Dissemination and Mechanism for the MCR-1 Colistin Resistance

PLoS Pathogens

Volumn 12, Issue 11, 2016, Pages

  Gao, Rongsui ^a   Hu, Yongfei ^b   Li, Zhencui ^a   Sun, Jian ^c   Wang, Qingjing ^a   Lin, Jingxia ^a   Ye, Huiyan ^a   Liu, Fei ^b   Srinivas, Swaminath ^d   Li, Defeng ^e   Zhu, Baoli ^b   Liu, Ya Hong ^c   Tian, Guo Bao ^f   Feng, Youjun ^a  

^a ZHEJIANG UNIVERSITY SCHOOL OF MEDICINE   (China)

^b INSTITUTE OF MICROBIOLOGY   (China)

^c SOUTH CHINA AGRICULTURAL UNIVERSITY   (China)

^d UNIVERSITY OF ILLINOIS AT URBANA CHAMPAIGN   (United States)

^e INSTITUTE OF BIOPHYSICS   (China)

^f SUN YAT SEN UNIVERSITY   (China)

Author keywords

[No Author keywords available]

Indexed keywords

COLISTIN; ESCHERICHIA COLI PROTEIN; MCR-1 PROTEIN, E COLI;

ANTIBIOTIC SENSITIVITY; ARTICLE; BACTERIAL STRAIN; DIARRHEA; ELECTROSPRAY MASS SPECTROMETRY; ESCHERICHIA COLI; GENE; GENE SEQUENCE; GENETIC ANALYSIS; GENETIC MANIPULATION; HUMAN; INTESTINE FLORA; MINIMUM INHIBITORY CONCENTRATION; MOBILE COLISTIN RESISTANCE 1 GENE; MUTAGENESIS; NEISSERIA GONORRHOEAE; NUCLEOTIDE SEQUENCE; PLASMID; POLYMERASE CHAIN REACTION; SALMONELLA ENTERICA; WESTERN BLOTTING; ANTIBIOTIC RESISTANCE; DRUG EFFECTS; GENETICS; MICROBIAL SENSITIVITY TEST; MULTIDRUG RESISTANCE; PHYLOGENY; PHYSIOLOGY;

BASE SEQUENCE; COLISTIN; DRUG RESISTANCE, BACTERIAL; DRUG RESISTANCE, MULTIPLE; ESCHERICHIA COLI PROTEINS; HUMANS; MICROBIAL SENSITIVITY TESTS; PHYLOGENY; PLASMIDS;

EID: 85002328209     PISSN: 15537366     EISSN: 15537374     Source Type: Journal    
DOI: 10.1371/journal.ppat.1005957     Document Type: Article

References (49)

