Deciphering MCR-2 colistin resistance

mBio

Volumn 8, Issue 3, 2017, Pages

  Sun, Jian ^a,b   Xu, Yongchang ^a   Gao, Rongsui ^a   Lin, Jingxia ^a   Wei, Wenhui ^a   Srinivas, Swaminath ^c   Li, Defeng ^d   Yang, Run Shi ^b   Li, Xing Ping ^b   Liao, Xiao Ping ^b   Liu, Ya Hong ^b   Feng, Youjun ^a,b  

^a ZHEJIANG UNIVERSITY SCHOOL OF MEDICINE   (China)

^b SOUTH CHINA AGRICULTURAL UNIVERSITY   (China)

^c UNIVERSITY OF ILLINOIS AT URBANA CHAMPAIGN   (United States)

^d INSTITUTE OF BIOPHYSICS   (China)

Author keywords

Colistin resistance; Dissemination; Domain swapping; MCR 1; MCR 2; Origin; Plasmid transfer; Structure guided mutagenesis

Indexed keywords

BACTERIAL PROTEIN; COLISTIN; LIPID A; MCR 1 PROTEIN; MCR 2 PROTEIN; MEMBRANE PROTEIN; PHOSPHOETHANOLAMINE; TM1 PROTEIN; TM2 PROTEIN; UNCLASSIFIED DRUG; ANTIINFECTIVE AGENT; ESCHERICHIA COLI PROTEIN; POLYMYXIN;

ANTIBIOTIC RESISTANCE; ARTICLE; BACTERIAL GENE; CONTROLLED STUDY; DRUG EFFECT; GENE DELETION; GENETIC TRANSCRIPTION; MATRIX ASSISTED LASER DESORPTION IONIZATION TIME OF FLIGHT MASS SPECTROMETRY; MCR 2 GENE; MOLECULAR EVOLUTION; MOLECULAR PHYLOGENY; NONHUMAN; NUCLEOTIDE SEQUENCE; PAENIBACILLUS; PERIPLASM; PRIORITY JOURNAL; PROTEIN MODIFICATION; TRANSPOSON; BIOSYNTHESIS; CHEMISTRY; DRUG EFFECTS; ESCHERICHIA; GENETICS; MATRIX-ASSISTED LASER DESORPTION-IONIZATION MASS SPECTROMETRY; METABOLISM; PLASMID; SITE DIRECTED MUTAGENESIS; X RAY CRYSTALLOGRAPHY;

ANTI-BACTERIAL AGENTS; COLISTIN; CRYSTALLOGRAPHY, X-RAY; DRUG RESISTANCE, BACTERIAL; ESCHERICHIA; ESCHERICHIA COLI PROTEINS; MUTAGENESIS, SITE-DIRECTED; PAENIBACILLUS; PLASMIDS; POLYMYXINS; SPECTROMETRY, MASS, MATRIX-ASSISTED LASER DESORPTION-IONIZATION;

EID: 85022342864     PISSN: 21612129     EISSN: 21507511     Source Type: Journal    
DOI: 10.1128/mBio.00625-17     Document Type: Article

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