-
2
-
-
84994558965
-
NAFLD: the clinical and economic burden of NAFLD: time to turn the tide
-
Abdelmalek, M.F., NAFLD: the clinical and economic burden of NAFLD: time to turn the tide. Nat. Rev. Gastroenterol. Hepatol. 13 (2016), 685–686.
-
(2016)
Nat. Rev. Gastroenterol. Hepatol.
, vol.13
, pp. 685-686
-
-
Abdelmalek, M.F.1
-
3
-
-
84964506792
-
Transcriptomics resources of human tissues and organs
-
Uhlen, M., et al. Transcriptomics resources of human tissues and organs. Mol. Syst. Biol., 12, 2016, 862.
-
(2016)
Mol. Syst. Biol.
, vol.12
, pp. 862
-
-
Uhlen, M.1
-
4
-
-
84934288620
-
Modeling cancer metabolism on a genome scale
-
Yizhak, K., et al. Modeling cancer metabolism on a genome scale. Mole. Syst. Biol., 11, 2015, 817.
-
(2015)
Mole. Syst. Biol.
, vol.11
, pp. 817
-
-
Yizhak, K.1
-
5
-
-
85028310865
-
The employment of systems biology in gastroenterology and hepatology
-
(in press)
-
Mardinoglu, A., et al. The employment of systems biology in gastroenterology and hepatology. Nat. Rev. Gastroenterol. Hepatol., 2017 (in press).
-
(2017)
Nat. Rev. Gastroenterol. Hepatol.
-
-
Mardinoglu, A.1
-
6
-
-
85014511212
-
Systems biology of metabolism: a driver for developing personalized and precision medicine
-
Nielsen, J., Systems biology of metabolism: a driver for developing personalized and precision medicine. Cell Metab. 25 (2017), 572–579.
-
(2017)
Cell Metab.
, vol.25
, pp. 572-579
-
-
Nielsen, J.1
-
7
-
-
84992391872
-
Integrated network analysis reveals an association between plasma mannose levels and insulin resistance
-
Lee, S., et al. Integrated network analysis reveals an association between plasma mannose levels and insulin resistance. Cell Metab. 24 (2016), 172–184.
-
(2016)
Cell Metab.
, vol.24
, pp. 172-184
-
-
Lee, S.1
-
10
-
-
85008354911
-
OPTN/SRTR 2015 annual data report: liver
-
Kim, W.R., et al. OPTN/SRTR 2015 annual data report: liver. Am J. Transplant. 17:Suppl. 1 (2017), 174–251.
-
(2017)
Am J. Transplant.
, vol.17
, pp. 174-251
-
-
Kim, W.R.1
-
11
-
-
85031718738
-
Nonalcoholic Steatohepatitis – Epidemiology Forecast to 2022
-
Report Linker
-
Anon, Nonalcoholic Steatohepatitis – Epidemiology Forecast to 2022., 2013, Report Linker.
-
(2013)
-
-
Anon1
-
12
-
-
84941365920
-
Future economics of liver transplantation: a 20-year cost modeling forecast and the prospect of bioengineering autologous liver grafts
-
Habka, D., et al. Future economics of liver transplantation: a 20-year cost modeling forecast and the prospect of bioengineering autologous liver grafts. PLoS One, 10, 2015, e0131764.
-
(2015)
PLoS One
, vol.10
, pp. e0131764
-
-
Habka, D.1
-
13
-
-
85031729672
-
-
Global Non-Alcoholic Steatohepatitis (NASH) Market is Expected to Reach $1.6 Billion by 2020, Allied Market Research.
-
Anon. (2014) Global Non-Alcoholic Steatohepatitis (NASH) Market is Expected to Reach $1.6 Billion by 2020, Allied Market Research.
-
(2014)
-
-
-
14
-
-
85031762729
-
NASH: The Next Breakout Biotech Market
-
Wealth Daily
-
Anon, NASH: The Next Breakout Biotech Market. 2017, Wealth Daily.
