-
2
-
-
23044443893
-
Substitutions at Aliphatic Centers and Thermal Isomerizations/Rearrangements
-
University Science Books: Sausalito, CA, Chapter 11
-
Anslyn, E. V. and Dougherty, D. A. Substitutions at Aliphatic Centers and Thermal Isomerizations/Rearrangements. Modern Physical Organic Chemistry; University Science Books: Sausalito, CA, 2006; Chapter 11.
-
(2006)
Modern Physical Organic Chemistry
-
-
Anslyn, E.V.1
Dougherty, D.A.2
-
3
-
-
44949230317
-
Enantioselective Thiourea-Catalyzed Additions to Oxocarbenium Ions
-
For examples of interesting exceptions (albeit with limited scope with respect to the nucleophile and the electrophile), see: Reisman, S. E.; Doyle, A. G.; Jacobsen, E. N. Enantioselective Thiourea-Catalyzed Additions to Oxocarbenium Ions J. Am. Chem. Soc. 2008, 130, 7198-7199 10.1021/ja801514m
-
(2008)
J. Am. Chem. Soc.
, vol.130
, pp. 7198-7199
-
-
Reisman, S.E.1
Doyle, A.G.2
Jacobsen, E.N.3
-
4
-
-
85013074396
-
Asymmetric Catalysis via Cyclic, Aliphatic Oxocarbenium Ions
-
Lee, S.; Kaib, P. S. J.; List, B. Asymmetric Catalysis via Cyclic, Aliphatic Oxocarbenium Ions J. Am. Chem. Soc. 2017, 139, 2156-2159 10.1021/jacs.6b11993
-
(2017)
J. Am. Chem. Soc.
, vol.139
, pp. 2156-2159
-
-
Lee, S.1
Kaib, P.S.J.2
List, B.3
-
5
-
-
84862516895
-
-
Eds. John Wiley & Sons, Chichester, U.K. Vols. and 2
-
Encyclopedia of Radicals in Chemistry, Biology and Materials; Chatgilialoglu, C.; Studer, A., Eds.; John Wiley & Sons, Chichester, U.K., 2012; Vols. 1 and 2.
-
(2012)
Encyclopedia of Radicals in Chemistry, Biology and Materials
, vol.1
-
-
Chatgilialoglu, C.1
Studer, A.2
-
6
-
-
85017989352
-
-
Eds. Wiley-VCH: Weinheim, Germany
-
Metal-Catalyzed Cross-Coupling Reactions and More; de Meijere, A.; Bräse, S.; Oestreich, M., Eds.; Wiley-VCH: Weinheim, Germany, 2014.
-
(2014)
Metal-Catalyzed Cross-Coupling Reactions and More
-
-
De Meijere, A.1
Bräse, S.2
Oestreich, M.3
-
7
-
-
84919644183
-
-
Ed. Royal Society of Chemistry: Cambridge, U.K
-
New Trends in Cross-Coupling; Colacot, T. J., Ed.; Royal Society of Chemistry: Cambridge, U.K., 2015.
-
(2015)
New Trends in Cross-Coupling
-
-
Colacot, T.J.1
-
8
-
-
84945933950
-
Tutorial on Oxidative Addition
-
For leading references, see: Labinger, J. A. Tutorial on Oxidative Addition Organometallics 2015, 34, 4784-4795 10.1021/acs.organomet.5b00565
-
(2015)
Organometallics
, vol.34
, pp. 4784-4795
-
-
Labinger, J.A.1
-
9
-
-
84858110887
-
Radicals in Transition Metal Catalyzed Reactions? Transition Metal Catalyzed Radical Reactions?: A Fruitful Interplay Anyway
-
For leading references, see: Jahn, U. Radicals in Transition Metal Catalyzed Reactions? Transition Metal Catalyzed Radical Reactions?: A Fruitful Interplay Anyway Top. Curr. Chem. 2011, 320, 323-452 10.1007/128-2011-288
-
(2011)
Top. Curr. Chem.
, vol.320
, pp. 323-452
-
-
Jahn, U.1
-
11
-
-
84903493026
-
2 carbon centers
-
Knochel, P. Molander, G. A. Elsevier: Amsterdam
-
2 carbon centers. In Comprehensive Organic Synthesis; Knochel, P.; Molander, G. A., Eds.; Elsevier: Amsterdam, 2014; Vol. 3, pp 392-464.
-
(2014)
Comprehensive Organic Synthesis
, vol.3
, pp. 392-464
-
-
Manolikakes, G.1
-
12
-
-
85018502103
-
Transition metal-catalyzed alkyl-alkyl bond formation: Another dimension in cross-coupling chemistry
-
Choi, J.; Fu, G. C. Transition metal-catalyzed alkyl-alkyl bond formation: Another dimension in cross-coupling chemistry Science 2017, 356, eaaf7230 10.1126/science.aaf7230
-
(2017)
Science
, vol.356
, pp. eaaf7230
-
-
Choi, J.1
Fu, G.C.2
-
13
-
-
84983143772
-
The Wacker Oxidation
-
Michel, B. W.; Steffens, L. D.; Sigman, M. S. The Wacker Oxidation Org. React. 2014, 84, 75-413 10.1002/0471264180.or084.02
-
(2014)
Org. React.
