Regulatory T-Cell Distribution within Lung Compartments in COPD

COPD: Journal of Chronic Obstructive Pulmonary Disease

Volumn 14, Issue 5, 2017, Pages 533-542

  Sales, Davi S ^a   Ito, Juliana T ^a   Zanchetta, Ivy A ^a   Annoni, Raquel ^a   Aun, Marcelo V ^a   Ferraz, Luiz Fernando S ^a   Cervilha, Daniela A B ^a   Negri, Elnara ^a   Mauad, Thais ^a   Martins, Mílton A ^a   Lopes, Fernanda D T Q S ^a  

^a UNIVERSITY OF SÃO PAULO   (Brazil)

Author keywords

Adaptive immunity; COPD; interleukin 10; regulatory T cells; T cells; TGF

Indexed keywords

B CELL ACTIVATING FACTOR; CD20 ANTIGEN; CD4 ANTIGEN; CD8 ANTIGEN; INTERLEUKIN 10; INTERLEUKIN 17; TRANSCRIPTION FACTOR FOXP3; TRANSFORMING GROWTH FACTOR BETA; TNFSF13B PROTEIN, HUMAN;

ADAPTIVE IMMUNITY; ADULT; AGED; AIRWAY; ARTICLE; B LYMPHOCYTE; CHRONIC OBSTRUCTIVE LUNG DISEASE; CONTROLLED STUDY; FEMALE; FORCED EXPIRATORY VOLUME; HISTOPATHOLOGY; HUMAN; HUMAN CELL; HUMAN TISSUE; LUNG PARENCHYMA; LYMPHOID TISSUE; MAJOR CLINICAL STUDY; MALE; PRIORITY JOURNAL; REGULATORY T LYMPHOCYTE; CD8+ T LYMPHOCYTE; IMMUNOLOGY; LUNG; LYMPHOCYTE COUNT; METABOLISM; MIDDLE AGED; PATHOLOGY; PATHOPHYSIOLOGY; SMOKING; VITAL CAPACITY;

ADAPTIVE IMMUNITY; ADULT; AGED; B-CELL ACTIVATING FACTOR; B-LYMPHOCYTES; CD8-POSITIVE T-LYMPHOCYTES; FEMALE; FORCED EXPIRATORY VOLUME; HUMANS; INTERLEUKIN-10; INTERLEUKIN-17; LUNG; LYMPHOCYTE COUNT; LYMPHOID TISSUE; MALE; MIDDLE AGED; PULMONARY DISEASE, CHRONIC OBSTRUCTIVE; SMOKING; T-LYMPHOCYTES, REGULATORY; TRANSFORMING GROWTH FACTOR BETA; VITAL CAPACITY;

EID: 85026251041     PISSN: 15412555     EISSN: 15412563     Source Type: Journal    
DOI: 10.1080/15412555.2017.1346069     Document Type: Article

References (34)

