E, Ma YP, Barlogie B, Shaughnessy JD Jr N ENGL J MED 2003 349 26 2483-2494
-
(2003)
N. Engl. J. Med.
, vol.349
, Issue.26
, pp. 2483-2494
-
-
Tian, E.1
Zhan, F.H.2
Walker, R.3
Rasmussen, E.4
Ma, Y.P.5
Barlogie, B.6
Shaughnessy Jr., J.D.7
-
62
-
-
4944230728
-
Osteoclasts enhance myeloma cell growth and survival via cell-cell contact: A vicious cycle between bone destruction and myeloma expansion
-
Osteoclasts enhance myeloma cell growth and survival via cell-cell contact: A vicious cycle between bone destruction and myeloma expansion. Abe M, Hiura K, Wilde J, Shioyasono A, Moriyama K, Hashimoto T, Kido S, Oshima T, Shibata H, Ozaki S, Inoue D et al BLOOD 2004 104 8 2484-2491
-
(2004)
Blood
, vol.104
, Issue.8
, pp. 2484-2491
-
-
Abe, M.1
Hiura, K.2
Wilde, J.3
Shioyasono, A.4
Moriyama, K.5
Hashimoto, T.6
Kido, S.7
Oshima, T.8
Shibata, H.9
Ozaki, S.10
Inoue, D.11
-
63
-
-
33745494534
-
A crosstalk between myeloma cells and marrow stromal cells stimulates production of DKK1 and interleukin-6: A potential role in the development of lytic bone disease and tumor progression in multiple myeloma
-
A crosstalk between myeloma cells and marrow stromal cells stimulates production of DKK1 and interleukin-6: A potential role in the development of lytic bone disease and tumor progression in multiple myeloma. Gunn WG, Conley A, Deininger L, Olson SD, Prockop DJ, Gregory CA STEM CELLS 2006 24 4 986-991
-
(2006)
Stem. Cells
, vol.24
, Issue.4
, pp. 986-991
-
-
Gunn, W.G.1
Conley, A.2
Deininger, L.3
Olson, S.D.4
Prockop, D.J.5
Gregory, C.A.6
-
64
-
-
14744278436
-
Anemia of chronic disease
-
Anemia of chronic disease. Weiss G, Goodnough LT N ENGL J MED 2005 352 10 1011-1023
-
(2005)
N. Engl. J. Med.
, vol.352
, Issue.10
, pp. 1011-1023
-
-
Weiss, G.1
Goodnough, L.T.2
-
65
-
-
65449117261
-
Recombinant human erythropoiesis-stimulating agents and mortality in patients with cancer: A meta-analysis of randomised trials
-
Recombinant human erythropoiesis-stimulating agents and mortality in patients with cancer: A meta-analysis of randomised trials. Bohlius J, Schmidlin K, Brillant C, Schwarzer G, Trelle S, Seidenfeld J, Zwahlen M, Clarke M, Weingart O, Kluge S, Piper M et al LANCET 2009 373 9674 1532-1542
-
(2009)
Lancet
, vol.373
, Issue.9674
, pp. 1532-1542
-
-
Bohlius, J.1
Schmidlin, K.2
Brillant, C.3
Schwarzer, G.4
Trelle, S.5
Seidenfeld, J.6
Zwahlen, M.7
Clarke, M.8
Weingart, O.9
Kluge, S.10
Piper, M.11
-
66
-
-
33646036678
-
FSH directly regulates bone mass
-
FSH directly regulates bone mass. Sun L, Peng Y, Sharrow AC, Iqbal J, Zhang Z, Papachristou DJ, Zaidi S, Zhu LL, Yaroslavskiy BB, Zhou H, Zallone A et al CELL 2006 125 2 247-260
-
(2006)
Cell
, vol.125
, Issue.2
, pp. 247-260
-
-
Sun, L.1
Peng, Y.2
Sharrow, A.C.3
Iqbal, J.4
Zhang, Z.5
Papachristou, D.J.6
Zaidi, S.7
Zhu, L.L.8
Yaroslavskiy, B.B.9
Zhou, H.10
Zallone, A.11
-
67
-
-
77950438331
-
Activin A promotes multiple myeloma-induced osteolysis and is a promising target for myeloma bone disease
-
Activin A promotes multiple myeloma-induced osteolysis and is a promising target for myeloma bone disease. Vallet S, Mukherjee S, Vaghela N, Hideshima T, Fulciniti M, Pozzi S, Santo L, Cirstea D, Patel K, Sohani AR, Guimaraes A et al PROC NATL ACAD SCI USA 2010 107 11 5124-5129
-
(2010)
Proc. Natl. Acad. Sci. USA
, vol.107
, Issue.11
, pp. 5124-5129
-
-
Vallet, S.1
Mukherjee, S.2
Vaghela, N.3
Hideshima, T.4
Fulciniti, M.5
Pozzi, S.6
Santo, L.7
Cirstea, D.8
Patel, K.9
Sohani, A.R.10
Guimaraes, A.11
-
68
-
-
20444486612
-
Bisphosphonates and cancer-induced bone disease: Beyond their antiresorptive activity
-
Bisphosphonates and cancer-induced bone disease: Beyond their antiresorptive activity. Clezardin P, Ebetino FH, Fournier PG CANCER RES 2005 65 12 4971-4974
-
(2005)
Cancer Res.