-
(2017)
-
-
Anon1
-
15
-
-
77649234756
-
How to improve R&D productivity: the pharmaceutical industry's grand challenge
-
Paul, S.M., et al. How to improve R&D productivity: the pharmaceutical industry's grand challenge. Nat. Rev. Drug Discov. 9 (2010), 203–214.
-
(2010)
Nat. Rev. Drug Discov.
, vol.9
, pp. 203-214
-
-
Paul, S.M.1
-
16
-
-
84983059114
-
MicroRNA expression profiling predicts clinical outcome of carboplatin/paclitaxel-based therapy in metastatic melanoma treated on the ECOG-ACRIN trial E2603
-
Villaruz, L.C., et al. MicroRNA expression profiling predicts clinical outcome of carboplatin/paclitaxel-based therapy in metastatic melanoma treated on the ECOG-ACRIN trial E2603. Clin. Epigenet., 7, 2015, 58.
-
(2015)
Clin. Epigenet.
, vol.7
, pp. 58
-
-
Villaruz, L.C.1
-
17
-
-
77149177995
-
Implications of diet on nonalcoholic fatty liver disease
-
Sullivan, S., Implications of diet on nonalcoholic fatty liver disease. Curr. Opin. Gastroenterol. 26 (2010), 160–164.
-
(2010)
Curr. Opin. Gastroenterol.
, vol.26
, pp. 160-164
-
-
Sullivan, S.1
-
18
-
-
84895491638
-
Diet macronutrients composition in nonalcoholic fatty liver disease: a review on the related documents
-
Hashemi Kani, A., et al. Diet macronutrients composition in nonalcoholic fatty liver disease: a review on the related documents. Hepatitis Monthly, 14, 2014, e10939.
-
(2014)
Hepatitis Monthly
, vol.14
, pp. e10939
-
-
Hashemi Kani, A.1
-
19
-
-
84950149794
-
Carbohydrate intake and nonalcoholic fatty liver disease: fructose as a weapon of mass destruction
-
Basaranoglu, M., et al. Carbohydrate intake and nonalcoholic fatty liver disease: fructose as a weapon of mass destruction. Hepatobiliary Surg. Nutr. 4 (2015), 109–116.
-
(2015)
Hepatobiliary Surg. Nutr.
, vol.4
, pp. 109-116
-
-
Basaranoglu, M.1
-
20
-
-
85003946062
-
Quantitative systems pharmacology: a promising approach for translational pharmacology
-
Gadkar, K., et al. Quantitative systems pharmacology: a promising approach for translational pharmacology. Drug Discov. Today Technol. 21–22 (2016), 57–65.
-
(2016)
Drug Discov. Today Technol.
, vol.21-22
, pp. 57-65
-
-
Gadkar, K.1
-
21
-
-
84991710984
-
The promises of quantitative systems pharmacology modelling for drug development
-
Knight-Schrijver, V.R., et al. The promises of quantitative systems pharmacology modelling for drug development. Comput. Struct. Biotechnol. J. 14 (2016), 363–370.
-
(2016)
Comput. Struct. Biotechnol. J.
, vol.14
, pp. 363-370
-
-
Knight-Schrijver, V.R.1
-
22
-
-
85081146096
-
Systems pharmacology modeling in type 2 diabetes mellitus
-
D. Mager H. Kimko Springer
-
Bosley, J., et al. Systems pharmacology modeling in type 2 diabetes mellitus. Mager, D., Kimko, H., (eds.) Systems Pharmacology and Pharmacodynamics, 2016, Springer, 465–507.
-
(2016)
Systems Pharmacology and Pharmacodynamics
, pp. 465-507
-
-
Bosley, J.1
-
23
-
-
35649001607
-
A quantitative description of membrane current and its application to conduction and excitation in nerve
-
Hodgkin, A.L., Huxley, A.F., A quantitative description of membrane current and its application to conduction and excitation in nerve. J. Physiol. 117 (1952), 500–544.
