Anaemia in the elderly;Anemia del anciano

Medicina Clinica

Volumn 149, Issue 11, 2017, Pages 496-503

  Gómez Ramírez, Susana ^a,b   Remacha Sevilla, Ángel Francisco ^a,c   Muñoz Gómez, Manuel ^a,d  

^a Anemia Working Group España AWGE   (United States)

^b HOSPITAL UNIVERSITARIO VIRGEN DE LA VICTORIA   (Spain)

^c HOSPITAL DE LA SANTA CREU I SANT PAU   (Spain)

^d UNIVERSIDAD DE MÁLAGA   (Spain)

Author keywords

Anaemia; Elderly; Erythropoietin; Indeterminate anaemia; Inflammation; Nutritional deficiencies

Indexed keywords

ANTIANEMIC AGENT; IRON; TRACE ELEMENT;

ALGORITHM; ANEMIA; CHRONIC DISEASE; COGNITIVE DEFECT; ERYTHROCYTE TRANSFUSION; FUNCTIONAL STATUS; HOSPITALIZATION; HUMAN; KIDNEY FAILURE; MORTALITY; PHYSICAL ACTIVITY; PHYSICAL EXAMINATION; REVIEW; AGE; AGED; ANAMNESIS; DIETARY SUPPLEMENT; RISK FACTOR; VERY ELDERLY;

AGE FACTORS; AGED; AGED, 80 AND OVER; ANEMIA; DIETARY SUPPLEMENTS; HEMATINICS; HUMANS; IRON; MEDICAL HISTORY TAKING; PHYSICAL EXAMINATION; RISK FACTORS; TRACE ELEMENTS;

EID: 85025123299     PISSN: 00257753     EISSN: 15788989     Source Type: Journal    
DOI: 10.1016/j.medcli.2017.06.025     Document Type: Review

References (60)

