메뉴 건너뛰기




Volumn 5, Issue 1, 2015, Pages 101-116

Vascular endothelial growth factor receptor 3 signaling contributes to angioobliterative pulmonary hypertension

Author keywords

Capillary rarefaction; Chronic hypoxia; MAZ51; Right heart failure; SFlt 1; Sugen 5416; VEGF isoforms; VEGF receptor 3

Indexed keywords


EID: 85026337409     PISSN: 20458932     EISSN: 20458940     Source Type: Journal    
DOI: 10.1086/679704     Document Type: Review
Times cited : (25)

References (74)
  • 1
    • 84871211326 scopus 로고    scopus 로고
    • Pathobiology of pulmonary arterial hypertension and right ventricular failure
    • Voelkel NF, Gomez-Arroyo J, Abbate A, Bogaard HJ, Nicolls MR. Pathobiology of pulmonary arterial hypertension and right ventricular failure. Eur Respir J 2012;40(6):1555-1565.
    • (2012) Eur Respir J , vol.40 , Issue.6 , pp. 1555-1565
    • Voelkel, N.F.1    Gomez-Arroyo, J.2    Abbate, A.3    Bogaard, H.J.4    Nicolls, M.R.5
  • 4
    • 84887271779 scopus 로고    scopus 로고
    • Bronchus-associated lymphoid tissue in pulmonary hypertension produces pathologic autoantibodies
    • Colvin KL, Cripe PJ, Ivy DD, Stenmark KR, Yeager ME. Bronchus-associated lymphoid tissue in pulmonary hypertension produces pathologic autoantibodies. Am J Respir Crit Care Med 2013;188(9):1126-1136.
    • (2013) Am J Respir Crit Care Med , vol.188 , Issue.9 , pp. 1126-1136
    • Colvin, K.L.1    Cripe, P.J.2    Ivy, D.D.3    Stenmark, K.R.4    Yeager, M.E.5
  • 5
    • 84883849935 scopus 로고    scopus 로고
    • Blocking macrophage leukotriene B4 prevents endothelial injury and reverses pulmonary hypertension
    • Tian W, Jiang X, Tamosiuniene R, Sung YK, Qian J, Dhillon G, et al. Blocking macrophage leukotriene B4 prevents endothelial injury and reverses pulmonary hypertension. Sci Transl Med 2013;5(200):200ra117.
    • (2013) Sci Transl Med , vol.5 , Issue.200
    • Tian, W.1    Jiang, X.2    Tamosiuniene, R.3    Sung, Y.K.4    Qian, J.5    Dhillon, G.6
  • 6
    • 84890032027 scopus 로고    scopus 로고
    • Dysfunctional resident lung mesenchymal stem cells contribute to pulmonary microvascular remodeling
    • Chow K, Fessel JP, Ihida-Stansbury K, Schmidt EP, Gaskill C, Alvarez D, et al. Dysfunctional resident lung mesenchymal stem cells contribute to pulmonary microvascular remodeling. Pulm Circ 2013;3(1):31-49.
    • (2013) Pulm Circ , vol.3 , Issue.1 , pp. 31-49
    • Chow, K.1    Fessel, J.P.2    Ihida-Stansbury, K.3    Schmidt, E.P.4    Gaskill, C.5    Alvarez, D.6
  • 7
    • 84870523226 scopus 로고    scopus 로고
    • Molecular pathogenesis of pulmonary arterial hypertension
    • Rabinovitch M. Molecular pathogenesis of pulmonary arterial hypertension. J Clin Invest 2012;122(12):4306-4313.
    • (2012) J Clin Invest , vol.122 , Issue.12 , pp. 4306-4313
    • Rabinovitch, M.1
  • 8
    • 84881240287 scopus 로고    scopus 로고
    • FK506 activates BMPR2, rescues endothelial dysfunction, and reverses pulmonary hypertension
    • Spiekerkoetter E, Tian X, Cai J, Hopper RK, Sudheendra D, Li CG, et al. FK506 activates BMPR2, rescues endothelial dysfunction, and reverses pulmonary hypertension. J Clin Invest 2013;123(8):3600-3613.
    • (2013) J Clin Invest , vol.123 , Issue.8 , pp. 3600-3613
    • Spiekerkoetter, E.1    Tian, X.2    Cai, J.3    Hopper, R.K.4    Sudheendra, D.5    Li, C.G.6
  • 10
    • 77954243018 scopus 로고    scopus 로고
    • Formation of plexiform lesions in experimental severe pulmonary arterial hypertension
    • Abe K, Toba M, Alzoubi A, Ito M, Fagan KA, Cool CD, et al. Formation of plexiform lesions in experimental severe pulmonary arterial hypertension. Circulation 2010;121(25):2747-2754.