, vol.65
, Issue.12
, pp. 4971-4974
-
-
Clezardin, P.1
Ebetino, F.H.2
Fournier, P.G.3
-
69
-
-
77957739765
-
ACE-011, a soluble activin type IIA receptor IgG-Fc fusion protein, significantly increases bone mineral density in healthy postmenopausal women with normal or low bone mass
-
Abs
-
ACE-011, a soluble activin type IIA receptor IgG-Fc fusion protein, significantly increases bone mineral density in healthy postmenopausal women with normal or low bone mass. Borgstein NG, Yang Y, Mook L, Haltom E, Wilson DM, Sherman ML BONE 2010 47 Suppl 2 Abs S40
-
(2010)
Bone
, vol.47
, Issue.2 SUPPL.
-
-
Borgstein, N.G.1
Yang, Y.2
Mook, L.3
Haltom, E.4
Wilson, D.M.5
Sherman, M.L.6
-
70
-
-
77957747475
-
RAP-011, a soluble activin receptor type IIA IgG-Fc fusion protein, is a novel bone anabolic agent that prevents bone loss and skeletal metastatses in a mouse model of metastatic breast cancer
-
Abs
-
RAP-011, a soluble activin receptor type IIA IgG-Fc fusion protein, is a novel bone anabolic agent that prevents bone loss and skeletal metastatses in a mouse model of metastatic breast cancer. Mulivor AW, Barbosa D, Kumar R, Pearsall AE, Underwood KW, Ucran JA, Seehra J, Pearsall RS CANCER RES 2009 69 2 Suppl Abs 1158
-
(2009)
Cancer Res.
, vol.69
, Issue.2 SUPPL.
, pp. 1158
-
-
Mulivor, A.W.1
Barbosa, D.2
Kumar, R.3
Pearsall, A.E.4
Underwood, K.W.5
Ucran, J.A.6
Seehra, J.7
Pearsall, R.S.8
-
71
-
-
77957740390
-
Comparison of a soluble activin receptor type IIA (ACTRIIA), PTH and zoledronate for treatment of established bone loss in OVX mice
-
Comparison of a soluble activin receptor type IIA (ACTRIIA), PTH and zoledronate for treatment of established bone loss in OVX mice. Rosen E, Pearsall S, Glatt V, Bouxsein ML BONE 2007 40 6 S158
-
(2007)
Bone
, vol.40
, Issue.6
-
-
Rosen, E.1
Pearsall, S.2
Glatt, V.3
Bouxsein, M.L.4
-
72
-
-
77957746244
-
-
Acceleron Pharma Inc COMPANY WORLD WIDE WEB SITE, September 06
-
Products - ACE-011 (Treatment of anemia). Acceleron Pharma Inc COMPANY WORLD WIDE WEB SITE 2010 September 06
-
(2010)
Products - Ace-011 (Treatment of Anemia)
-
-
-
73
-
-
77957742679
-
-
Celgene Corp COMPANY WORLD WIDE WEB SITE, February 17
-
Product Pipeline. Celgene Corp COMPANY WORLD WIDE WEB SITE 2010 February 17
-
(2010)
Product Pipeline
-
-
-
74
-
-
0032055268
-
Regulation of cellular and system function by activin
-
Regulation of cellular and system function by activin. Woodruff TK BIOCHEM PHARMACOL 1998 55 7 953-963
-
(1998)
Biochem. Pharmacol.
, vol.55
, Issue.7
, pp. 953-963
-
-
Woodruff, T.K.1
-
75
-
-
0034785348
-
TGF-β signaling in tumor suppression and cancer progression
-
TGF-β signaling in tumor suppression and cancer progression. Derynck R, Akhurst RJ, Balmain A NAT GENET 2001 29 2 117-129
-
(2001)
Nat. Genet.