, vol.84
, pp. 75-413
-
-
Michel, B.W.1
Steffens, L.D.2
Sigman, M.S.3
-
15
-
-
33645524221
-
Palladium-Catalyzed Cross-Coupling Reactions of Unactivated Alkyl Electrophiles with Organometallic Compounds
-
For leading references to synthetic and mechanistic studies, see: Netherton, M. R.; Fu, G. C. Palladium-Catalyzed Cross-Coupling Reactions of Unactivated Alkyl Electrophiles with Organometallic Compounds. Topics in Organometallic Chemistry: Palladium in Organic Synthesis; Tsuji, J., Ed.; Springer: New York, 2005; pp 85-108.
-
(2005)
Topics in Organometallic Chemistry: Palladium in Organic Synthesis
, pp. 85-108
-
-
Netherton, M.R.1
Fu, G.C.2
-
16
-
-
84900544451
-
Recent advances in homogeneous nickel catalysis
-
For a discussion and leading references, see: Tasker, S. Z.; Standley, E. A.; Jamison, T. F. Recent advances in homogeneous nickel catalysis Nature 2014, 509, 299-309 10.1038/nature13274
-
(2014)
Nature
, vol.509
, pp. 299-309
-
-
Tasker, S.Z.1
Standley, E.A.2
Jamison, T.F.3
-
18
-
-
0344861888
-
Cross-Couplings of Unactivated Secondary Alkyl Halides: Room-Temperature Nickel-Catalyzed Negishi Reactions of Alkyl Bromides and Iodides
-
Organozinc nucleophiles
-
Organozinc nucleophiles: Zhou, J.; Fu, G. C. Cross-Couplings of Unactivated Secondary Alkyl Halides: Room-Temperature Nickel-Catalyzed Negishi Reactions of Alkyl Bromides and Iodides J. Am. Chem. Soc. 2003, 125, 14726-14727 10.1021/ja0389366
-
(2003)
J. Am. Chem. Soc.
, vol.125
, pp. 14726-14727
-
-
Zhou, J.1
Fu, G.C.2
-
19
-
-
1042288193
-
Suzuki Cross-Couplings of Unactivated Secondary Alkyl Bromides and Iodides
-
Organoboron nucleophiles
-
Organoboron nucleophiles: Zhou, J.; Fu, G. C. Suzuki Cross-Couplings of Unactivated Secondary Alkyl Bromides and Iodides J. Am. Chem. Soc. 2004, 126, 1340-1341 10.1021/ja039889k
-
(2004)
J. Am. Chem. Soc.
, vol.126
, pp. 1340-1341
-
-
Zhou, J.1
Fu, G.C.2
-
20
-
-
77956500677
-
Alkyl-Alkyl Suzuki Cross-Coupling of Unactivated Secondary Alkyl Chlorides
-
Lu, Z.; Fu, G. C. Alkyl-Alkyl Suzuki Cross-Coupling of Unactivated Secondary Alkyl Chlorides Angew. Chem., Int. Ed. 2010, 49, 6676-6678 10.1002/anie.201003272
-
(2010)
Angew. Chem., Int. Ed.
, vol.49
, pp. 6676-6678
-
-
Lu, Z.1
Fu, G.C.2
-
21
-
-
33646447380
-
Amino Alcohols as Ligands for Nickel-Catalyzed Suzuki Reactions of Unactivated Alkyl Halides, Including Secondary Alkyl Chlorides, with Arylboronic Acids
-
See also
-
See also: González-Bobes, F.; Fu, G. C. Amino Alcohols as Ligands for Nickel-Catalyzed Suzuki Reactions of Unactivated Alkyl Halides, Including Secondary Alkyl Chlorides, with Arylboronic Acids J. Am. Chem. Soc. 2006, 128, 5360-5361 10.1021/ja0613761
-
(2006)
J. Am. Chem. Soc.
, vol.128
, pp. 5360-5361
-
-
González-Bobes, F.1
Fu, G.C.2
-
22
-
-
34547789922
-
Alkyl-Alkyl Suzuki Cross-Couplings of Unactivated Secondary Alkyl Halides at Room Temperature
-
Saito, B.; Fu, G. C. Alkyl-Alkyl Suzuki Cross-Couplings of Unactivated Secondary Alkyl Halides at Room Temperature J. Am. Chem. Soc. 2007, 129, 9602-9603 10.1021/ja074008l
-
(2007)
J. Am. Chem. Soc.
, vol.129
, pp. 9602-9603
-
-
Saito, B.1
Fu, G.C.2
-
23
-
-
3042542346
-
Nickel-Catalyzed Cross-Couplings of Organosilicon Reagents with Unactivated Secondary Alkyl Bromides
-
Organosilicon nucleophiles
-
Organosilicon nucleophiles: Powell, D. A.; Fu, G. C. Nickel-Catalyzed Cross-Couplings of Organosilicon Reagents with Unactivated Secondary Alkyl Bromides J. Am. Chem. Soc. 2004, 126, 7788-7789 10.1021/ja047433c
-
(2004)
J. Am. Chem. Soc.
, vol.126
, pp. 7788-7789
-
-
Powell, D.A.1
Fu, G.C.2
-
24
-
-
34250821753
-
Hiyama Reactions of Activated and Unactivated Secondary Alkyl Halides Catalyzed by a Nickel/Norephedrine Complex
-
See also
-
See also: Strotman, N. A.; Sommer, S.; Fu, G. C. Hiyama Reactions of Activated and Unactivated Secondary Alkyl Halides Catalyzed by a Nickel/Norephedrine Complex Angew. Chem., Int. Ed. 2007, 46, 3556-3558 10.1002/anie.200700440
-
(2007)
Angew. Chem., Int. Ed.