    • (2010) Circulation , vol.121 , Issue.25 , pp. 2747-2754
    • Abe, K.1    Toba, M.2    Alzoubi, A.3    Ito, M.4    Fagan, K.A.5    Cool, C.D.6
  • 11
    • 0035130107 scopus 로고    scopus 로고
    • Inhibition of the VEGF receptor 2 combined with chronic hypoxia causes cell death- dependent pulmonary endothelial cell proliferation and severe pulmonary hypertension
    • Taraseviciene-Stewart L, Kasahara Y, Alger L, Hirth P, Mc- Mahon G, Waltenberger J, et al. Inhibition of the VEGF receptor 2 combined with chronic hypoxia causes cell death- dependent pulmonary endothelial cell proliferation and severe pulmonary hypertension. FASEB J 2001;15(2):427-438.
    • (2001) FASEB J , vol.15 , Issue.2 , pp. 427-438
    • Taraseviciene-Stewart, L.1    Kasahara, Y.2    Alger, L.3    Hirth, P.4    Mc-Mahon, G.5    Waltenberger, J.6
  • 12
    • 84884185388 scopus 로고    scopus 로고
    • Critical role for the advanced glycation endproducts receptor in pulmonary arterial hypertension etiology
    • Meloche J, Courchesne A, Barrier M, Carter S, Bisserier M, Paulin R, et al. Critical role for the advanced glycation endproducts receptor in pulmonary arterial hypertension etiology. J Am Heart Assoc 2013;2(1):e005157
    • (2013) J am Heart Assoc , vol.2 , Issue.1
    • Meloche, J.1    Courchesne, A.2    Barrier, M.3    Carter, S.4    Bisserier, M.5    Paulin, R.6
  • 13
    • 84887456534 scopus 로고    scopus 로고
    • Role of endothelial cell metabolism in vessel sprouting
    • De Bock K, Georgiadou M, Carmeliet P. Role of endothelial cell metabolism in vessel sprouting. Cell Metab 2013;18 (5):634-647
    • (2013) Cell Metab , vol.18 , Issue.5 , pp. 634-647
    • De Bock, K.1    Georgiadou, M.2    Carmeliet, P.3
  • 14
    • 84859453770 scopus 로고    scopus 로고
    • Notch-dependent VEGFR3 upregulation allows angiogenesis without VEGF-VEGFR2 signalling
    • Benedito R, Rocha SF, Woeste M, Zamykal M, Radtke F, Casanovas O, et al. Notch-dependent VEGFR3 upregulation allows angiogenesis without VEGF-VEGFR2 signalling. Nature 2012;484(7392):110-114
    • (2012) Nature , vol.484 , Issue.7392 , pp. 110-114
    • Benedito, R.1    Rocha, S.F.2    Woeste, M.3    Zamykal, M.4    Radtke, F.5    Casanovas, O.6
  • 15
    • 39749140405 scopus 로고    scopus 로고
    • HIF-independent regulation of VEGF and angiogenesis by the transcriptional coactivator PGC-1α
    • Arany Z, Foo S-Y, Ma Y, Ruas JL, Bommi-Reddy A, Girnun G, et al. HIF-independent regulation of VEGF and angiogenesis by the transcriptional coactivator PGC-1α. Nature 2008;451(7181):1008-1012
    • (2008) Nature , vol.451 , Issue.7181 , pp. 1008-1012
    • Arany, Z.1    Foo, S.-Y.2    Ma, Y.3    Ruas, J.L.4    Bommi-Reddy, A.5    Girnun, G.6
  • 16
    • 84891890658 scopus 로고    scopus 로고
    • Bevacizumab and micrometastases: Revisiting the preclinical and clinical rollercoaster
    • Mountzios G, Pentheroudakis G, Carmeliet P. Bevacizumab and micrometastases: revisiting the preclinical and clinical rollercoaster. Pharmacol Ther 2014;141(2):117-124
    • (2014) Pharmacol Ther , vol.141 , Issue.2 , pp. 117-124
    • Mountzios, G.1    Pentheroudakis, G.2    Carmeliet, P.3
  • 17
    • 84876586696 scopus 로고    scopus 로고
    • Phosphoproteomic analysis implicates the mTORC2-FoxO1 axis in VEGF signaling and feedback activation of receptor tyrosine kinases
    • Zhuang G, Yu K, Jiang Z, Chung A, Yao J, Ha C, et al. Phosphoproteomic analysis implicates the mTORC2-FoxO1 axis in VEGF signaling and feedback activation of receptor tyrosine kinases. Sci Signal 2013;6(271):ra25
    • (2013) Sci Signal , vol.6 , Issue.271
    • Zhuang, G.1    Yu, K.2    Jiang, Z.3    Chung, A.4    Yao, J.5    Ha, C.6
  • 18
    • 84866693927 scopus 로고    scopus 로고
    • Controlling escape from angiogenesis inhibitors
    • Sennino B, McDonald DM. Controlling escape from angiogenesis inhibitors. Nat Rev Cancer 2012;12(10):699-709
