Vascular endothelial growth factor stimulates protein kinase C-dependent phospholipase D activity in endothelial cells

Laboratory Investigation

Volumn 75, Issue 3, 1996, Pages 427-437

  Seymour, Leonard W ^a   Shoaibi, Mahmood A ^a   Martin, Ashley ^c   Ahmed, Asif ^a   Elvin, Paul ^b   Kerr, David J ^a   Wakelam, Michael J O ^a  

^a UNIVERSITY DEPARTMENT OF MEDICINE   (United Kingdom)

^b ASTRAZENECA   (United Kingdom)

^c NONE

Author keywords

[No Author keywords available]

Indexed keywords

2 [1 (3 AMIDINOTHIOPROPYL) 1H INDOL 3 YL] 3 (1 METHYL 1H INDOL 3 YL)MALEIMIDE; BASIC FIBROBLAST GROWTH FACTOR; CALCIUM ION; FURA 2; GENISTEIN; INOSITOL; INOSITOL PHOSPHATE; PHORBOL 13 ACETATE 12 MYRISTATE; PHOSPHOLIPASE C; PHOSPHOLIPASE D; PROTEIN KINASE C; VASCULOTROPIN;

ANGIOGENESIS; ARTICLE; BLOOD VESSEL PERMEABILITY; CALCIUM CELL LEVEL; CALCIUM TRANSPORT; CANCER CHEMOTHERAPY; CELL MIGRATION; CONTROLLED STUDY; CYTOSKELETON; DRUG TARGETING; ENDOTHELIUM CELL; ENZYME ACTIVITY; HUMAN; HUMAN CELL; MITOGENESIS; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; SIGNAL TRANSDUCTION; UMBILICAL VEIN;

CALCIUM; CELL DIVISION; CELLS, CULTURED; ENDOTHELIAL GROWTH FACTORS; ENDOTHELIUM, VASCULAR; HUMANS; INOSITOL PHOSPHATES; INTRACELLULAR MEMBRANES; LYMPHOKINES; PHOSPHOLIPASE D; PHOSPHORYLATION; PROTEIN KINASE C; TYROSINE; VASCULAR ENDOTHELIAL GROWTH FACTOR A; VASCULAR ENDOTHELIAL GROWTH FACTORS;

EID: 0029830987     PISSN: 00236837     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (35)