, vol.29
, Issue.2
, pp. 117-129
-
-
Derynck, R.1
Akhurst, R.J.2
Balmain, A.3
-
76
-
-
0023598057
-
Importance of FSH-releasing protein and inhibin in erythrodifferentiation
-
Importance of FSH-releasing protein and inhibin in erythrodifferentiation. Yu J, Shao LE, Lemas V, Yu AL, Vaughan J, Rivier J, Vale W NATURE 1987 330 6150 765-767
-
(1987)
Nature
, vol.330
, Issue.6150
, pp. 765-767
-
-
Yu, J.1
Shao, L.E.2
Lemas, V.3
Yu, A.L.4
Vaughan, J.5
Rivier, J.6
Vale, W.7
-
77
-
-
0037440420
-
Regulation of human erythropoiesis by activin A, BMP2, and BMP4, members of the TGFβ family
-
Regulation of human erythropoiesis by activin A, BMP2, and BMP4, members of the TGFβ family. Maguer-Satta V, Bartholin L, Jeanpierre S, Ffrench M, Martel S, Magaud JP, Rimokh R EXP CELL RES 2003 282 2 110-120
-
(2003)
Exp. Cell Res.
, vol.282
, Issue.2
, pp. 110-120
-
-
Maguer-Satta, V.1
Bartholin, L.2
Jeanpierre, S.3
Ffrench, M.4
Martel, S.5
Magaud, J.P.6
Rimokh, R.7
-
78
-
-
0026595714
-
Effect of activin A on globin gene expression in purified human erythroid progenitors
-
Effect of activin A on globin gene expression in purified human erythroid progenitors. Shao L, Frigon NL, Young AL, Yu AL, Mathews LS, Vaughan J, Vale W, Yu J BLOOD 1992 79 3 773-781
-
(1992)
Blood
, vol.79
, Issue.3
, pp. 773-781
-
-
Shao, L.1
Frigon, N.L.2
Young, A.L.3
Yu, A.L.4
Mathews, L.S.5
Vaughan, J.6
Vale, W.7
Yu, J.8
-
79
-
-
0034781894
-
Interleukin-1 β enhances and interferon-γ suppresses activin A actions by reciprocally regulating activin A and follistatin secretion from bone marrow stromal fibroblasts
-
Interleukin-1 β enhances and interferon-γ suppresses activin A actions by reciprocally regulating activin A and follistatin secretion from bone marrow stromal fibroblasts. Abe M, Shintani Y, Eto Y, Harada K, Fujinaka Y, Kosaka M, Matsumoto T CLIN EXP IMMUNOL 2001 126 1 64-68
-
(2001)
Clin. Exp. Immunol.
, vol.126
, Issue.1
, pp. 64-68
-
-
Abe, M.1
Shintani, Y.2
Eto, Y.3
Harada, K.4
Fujinaka, Y.5
Kosaka, M.6
Matsumoto, T.7
-
80
-
-
0042822157
-
Activin A stimulates IκB-α/NFκ B and RANK expression for osteoclast differentiation, but not AKT survival pathway in osteoclast precursors
-
Activin A stimulates IκB-α/NFκ B and RANK expression for osteoclast differentiation, but not AKT survival pathway in osteoclast precursors. Sugatani T, Alvarez UM, Hruska KA J CELL BIOCHEM 2003 90 1 59-67
-
(2003)
J. Cell Biochem.
, vol.90
, Issue.1
, pp. 59-67
-
-
Sugatani, T.1
Alvarez, U.M.2
Hruska, K.A.3
-
81
-
-
0026699589
-
Functional regulation of osteoblastic cells by the interaction of activin-A with follistatin
-
Functional regulation of osteoblastic cells by the interaction of activin-A with follistatin. Hashimoto M, Shoda A, Inoue S, Yamada R, Kondo T, Sakurai T, Ueno N, Muramatsu M J BIOL CHEM 1992 267 7 4999-5004
-
(1992)