    • (2012) Nat Rev Cancer , vol.12 , Issue.10 , pp. 699-709
    • Sennino, B.1    McDonald, D.M.2
  • 19
    • 0033558798 scopus 로고    scopus 로고
    • VEGF prevents apoptosis of human microvascular endothelial cells via opposing effects on MAPK/ERK and SAPK/JNK signaling
    • Gupta K, Kshirsagar S, Li W, Gui L, Ramakrishnan S, Gupta P, et al. VEGF prevents apoptosis of human microvascular endothelial cells via opposing effects on MAPK/ERK and SAPK/JNK signaling. Exp Cell Res 1999;247(2):495-504
    • (1999) Exp Cell Res , vol.247 , Issue.2 , pp. 495-504
    • Gupta, K.1    Kshirsagar, S.2    Li, W.3    Gui, L.4    Ramakrishnan, S.5    Gupta, P.6
  • 20
    • 0034076189 scopus 로고    scopus 로고
    • Mechanisms of angiogenesis and arteriogenesis
    • Carmeliet P. Mechanisms of angiogenesis and arteriogenesis. Nat Med 2000;6(4):389-395
    • (2000) Nat Med , vol.6 , Issue.4 , pp. 389-395
    • Carmeliet, P.1
  • 21
    • 30744432102 scopus 로고    scopus 로고
    • Akt1 regulates pathological angiogenesis, vascular maturation and permeability in vivo
    • Chen J, Somanath PR, Razorenova O, Chen WS, Hay N, Bornstein P, et al. Akt1 regulates pathological angiogenesis, vascular maturation and permeability in vivo. Nat Med 2005;11(11):1188-1196
    • (2005) Nat Med , vol.11 , Issue.11 , pp. 1188-1196
    • Chen, J.1    Somanath, P.R.2    Razorenova, O.3    Chen, W.S.4    Hay, N.5    Bornstein, P.6
  • 22
    • 33750529948 scopus 로고    scopus 로고
    • VEGF controls endothelial-cell permeability by promoting the β-arrestin-dependent endocytosis of VE-cadherin
    • Gavard J, Gutkind JS. VEGF controls endothelial-cell permeability by promoting the β-arrestin-dependent endocytosis of VE-cadherin. Nat Cell Biol 2006;8(11):1223-1234
    • (2006) Nat Cell Biol , vol.8 , Issue.11 , pp. 1223-1234
    • Gavard, J.1    Gutkind, J.S.2
  • 23
    • 84880742193 scopus 로고    scopus 로고
    • Signal transduction by vascular endothelial growth factor receptors
    • Koch S, Claesson-Welsh L. Signal transduction by vascular endothelial growth factor receptors. Cold Spring Harb Perspect Med 2012;2(7):a006502
    • (2012) Cold Spring Harb Perspect Med , vol.2 , Issue.7
    • Koch, S.1    Claesson-Welsh, L.2
  • 25
    • 0034772039 scopus 로고    scopus 로고
    • Expression of angiogenesisrelated molecules in plexiform lesions in severe pulmonary hypertension: Evidence for a process of disordered angiogenesis
    • Tuder RM, Chacon M, Alger L, Wang J, Taraseviciene- Stewart L, Kasahara Y, et al. Expression of angiogenesisrelated molecules in plexiform lesions in severe pulmonary hypertension: evidence for a process of disordered angiogenesis. J Pathol 2001;195(3):367-374
    • (2001) J Pathol , vol.195 , Issue.3 , pp. 367-374
    • Tuder, R.M.1    Chacon, M.2    Alger, L.3    Wang, J.4    Taraseviciene-Stewart, L.5    Kasahara, Y.6
  • 26
    • 0029664716 scopus 로고    scopus 로고
    • Coexpression of flt-1, flt-4 and KDR in freshly isolated and cultured human endothelial cells
    • Hewett PW, Murray JC. Coexpression of flt-1, flt-4 and KDR in freshly isolated and cultured human endothelial cells. Biochem Biophys Res Commun 1996;221(3):697-702
    • (1996) Biochem Biophys Res Commun , vol.221 , Issue.3 , pp. 697-702
    • Hewett, P.W.1    Murray, J.C.2
  • 27
    • 2642641324 scopus 로고    scopus 로고
    • Proinflammatory cytokines regulate expression of the lymphatic endothelial mitogen vascular endothelial growth factor-C
    • Ristimaki A, Narko K, Enholm B, Joukov V, Alitalo K. Proinflammatory cytokines regulate expression of the lymphatic endothelial mitogen vascular endothelial growth factor-C. J Biol Chem 1998;273(14):8413-8418
    • (1998) J Biol Chem , vol.273 , Issue.14 , pp. 8413-8418
    • Ristimaki, A.1    Narko, K.2    Enholm, B.3    Joukov, V.4    Alitalo, K.5
  • 28
    • 33746614247 scopus 로고    scopus 로고