, vol.46
, pp. 3556-3558
-
-
Strotman, N.A.1
Sommer, S.2
Fu, G.C.3
-
25
-
-
12944309312
-
Stille Cross-Couplings of Unactivated Secondary Alkyl Halides Using Monoorganotin Reagents
-
Organotin nucleophiles
-
Organotin nucleophiles: Powell, D. A.; Maki, T.; Fu, G. C. Stille Cross-Couplings of Unactivated Secondary Alkyl Halides Using Monoorganotin Reagents J. Am. Chem. Soc. 2005, 127, 510-511 10.1021/ja0436300
-
(2005)
J. Am. Chem. Soc.
, vol.127
, pp. 510-511
-
-
Powell, D.A.1
Maki, T.2
Fu, G.C.3
-
26
-
-
84913539477
-
Nickel-Catalyzed Negishi Arylations of Propargylic Bromides: A Mechanistic Investigation
-
For a mechanistic study that implicates radical intermediates in a nickel-catalyzed enantioconvergent coupling of an activated electrophile, see: Schley, N. D.; Fu, G. C. Nickel-Catalyzed Negishi Arylations of Propargylic Bromides: A Mechanistic Investigation J. Am. Chem. Soc. 2014, 136, 16588-16593 10.1021/ja508718m
-
(2014)
J. Am. Chem. Soc.
, vol.136
, pp. 16588-16593
-
-
Schley, N.D.1
Fu, G.C.2
-
27
-
-
84872563127
-
Nickel-Catalyzed Carbon-Carbon Bond-Forming Reactions of Unactivated Tertiary Alkyl Halides: Suzuki Arylations
-
Zultanski, S. L.; Fu, G. C. Nickel-Catalyzed Carbon-Carbon Bond-Forming Reactions of Unactivated Tertiary Alkyl Halides: Suzuki Arylations J. Am. Chem. Soc. 2013, 135, 624-627 10.1021/ja311669p
-
(2013)
J. Am. Chem. Soc.
, vol.135
, pp. 624-627
-
-
Zultanski, S.L.1
Fu, G.C.2
-
28
-
-
79251471974
-
Enantioselective allylic substitutions with carbon nucleophiles
-
Ojima, I. John Wiley & Sons: Hoboken, NJ
-
Helmchen, G.; Kazmaier, U.; Förster, S. Enantioselective allylic substitutions with carbon nucleophiles. In Catalytic Asymmetric Synthesis; Ojima, I., Ed.; John Wiley & Sons: Hoboken, NJ, 2010; pp 497-641.
-
(2010)
Catalytic Asymmetric Synthesis
, pp. 497-641
-
-
Helmchen, G.1
Kazmaier, U.2
Förster, S.3
-
29
-
-
84941112141
-
Enantioselective and Enantiospecific Transition-Metal-Catalyzed Cross-Coupling Reactions of Organometallic Reagents to Construct C-C Bonds
-
For leading references, see: Cherney, A. H.; Kadunce, N. T.; Reisman, S. E. Enantioselective and Enantiospecific Transition-Metal-Catalyzed Cross-Coupling Reactions of Organometallic Reagents To Construct C-C Bonds Chem. Rev. 2015, 115, 9587-9652 10.1021/acs.chemrev.5b00162
-
(2015)
Chem. Rev.
, vol.115
, pp. 9587-9652
-
-
Cherney, A.H.1
Kadunce, N.T.2
Reisman, S.E.3
-
30
-
-
16844363000
-
Asymmetric Nickel-Catalyzed Negishi Cross-Couplings of Secondary α-Bromo Amides with Organozinc Reagents
-
Fischer, C.; Fu, G. C. Asymmetric Nickel-Catalyzed Negishi Cross-Couplings of Secondary α-Bromo Amides with Organozinc Reagents J. Am. Chem. Soc. 2005, 127, 4594-4595 10.1021/ja0506509
-
(2005)
J. Am. Chem. Soc.
, vol.127
, pp. 4594-4595
-
-
Fischer, C.1
Fu, G.C.2
-
31
-
-
58249115061
-
Catalytic Asymmetric Cross-Couplings of Racemic α-Bromoketones with Arylzinc Reagents
-
See also: Lundin, P. M.; Esquivias, J.; Fu, G. C. Catalytic Asymmetric Cross-Couplings of Racemic α-Bromoketones with Arylzinc Reagents Angew. Chem., Int. Ed. 2009, 48, 154-156 10.1002/anie.200804888
-
(2009)
Angew. Chem., Int. Ed.
