Uric acid promotes vascular stiffness, maladaptive inflammatory responses and proteinuria in western diet fed mice

Metabolism: Clinical and Experimental

Volumn 74, Issue , 2017, Pages 32-40

  Aroor, Annayya R ^a   Jia, Guanghong ^a   Habibi, Javad ^a   Sun, Zhe ^c   Ramirez Perez, Francisco I ^c   Brady, Barron ^a   Chen, Dongqing ^a   Martinez Lemus, Luis A ^a,b,c   Manrique, Camila ^a   Nistala, Ravi ^a   Whaley Connell, Adam T ^a   Demarco, Vincent G ^a,b   Meininger, Gerald A ^b,c   Sowers, James R ^a,b  

^a University of Missouri   (United States)

^b UNIVERSITY OF MISSOURI   (United States)

^c UNIVERSITY OF MISSOURI   (United States)

Author keywords

Arterial stiffness; Macrophage polarization; Obesity; Proteinuria; Uric acid

Indexed keywords

3 NITROTYROSINE; ALLOPURINOL; BIOLOGICAL MARKER; CD86 ANTIGEN; FAT; FIBRONECTIN; FRUCTOSE; INTERLEUKIN 6; MESSENGER RNA; MONOCYTE CHEMOTACTIC PROTEIN 1; REACTIVE OXYGEN METABOLITE; SODIUM CHANNEL; TOLL LIKE RECEPTOR 4; URIC ACID; XANTHINE OXIDASE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; AORTIC ENDOTHELIAL CELL; ARTERIAL STIFFNESS; ARTICLE; ATOMIC FORCE MICROSCOPY; BIOCHEMICAL ANALYSIS; CONTROLLED STUDY; DIET INDUCED OBESITY; ENZYME ACTIVITY; ENZYME INHIBITION; EXTRACELLULAR MATRIX; GENE EXPRESSION; IMMUNE RESPONSE; IMMUNOHISTOCHEMISTRY; INFLAMMATION; KIDNEY FIBROSIS; MACROPHAGE; MALE; MESENTERIC ARTERY; MOUSE; NONHUMAN; OXIDATIVE STRESS; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEINURIA; STRESS STRAIN RELATIONSHIP; URIC ACID BLOOD LEVEL; VASCULAR SMOOTH MUSCLE CELL; WESTERN DIET; YOUNG MODULUS; ANIMAL; ANTAGONISTS AND INHIBITORS; BLOOD; C57BL MOUSE; CHEMICALLY INDUCED; DRUG EFFECTS;

ALLOPURINOL; ANIMALS; DIET, WESTERN; INFLAMMATION; MALE; MICE; MICE, INBRED C57BL; PROTEINURIA; URIC ACID; VASCULAR STIFFNESS; XANTHINE OXIDASE;

EID: 85025089804     PISSN: 00260495     EISSN: 15328600     Source Type: Journal    
DOI: 10.1016/j.metabol.2017.06.006     Document Type: Article

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