    • Pulmonary vascular endothelial growth factor- C in development and lung injury in preterm infants
    • Janer J, Lassus P, Haglund C, Paavonen K, Alitalo K, Andersson S. Pulmonary vascular endothelial growth factor- C in development and lung injury in preterm infants. Am J Respir Crit Care Med 2006;174(3):326-330
    • (2006) Am J Respir Crit Care Med , vol.174 , Issue.3 , pp. 326-330
    • Janer, J.1    Lassus, P.2    Haglund, C.3    Paavonen, K.4    Alitalo, K.5    Ersson, S.6
  • 29
    • 48349129069 scopus 로고    scopus 로고
    • Blocking VEGFR-3 suppresses angiogenic sprouting and vascular network formation
    • Tammela T, Zarkada G, Wallgard E, Murtomaki A, Suchting S, Wirzenius M, et al. Blocking VEGFR-3 suppresses angiogenic sprouting and vascular network formation. Nature 2008;454(7204):656-660
    • (2008) Nature , vol.454 , Issue.7204 , pp. 656-660
    • Tammela, T.1    Zarkada, G.2    Wallgard, E.3    Murtomaki, A.4    Suchting, S.5    Wirzenius, M.6
  • 31
    • 77955510391 scopus 로고    scopus 로고
    • VEGF-mediated signal transduction in lymphatic endothelial cells
    • Bahram F, Claesson-Welsh L. VEGF-mediated signal transduction in lymphatic endothelial cells. Pathophysiology 2010; 17(4):253-261
    • (2010) Pathophysiology , vol.17 , Issue.4 , pp. 253-261
    • Bahram, F.1    Claesson-Welsh, L.2
  • 32
    • 8644256083 scopus 로고    scopus 로고
    • MAZ51, an indolinone that inhibits endothelial cell and tumor cell growth in vitro, suppresses tumor growth in vivo
    • Kirkin V, Thiele W, Baumann P, Mazitschek R, Rohde K, Fellbrich G, et al. MAZ51, an indolinone that inhibits endothelial cell and tumor cell growth in vitro, suppresses tumor growth in vivo. Int J Cancer 2004;112(6):986-993
    • (2004) Int J Cancer , vol.112 , Issue.6 , pp. 986-993
    • Kirkin, V.1    Thiele, W.2    Baumann, P.3    Mazitschek, R.4    Rohde, K.5    Fellbrich, G.6
  • 33
    • 51349112099 scopus 로고    scopus 로고
    • Lysophosphatidic acid up-regulates vascular endothelial growth factor-C and lymphatic marker expressions in human endothelial cells
    • Lin CI, Chen CN, Huang MT, Lee SJ, Lin CH, Chang CC, et al. Lysophosphatidic acid up-regulates vascular endothelial growth factor-C and lymphatic marker expressions in human endothelial cells. Cell Mol Life Sci 2008;65(17):2740-2751
    • (2008) Cell Mol Life Sci , vol.65 , Issue.17 , pp. 2740-2751
    • Lin, C.I.1    Chen, C.N.2    Huang, M.T.3    Lee, S.J.4    Lin, C.H.5    Chang, C.C.6
  • 35
    • 77957694135 scopus 로고    scopus 로고
    • Adrenergic receptor blockade reverses right heart remodeling and dysfunction in pulmonary hypertensive rats
    • Bogaard HJ, Natarajan R, Mizuno S, Abbate A, Chang PJ, hau VQ, et al. Adrenergic receptor blockade reverses right heart remodeling and dysfunction in pulmonary hypertensive rats. Am J Respir Crit Care Med 2010:182(5):652-660
    • (2010) Am J Respir Crit Care Med , vol.182 , Issue.5 , pp. 652-660
    • Bogaard, H.J.1    Natarajan, R.2    Mizuno, S.3    Abbate, A.4    Chang, P.J.5    Hau, V.Q.6
  • 37
    • 13144266696 scopus 로고    scopus 로고
    • Vascular endothelial growth factor B (VEGF-B) binds to VEGF receptor-1 and regulates plasminogen activator activity in endothelial cells
    • Olofsson B, Korpelainen E, Pepper MS, Mandriota SJ, Aase K, Kumar V, et al. Vascular endothelial growth factor B (VEGF-B) binds to VEGF receptor-1 and regulates plasminogen activator activity in endothelial cells. Proc Natl Acad Sci USA 1998;95(20):11709-11714
    • (1998) Proc Natl Acad Sci USA , vol.95 , Issue.20 , pp. 11709-11714
    • Olofsson, B.1    Korpelainen, E.2    Pepper, M.S.3    Mandriota, S.J.4    Aase, K.5    Kumar, V.6
  • 38
    • 78149281188 scopus 로고    scopus 로고
    • Vascular endothelial growth factor-B acts as a coronary growth factor in transgenic rats without inducing angiogenesis, vascular leak, or inflammation