1. Aunan, J.R., Watson, M.M., Hagland, H.R., Søreide, K., Molecular and biological hallmarks of ageing. Br J Surg 103 (2016), e29–e46.
2. Chomienne, C., McCann, S., Green, T., Hagenbeek, A., Lacombe, C., Guenova, M., et al. Age and aging in blood disorders: EHA theme of the year 2013-2014. Haematologica 98 (2013), 831–832.
3. WHO. Haemoglobin concentrations for the diagnosis of anaemia and assessment of severity. WHO/NMH/NHD/MNM/11.1 [consultado May 2017]. Disponible en: http://www.who.int/vmnis/indicators/haemoglobin.pdf.
4. Worldwide prevalence of anaemia report 1993-2005. WHO global database on anaemia. Geneva, World Health Organization, 2008 [consultado May 2017]. Disponible en: http://apps.who.int/iris/bitstream/10665/43894/1/9789241596657_eng.pdf.
5. Chaves, P.H., Xue, Q.L., Guralnik, J.M., Ferrucci, L., Volpato, S., Fried, L.P., What constitutes normal hemoglobin concentration in community-dwelling disabled older women. J Am Geriatr Soc. 52 (2004), 1811–1816.
6. Guralnik, J.M., Eisenntaedt, R.S., Ferrucci, L., Klein, H.G., Woodman, R.C., Prevalence of anemia in persons 65 years and older in the United States: Evidence for a high rate of unexplained anemia. Blood 104 (2004), 2263–2268.
7. Robalo Nunes, A., Fonseca, C., Marques, F., Belo, A., Brilhante, D., Cortez, J., Prevalence of anemia and iron deficiency in older Portuguese adults: An EMPIRE substudy. Geriatr Gerontol Int., 2017, 10.1111/ggi.12966 Epub ahead of print.
8. Anía, B.J., Suman, V.J., Fairbanks, V.F., Rademacher, D.M., Melton, L.J. 3rd., Incidence of anemia in older people: An epidemiologic study in a well-defined population. J Am Geriatr Soc 45 (1997), 825–831.
9. Tettamanti, M., Lucca, U., Gandini, F., Recchia, A., Mosconi, P., Apolone, G., et al. Prevalence, incidence and types of mild anemia in the elderly: The Health and Anemia population-based study. Haematologica 95 (2010), 1849–1856.
10. Gaskell, H., Derry, S., Andrew Moore, R., McQuay, H.J., Prevalence of anaemia in older persons: Systematic review. BMC Geriatr, 8, 2008, 1.
11. Ferrucci, L., Bandinelli, S., Benvenuti, E., di Iorio, A., Macchi, C., Harris, T.B., et al. Subsystems contributing to the decline in ability to walk: Bridging the gap between epidemiology and geriatric practice in the InCHIANTI study. J Am Geriatr Soc. 48 (2000), 1618–1625.
12. Wu, W.C., Schifftner, T.L., Henderson, W.G., Eaton, C.B., Poses, R.M., Uttley, G., et al. Preoperative hematocrit levels and postoperative outcomes in older patients undergoing noncardiac surgery. JAMA. 297 (2007), 2481–2488.
13. Muñoz, M., Laso-Morales, M.J., Gómez-Ramírez, S., Cadellas, M., Núñez-Matas, M.J., García-Erce, J.A., Pre-operative haemoglobin levels and iron status in a large multicentre cohort of patients undergoing major elective surgery. Anaesthesia., 2017, 10.1111/anae.13840 Epub ahead of print.
14. Muñoz, M., Gómez-Ramírez, S., Cobos, A., Enguix, A., Prevalence and severity of anaemia among medical patients from different hospital departments. Transfus Altern Transfus Med, 12, 2011, 30.
15. Rivilla L, Lorente T, Molinero M, García-Erce JA. Estudio de Prevalencia de Anemia en el Sector Huesca (CO-075). LVIII Congreso Nacional SEHH, Santiago de Compostela, 20-22 octubre, 2016.
16. Penninx, B.W., Pahor, M., Cesari, M., Corsi, A.M., Woodman, R., Bandinelli, S., et al. Anemia is associated with disability and decreased physical performance and muscle strength in the elderly. J Am Geriatr Soc 52 (2004), 719–724.
17. Stauder, R., Thein, S.L., Anemia in the elderly: Clinical implications and new therapeutic concepts. Haematologica 99 (2014), 1127–1130.
18. Shavelle, R.M., MacKenzie, R., Paculdo, D.R., Anemia and mortality in older persons: Does the type of anemia affect survival?. Int J Hematol 95 (2012), 248–256.
19. Fowler, A.J., Ahmad, T., Phull, M.K., Allard, S., Gillies, M.A., Pearse, R.M., Meta-analysis of the association between preoperative anaemia and mortality after surgery. Br J Surg 102 (2015), 1314–1324.