1. Global Initiative for Chronic Obstructive Lung Disease (GOLD). Global Strategy for the Diagnosis, Management, and Prevention of COPD:Updated 2016. Available from:http://goldcopd.org/global-strategy-diagnosis-management-prevention-copd-2016/
2. Eisner MD, Balmes J, Katz PP, Trupin L, Yelin EH, Blanc PD. Lifetime environmental tobacco smoke exposure and the risk of chronic obstructive pulmonary disease. Environ Health. 2005; 4(1):7.
3. Baraldo S, Saetta M. To reg or not to reg:that is the question in COPD. Eur Respir J. 2008; 31(3):486–488.
4. Sinden NJ, Stockley RA. Systemic inflammation and comorbidity in COPD:a result of “overspill” of inflammatory mediators from the lungs? Review of the evidence. Thorax. 2010; 65(10):930–936.
5. Plumb J, Smyth LJ, Adams HR, Vestbo J, Bentley A, Singh SD. Increased T-regulatory cells within lymphocyte follicles in moderate COPD. Eur Respir J. 2009; 34(1):89–94.
6. Barceló B, Pons J, Ferrer JM, Sauleda J, Fuster A, Agustí AG. Phenotypic characterisation of T-lymphocytes in COPD:abnormal CD4+ T + CD25+ regulatory T-lymphocyte response to tobacco smoking. Eur Respir J. 2008; 31(3):555–62.
7. Smyth LJ, Starkey C, Vestbo J, Singh D. CD4+ T-regulatory cells in COPD patients. Chest. 2007; 132(1):156–163.
8. Brusselle GC, Joos GF, Bracke KR. New Insights into the immunology of chronic obstructive pulmonary disease. Lancet. 2011; 378(9795):1015–1026.
9. Di Stefano A, Caramori G, Capelli A, Gnemmi I, Ricciardolo FL, Oates T, et al. STAT4 activation in smokers and patients with chronic obstructive pulmonary disease. Eur Respir J. 2004; 24(1):78–85.
10. Isajevs S, Taivans I, Strazda G, Kopeika U, Bukovskis M, Gordjusina V, Kratovska A. Decreased FOXP3 expression in small airways of smokers with COPD. Eur Respir J. 2009; 33(1):61–67.
11. Vargas-Rojas MI, Ramírez-Venegas A, Limón-Camacho L, Ochoa L, Hernández-Zenteno R, Sansores RH. Increase of Th17 cells in peripheral blood of patients with chronic obstructive pulmonary disease. Respir Med. 2011; 105(11):1648–1654.
12. Lee SH, Goswami S, Grudo A, Song LZ, Bandi V, Goodnight-White S, et al. Antielastin autoimmunity in tobacco smoking-induced emphysema. Nat Med. 2007; 13(5):567–9.
13. Hogg JC, Chu F, Utokaparch S, Woods R, Elliott WM, Buzatu L, et al. The nature of small-airway obstruction in chronic obstructive pulmonary disease. N Engl J Med. 2004; 350(26):2645–2653.
14. van der Strate BW, Postma DS, Brandsma CA, Melgert BN, Luinge MA, Geerlings M, et al. Cigarette smoke-induced emphysema:A role for the B cell? Am J Respir Crit Care Med. 2006; 173(7):751–758.
15. Brusselle GG, Demoor T, Bracke KR, Brandsma CA, Timens W. Lymphoid follicles in (very) severe COPD:beneficial or harmful? Eur Respir J. 2009; 34(1):219–230.
16. Randall TD. Bronchus-associated lymphoid tissue (BALT) structure and function. Adv Immunol. 2010; 107:187–241.
17. Aloisi F1, Pujol-Borrell R. Lymphoid neogenesis in chronic inflammatory diseases. Nat Rev Immunol. 2006; 6(3):205–217.
18. Annoni R, Lanças T, Yukimatsu Tanigawa R, de Medeiros Matsushita M, de Morais Fernezlian S, Bruno A, et al. Extracellular matrix composition in COPD. Eur Respir J. 2012; 40(6):1362–1373.
19. Mauad T, Silva LF, Santos MA, Grinberg L, Bernardi FD, Martins MA, et al. Abnormal alveolar attachments with decreased elastic fiber content in distal lung in fatal asthma. Am J Respir Crit Care Med. 2004; 170(8):85–62.
20. Pereira CA, Sato T, Rodrigues SC. New reference values for forced spirometry in white adults in Brazil. J Bras Pneumol. 2007; 33(4):397–406.
21. Tsoumakidou M, Demedts IK, Brusselle GG, Jeffery PK. Dendritic cells in chronic obstructive pulmonary disease:new players in an old game. Am J Respir Crit Care Med. 2008; 177(11):1180–1186.
22. Saetta M, Baraldo S, Turato G, Beghé B, Casoni GL, Bellettato CM, Rea F, Zuin R, Fabbri LM, Papi A. Increased proportion of CD8+ T-lymphocytes in the paratracheal lymph nodes of smokers with mild COPD. Sarcoidosis Vasc Diffuse Lung Dis. 2003; 20(1):28–32.
23. Chen Z, Lin F, Gao Y, Li Z, Zhang J, Xing Y, et al. FOXP3 and RORyt:Transcriptional regulation of Treg and Th17. Int Immunopharmacol. 2011; 11(5):536–542.
24. Takizawa H, Tanaka M, Takami K, Ohtoshi T, Ito K, Satoh M, et al. A. Increased expression of transforming growth factor-beta1 in small airway epithelium from tobacco smokers and patients with chronic obstructive pulmonary disease (COPD). Am J Respir Crit Care Med. 2001; 163(6):1476–1483.
25. Königshoff M, Kneidinger N, Eickelberg O. TGF-beta signaling in COPD:deciphering genetic and cellular susceptibilities for future therapeutic regimen. Swiss Med Wkly. 2009; 139(39–40):554–563.
26. Pons AR, Sauleda J, Noguera A, Pons J, Barceló B, Fuster A, Agustí AG. Decreased macrophage release of TGF-beta and TIMP-1 in chronic obstructive pulmonary disease. Eur Respir J. 2005; 26(1):60–66.
27. Zandvoort A, Postma DS, Jonker MR, Noordhoek JA, Vos JT, van der Geld YM, Timens W. Altered expression of the Smad signaling pathway:implications for COPD pathogenesis. Eur Respir J. 2006; 28(3):533–541.
28. Wouters EF. Local and systemic inflammation in chronic obstructive pulmonary disease. Proc Am Thorac Soc. 2005; 2(1):26–33.
29. Hodge SJ, Hodge GL, Reynolds PN, Scicchitano R, Holmes M. Increased production of TGF-beta and apoptosis of T lymphocytes isolated from peripheral blood in COPD. Am J Physiol Lung Cell Mol Physiol. 2003; 285(2):L492–l499.
30. Tan DB, Fernandez S, Price P, French MA, Thompson PJ, Moodley YP. Impaired function of T-cells in chronic obstructive pulmonary disease (COPD). Immunobiol. 2014; 219(12):975–979.
31. Pridgeon C, Bugeon L, Donnelly L, Straschil U, Tudhope SJ, Fenwick P, et al. Regulation of IL-17 in chronic inflammation in the human lung. Clin Sci. 2011; 120(12):515–524.
32. Chu S, Zhong X, Zhang J, Lao Q, He Z, Bai J. The expression of FOXP3 and ROR gamma t in lung tissues from normal smokers and chronic obstructive pulmonary disease patients. Int Immunopharmacol. 2011; 11(11):1780–1788.
33. Foo SY, Phipps S. Regulation of inducible BALT formation and contribution to immunity and pathology. Mucosal Immunol. 2010; 3(6):537–544.
34. Pabst O. Trafficking of regulatory T cells in the intestinal immune system. Int Immunology 2013; 25(3):139–143.