Transcription elongation factors represent in vivo cancer dependencies in glioblastoma

Nature

Volumn 547, Issue 7663, 2017, Pages 355-359

  Miller, Tyler E ^a,b   Liau, Brian B ^c,d,e   Wallace, Lisa C ^a   Morton, Andrew R ^a,b   Xie, Qi ^a   Dixit, Deobrat ^a   Factor, Daniel C ^b   Kim, Leo J Y ^a,b   Morrow, James J ^b   Wu, Qiulian ^a   Mack, Stephen C ^a,b   Hubert, Christopher G ^a,b   Gillespie, Shawn M ^c,d,e   Flavahan, William A ^a,b   Hoffmann, Thomas ^f   Thummalapalli, Rohit ^c,d,e   Hemann, Michael T ^g   Paddison, Patrick J ^h   Horbinski, Craig M ⁱ   Zuber, Johannes ^f   Scacheri, Peter C ^b   Bernstein, Bradley E ^c,d,e   Tesar, Paul J ^b   Rich, Jeremy N ^a,b,j   more..

^a LERNER RESEARCH INSTITUTE   (United States)

^b CASE WESTERN RESERVE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^c HARVARD MEDICAL SCHOOL   (United States)

^d BROAD INSTITUTE OF MIT AND HARVARD   (United States)

^e MASSACHUSETTS GENERAL HOSPITAL   (United States)

^f RESEARCH INSTITUTE OF MOLECULAR PATHOLOGY   (Austria)

^g MASSACHUSETTS INSTITUTE OF TECHNOLOGY   (United States)

^h USA   (United States)

ⁱ NORTHWESTERN UNIVERSITY   (United States)

^j UNIVERSITY OF CALIFORNIA SAN DIEGO   (United States)

more..

Author keywords

[No Author keywords available]

Indexed keywords

TRANSCRIPTION ELONGATION FACTOR; HISTONE DEMETHYLASE; JMJD6 PROTEIN, HUMAN;

BIOTECHNOLOGY; CANCER; CELLS AND CELL COMPONENTS; DISEASE CONTROL; GENE EXPRESSION; RODENT; TUMOR;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CELL PROLIFERATION; CLUSTERED REGULARLY INTERSPACED SHORT PALINDROMIC REPEAT; COMPARATIVE STUDY; CONTROLLED STUDY; ENHANCER REGION; FEMALE; GENE EXPRESSION; GLIOBLASTOMA; HEK293T CELL LINE; HELA CELL LINE; HIGH THROUGHPUT SEQUENCING; HUMAN; HUMAN CELL; IN VIVO STUDY; MALE; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN DEPLETION; TRANSCRIPTION ELONGATION; TUMOR MICROENVIRONMENT; TUMOR XENOGRAFT; UPREGULATION; ANIMAL; ANTAGONISTS AND INHIBITORS; CELL SURVIVAL; CHROMATIN; DRUG SCREENING; GENE EXPRESSION REGULATION; GENETIC TRANSCRIPTION; GENETICS; METABOLISM; MOLECULARLY TARGETED THERAPY; PATHOLOGY; PRECLINICAL STUDY; PROCEDURES; RNA INTERFERENCE; TRENDS; TUMOR CELL LINE;

ANIMALS; CELL LINE, TUMOR; CELL SURVIVAL; CHROMATIN; DRUG EVALUATION, PRECLINICAL; ENHANCER ELEMENTS, GENETIC; FEMALE; GENE EXPRESSION REGULATION, NEOPLASTIC; GLIOBLASTOMA; HUMANS; JUMONJI DOMAIN-CONTAINING HISTONE DEMETHYLASES; MALE; MICE; MOLECULAR TARGETED THERAPY; RNA INTERFERENCE; TRANSCRIPTION, GENETIC; TRANSCRIPTIONAL ELONGATION FACTORS; TUMOR MICROENVIRONMENT; XENOGRAFT MODEL ANTITUMOR ASSAYS;

EID: 85025154131     PISSN: 00280836     EISSN: 14764687     Source Type: Journal    
DOI: 10.1038/nature23000     Document Type: Article

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