20. Pratt, J.J., Khan, K.S., Non-anaemic iron deficiency — a disease looking for recognition of diagnosis: A systematic review. Eur J Haematol 96 (2016), 618–628.
21. Goodnough, L.T., Comin-Colet, J., Leal-Noval, S., Ozawa, S., Takere, J., Henry, D., et al. Management of anemia in patients with congestive heart failure. Am J Hematol 92 (2017), 88–93.
22. Evstatiev, R., Iron deficiency, thrombocytosis and thromboembolism. Wien Med Wochenschr. 166 (2016), 437–446.
23. 12 deficiency in adults and in elderly patients: What is the problem. Rev Med Interne 37 (2016), 511–513.
24. 12 and/or folate deficiency: Role of hyperhomocysteinemia. Ann Hematol 81 (2002), 616–621.
25. Pautas, E., Siguret, V., Kim, T.M., Chaïbi, P., Golmard, J.L., Gouronnec, A., et al. Anemia in the elderly: Usefulness of an easy and comprehensive laboratory screen. Ann Biol Clin (Paris). 70 (2012), 643–647.
26. Muñoz, M., García-Erce, J.A., Remacha, A.F., Disorders of iron metabolism. Part I: Molecular basis of iron homoeostasis. J Clin Pathol 64 (2011), 281–286.
27. Muñoz, M., García-Erce, J.A., Remacha, A.F., Disorders of iron metabolism. Part II: Iron deficiency and iron overload. J Clin Pathol 64 (2011), 287–296.
28. 12 deficiency. N Engl J Med 368 (2013), 149–160.
29. Smith, E.M., Tangpricha, V., Vitamin D and anemia: Insights into an emerging association. Curr Opin Endocrinol Diabetes Obes 22 (2015), 432–438.
30. Monlezun, D.J., Camargo, C.A. Jr., Mullen, J.T., Quraishi, S.A., Vitamin D status and the risk of anemia in community-dwelling adults: Results from the National Health and Nutrition Examination Survey 2001-2006. Medicine (Baltimore), 94, 2015, e1799.
31. Bacchetta, J., Zaritsky, J.J., Sea, J.L., Chun, R.F., Lisse, T.S., Zavala, K., et al. Suppression of iron-regulatory hepcidin by vitamin D. J Am Soc Nephrol 25 (2014), 564–572.
32. Lane, D.J., Richardson, D.R., The active role of vitamin C in mammalian iron metabolism: Much more than just enhanced iron absorption!. Free Radic Biol Med 75 (2014), 69–83.
33. Weiss, G., Anemia of chronic disorders: New diagnostic tools and new treatment strategies. Semin Hematol 52 (2015), 313–320.
34. Goodnough, L.T., Schrier, S.L., Evaluation and management of anemia in the elderly. Am J Hematol 89 (2014), 88–96.
35. Bach, V., Schruckmayer, G., Sam, I., Kemmler, G., Stauder, R., Prevalence and possible causes of anemia in the elderly: A cross-sectional analysis of a large European university hospital cohort. Clin Interv Aging 9 (2014), 1187–1196.
36. Steensma, D.P., Clonal hematopoiesis of indeterminate potential and its distinction from myelodysplastic syndromes. Blood 126 (2015), 9–16.
37. Malcovati, L., Cazzola, M., The shadowlands of MDS: Idiopathic cytopenias of undetermined significance (ICUS) and clonal hematopoiesis of indeterminate potential (CHIP). Hematology Am Soc Hematol Educ Program. 2015 (2015), 299–307.
38. Makipour, S., Kanapuru, B., Ershler, W.B., Unexplained anemia in the elderly. Semin Hematol 45 (2008), 250–254.
39. Ferrucci, L., Semba, R.D., Guralnik, J.M., Ershler, W.B., Bandinelli, S., Patel, K.V., et al. Proinflammatory state, hepcidin, and anemia in older persons. Blood 115 (2010), 3810–3816.
40. Merchant, A.A., Roy, C.N., Not so benign haematology: Anaemia of the elderly. Br J Haematol. 156 (2012), 173–185.
41. Baylis, D., Bartlett, D.B., Patel, H.P., Roberts, H.C., Understanding how we age: Insights into inflammaging. Longev Healthspan, 2, 2013, 8.
42. Gowanlock, Z., Sriram, S., Martin, A., Xenocostas, A., Lazo-Langner, A., Erythropoietin levels in elderly patients with anemia of unknown etiology. PLoS One, 11, 2016, e0157279.
43. Anpalahan, M., Savvas, S., Lo, K.Y., Ng, H.Y., Gibson, S., Chronic idiopathic normocytic anaemia in older people: The risk factors and the role of age-associated renal impairment. Aging Clin Exp Res 29 (2017), 147–155.