    • Bry M, Kivela R, Holopainen T, Anisimov A, Tammela T, Soronen J, et al. Vascular endothelial growth factor-B acts as a coronary growth factor in transgenic rats without inducing angiogenesis, vascular leak, or inflammation. Circulation 2010;122(17):1725-1733
    • (2010) Circulation , vol.122 , Issue.17 , pp. 1725-1733
    • Bry, M.1    Kivela, R.2    Holopainen, T.3    Anisimov, A.4    Tammela, T.5    Soronen, J.6
  • 39
    • 38349138807 scopus 로고    scopus 로고
    • Transgenic system for conditional induction and rescue of chronic myocardial hibernation provides insights into genomic programs of hibernation
    • May D, Gilon D, Djonov V, Itin A, Lazarus A, Gordon O, et al. Transgenic system for conditional induction and rescue of chronic myocardial hibernation provides insights into genomic programs of hibernation. Proc Natl Acad Sci USA 2008;105(1):282-287
    • (2008) Proc Natl Acad Sci USA , vol.105 , Issue.1 , pp. 282-287
    • May, D.1    Gilon, D.2    Djonov, V.3    Itin, A.4    Lazarus, A.5    Gordon, O.6
  • 41
  • 43
    • 0035942271 scopus 로고    scopus 로고
    • Significance analysis of microarrays applied to the ionizing radiation response
    • Tusher VG, Tibshirani R, Chu G. Significance analysis of microarrays applied to the ionizing radiation response. Proc Natl Acad Sci USA 2001;98:5116-5121
    • (2001) Proc Natl Acad Sci USA , vol.98 , pp. 5116-5121
    • Tusher, V.G.1    Tibshirani, R.2    Chu, G.3
  • 45
    • 82755165210 scopus 로고    scopus 로고
    • Molecular signature of a right heart failure program in chronic severe pulmonary hypertension
    • Drake JI, Bogaard HJ, Mizuno S, Clifton B, Xie B, Gao Y, et al. Molecular signature of a right heart failure program in chronic severe pulmonary hypertension. Am J Respir Cell Mol Biol 2011;45(6):1239-1247
    • (2011) Am J Respir Cell Mol Biol , vol.45 , Issue.6 , pp. 1239-1247
    • Drake, J.I.1    Bogaard, H.J.2    Mizuno, S.3    Clifton, B.4    Xie, B.5    Gao, Y.6
  • 46
    • 0029830987 scopus 로고    scopus 로고
    • Vascular endothelial growth factor stimulates protein kinase C-dependent phospholipase D activity in endothelial cells
    • Seymour LW, Shoaibi MA, Martin A, Ahmed A, Elvin P, Kerr DJ, et al. Vascular endothelial growth factor stimulates protein kinase C-dependent phospholipase D activity in endothelial cells. Lab Invest 1996;75(3):427-437
    • (1996) Lab Invest , vol.75 , Issue.3 , pp. 427-437
    • Seymour, L.W.1    Shoaibi, M.A.2    Martin, A.3    Ahmed, A.4    Elvin, P.5    Kerr, D.J.6
  • 47
    • 1942469316 scopus 로고    scopus 로고
    • Localization of VEGFR-2 and PLD2 in endothelial caveolae is involved in VEGF-induced phosphorylation of MEK and ERK
    • Cho CH, Lee CS, Chang M, Jang IH, Kim SJ, Hwang I, et al. Localization of VEGFR-2 and PLD2 in endothelial caveolae is involved in VEGF-induced phosphorylation of MEK and ERK. Am J Physiol Heart Circ Physiol 2004;286(5):H1881-H1888
    • (2004) Am J Physiol Heart Circ Physiol , vol.286 , Issue.5 , pp. H1881-H1888
    • Cho, C.H.1    Lee, C.S.2    Chang, M.3    Jang, I.H.4    Kim, S.J.5    Hwang, I.6
  • 48
    • 0032529242 scopus 로고    scopus 로고
    • Isolation and characterization of a novel human lung-specific gene homologous to lysosomal membrane glycoproteins 1 and 2: Significantly increased expression in cancers of various tissues
    • Ozaki K, Nagata M, Suzuki M, Fujiwara T, Ueda K, Miyoshi Y, et al. Isolation and characterization of a novel human lung-specific gene homologous to lysosomal membrane glycoproteins 1 and 2: significantly increased expression in cancers of various tissues. Cancer Res 1998;58(16):3499-3503
    • (1998) Cancer Res , vol.58 , Issue.16 , pp. 3499-3503
    • Ozaki, K.1    Nagata, M.2    Suzuki, M.3    Fujiwara, T.4    Ueda, K.5    Miyoshi, Y.6
  • 49
    • 25444518176 scopus 로고    scopus 로고