J. Biol. Chem.
, vol.267
, Issue.7
, pp. 4999-5004
-
-
Hashimoto, M.1
Shoda, A.2
Inoue, S.3
Yamada, R.4
Kondo, T.5
Sakurai, T.6
Ueno, N.7
Muramatsu, M.8
-
82
-
-
0031879472
-
Activin A regulates the production of mature interleukin-1p and interleukin-1 receptor antagonist in human monocytic cells
-
Activin A regulates the production of mature interleukin-1p and interleukin-1 receptor antagonist in human monocytic cells. Ohguchi M, Yamato K, Ishihara Y, Koide M, Ueda N, Okahashi N, Noguchi T, Kizaki M, Ikeda Y, Sugino H, Nisihara T J INTERFERON CYTOKINE RES 1998 18 7 491-498
-
(1998)
J. Interferon Cytokine Res.
, vol.18
, Issue.7
, pp. 491-498
-
-
Ohguchi, M.1
Yamato, K.2
Ishihara, Y.3
Koide, M.4
Ueda, N.5
Okahashi, N.6
Noguchi, T.7
Kizaki, M.8
Ikeda, Y.9
Sugino, H.10
Nisihara, T.11
-
83
-
-
0041633625
-
Modulation of endogenous osteogenic protein-1 (OP-1) by interleukin-1 in adult human articular cartilage
-
Modulation of endogenous osteogenic protein-1 (OP-1) by interleukin-1 in adult human articular cartilage. Merrihew C, Soeder S, Rueger DC, Kuettner KE, Chubinskaya S J BONE JT SURG SER A 2003 85-A Suppl 3 67-74 (Pubitemid 36951119)
-
(2003)
Journal of Bone and Joint Surgery - Series A
, vol.85
, Issue.SUPPL. 3
, pp. 67-74
-
-
Merrihew, C.1
Soeder, S.2
Rueger, D.C.3
Kuettner, K.E.4
Chubinskaya, S.5
-
84
-
-
2042447264
-
Modulation of bone morphogenetic protein-2 and bone morphogenetic protein-4 gene expression in osteoblastic cell lines
-
Modulation of bone morphogenetic protein-2 and bone morphogenetic protein-4 gene expression in osteoblastic cell lines. Virdi AS, Cook LJ, Oreffo ROC, Trifftt JT CELL MOL BIOL 1998 44 8 1237-1246
-
(1998)
Cell. Mol. Biol.
, vol.44
, Issue.8
, pp. 1237-1246
-
-
Virdi, A.S.1
Cook, L.J.2
Oreffo, R.O.C.3
Trifftt, J.T.4
-
85
-
-
0034942922
-
Possible involvement of protein kinases and SMAD2 signaling pathways on osteoclast differentiation enhanced by activin A
-
Possible involvement of protein kinases and SMAD2 signaling pathways on osteoclast differentiation enhanced by activin A. Murase Y, Okahashi N, Koseki T, Itoh K, Udagawa N, Hashimoto O, Sugino H, Noguchi T, Nishihara T J CELL PHYSIOL 2001 188 2 236-242
-
(2001)
J. Cell. Physiol.
, vol.188
, Issue.2
, pp. 236-242
-
-
Murase, Y.1
Okahashi, N.2
Koseki, T.3
Itoh, K.4
Udagawa, N.5
Hashimoto, O.6
Sugino, H.7
Noguchi, T.8
Nishihara, T.9
-
86
-
-
15844405843
-
Synergistic activity of activin A and basic fibroblast growth factor on tyrosine hydroxylase expression through SMAD3 and ERK1/ERK2 MAPK signaling pathways
-
Synergistic activity of activin A and basic fibroblast growth factor on tyrosine hydroxylase expression through SMAD3 and ERK1/ERK2 MAPK signaling pathways. Bao YL, Tsuchida K, Liu B, Kurisaki A, Matsuzaki T, Sugino H J ENDOCRINOL 2005 184 3 493-504
-
(2005)
J. Endocrinol.
, vol.184
, Issue.3
, pp. 493-504
-
-
Bao, Y.L.1
Tsuchida, K.2
Liu, B.3
Kurisaki, A.4
Matsuzaki, T.5
Sugino, H.6
-
87
-
-
33747597788
-
Activin inhibits the human PIT-1 gene promoter through the p38 kinase pathway in a SMAD-independent manner
-
Activin inhibits the human PIT-1 gene promoter through the p38 kinase pathway in a SMAD-independent manner. de Guise C, Lacerte A, Rafiei S, Reynaud R, Roy M, Brue T, Lebrun JJ ENDOCRINOLOGY 2006 147 9 4351-4362
-
(2006)
Endocrinology
, vol.147
, Issue.9
, pp. 4351-4362
-
-
De Guise, C.1
Lacerte, A.2
Rafiei, S.3
Reynaud, R.4
Roy, M.5
Brue, T.6
Lebrun, J.J.7
|