44. Remacha, A.F., Sardà, M.P., Canals, C., Queraltò, J.M., Zapico, E., Remacha, J., et al. Combined cobalamin and iron deficiency anemia: A diagnostic approach using a model based on age and homocysteine assessment. Ann Hematol 92 (2013), 527–531.
45. Tolkien, Z., Stecher, L., Mander, A.P., Pereira, D.I.A., Powell, J.J., Ferrous sulfate supplementation causes significant gastrointestinal side-effects in adults: A systematic review and meta-analysis. PLoS One, 10, 2015, e0117383.
46. Moretti, D., Goede, J.S., Zeder, C., Jiskra, M., Chatzinakou, V., Tjalsma, H., et al. Oral iron supplements increase hepcidin and decrease iron absorption from daily or twice-daily doses in iron-depleted young women. Blood 126 (2015), 1981–1989.
47. Rimon, E., Kagansky, N., Kagansky, M., Mechnick, L., Mashiah, T., Namir, M., et al. Are we giving too much iron? Low-dose iron therapy is effective in octogenarians. Am J Med 118 (2005), 1142–1147.
48. Cancelo-Hidalgo, M.J., Castelo-Branco, C., Palacios, S., Haya-Palazuelos, J., Ciria-Recasens, M., Manasanch, J., et al. Tolerability of different oral iron supplements: A systematic review. Curr Med Res Opin. 29 (2013), 291–303.
49. Pisani, A., Riccio, E., Sabbatini, M., Andreucci, M., del Rio, A., Visciano, B., Effect of oral liposomal iron versus intravenous iron for treatment of iron deficiency anaemia in CKD patients: A randomized trial. Nephrol Dial Transplant 30 (2015), 645–652.
50. Muñoz, M., Gómez-Ramírez, S., Kozek-Langeneker, S., Shander, A., Richards, T., Pavía, J., et al. ‘Fit to fly’: Overcoming barriers to preoperative haemoglobin optimization in surgical patients. Br J Anaesth 115 (2015), 15–24.
51. European Medicines Agency. New recommendations to manage risk of allergic reactions with intravenous iron containing medicines. EMA/579491/2013 [consultado Ene 2017]. Disponible en: http://www.ema.europa.eu/docs/en_GB/document_library/Referrals_document/IV_iron_31/WC500151308.pdf.
52. Rampton, D., Folkersen, J., Fishbane, S., Hedenus, M., Howaldt, S., Locatelli, F., et al. Hypersensitivity reactions to intravenous iron: Guidance for risk minimization and management. Haematologica 99 (2014), 1671–1676.
53. Remacha, A.F., Hematínicos y factores de crecimiento eritropoyéticos. Muñoz, M., (eds.) Actualización en medicina transfusional perioperatoria, 2014, SPICUM, Málaga, 61–68.
54. Muñoz Gómez, M., Bisbe Vives, E., Basora Macaya, M., García Erce, J.A., Gómez Luque, A., Leal-Noval, S.R., et al. Foro de debate: Seguridad de las alternativas a la transfusión alogénica en el paciente quirúrgico y/o crítico. Med Intensiva 39 (2015), 552–562.
55. Carson, J.L., Stanworth, S.J., Roubinian, N., Fergusson, D.A., Triulzi, D., Doree, C., et al. Transfusion thresholds and other strategies for guiding allogeneic red blood cell transfusion. Cochrane Database Syst Rev, 10, 2016, CD002042.
56. Carson, J.L., Guyatt, G., Heddle, N.M., Grossman, B.J., Cohn, C.S., Fung, M.K., et al. Clinical practice guidelines from the AABB: Red blood cell transfusion thresholds and storage. JAMA 316 (2016), 2025–2035.
57. Carson, J.L., Brooks, M.M., Abbott, J.D., Chaitman, B., Kelsey, S.F., Triulzi, D.J., et al. Liberal versus restrictive transfusion thresholds for patients with symptomatic coronary artery disease. Am Heart J 165 (2013), 964–971.
58. Murphy, G.J., Pike, K., Rogers, C.A., Wordsworth, S., Stokes, E.A., Angelini, G.D., et al. Liberal or restrictive transfusion after cardiac surgery. N Engl J Med 372 (2015), 997–1008.
59. De Almeida, J.P., Vincent, J.L., Galas, F.R., de Almeida, E.P., Fukushima, J.T., Osawa, E.A., et al. Transfusion requirements in surgical oncology patients: A prospective, randomized controlled trial. Anesthesiology 122 (2015), 29–38.
60. Vamvakas, E.C., Reasons for moving toward a patient-centric paradigm of clinical transfusion medicine practice. Transfusion 53 (2013), 888–901.