, vol.48
, pp. 154-156
-
-
Lundin, P.M.1
Esquivias, J.2
Fu, G.C.3
-
32
-
-
84897970502
-
Catalytic Asymmetric Synthesis of Tertiary Alkyl Fluorides: Negishi Cross-Couplings of Racemic α,α-Dihaloketones
-
Liang, Y.; Fu, G. C. Catalytic Asymmetric Synthesis of Tertiary Alkyl Fluorides: Negishi Cross-Couplings of Racemic α,α-Dihaloketones J. Am. Chem. Soc. 2014, 136, 5520-5524 10.1021/ja501815p
-
(2014)
J. Am. Chem. Soc.
, vol.136
, pp. 5520-5524
-
-
Liang, Y.1
Fu, G.C.2
-
33
-
-
84867556242
-
Catalytic Enantioselective Cross-Couplings of Secondary Alkyl Electrophiles with Secondary Alkylmetal Nucleophiles: Negishi Reactions of Racemic Benzylic Bromides with Achiral Alkylzinc Reagents
-
Benzylic halides
-
Benzylic halides: Binder, J. T.; Cordier, C. J.; Fu, G. C. Catalytic Enantioselective Cross-Couplings of Secondary Alkyl Electrophiles with Secondary Alkylmetal Nucleophiles: Negishi Reactions of Racemic Benzylic Bromides with Achiral Alkylzinc Reagents J. Am. Chem. Soc. 2012, 134, 17003-17006 10.1021/ja308460z
-
(2012)
J. Am. Chem. Soc.
, vol.134
, pp. 17003-17006
-
-
Binder, J.T.1
Cordier, C.J.2
Fu, G.C.3
-
34
-
-
23044496800
-
Catalytic Enantioselective Negishi Reactions of Racemic Secondary Benzylic Halides
-
See also: Arp, F. O.; Fu, G. C. Catalytic Enantioselective Negishi Reactions of Racemic Secondary Benzylic Halides J. Am. Chem. Soc. 2005, 127, 10482-10483 10.1021/ja053751f
-
(2005)
J. Am. Chem. Soc.
, vol.127
, pp. 10482-10483
-
-
Arp, F.O.1
Fu, G.C.2
-
35
-
-
84887750453
-
Nickel/Bis(oxazoline)-Catalyzed Asymmetric Negishi Arylations of Racemic Secondary Benzylic Electrophiles to Generate Enantioenriched 1,1-Diarylalkanes
-
Do, H.-Q.; Chandrashekar, E. R. R.; Fu, G. C. Nickel/Bis(oxazoline)-Catalyzed Asymmetric Negishi Arylations of Racemic Secondary Benzylic Electrophiles to Generate Enantioenriched 1,1-Diarylalkanes J. Am. Chem. Soc. 2013, 135, 16288-16291 10.1021/ja408561b
-
(2013)
J. Am. Chem. Soc.
, vol.135
, pp. 16288-16291
-
-
Do, H.-Q.1
Chandrashekar, E.R.R.2
Fu, G.C.3
-
36
-
-
40949123444
-
Nickel-Catalyzed Asymmetric Negishi Cross-Couplings of Secondary Allylic Chlorides with Alkylzincs
-
Allylic halides
-
Allylic halides: Son, S.; Fu, G. C. Nickel-Catalyzed Asymmetric Negishi Cross-Couplings of Secondary Allylic Chlorides with Alkylzincs J. Am. Chem. Soc. 2008, 130, 2756-2757 10.1021/ja800103z
-
(2008)
J. Am. Chem. Soc.
, vol.130
, pp. 2756-2757
-
-
Son, S.1
Fu, G.C.2
-
37
-
-
84863116000
-
Nickel-Catalyzed Enantioselective Cross-Couplings of Racemic Secondary Electrophiles That Bear an Oxygen Leaving Group
-
Propargylic electrophiles
-
Propargylic electrophiles: Oelke, A. J.; Sun, J.; Fu, G. C. Nickel-Catalyzed Enantioselective Cross-Couplings of Racemic Secondary Electrophiles That Bear an Oxygen Leaving Group J. Am. Chem. Soc. 2012, 134, 2966-2969 10.1021/ja300031w
-
(2012)
J. Am. Chem. Soc.
, vol.134
, pp. 2966-2969
-
-
Oelke, A.J.1
Sun, J.2
Fu, G.C.3
-
38
-
-
52449132069
-
Nickel-Catalyzed Asymmetric Cross-Couplings of Racemic Propargylic Halides with Arylzinc Reagents
-
See also: Smith, S. W.; Fu, G. C. Nickel-Catalyzed Asymmetric Cross-Couplings of Racemic Propargylic Halides with Arylzinc Reagents J. Am. Chem. Soc. 2008, 130, 12645-12647 10.1021/ja805165y
-
(2008)
