Anemia in the elderly: Clinical implications and new therapeutic concepts

Haematologica

Volumn 99, Issue 7, 2014, Pages 1127-1130

  Stauder, Reinhard ^a   Thein, Swee Lay ^b,c  

^a INNSBRUCK MEDICAL UNIVERSITY   (Austria)

^b KING'S COLLEGE LONDON   (United Kingdom)

^c KING'S COLLEGE HOSPITAL NHS FOUNDATION TRUST   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

ERYTHROPOIETIN; FERRITIN; HEMOJUVELIN; HEPCIDIN; INTERLEUKIN 1; INTERLEUKIN 6; IRON; MACROPHAGE MIGRATION INHIBITION FACTOR; TRANSFERRIN; TUMOR NECROSIS FACTOR ALPHA;

AGED; ANEMIA; APOPTOSIS; BLEEDING TENDENCY; CARDIOVASCULAR DISEASE; CHRONIC KIDNEY DISEASE; COGNITIVE DEFECT; CYANOCOBALAMIN DEFICIENCY; EDITORIAL; ERYTHROID PRECURSOR CELL; FOLIC ACID DEFICIENCY; HEMATOLOGIC MALIGNANCY; HUMAN; IRON DEFICIENCY ANEMIA; KIDNEY FAILURE; LENGTH OF STAY; MYELODYSPLASTIC SYNDROME; NUTRITIONAL DEFICIENCY; PHYSICAL PERFORMANCE; QUALITY OF LIFE; RETICULOCYTE HEMOGLOBIN CONTENT; THALASSEMIA; AGE; PREVALENCE; VERY ELDERLY;

AGE FACTORS; AGED; AGED, 80 AND OVER; ANEMIA; HUMANS; PREVALENCE;

EID: 84903626057     PISSN: 03906078     EISSN: 15928721     Source Type: Journal    
DOI: 10.3324/haematol.2014.109967     Document Type: Editorial

References (22)

1. Blanc B, Finch CA, Hallberg L, Lawkowicz W, Layrisse M, Mollin DL, et al. Nutritional Anaemias. Report of a WHO Scientific Group. World Health Organization, Technical Report Series. Geneva: World Health Organization, 1968:40.
2. Cheng CK, Chan J, Cembrowski GS, van Assendelft OW. Complete blood count reference interval diagrams derived from NHANES III: stratification by age, sex, and race. Lab Hematol. 2004;10(1):42-53.
3. Zakai NA, Katz R, Hirsch C, Shlipak MG, Chaves PHM, Newman AB, et al. A Prospective Study of Anemia Status, Hemoglobin Concentration, and Mortality in an Elderly Cohort: The Cardiovascular Health Study. Arch Intern Med. 2005;165(19):2214-20.
4. Culleton BF, Manns BJ, Zhang J, Tonelli M, Klarenbach S, Hemmelgarn BR. Impact of anemia on hospitalization and mortality in older adults. Blood. 2006;107(10):3841-6.
5. van Houwelingen AH, den Elzen WP, Mooijaart SP, Heijmans M, Blom JW, de Craen AJ, et al. Predictive value of a profile of routine blood measurements on mortality in older persons in the general population: the Leiden 85-plus Study. PloS One. 2013;8(3):e58050.
6. Guralnik JM, Eisenstaedt RS, Ferrucci L, Klein HG, Woodman RC. Prevalence of anemia in persons 65 years and older in the United States: evidence for a high rate of unexplained anemia. Blood. 2004;104(8):2263-8.
7. Shavelle RM, MacKenzie R, Paculdo DR. Anemia and mortality in older persons: does the type of anemia affect survival? Int J Hem. 2012:95(3):248-56.
8. Tettamanti M, Lucca U, Gandini F, Recchia A, Mosconi P, Apolone G, et al. Prevalence, incidence and types of mild anemia in the elderly: the "Health and Anemia" population-based study. Haematologica. 2010;95(11):1849-56.
9. Price EA, Mehra R, Holmes TH, Schrier SL. Anemia in older persons: etiology and evaluation. Blood Cells Mol Dis. 2011;46(2):159-65.
10. Artz AS, Thirman MJ. Unexplained anemia predominates despite an intensive evaluation in a racially diverse cohort of older adults from a referral anemia clinic. J Gerontol. 2011;66(8):925-32.
11. Ferrucci L, Semba RD, Guralnik JM, Ershler WB, Bandinelli S, Patel KV, et al. Proinflammatory state, hepcidin, and anemia in older persons. Blood. 2010;115(18):3810-6.
12. den Elzen WP, de Craen AJ, Wiegerinck ET, Westendorp RG, Swinkels DW, Gussekloo J. Plasma hepcidin levels and anemia in old age. The Leiden 85-Plus Study. Haematologica. 2013;98(3):448-54.
13. Bach V, Schruckmayer G, Sam I, Kemmler G, Stauder R. Prevalence and possible causes of anemia in the elderly: a cross-sectional analysis of a large European university hospital cohort. Clin Interv Aging 2014:9 1-10.
14. Gaskell H, Derry S, Andrew Moore R, McQuay HJ. Prevalence of anaemia in older persons: systematic review. BMC Geriatrics. 2008;8:1.
15. Denny SD, Kuchibhatla MN, Cohen HJ. Impact of anemia on mortality, cognition, and function in community-dwelling elderly. Am J Med. 2006;119(4):327-34.
16. Beghe C, Wilson A, Ershler WB. Prevalence and outcomes of anemia in geriatrics: a systematic review of the literature. Am J Med. 2004;116(Suppl 7A):3S-10S.
17. den Elzen WP, Willems JM, Westendorp RG, de Craen AJ, Assendelft WJ, Gussekloo J. Effect of anemia and comorbidity on functional status and mortality in old age: results from the Leiden 85-plus Study. Can Med Assoc J. 2009;181(3-4):151-7.
18. Penninx BW, Pahor M, Cesari M, Corsi AM, Woodman RC, Bandinelli S, et al. Anemia is associated with disability and decreased physical performance and muscle strength in the elderly. J Am Geriatr Soc. 2004;52(5):719-24.
19. Penninx BW, Pahor M, Woodman RC, Guralnik JM. Anemia in old age is associated with increased mortality and hospitalization. J Gerontol A Biol Sci Med Sci. 2006;61(5):474-9.
20. Edgren G, Bagnardi V, Bellocco R, Hjalgrim H, Rostgaard K, Melbye M, et al. Pattern of declining hemoglobin concentration before cancer diagnosis. Int J Cancer. 2010;127(6):1429-36.
21. Weiss G, Goodnough LT. Anemia of chronic disease. N Engl J Med. 2005;352(10):1011-23.
22. Fung E, Nemeth E. Manipulation of the hepcidin pathway for therapeutic purposes. Haematologica. 2013;98(11):1667-76.