1. Ahmed A, Plevin R, Shoaibi MA, Fountain SA, Ferriani RA, and Smith SK (1994). Basic FGF stimulates phospholipase D in endothelial cells in the absence of inositol lipid hydrolysis. Am J Physiol 266:C206-C212.
2. Black FM and Wakelam MJO (1990). Activation of inositol phospholipid breakdown by prostaglandin-F2-alpha without any stimulation of proliferation in quiescent NIH-3T3 fibroblasts. Biochem J 266:661-667.
3. Bonser RW, Thompson NT, Randall RW, Tateson JE, Spacey GD, Hodson HF, and Garland LG (1991). Demethoxyviridin and wortmannin block phospholipase C and phospholipase D activation in the human neutrophil. Br J Pharmacol 103:1237-1241.
4. 2+ and von Willebrand factor release in human endothelial cells. Am J Pathol 138:213-221.
5. Brown LF, Berse B, Jackman RW, Tognazzi K, Guidi AJ, Dvorak HF, Senger DR, Connolly JL, and Schnitt SJ (1995). Expression of vascular permeability factor (vascular endothelial growth factor) and its receptors in breast cancer. Hum Pathol 26:86-91.
6. Brown LF, Berse B, Jackman RW, Tognazzi K, Manseau EJ, Senger DR, and Dvorak HF (1993). Expression of vascular permeability factor (vascular endothelial growth factor) and its receptors in adenocarcinomas of the gastrointestinal tract. Cancer Res 53:4727-4735.
7. Collard JG (1996). Signalling pathways regulated by rho-like proteins: A possible role in tumour formation and metastasis. Int J Oncol 8:131-137.
8. Cook SJ, Briscoe CP, and Wakelam MJO (1991). Regulation of phospholipase D and its role in sn 1:2-diradylglycerol formation in bombesin and phorbol 12-myristate and 13-acetate-stimulated Swiss 3T3 cells. Biochem J 280:431-438.
9. Cook SJ and Wakelam MJO (1992). Epidermal growth factor increases sn-1,2-diacylglycerol levels and activates phospholipase D-catalysed phosphatidylcholine breakdown in Swiss 3T3 cells in the absence of inositol-lipid hydrolysis. Biochem J 285:247-253.
10. Cross MJ, Roberts S, Ridley AJ, Hodgkin MN, Stewart A, Claesson-Welsh L, and Wakelam MJO (1996). Stimulation of actin stress fibre formation mediated by activation of phospholipase D. Curr Biol 6:588-597.
11. Devries C, Escobedo JA, Ueno H, Houck K, Ferrara N, and Williams IT (1992). The fms-like tyrosine kinase, a receptor for vascular endothelial growth factor. Science 255:989-991.
12. Ferrara N (1995). The role of vascular endothelial growth factor in pathological angiogenesis. Breast Cancer Res Treat 36:127-137.
13. Grynkiewicz G, Poenie M, and Tsien RY (1985). A new generation of calcium indicators with greatly improved fluorescence properties. J Biol Chem 260:3440-3450.
14. Guo D, Jia Q, Song HY, Warren R, and Donner DB (1995). Vascular endothelial cell growth factor promotes tyrosine phosphorylation of mediators of signal transduction that contain SH2 domains. J Biol Chem 270:6729-6733.
15. Ha KS and Exton JH (1993). Activation of actin polymerisation by phosphatidic acid derived from phosphatidylcholine in IIC9 fibroblasts. J Cell Biol 123:1789-1796.
16. Jaffe EA, Nachman RL, Becker CG, and Minick CR (1973). Culture of human endothelial cells derived from umbilical veins. J Clin Invest 52:2745-2756.
17. Jiang H, Luo JQ, Urano T, Frankel P, Lu Z, Foster DA, and Feig LA (1995). Involvement of Ral GTPase in v-Src-induced phospholipase D activation. Nature 378:409-412.
18. Kim KJ, Li B, Winer J, Armanini M, Gillett N, Phillips HS, and Ferrara N (1993). Inhibition of vascular endothelial growth factor-induced angiogenesis suppresses tumour growth in vivo. Nature 362:841-846.
19. Klagsbrun M and Soker S (1993). VEGF/VPF: The angiogenesis factor found? Curr Biol 3:699-702.
20. Kuribara, H, Tago K, Yokozeki T, Sasaki T, Takai Y, Morii N, Narumiya S, Katada T, and Kanaho Y (1995). Synergistic activation of rat brain phospholipase D by ADP-ribosylation factor and rhoA p21, and its inhibition by clostridium botulinum C3 exoenzyme. J Biol Chem 270:25667-25671.
21. Lopez I, Burns DJ, and Lambeth JD (1995). Regulation of phospholipase D by protein kinase C in human neutrophils. J Biol Chem 270:19465-19472.
22. Meldrum E, Parker P, and Carozzi A (1991). The Ptdlns-PLC superfamily and signal transduction. Biochim Biophys Acta 1092:49-71.
23. Millauer B, Shawver LK, Plate KH, Risau W, and Ullrich A (1994). Glioblastoma growth inhibited in vivo by a dominant negative flk-1 mutant. Nature 367:576-579.
24. Pai JK, Frank EA, Blood C, and Chu M (1994). Novel ketoepoxides block phospholipase D activation and tumor cell invasion. Anticancer Drug Dev 9:363-372.
25. Pepper MS, Ferrara N, Orci L, and Montesano R (1992). Potent synergism between vascular endothelial growth factor and fibroblast growth factor in the induction of angiogenesis in vitro. Biochem Biophys Res Commun 189:824-831.
26. Pepper MS, Ferrara N, Orci L, and Montesano R (1991). Vascular endothelial growth factor (VEGF) induces plasminogen activators and plasminogen activator inhibitor-1 in microvascular endothelial cells. Biochem Biophys Res Commun 181:902-906.
27. Plate KH, Breier G, Weich HA, and Risau W (1992). Vascular endothelial growth factor is a potential tumour angiogenesis factor in human gliomas in vivo. Nature 359:845-848.
28. Powis G (1994). Pharmacological intervention with signal transduction. In: Workman P, editor. New approaches in cancer pharmacology: Drug design and development, vol. 2. Berlin: Springer-Verlag, 39-54.
29. Senger DR, Galli SJ, Dvorak AM, Perruzzi CA, Harvey VS, and Dvorak HF (1983). Tumor cells secrete a vascular permeability factor that promotes accumulation of ascites fluid. Science 219:983-985.
30. Senger DR, Van de Water L, Brown LF, Nagy JA, Yeo KT, Yeo TK, Berse B, Jackman RW, Dvorak AM, and Dvorak HF (1993). Vascular permeability factor in tumour biology. Cancer Metast Rev 12:303-324.
31. Shweiki D, Itin A, Soffer D, and Keshet E (1992). Vascular endothelial growth factor induced by hypoxia may mediate hypoxia-initiated angiogenesis. Nature 359:843-845.
32. Takahashi Y, Kitadai Y, Buana CD, Cleary KR, and Ellis LM (1995). Expression of vascular endothelial growth factor and its receptor, KDR, correlates with vascularity, metastasis and proliferation of human colon cancer. Cancer Res 55:3964-3968.
33. Terman BI, Dougher-Vermazen M, Carrion ME, Dimitrov D, Armellino DC, Gospodarowicz D, and Böhlen P (1992). Identification of kdr tyrosine kinase as a receptor for vascular endothelial cell growth factor. Biochem Biophys Res Commun 187:1579-1586.
34. Waltenberger J, Claesson-Welsh L, Siegbahn A, Shibuya M, and Heldin CH (1994). Different signal transduction properties of KDR and Flt-1, two receptors for vascular endothelial growth factor. J Biol Chem 269:26988-26995.
35. Williger BT, Reich R, Neeman M, Bercovici T, and Liscovitch M (1995). Release of gelatinase A induced by photolysis of caged phosphatidic acid. FASEB J 9:A1369.