J. Am. Chem. Soc.
, vol.130
, pp. 12645-12647
-
-
Smith, S.W.1
Fu, G.C.2
-
39
-
-
84861902827
-
Catalytic Asymmetric Synthesis of Secondary Nitriles via Stereoconvergent Negishi Arylations and Alkenylations of Racemic α-Bromonitriles
-
Halonitriles
-
α-Halonitriles: Choi, J.; Fu, G. C. Catalytic Asymmetric Synthesis of Secondary Nitriles via Stereoconvergent Negishi Arylations and Alkenylations of Racemic α-Bromonitriles J. Am. Chem. Soc. 2012, 134, 9102-9105 10.1021/ja303442q
-
(2012)
J. Am. Chem. Soc.
, vol.134
, pp. 9102-9105
-
-
Choi, J.1
Fu, G.C.2
-
40
-
-
84856021728
-
Total Synthesis of Carolacton, a Highly Potent Biofilm Inhibitor
-
Carolacton
-
Carolacton: Schmidt, T.; Kirschning, A. Total Synthesis of Carolacton, a Highly Potent Biofilm Inhibitor Angew. Chem., Int. Ed. 2012, 51, 1063-1066 10.1002/anie.201106762
-
(2012)
Angew. Chem., Int. Ed.
, vol.51
, pp. 1063-1066
-
-
Schmidt, T.1
Kirschning, A.2
-
41
-
-
84981764237
-
Total Synthesis of (-)-Daphenylline
-
Daphenylline
-
Daphenylline: Yamada, R.; Adachi, Y.; Yokoshima, S.; Fukuyama, T. Total Synthesis of (-)-Daphenylline Angew. Chem., Int. Ed. 2016, 55, 6067-6070 10.1002/anie.201601958
-
(2016)
Angew. Chem., Int. Ed.
, vol.55
, pp. 6067-6070
-
-
Yamada, R.1
Adachi, Y.2
Yokoshima, S.3
Fukuyama, T.4
-
42
-
-
84964558188
-
A general alkyl-alkyl cross-coupling enabled by redox-active esters and alkylzinc reagents
-
For example, see: Qin, T.; Cornella, J.; Li, C.; Malins, L. R.; Edwards, J. T.; Kawamura, S.; Maxwell, B. D.; Eastgate, M. D.; Baran, P. S. A general alkyl-alkyl cross-coupling enabled by redox-active esters and alkylzinc reagents Science 2016, 352, 801-805 10.1126/science.aaf6123
-
(2016)
Science
, vol.352
, pp. 801-805
-
-
Qin, T.1
Cornella, J.2
Li, C.3
Malins, L.R.4
Edwards, J.T.5
Kawamura, S.6
Maxwell, B.D.7
Eastgate, M.D.8
Baran, P.S.9
-
43
-
-
77950503735
-
Nickel/Bis(oxazoline)-Catalyzed Asymmetric Kumada Reactions of Alkyl Electrophiles: Cross-Couplings of Racemic α-Bromoketones
-
Organomagnesium nucleophiles
-
Organomagnesium nucleophiles: Lou, S.; Fu, G. C. Nickel/Bis(oxazoline)-Catalyzed Asymmetric Kumada Reactions of Alkyl Electrophiles: Cross-Couplings of Racemic α-Bromoketones J. Am. Chem. Soc. 2010, 132, 1264-1266 10.1021/ja909689t
-
(2010)
J. Am. Chem. Soc.
, vol.132
, pp. 1264-1266
-
-
Lou, S.1
Fu, G.C.2
-
44
-
-
41449104100
-
Catalytic Asymmetric Hiyama Cross-Couplings of Racemic α-Bromo Esters
-
Organosilicon nucleophiles
-
Organosilicon nucleophiles: Dai, X.; Strotman, N. A.; Fu, G. C. Catalytic Asymmetric Hiyama Cross-Couplings of Racemic α-Bromo Esters J. Am. Chem. Soc. 2008, 130, 3302-3303 10.1021/ja8009428
-
(2008)
J. Am. Chem. Soc.
, vol.130
, pp. 3302-3303
-
-
Dai, X.1
Strotman, N.A.2
Fu, G.C.3
-
45
-
-
77950807083
-
Enantioselective Alkenylation via Nickel-Catalyzed Cross-Coupling with Organozirconium Reagents
-
Organozirconium nucleophiles
-
Organozirconium nucleophiles: Lou, S.; Fu, G. C. Enantioselective Alkenylation via Nickel-Catalyzed Cross-Coupling with Organozirconium Reagents J. Am. Chem. Soc. 2010, 132, 5010-5011 10.1021/ja1017046
-
(2010)
J. Am. Chem. Soc.
, vol.132
, pp. 5010-5011
-
-
Lou, S.1
Fu, G.C.2
-
46
-
-
84906766693
-
Stereoconvergent Arylations and Alkenylations of Unactivated Alkyl Electrophiles: Catalytic Enantioselective Synthesis of Secondary Sulfonamides and Sulfones
-
See also: Choi, J.; Martín-Gago, P.; Fu, G. C. Stereoconvergent Arylations and Alkenylations of Unactivated Alkyl Electrophiles: Catalytic Enantioselective Synthesis of Secondary Sulfonamides and Sulfones J. Am. Chem. Soc. 2014, 136, 12161-12165 10.1021/ja506885s
-
(2014)
