Genome-scale study reveals reduced metabolic adaptability in patients with non-alcoholic fatty liver disease

Nature Communications

Volumn 7, Issue , 2016, Pages

  Hyötyläinen, Tuulia ^a,b   Jerby, Livnat ^c   Petäjä, Elina M ^d,e   Mattila, Ismo ^a,b   Jäntti, Sirkku ^b,d   Auvinen, Petri ^f   Gastaldelli, Amalia ^g   Yki Järvinen, Hannele ^d,e   Ruppin, Eytan ^c,h   Orešič, Matej ^a,b,i  

^a STENO DIABETES CENTER   (Denmark)

^b VTT TECHNICAL RESEARCH CENTRE OF FINLAND   (Finland)

^c TEL AVIV UNIVERSITY   (Israel)

^d UNIVERSITY OF HELSINKI   (Finland)

^e MINERVA FOUNDATION INSTITUTE FOR MEDICAL RESEARCH   (Finland)

^f UNIVERSITY OF HELSINKI   (Finland)

^g INSTITUTE OF CLINICAL PHYSIOLOGY   (Italy)

^h Åbo Akademi University ^*  (United States)

ⁱ UNIVERSITY OF TURKU   (Finland)

Author keywords

[No Author keywords available]

Indexed keywords

GLYCEROL; LACTIC ACID; GLUCOSE BLOOD LEVEL;

ANATOMY; DIABETES; DISEASE INCIDENCE; FAT; GENOME; METABOLISM; ORGANIC COMPOUND; RISK FACTOR; SUBSTRATE;

ADULT; ARTICLE; CLINICAL ARTICLE; COMORBIDITY; CONTROLLED STUDY; ENZYME SUBSTRATE; GENE EXPRESSION; GENOME; GLUCONEOGENESIS; GLYCEMIC CONTROL; HUMAN; HUMAN TISSUE; LIPID STORAGE; LIPOLYSIS; LIVER BIOPSY; LIVER FUNCTION; LIVER METABOLISM; MITOCHONDRIAL RESPIRATION; NONALCOHOLIC FATTY LIVER; SPLANCHNIC NERVE; TRANSCRIPTOMICS; ADAPTATION; CASE CONTROL STUDY; FEMALE; GENE EXPRESSION PROFILING; GENE REGULATORY NETWORK; GENETICS; GLUCOSE BLOOD LEVEL; INTRAABDOMINAL FAT; LIVER; LIVER MITOCHONDRION; MALE; METABOLIC FLUX ANALYSIS; METABOLISM; METABOLOME; MIDDLE AGED; SPLANCHNIC BLOOD FLOW;

ADAPTATION, PHYSIOLOGICAL; ADULT; BLOOD GLUCOSE; CASE-CONTROL STUDIES; FEMALE; GENE EXPRESSION PROFILING; GENE REGULATORY NETWORKS; GLUCONEOGENESIS; GLYCEROL; HUMANS; INTRA-ABDOMINAL FAT; LACTIC ACID; LIPOLYSIS; LIVER; MALE; METABOLIC FLUX ANALYSIS; METABOLOME; MIDDLE AGED; MITOCHONDRIA, LIVER; NON-ALCOHOLIC FATTY LIVER DISEASE; SPLANCHNIC CIRCULATION;

EID: 84957575229     PISSN: None     EISSN: 20411723     Source Type: Journal    
DOI: 10.1038/ncomms9994     Document Type: Article

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