    • Overexpression of LAMP3/TSC403/DC-LAMP promotes metastasis in uterine cervical cancer
    • Kanao H, Enomoto T, Kimura T, Fujita M, Nakashima R, Ueda Y, et al. Overexpression of LAMP3/TSC403/DC-LAMP promotes metastasis in uterine cervical cancer. Cancer Res 2005;65(19):8640-8645
    • (2005) Cancer Res , vol.65 , Issue.19 , pp. 8640-8645
    • Kanao, H.1    Enomoto, T.2    Kimura, T.3    Fujita, M.4    Nakashima, R.5    Ueda, Y.6
  • 50
    • 0034108631 scopus 로고    scopus 로고
    • The tetraspanin CD63/lamp3 cycles between endocytic and secretory compartments in human endothelial cells
    • Kobayashi T, Vischer UM, Rosnoblet C, Lebrand C, Lindsay M, Parton RG, et al. The tetraspanin CD63/lamp3 cycles between endocytic and secretory compartments in human endothelial cells. Mol Biol Cell 2000;11(5):1829-1843
    • (2000) Mol Biol Cell , vol.11 , Issue.5 , pp. 1829-1843
    • Kobayashi, T.1    Vischer, U.M.2    Rosnoblet, C.3    Lebrand, C.4    Lindsay, M.5    Parton, R.G.6
  • 52
    • 0032491588 scopus 로고    scopus 로고
    • SPARC (BM-40, osteonectin) inhibits the mitogenic effect of vascular endothelial growth factor on microvascular endothelial cells
    • Kupprion C, Motamed K, Sage EH. SPARC (BM-40, osteonectin) inhibits the mitogenic effect of vascular endothelial growth factor on microvascular endothelial cells. J Biol Chem 1998;273(45):29635-29640
    • (1998) J Biol Chem , vol.273 , Issue.45 , pp. 29635-29640
    • Kupprion, C.1    Motamed, K.2    Sage, E.H.3
  • 53
    • 35349021966 scopus 로고    scopus 로고
    • Molecular docking and analysis of interactions between vas- cular endothelial growth factor (VEGF) and SPARC protein
    • Chandrasekaran V, Ambati J, Ambati BK, Taylor EW. Molecular docking and analysis of interactions between vas- cular endothelial growth factor (VEGF) and SPARC protein. J Mol Graph Model 2007;26(4):775-782
    • (2007) J Mol Graph Model , vol.26 , Issue.4 , pp. 775-782
    • Chandrasekaran, V.1    Ambati, J.2    Ambati, B.K.3    Taylor, E.W.4
  • 54
    • 32444431828 scopus 로고    scopus 로고
    • Loss of SPARC-mediated VEGFR-1 suppression after injury reveals a novel antiangiogenic activity of VEGFA
    • Nozaki M, Sakurai E, Raisler BJ, Baffi JZ, Witta J, Ogura Y, et al. Loss of SPARC-mediated VEGFR-1 suppression after injury reveals a novel antiangiogenic activity of VEGFA. J Clin Invest 2006;116(2):422-429
    • (2006) J Clin Invest , vol.116 , Issue.2 , pp. 422-429
    • Nozaki, M.1    Sakurai, E.2    Raisler, B.J.3    Baffi, J.Z.4    Witta, J.5    Ogura, Y.6
  • 56
    • 80052949838 scopus 로고    scopus 로고
    • The regulatory function of SPARC in vascular biology
    • Rivera LB, Bradshaw AD, Brekken RA. The regulatory function of SPARC in vascular biology. Cell Mol Life Sci 2011;68 (19):3165-3173
    • (2011) Cell Mol Life Sci , vol.68 , Issue.19 , pp. 3165-3173
    • Rivera, L.B.1    Bradshaw, A.D.2    Brekken, R.A.3
  • 57
    • 77952234421 scopus 로고    scopus 로고
    • Basic science of pulmonary arterial hypertension for clinicians: New concepts and experimental therapies
    • Archer SL, Weir EK, Wilkins MR. Basic science of pulmonary arterial hypertension for clinicians: new concepts and experimental therapies. Circulation 2010;121(18):2045-2066
    • (2010) Circulation , vol.121 , Issue.18 , pp. 2045-2066
    • Archer, S.L.1    Weir, E.K.2    Wilkins, M.R.3
  • 58
    • 84870239895 scopus 로고    scopus 로고
    • Exosomes mediate the cytoprotective action of mesenchymal stromal cells on hypoxia-induced pulmonary hypertension
    • Lee C, Mitsialis SA, Aslam M, Vitali SH, Vergadi E, Konstantinou G, et al. Exosomes mediate the cytoprotective action of mesenchymal stromal cells on hypoxia-induced pulmonary hypertension. Circulation 2012;126(22):2601-2611
    • (2012) Circulation , vol.126 , Issue.22 , pp. 2601-2611
    • Lee, C.1    Mitsialis, S.A.2    Aslam, M.3    Vitali, S.H.4    Vergadi, E.5    Konstantinou, G.6