J. Am. Chem. Soc.
, vol.136
, pp. 12161-12165
-
-
Choi, J.1
Martín-Gago, P.2
Fu, G.C.3
-
47
-
-
77955573357
-
Asymmetric Suzuki Cross-Couplings of Activated Secondary Alkyl Electrophiles: Arylations of Racemic α-Chloroamides
-
Organoboron nucleophiles
-
Organoboron nucleophiles: Lundin, P. M.; Fu, G. C. Asymmetric Suzuki Cross-Couplings of Activated Secondary Alkyl Electrophiles: Arylations of Racemic α-Chloroamides J. Am. Chem. Soc. 2010, 132, 11027-11029 10.1021/ja105148g
-
(2010)
J. Am. Chem. Soc.
, vol.132
, pp. 11027-11029
-
-
Lundin, P.M.1
Fu, G.C.2
-
48
-
-
44349182541
-
Enantioselective Alkyl-Alkyl Suzuki Cross-Couplings of Unactivated Homobenzylic Halides
-
Aromatic ring
-
Aromatic ring: Saito, B.; Fu, G. C. Enantioselective Alkyl-Alkyl Suzuki Cross-Couplings of Unactivated Homobenzylic Halides J. Am. Chem. Soc. 2008, 130, 6694-6695 10.1021/ja8013677
-
(2008)
J. Am. Chem. Soc.
, vol.130
, pp. 6694-6695
-
-
Saito, B.1
Fu, G.C.2
-
49
-
-
77956083484
-
Asymmetric Alkyl-Alkyl Cross-Couplings of Unactivated Secondary Alkyl Electrophiles: Stereoconvergent Suzuki Reactions of Racemic Acylated Halohydrins
-
Carbonyl
-
Carbonyl: Owston, N. A.; Fu, G. C. Asymmetric Alkyl-Alkyl Cross-Couplings of Unactivated Secondary Alkyl Electrophiles: Stereoconvergent Suzuki Reactions of Racemic Acylated Halohydrins J. Am. Chem. Soc. 2010, 132, 11908-11909 10.1021/ja105924f
-
(2010)
J. Am. Chem. Soc.
, vol.132
, pp. 11908-11909
-
-
Owston, N.A.1
Fu, G.C.2
-
50
-
-
80053339478
-
Catalytic Asymmetric γ-Alkylation of Carbonyl Compounds via Stereoconvergent Suzuki Cross-Couplings
-
See also: Zultanski, S. L.; Fu, G. C. Catalytic Asymmetric γ-Alkylation of Carbonyl Compounds via Stereoconvergent Suzuki Cross-Couplings J. Am. Chem. Soc. 2011, 133, 15362-15364 10.1021/ja2079515
-
(2011)
J. Am. Chem. Soc.
, vol.133
, pp. 15362-15364
-
-
Zultanski, S.L.1
Fu, G.C.2
-
51
-
-
79957675617
-
Stereoconvergent Amine-Directed Alkyl-Alkyl Suzuki Reactions of Unactivated Secondary Alkyl Chlorides
-
Nitrogen
-
Nitrogen: Lu, Z.; Wilsily, A.; Fu, G. C. Stereoconvergent Amine-Directed Alkyl-Alkyl Suzuki Reactions of Unactivated Secondary Alkyl Chlorides J. Am. Chem. Soc. 2011, 133, 8154-8157 10.1021/ja203560q
-
(2011)
J. Am. Chem. Soc.
, vol.133
, pp. 8154-8157
-
-
Lu, Z.1
Wilsily, A.2
Fu, G.C.3
-
52
-
-
84859355289
-
New Directing Groups for Metal-Catalyzed Asymmetric Carbon-Carbon Bond-Forming Processes: Stereoconvergent Alkyl-Alkyl Suzuki Cross-Couplings of Unactivated Electrophiles
-
Sulfonamide
-
Sulfonamide: Wilsily, A.; Tramutola, F.; Owston, N. A.; Fu, G. C. New Directing Groups for Metal-Catalyzed Asymmetric Carbon-Carbon Bond-Forming Processes: Stereoconvergent Alkyl-Alkyl Suzuki Cross-Couplings of Unactivated Electrophiles J. Am. Chem. Soc. 2012, 134, 5794-5797 10.1021/ja301612y
-
(2012)
J. Am. Chem. Soc.
, vol.134
, pp. 5794-5797
-
-
Wilsily, A.1
Tramutola, F.2
Owston, N.A.3
Fu, G.C.4
-
53
-
-
84938894515
-
3 and an Alkyl Group
-
3 and an Alkyl Group J. Am. Chem. Soc. 2015, 137, 9523-9526 10.1021/jacs.5b04725
-
(2015)