-
(1952)
J. Physiol.
, vol.117
, pp. 500-544
-
-
Hodgkin, A.L.1
Huxley, A.F.2
-
24
-
-
0015264958
-
Circulation: overall regulation
-
Guyton, A.C., et al. Circulation: overall regulation. Annu. Rev. Physiol. 34 (1972), 13–46.
-
(1972)
Annu. Rev. Physiol.
, vol.34
, pp. 13-46
-
-
Guyton, A.C.1
-
25
-
-
0032713507
-
Effects of liver disease on pharmacokinetics. An update
-
Rodighiero, V., Effects of liver disease on pharmacokinetics. An update. Clin. Pharmacokinetics 37 (1999), 399–431.
-
(1999)
Clin. Pharmacokinetics
, vol.37
, pp. 399-431
-
-
Rodighiero, V.1
-
26
-
-
84989361170
-
A computational model of hepatic energy metabolism: understanding zonated damage and steatosis in NAFLD
-
Ashworth, W.B., et al. A computational model of hepatic energy metabolism: understanding zonated damage and steatosis in NAFLD. PLoS Comput. Biol., 12, 2016, e1005105.
-
(2016)
PLoS Comput. Biol.
, vol.12
, pp. e1005105
-
-
Ashworth, W.B.1
-
27
-
-
84912103306
-
Systems biology approaches for studying the pathogenesis of non-alcoholic fatty liver disease
-
Fisher, C.P., et al. Systems biology approaches for studying the pathogenesis of non-alcoholic fatty liver disease. World J. Gastroenterol. 20 (2014), 15070–15078.
-
(2014)
World J. Gastroenterol.
, vol.20
, pp. 15070-15078
-
-
Fisher, C.P.1
-
28
-
-
84855955467
-
Systems medicine and metabolic modelling
-
Mardinoglu, A., Nielsen, J., Systems medicine and metabolic modelling. J. Intern. Med. 271 (2012), 142–154.
-
(2012)
J. Intern. Med.
, vol.271
, pp. 142-154
-
-
Mardinoglu, A.1
Nielsen, J.2
-
29
-
-
84883384697
-
Genome-scale modeling of human metabolism – a systems biology approach
-
Mardinoglu, A., et al. Genome-scale modeling of human metabolism – a systems biology approach. Biotechnol. J. 8 (2013), 985–996.
-
(2013)
Biotechnol. J.
, vol.8
, pp. 985-996
-
-
Mardinoglu, A.1
-
30
-
-
84953258162
-
Cancer metabolism: a modeling perspective
-
Ghaffari, P., et al. Cancer metabolism: a modeling perspective. Front. Physiol., 6, 2015, 382.
-
(2015)
Front. Physiol.
, vol.6
, pp. 382
-
-
Ghaffari, P.1
-
31
-
-
84920286423
-
New paradigms for metabolic modeling of human cells
-
Mardinoglu, A., Nielsen, J., New paradigms for metabolic modeling of human cells. Curr. Opin. Biotechnol. 34 (2015), 91–97.
-
(2015)
Curr. Opin. Biotechnol.
, vol.34
, pp. 91-97
-
-
Mardinoglu, A.1
Nielsen, J.2
-
32
-
-
84962649780
-
Personalized cardiovascular disease prediction and treatment: a review of existing strategies and novel systems medicine tools
-
Bjornson, E., et al. Personalized cardiovascular disease prediction and treatment: a review of existing strategies and novel systems medicine tools. Front. Physiol., 7, 2016, 2.
-
(2016)
Front. Physiol.
, vol.7
, pp. 2
-
-
Bjornson, E.1
-
33
-
-
84920269464
-
Tissue-based map of the human proteome
-
Uhlen, M., et al. Tissue-based map of the human proteome. Science, 347, 2015, 1260419.