  • 59
    • 0034681392 scopus 로고    scopus 로고
    • Utilization of distinct signaling pathways by receptors for vascular endothelial cell growth factor and other mitogens in the induction of endothelial cell proliferation
    • Wu LW, Mayo LD, Dunbar JD, Kessler KM, Baerwald MR, Jaffe EA, et al. Utilization of distinct signaling pathways by receptors for vascular endothelial cell growth factor and other mitogens in the induction of endothelial cell proliferation. J Biol Chem 2000;275(7):5096-5103
    • (2000) J Biol Chem , vol.275 , Issue.7 , pp. 5096-5103
    • Wu, L.W.1    Mayo, L.D.2    Dunbar, J.D.3    Kessler, K.M.4    Baerwald, M.R.5    Jaffe, E.A.6
  • 60
    • 35948964028 scopus 로고    scopus 로고
    • VEGF-R blockade causes endothelial cell apoptosis, expansion of surviving CD34 þ precursor cells and transdifferentiation to smooth muscle-like and neuronal-like cells
    • Sakao S, Taraseviciene-Stewart L, Cool CD, Tada Y, Kasahara Y, Kurosu K, et al. VEGF-R blockade causes endothelial cell apoptosis, expansion of surviving CD34 þ precursor cells and transdifferentiation to smooth muscle-like and neuronal-like cells. FASEB J 2007;21(13):3640-3652
    • (2007) FASEB J , vol.21 , Issue.13 , pp. 3640-3652
    • Sakao, S.1    Taraseviciene-Stewart, L.2    Cool, C.D.3    Tada, Y.4    Kasahara, Y.5    Kurosu, K.6
  • 61
    • 84886437293 scopus 로고    scopus 로고
    • Pulmonary arterial hypertension: Challenges in translational research and a vision for change
    • Sutendra G, Michelakis ED. Pulmonary arterial hypertension: challenges in translational research and a vision for change. Sci Transl Med 2013;5(208):208sr5
    • (2013) Sci Transl Med , vol.5 , Issue.208
    • Sutendra, G.1    Michelakis, E.D.2
  • 62
    • 85026340238 scopus 로고    scopus 로고
    • Overexpression of ID3 promotes a stem-like molecular signature in human endothelial cells: It’s implications in the development of hyperproliferative endothelial lesions associated with pulmonary hypertension
    • (forthcoming)
    • Das JK, Voelkel NF, Felty Q. Overexpression of ID3 promotes a stem-like molecular signature in human endothelial cells: it’s implications in the development of hyperproliferative endothelial lesions associated with pulmonary hypertension. Pulm Circ (forthcoming)
    • Pulm Circ
    • Das, J.K.1    Voelkel, N.F.2    Felty, Q.3
  • 64
    • 4043049430 scopus 로고    scopus 로고
    • Vascular endothelial growth factor receptor-3 mediates induction of corneal alloimmunity
    • Chen L, Hamrah P, Cursiefen C, Zhang Q, Pytowski B, Streilein JW, et al. Vascular endothelial growth factor receptor-3 mediates induction of corneal alloimmunity. Nat Med 2004;10(8):813-815
    • (2004) Nat Med , vol.10 , Issue.8 , pp. 813-815
    • Chen, L.1    Hamrah, P.2    Cursiefen, C.3    Zhang, Q.4    Pytowski, B.5    Streilein, J.W.6
  • 65
    • 84881636538 scopus 로고    scopus 로고
    • Id proteins are critical downstream effectors of BMP signaling in human pulmonary arterial smooth muscle cells
    • Yang J, Li X, Li Y, Southwood M, Ye L, Long L, et al. Id proteins are critical downstream effectors of BMP signaling in human pulmonary arterial smooth muscle cells. Am J Physiol Lung Cell Mol Physiol 2013;305(4):L312-L321
    • (2013) Am J Physiol Lung Cell Mol Physiol , vol.305 , Issue.4 , pp. L312-L321
    • Yang, J.1    Li, X.2    Li, Y.3    Southwood, M.4    Ye, L.5    Long, L.6
  • 66
    • 82955163263 scopus 로고    scopus 로고
    • C/EBP-δ regulates VEGF-C autocrine signaling in lymphangiogenesis and metastasis of lung cancer through HIF-1α
    • Min Y, Ghose S, Boelte K, Li J, Yang L, Lin PC. C/EBP-δ regulates VEGF-C autocrine signaling in lymphangiogenesis and metastasis of lung cancer through HIF-1α. Oncogene 2011;30(49):4901-4909
    • (2011) Oncogene , vol.30 , Issue.49 , pp. 4901-4909