J. Am. Chem. Soc.
, vol.137
, pp. 9523-9526
-
-
Liang, Y.1
Fu, G.C.2
-
54
-
-
85003022498
-
A general, modular method for the catalytic asymmetric synthesis of alkylboronate esters
-
Schmidt, J.; Choi, J.; Liu, A. T.; Slusarczyk, M.; Fu, G. C. A general, modular method for the catalytic asymmetric synthesis of alkylboronate esters Science 2016, 354, 1265-1269 10.1126/science.aai8611
-
(2016)
Science
, vol.354
, pp. 1265-1269
-
-
Schmidt, J.1
Choi, J.2
Liu, A.T.3
Slusarczyk, M.4
Fu, G.C.5
-
57
-
-
84863469858
-
Nickel-Catalyzed Coupling Reactions of Alkyl Electrophiles, Including Unactivated Tertiary Halides, to Generate Carbon-Boron Bonds
-
Boron nucleophile
-
Boron nucleophile: Dudnik, A. S.; Fu, G. C. Nickel-Catalyzed Coupling Reactions of Alkyl Electrophiles, Including Unactivated Tertiary Halides, To Generate Carbon-Boron Bonds J. Am. Chem. Soc. 2012, 134, 10693-10697 10.1021/ja304068t
-
(2012)
J. Am. Chem. Soc.
, vol.134
, pp. 10693-10697
-
-
Dudnik, A.S.1
Fu, G.C.2
-
58
-
-
84971379323
-
Silicon-Carbon Bond Formation via Nickel-Catalyzed Cross-Coupling of Silicon Nucleophiles with Unactivated Secondary and Tertiary Alkyl Electrophiles
-
Silicon nucleophile
-
Silicon nucleophile: Chu, C. K.; Liang, Y.; Fu, G. C. Silicon-Carbon Bond Formation via Nickel-Catalyzed Cross-Coupling of Silicon Nucleophiles with Unactivated Secondary and Tertiary Alkyl Electrophiles J. Am. Chem. Soc. 2016, 138, 6404-6407 10.1021/jacs.6b03465
-
(2016)
J. Am. Chem. Soc.
, vol.138
, pp. 6404-6407
-
-
Chu, C.K.1
Liang, Y.2
Fu, G.C.3
-
59
-
-
84855464257
-
Alkylboronic esters from copper-catalyzed borylation of primary and secondary alkyl halides and pseudohalides
-
Yang, C.-T.; Zhang, Z.-Q.; Tajuddin, H.; Wu, C.-C.; Liang, J.; Liu, J.-H.; Fu, Y.; Czyzewska, M.; Steel, P. G.; Marder, T. B.; Liu, L. Alkylboronic esters from copper-catalyzed borylation of primary and secondary alkyl halides and pseudohalides Angew. Chem., Int. Ed. 2012, 51, 528-532 10.1002/anie.201106299
-
(2012)
Angew. Chem., Int. Ed.
, vol.51
, pp. 528-532
-
-
Yang, C.-T.1
Zhang, Z.-Q.2
Tajuddin, H.3
Wu, C.-C.4
Liang, J.5
Liu, J.-H.6
Fu, Y.7
Czyzewska, M.8
Steel, P.G.9
Marder, T.B.10
Liu, L.11
-
60
-
-
84856693018
-
Copper(I)-Catalyzed Boryl Substitution of Unactivated Alkyl Halides
-
Ito, H.; Kubota, K. Copper(I)-Catalyzed Boryl Substitution of Unactivated Alkyl Halides Org. Lett. 2012, 14, 890-893 10.1021/ol203413w
-
(2012)
Org. Lett.
, vol.14
, pp. 890-893
-
-
Ito, H.1
Kubota, K.2
-
61
-
-
85010886029
-
-
For example, see: Academic Press: Waltham, MA
-
For example, see: Alkaloids: A Treasure of Poisons and Medicines; Funayama, S.; Cordell, G. A., Eds.; Academic Press: Waltham, MA, 2015.
-
(2015)
Alkaloids: A Treasure of Poisons and Medicines
-
-
Funayama, S.1
Cordell, G.A.2
-
62
-
-
84857360028
-
Synthesis and characterization of yellow and green light emitting novel polymers containing carbazole and electroactive moieties
-
There were isolated reports of N-alkylations of amines with unactivated alkyl halides that proceed in the presence of a substoichiometric quantity of a transition metal. For example, see: (165 °C; primary alkyl bromide)
-
There were isolated reports of N-alkylations of amines with unactivated alkyl halides that proceed in the presence of a substoichiometric quantity of a transition metal. For example, see: Aydin, A.; Kaya, I. Synthesis and characterization of yellow and green light emitting novel polymers containing carbazole and electroactive moieties Electrochim. Acta 2012, 65, 104-114 (165 °C; primary alkyl bromide) 10.1016/j.electacta.2012.01.028
-
(2012)
Electrochim. Acta
, vol.65
, pp. 104-114
-
-
Aydin, A.1
Kaya, I.2
-
63
-
-
77956094139
-
The synthesis and electrochemical properties of cathodic-anodic composite electrochromic materials
-
(80 °C; primary alkyl bromide)
-
Tu, X.; Fu, X.; Jiang, Q.; Liu, Z.; Chen, G. The synthesis and electrochemical properties of cathodic-anodic composite electrochromic materials Dyes Pigm. 2011, 88, 39-43 (80 °C; primary alkyl bromide) 10.1016/j.dyepig.2010.04.012
-
(2011)
Dyes Pigm.
