Chitosan oligosaccharides protect nucleus pulposus cells from hydrogen peroxide-induced apoptosis in a rat experimental model

Biomedicine and Pharmacotherapy

Volumn 93, Issue , 2017, Pages 807-815

  Jia, Peng ^a   Yu, Ling ^a   Tao, Chunjie ^a   Dai, Guo ^a   Zhang, Zhengpei ^a   Liu, Shiqing ^a  

^a RENMIN HOSPITAL OF WUHAN UNIVERSITY   (China)

Author keywords

Chitosan oligosaccharides; Intervertebral disc degeneration; Nucleus pulposus; PI3K Akt pathway

Indexed keywords

AGGRECAN; AGGRECANASE 1; CHITOSAN DERIVATIVE; CHITOSAN OLIGOSACCHARIDE; COLLAGEN TYPE 2; COLLAGENASE 3; FLUORESCEIN ISOTHIOCYANATE; HOE 33342; HYDROGEN PEROXIDE; LIPOCORTIN 5; MESSENGER RNA; OLIGOSACCHARIDE; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN KINASE B; UNCLASSIFIED DRUG; WORTMANNIN; CHITOSAN; PROTECTIVE AGENT;

ANIMAL CELL; APOPTOSIS; ARTICLE; ASSAY; CELL COUNTING KIT 8 ASSAY; CELL VIABILITY; CONTROLLED STUDY; ENZYME ACTIVITY; EXPERIMENTAL MODEL; EXTRACELLULAR MATRIX; GENE EXPRESSION; MALE; NERVE DEGENERATION; NEUROPROTECTION; NONHUMAN; NUCLEUS PULPOSUS; PRIORITY JOURNAL; PROPIDIUM IODIDE ASSAY; PROTEIN EXPRESSION; RAT; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SYNTHESIS; WESTERN BLOTTING; ANIMAL; ANIMAL MODEL; DRUG EFFECTS; INTERVERTEBRAL DISK; INTERVERTEBRAL DISK DEGENERATION; METABOLISM; OXIDATIVE STRESS; SIGNAL TRANSDUCTION; SPRAGUE DAWLEY RAT;

ANIMALS; APOPTOSIS; CHITOSAN; HYDROGEN PEROXIDE; INTERVERTEBRAL DISC; INTERVERTEBRAL DISC DEGENERATION; MALE; MODELS, ANIMAL; NUCLEUS PULPOSUS; OLIGOSACCHARIDES; OXIDATIVE STRESS; PHOSPHATIDYLINOSITOL 3-KINASES; PROTECTIVE AGENTS; PROTO-ONCOGENE PROTEINS C-AKT; RATS; RATS, SPRAGUE-DAWLEY; SIGNAL TRANSDUCTION;

EID: 85023619727     PISSN: 07533322     EISSN: 19506007     Source Type: Journal    
DOI: 10.1016/j.biopha.2017.06.101     Document Type: Article

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