-
(2015)
Science
, vol.347
, pp. 1260419
-
-
Uhlen, M.1
-
34
-
-
84901599553
-
A draft map of the human proteome
-
Kim, M.S., et al. A draft map of the human proteome. Nature 509 (2014), 575–581.
-
(2014)
Nature
, vol.509
, pp. 575-581
-
-
Kim, M.S.1
-
35
-
-
84901611036
-
Mass-spectrometry-based draft of the human proteome
-
Wilhelm, M., et al. Mass-spectrometry-based draft of the human proteome. Nature 509 (2014), 582–587.
-
(2014)
Nature
, vol.509
, pp. 582-587
-
-
Wilhelm, M.1
-
36
-
-
84938738177
-
The promise of metabolic phenotyping in gastroenterology and hepatology
-
Holmes, E., et al. The promise of metabolic phenotyping in gastroenterology and hepatology. Nat. Rev. Gastroenterol. Hepatol. 12 (2015), 458–471.
-
(2015)
Nat. Rev. Gastroenterol. Hepatol.
, vol.12
, pp. 458-471
-
-
Holmes, E.1
-
37
-
-
84949673329
-
Kinetic studies to elucidate impaired metabolism of triglyceride-rich lipoproteins in humans
-
Adiels, M., et al. Kinetic studies to elucidate impaired metabolism of triglyceride-rich lipoproteins in humans. Front. Physiol., 6, 2015, 342.
-
(2015)
Front. Physiol.
, vol.6
, pp. 342
-
-
Adiels, M.1
-
38
-
-
84883787394
-
Integration of clinical data with a genome-scale metabolic model of the human adipocyte
-
Mardinoglu, A., et al. Integration of clinical data with a genome-scale metabolic model of the human adipocyte. Mol. Syst. Biol., 9, 2013, 649.
-
(2013)
Mol. Syst. Biol.
, vol.9
, pp. 649
-
-
Mardinoglu, A.1
-
39
-
-
84898663879
-
Identification of anticancer drugs for hepatocellular carcinoma through personalized genome-scale metabolic modeling
-
Agren, R., et al. Identification of anticancer drugs for hepatocellular carcinoma through personalized genome-scale metabolic modeling. Mol. Syst. Biol., 10, 2014, 721.
-
(2014)
Mol. Syst. Biol.
, vol.10
, pp. 721
-
-
Agren, R.1
-
40
-
-
80052580351
-
Haem oxygenase is synthetically lethal with the tumour suppressor fumarate hydratase
-
Frezza, C., et al. Haem oxygenase is synthetically lethal with the tumour suppressor fumarate hydratase. Nature 477 (2011), 225–228.
-
(2011)
Nature
, vol.477
, pp. 225-228
-
-
Frezza, C.1
-
41
-
-
79959621970
-
Predicting selective drug targets in cancer through metabolic networks
-
Folger, O., et al. Predicting selective drug targets in cancer through metabolic networks. Mol. Syst. Biol., 7, 2011, 501.
-
(2011)
Mol. Syst. Biol.
, vol.7
, pp. 501
-
-
Folger, O.1
-
42
-
-
84929276343
-
Proteome- and transcriptome-driven reconstruction of the human myocyte metabolic network and its use for identification of markers for diabetes
-
Varemo, L., et al. Proteome- and transcriptome-driven reconstruction of the human myocyte metabolic network and its use for identification of markers for diabetes. Cell Rep. 11 (2015), 921–933.
-
(2015)
Cell Rep.
, vol.11
, pp. 921-933
-
-
Varemo, L.1
-
43
-
-
84978943152
-
Dysregulated signaling hubs of liver lipid metabolism reveal hepatocellular carcinoma pathogenesis
-
Lee, S., et al. Dysregulated signaling hubs of liver lipid metabolism reveal hepatocellular carcinoma pathogenesis. Nucleic Acids Res. 44 (2016), 5529–5539.
-
(2016)
Nucleic Acids Res.