, vol.88
, pp. 39-43
-
-
Tu, X.1
Fu, X.2
Jiang, Q.3
Liu, Z.4
Chen, G.5
-
64
-
-
20344374956
-
The direct synthesis of tertiary amines with three different substituents via the reaction of primary amines, alkyl halides, and α-chlorine substituted allylsilanes catalyzed by Lewis acids
-
(83 °C; primary alkyl bromide)
-
Kozuka, M.; Tsuchida, T.; Mitani, M. The direct synthesis of tertiary amines with three different substituents via the reaction of primary amines, alkyl halides, and α-chlorine substituted allylsilanes catalyzed by Lewis acids Tetrahedron Lett. 2005, 46, 4527-4530 (83 °C; primary alkyl bromide) 10.1016/j.tetlet.2005.05.022
-
(2005)
Tetrahedron Lett.
, vol.46
, pp. 4527-4530
-
-
Kozuka, M.1
Tsuchida, T.2
Mitani, M.3
-
65
-
-
84868238205
-
Photoinduced Ullmann C-N coupling: Demonstrating the viability of a radical pathway
-
Creutz, S. E.; Lotito, K. J.; Fu, G. C.; Peters, J. C. Photoinduced Ullmann C-N coupling: demonstrating the viability of a radical pathway Science 2012, 338, 647-651 10.1126/science.1226458
-
(2012)
Science
, vol.338
, pp. 647-651
-
-
Creutz, S.E.1
Lotito, K.J.2
Fu, G.C.3
Peters, J.C.4
-
66
-
-
84887451679
-
-
For an overview of Ullmann reactions, see: John Wiley & Sons: Hoboken, NJ
-
For an overview of Ullmann reactions, see: Copper-Mediated Cross-Coupling Reactions; Evano, G.; Blanchard, N., Eds.; John Wiley & Sons: Hoboken, NJ, 2014.
-
(2014)
Copper-Mediated Cross-Coupling Reactions
-
-
Evano, G.1
Blanchard, N.2
-
67
-
-
84877695378
-
Transition-metal-catalyzed alkylations of amines with alkyl halides: Photoinduced, copper-catalyzed couplings of carbazoles
-
Bissember, A. C.; Lundgren, R. J.; Creutz, S. E.; Peters, J. C.; Fu, G. C. Transition-metal-catalyzed alkylations of amines with alkyl halides: photoinduced, copper-catalyzed couplings of carbazoles Angew. Chem., Int. Ed. 2013, 52, 5129-5133 10.1002/anie.201301202
-
(2013)
Angew. Chem., Int. Ed.
, vol.52
, pp. 5129-5133
-
-
Bissember, A.C.1
Lundgren, R.J.2
Creutz, S.E.3
Peters, J.C.4
Fu, G.C.5
-
68
-
-
84969617464
-
Analysis of Past and Present Synthetic Methodologies on Medicinal Chemistry: Where Have All the New Reactions Gone?
-
For example, amides are the most frequently occurring functional group in the IBEX database of patents in the area of medicinal chemistry
-
For example, amides are the most frequently occurring functional group in the IBEX database of patents in the area of medicinal chemistry: Brown, D. G.; Boström, J. Analysis of Past and Present Synthetic Methodologies on Medicinal Chemistry: Where Have All the New Reactions Gone? J. Med. Chem. 2016, 59, 4443-4458 10.1021/acs.jmedchem.5b01409
-
(2016)
J. Med. Chem.
, vol.59
, pp. 4443-4458
-
-
Brown, D.G.1
Boström, J.2
-
69
-
-
84893773566
-
Photoinduced, Copper-Catalyzed Alkylation of Amides with Unactivated Secondary Alkyl Halides at Room Temperature
-
Do, H.-Q.; Bachman, S.; Bissember, A. C.; Peters, J. C.; Fu, G. C. Photoinduced, Copper-Catalyzed Alkylation of Amides with Unactivated Secondary Alkyl Halides at Room Temperature J. Am. Chem. Soc. 2014, 136, 2162-2167 10.1021/ja4126609
-
(2014)
J. Am. Chem. Soc.
, vol.136
, pp. 2162-2167
-
-
Do, H.-Q.1
Bachman, S.2
Bissember, A.C.3
Peters, J.C.4
Fu, G.C.5
-
70
-
-
84957899492
-
Asymmetric copper-catalyzed C-N cross-couplings induced by visible light
-
(mechanistic studies of this process are underway)
-
Kainz, Q. M.; Matier, C. M.; Bartoszewicz, A.; Zultanski, S. L.; Peters, J. C.; Fu, G. C. Asymmetric copper-catalyzed C-N cross-couplings induced by visible light Science 2016, 351, 681-684 (mechanistic studies of this process are underway) 10.1126/science.aad8313
-
(2016)
Science
, vol.351
, pp. 681-684
-
-
Kainz, Q.M.1
Matier, C.M.2
Bartoszewicz, A.3
Zultanski, S.L.4
Peters, J.C.5
Fu, G.C.6
-
72
-
-
84921490704
-
Catalytic enantioselective synthesis of quaternary carbon stereocentres
-
Quasdorf, K. W.; Overman, L. E. Catalytic enantioselective synthesis of quaternary carbon stereocentres Nature 2014, 516, 181-191 10.1038/nature14007
-
(2014)
Nature
, vol.516
, pp. 181-191
-
-
Quasdorf, K.W.1
Overman, L.E.2
|