Engineering Pak1 Allosteric Switches

ACS Synthetic Biology

Volumn 6, Issue 7, 2017, Pages 1257-1262

  Dagliyan, Onur ^a,b   Karginov, Andrei V ^c   Yagishita, Sho ^d   Gale, Madeline E ^e   Wang, Hui ^a   Dermardirossian, Celine ^f   Wells, Claire M ^e   Dokholyan, Nikolay V ^a,b   Kasai, Haruo ^d   Hahn, Klaus M ^a,b  

^a UNIVERSITY OF NORTH CAROLINA SCHOOL OF MEDICINE   (United States)

^b UNIVERSITY OF NORTH CAROLINA   (United States)

^c UNIVERSITY OF ILLINOIS AT CHICAGO   (United States)

^d UNIVERSITY OF TOKYO   (Japan)

^e KING'S COLLEGE LONDON   (United Kingdom)

^f SCRIPPS RESEARCH INSTITUTE   (United States)

Author keywords

allosteric switch; cell motility; dendritic spines; PAK; protein dynamics

Indexed keywords

AMINO ACID; P21 ACTIVATED KINASE 1; RAPAMYCIN; P21 ACTIVATED KINASE;

ALLOSTERISM; ANIMAL CELL; ARTICLE; BRAIN NERVE CELL; CANCER CELL; CELL SPREADING; CONTROLLED STUDY; DENDRITIC SPINE; ENZYME ACTIVATION; ENZYME ACTIVE SITE; ENZYME ENGINEERING; HIPPOCAMPAL CA1 REGION; MEMBRANE PERMEABILITY; METASTATIC BREAST CANCER; MOLECULAR DYNAMICS; MOUSE; NONHUMAN; PREDICTION; PRIORITY JOURNAL; ANIMAL; CELL MOTION; DRUG EFFECTS; GENETICS; HIPPOCAMPUS; HUMAN; IN VITRO STUDY; METABOLISM; PHYSIOLOGY; RAT; SIGNAL TRANSDUCTION; SPRAGUE DAWLEY RAT; TUMOR CELL LINE;

ALLOSTERIC REGULATION; ANIMALS; CA1 REGION, HIPPOCAMPAL; CATALYTIC DOMAIN; CELL LINE, TUMOR; CELL MOVEMENT; HIPPOCAMPUS; HUMANS; IN VITRO TECHNIQUES; MICE; P21-ACTIVATED KINASES; RATS; RATS, SPRAGUE-DAWLEY; SIGNAL TRANSDUCTION; SIROLIMUS;

EID: 85025121891     PISSN: None     EISSN: 21615063     Source Type: Journal    
DOI: 10.1021/acssynbio.6b00359     Document Type: Article

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