, vol.44
, pp. 5529-5539
-
-
Lee, S.1
-
44
-
-
84908884352
-
Defining the human adipose tissue proteome to reveal metabolic alterations in obesity
-
Mardinoglu, A., et al. Defining the human adipose tissue proteome to reveal metabolic alterations in obesity. J. Proteome Res. 13 (2014), 5106–5119.
-
(2014)
J. Proteome Res.
, vol.13
, pp. 5106-5119
-
-
Mardinoglu, A.1
-
45
-
-
84943328195
-
Extensive weight loss reveals distinct gene expression changes in human subcutaneous and visceral adipose tissue
-
Mardinoglu, A., et al. Extensive weight loss reveals distinct gene expression changes in human subcutaneous and visceral adipose tissue. Sci. Rep., 5, 2015, 14841.
-
(2015)
Sci. Rep.
, vol.5
, pp. 14841
-
-
Mardinoglu, A.1
-
46
-
-
84898011025
-
Genome-scale metabolic modelling of hepatocytes reveals serine deficiency in patients with non-alcoholic fatty liver disease
-
Mardinoglu, A., et al. Genome-scale metabolic modelling of hepatocytes reveals serine deficiency in patients with non-alcoholic fatty liver disease. Nat. Commun., 5, 2014, 3083.
-
(2014)
Nat. Commun.
, vol.5
, pp. 3083
-
-
Mardinoglu, A.1
-
47
-
-
85016333383
-
Personal model-assisted identification of NAD+ and glutathione metabolism as intervention target in NAFLD
-
Mardinoglu, A., et al. Personal model-assisted identification of NAD+ and glutathione metabolism as intervention target in NAFLD. Mol. Syst. Biol., 13, 2017, 916.
-
(2017)
Mol. Syst. Biol.
, vol.13
, pp. 916
-
-
Mardinoglu, A.1
-
48
-
-
84957575229
-
Genome-scale study reveals reduced metabolic adaptability in patients with non-alcoholic fatty liver disease
-
Hyötyläinen, T., et al. Genome-scale study reveals reduced metabolic adaptability in patients with non-alcoholic fatty liver disease. Nat. Commun., 7, 2016, 8994.
-
(2016)
Nat. Commun.
, vol.7
, pp. 8994
-
-
Hyötyläinen, T.1
-
49
-
-
84865739425
-
Architecture of the human regulatory network derived from ENCODE data
-
Gerstein, M.B., et al. Architecture of the human regulatory network derived from ENCODE data. Nature 489 (2012), 91–100.
-
(2012)
Nature
, vol.489
, pp. 91-100
-
-
Gerstein, M.B.1
-
50
-
-
85020459515
-
Early metabolic markers identify potential targets for the prevention of type 2 diabetes
-
Published online June 8, 2017.
-
Peddinti, G., et al. Early metabolic markers identify potential targets for the prevention of type 2 diabetes. Diabetologia, 2017, 10.1007/s00125-017-4325-0 Published online June 8, 2017.
-
(2017)
Diabetologia
-
-
Peddinti, G.1
-
51
-
-
85026260651
-
Plasma mannose levels are associated with incident type 2 diabetes and cardiovascular disease
-
Mardinoglu, A., et al. Plasma mannose levels are associated with incident type 2 diabetes and cardiovascular disease. Cell Metab., 26, 2017, 10.1016/j.cmet.2017.07.006.
-
(2017)
Cell Metab.
, vol.26
-
-
Mardinoglu, A.1
-
52
-
-
58149373780
-
Oral glutamine increases circulating glucagon-like peptide 1, glucagon, and insulin concentrations in lean, obese, and type 2 diabetic subjects
-
Greenfield, J.R., et al. Oral glutamine increases circulating glucagon-like peptide 1, glucagon, and insulin concentrations in lean, obese, and type 2 diabetic subjects. Am. J. Clin. Nutr. 89 (2009), 106–113.
-
(2009)
Am. J. Clin. Nutr.
, vol.89
, pp. 106-113
-
-
Greenfield, J.R.1
|