    • Min, Y.1    Ghose, S.2    Boelte, K.3    Li, J.4    Yang, L.5    Lin, P.C.6
  • 67
    • 84866049270 scopus 로고    scopus 로고
    • Secreted protein acidic and rich in cysteine (SPARC) suppresses angiogenesis by down-regulating the expression of VEGF and MMP-7 in gastric cancer
    • Zhang JL, Chen GW, Liu YC, Wang PY, Wang X, Wan YL, et al. Secreted protein acidic and rich in cysteine (SPARC) suppresses angiogenesis by down-regulating the expression of VEGF and MMP-7 in gastric cancer. PloS ONE 2012;7 (9):e44618
    • (2012) Plos ONE , vol.7 , Issue.9 , pp. 4618
    • Zhang, J.L.1    Chen, G.W.2    Liu, Y.C.3    Wang, P.Y.4    Wang, X.5    Wan, Y.L.6
  • 68
    • 84893414176 scopus 로고    scopus 로고
    • Phosphatidic acid, phospholipase D and tumorigenesis
    • Gomez-Cambronero J. Phosphatidic acid, phospholipase D and tumorigenesis. Adv Biol Regul 2014;54:197-206
    • (2014) Adv Biol Regul , vol.54 , pp. 197-206
    • Gomez-Cambronero, J.1
  • 69
    • 81255188905 scopus 로고    scopus 로고
    • The lymphatic vasculature in disease
    • Alitalo K. The lymphatic vasculature in disease. Nat Med 2011;17(11):1371-1380
    • (2011) Nat Med , vol.17 , Issue.11 , pp. 1371-1380
    • Alitalo, K.1
  • 70
    • 38049146371 scopus 로고    scopus 로고
    • Diagnostic potential of serum VEGF-D for lymphangioleiomyomatosis
    • Young LR, Inoue Y, McCormack FX. Diagnostic potential of serum VEGF-D for lymphangioleiomyomatosis. N Engl J Med 2008;358(2):199-200
    • (2008) N Engl J Med , vol.358 , Issue.2 , pp. 199-200
    • Young, L.R.1    Inoue, Y.2    McCormack, F.X.3
  • 71
    • 77950865464 scopus 로고    scopus 로고
    • Vascular endothelial growth factor B controls endothelial fatty acid uptake
    • Hagberg CE, Falkevall A, Wang X, Larsson E, Huusko J, Nilsson I, et al. Vascular endothelial growth factor B controls endothelial fatty acid uptake. Nature 2010;464(7290): 917-921
    • (2010) Nature , vol.464 , Issue.7290 , pp. 917-921
    • Hagberg, C.E.1    Falkevall, A.2    Wang, X.3    Larsson, E.4    Huusko, J.5    Nilsson, I.6
  • 72
    • 78650460365 scopus 로고    scopus 로고
    • Vascular endothelial growth factor-B gene transfer prevents angiotensin II-induced diastolic dysfunction via proliferation and capillary dilatation in rats
    • Serpi R, Tolonen AM, Huusko J, Rysa J, Tenhunen O, Yla- Herttuala S, et al. Vascular endothelial growth factor-B gene transfer prevents angiotensin II-induced diastolic dysfunction via proliferation and capillary dilatation in rats. Cardiovasc Res 2011;89(1):204-213
    • (2011) Cardiovasc Res , vol.89 , Issue.1 , pp. 204-213
    • Serpi, R.1    Tolonen, A.M.2    Huusko, J.3    Rysa, J.4    Tenhunen, O.5    Yla-Herttuala, S.6
  • 73
    • 78751550090 scopus 로고    scopus 로고
    • Up-regulation of soluble vascular endothelial growth factor receptor-1 prevents angiogenesis in hypertrophied myocardium
    • Kaza E, Ablasser K, Poutias D, Griffiths ER, Saad FA, Hofstaetter JG, et al. Up-regulation of soluble vascular endothelial growth factor receptor-1 prevents angiogenesis in hypertrophied myocardium. Cardiovasc Res 2011;89(2):410-418
    • (2011) Cardiovasc Res , vol.89 , Issue.2 , pp. 410-418
    • Kaza, E.1    Ablasser, K.2    Poutias, D.3    Griffiths, E.R.4    Saad, F.A.5    Hofstaetter, J.G.6
  • 74
    • 84895548343 scopus 로고    scopus 로고
    • Circulating angiogenic modulatory factors predict survival and functional class in pulmonary arterial hypertension
    • Malhotra R, Paskin-Flerlage S, Zamanian RT, Zimmerman P, Schmidt JW, Deng DY, et al. Circulating angiogenic modulatory factors predict survival and functional class in pulmonary arterial hypertension. Pulm Circ 2013;3(2): 369-380.
    • (2013) Pulm Circ , vol.3 , Issue.2 , pp. 369-380
    • Malhotra, R.1    Paskin-Flerlage, S.2    Zamanian, R.T.3    Zimmerman, P.4    Schmidt, J.W.5    Deng, D.Y.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.