1. Raetz CR, Guan Z, Ingram BO, Six DA, Song F, et al. (2009) Discovery of new biosynthetic pathways: the lipid A story. J Lipid Res50Suppl: S103–108.
2. Wanty C, Anandan A, Piek S, Walshe J, Ganguly J, et al. (2013) The structure of the neisserial lipooligosaccharide phosphoethanolamine transferase A (LptA) required for resistance to polymyxin. J Mol Biol425: 3389–3402. doi: 10.1016/j.jmb.2013.06.02923810904
3. Paterson DL, Harris PN, (2016) Colistin resistance: a major breach in our last line of defence. Lancet Infect Dis16: 132–133. doi: 10.1016/S1473-3099(15)00463-626603171
4. Baron S, Hadjadj L, Rolain JM, Olaitan AO, (2016) Molecular mechanisms of polymyxin resistance: knowns and unknowns. Int J Antimicrob Agentsdoi: 10.1016/j.ijantimicag.2016.06.023. [Epub ahead of print]: S0924-8579(0916)30193-30195. 27524102
5. Schwarz S, Johnson AP, (2016) Transferable resistance to colistin: a new but old threat. J Antimicrob Chemother71: 2066–2070. doi: 10.1093/jac/dkw27427342545
6. Cannatelli A, D'Andrea MM, Giani T, Di Pilato V, Arena F, et al. (2013) In vivo emergence of colistin resistance in Klebsiella pneumoniae producing KPC-type carbapenemases mediated by insertional inactivation of the PhoQ/PhoP mgrB regulator. Antimicrob Agents Chemother57: 5521–5526. doi: 10.1128/AAC.01480-1323979739
7. Liu YY, Wang Y, Walsh TR, Yi LX, Zhang R, et al. (2016) Emergence of plasmid-mediated colistin resistance mechanism MCR-1 in animals and human beings in China: a microbiological and molecular biological study. Lancet Infect Dis16: 161–168. doi: 10.1016/S1473-3099(15)00424-726603172
8. Gunn JS, (2008) The Salmonella PmrAB regulon: lipopolysaccharide modifications, antimicrobial peptide resistance and more. Trends Microbiol16: 284–290. doi: 10.1016/j.tim.2008.03.00718467098
9. Hasman H, Hammerum AM, Hansen F, Hendriksen RS, Olesen B, et al. (2015) Detection of mcr-1 encoding plasmid-mediated colistin-resistant Escherichia coli isolates from human bloodstream infection and imported chicken meat, Denmark 2015. Euro Surveill20.
10. Ye H, Li Y, Li Z, Gao R, Zhang H, et al. (2016) Diversified mcr-1-harbouring plasmid reservoirs confer resistance to colistin in human gut microbiota. mBio7: e00177. doi: 10.1128/mBio.00177-1627048797
11. Hu Y, Liu F, Lin IY, Gao GF, Zhu B, (2016) Dissemination of the mcr-1 colistin resistance gene. Lancet Infect Dis16: 146–147. doi: 10.1016/S1473-3099(15)00533-226711359
12. Zeng KJ, Doi Y, Patil S, Huang X, Tian GB, (2016) Emergence of plasmid-mediated mcr-1 gene in colistin-resistant Enterobacter aerogenes and Enterobacter cloacae. Antimicrob Agents Chemother60: 3862–3863. doi: 10.1128/AAC.00345-1626976876
13. Yang C, (2015) Emergence and spread of a plasmid-mediated polymyxin resistance mechanism, MCR-1: Are bacteria winning?Infectious Diseases and Translational Medicine1(2): 56.
14. Gao R, Li Y, Lin J, Tan C, Feng Y, (2016) Unexpected complexity of multidrug resistance in the mcr-1-harbouring Escherichia coli. Sci China Life Sci59: 732–734. doi: 10.1007/s11427-016-5070-127178474
15. Gao R, Wang Q, Li P, Li Z, Feng Y, (2016) Genome sequence and characteristics of plasmid pWH12, a variant of the mcr-1-harbouring plasmid pHNSHP45, from the multi-drug resistant E. coli. Virulence7: 732–735. doi: 10.1080/21505594.2016.119327927221541
16. Zhang H, Seward CH, Wu Z, Ye H, Feng Y, (2016) Genomic insights into the ESBL and MCR-1-producing ST648 Escherichia coli with multi-drug resistance. Sci Bull (Beijing)61: 875–878.
17. Zhang XF, Doi Y, Huang X, Li HY, Zhong LL, et al. (2016) Possible transmission of mcr-1-harboring Escherichia coli between companion animals and human. Emerg Infect Dis22: 1679–1681. doi: 10.3201/eid2209.16046427191649
18. Poirel L, Kieffer N, Liassine N, Thanh D, Nordmann P, (2016) Plasmid-mediated carbapenem and colistin resistance in a clinical isolate of Escherichia coli. Lancet Infect Dis16: 281.
19. Falgenhauer L, Waezsada SE, Yao Y, Imirzalioglu C, Käsbohrer A, et al. (2016) Colistin resistance gene mcr-1 in extended-spectrum β-lactamase-producing and carbapenemase-producing Gram-negative bacteria in Germany. Lancet Infect Dis16: 282–283. doi: 10.1016/S1473-3099(16)00009-826774242
20. Haenni M, Poirel L, Kieffer N, Chatre P, Saras E, et al. (2016) Co-occurrence of extended spectrum β-lactamase and MCR-1 encoding genes on plasmids. Lancet Infect Dis16: 281–282.
21. Haenni M, Metayer V, Gay E, Madec JY, (2016) Increasing trends in mcr-1 prevalence among ESBL-producing E. coli in French calves despite decreasing exposure to colistin. Antimicrob Agents Chemother60: 6433–6434. doi: 10.1128/AAC.01147-1627503658
22. Malhotra-Kumar S, Xavier BB, Das AJ, Lammens C, Butaye P, Goossens H, (2016) Colistin resistance gene mcr-1 harboured on a multidrug resistant plasmid. Lancet Infect Dis16: 283–284. doi: 10.1016/S1473-3099(16)00012-826774247
23. Du H, Chen L, Tang YW, Kreiswirth BN, (2016) Emergence of the mcr-1 colistin resistance gene in carbapenem-resistant Enterobacteriaceae. Lancet Infect Dis16: 287–288. doi: 10.1016/S1473-3099(16)00056-626842776
24. Yao X, Doi Y, Zeng L, Lv L, Liu JH, (2016) Carbapenem-resistant and colistin-resistant Escherichia coli co-producing NDM-9 and MCR-1. Lancet Infect Dis16: 288–289. doi: 10.1016/S1473-3099(16)00057-826842777
25. Partridge SR, Ellem JA, Tetu SG, Zong Z, Paulsen IT, et al. (2011) Complete sequence of pJIE143, a pir-type plasmid carrying ISEcp1-blaCTX-M-15 from an Escherichia coli ST131 isolate. Antimicrob Agents Chemother55: 5933–5935. doi: 10.1128/AAC.00639-1121911569
26. Stokes MO, Abuoun M, Umur S, Wu G, Partridge SR, et al. (2013) Complete sequence of pSAM7, an IncX4 plasmid carrying a novel blaCTX-M-14b transposition unit isolated from Escherichia coli and Enterobacter cloacae from cattle. Antimicrob Agents Chemother57: 4590–4594. doi: 10.1128/AAC.01157-1323836183
27. Li A, Yang Y, Miao M, Chavda KD, Mediavilla JR, et al. (2016) Complete sequences of mcr-1-harboring plasmids from extended-spectrum-beta-lactamase- and carbapenemase-producing Enterobacteriaceae. Antimicrob Agents Chemother60: 4351–4354. doi: 10.1128/AAC.00550-1627090180
28. Di Pilato V, Arena F, Tascini C, Cannatelli A, Henrici De Angelis L, et al. (2016) MCR-1.2: a new MCR variant encoded by a transferable plasmid from a colistin-resistant KPC carbapenemase-producing Klebsiella pneumoniae of sequence type 512. Antimicrob Agents Chemother60: 5612–5615. doi: 10.1128/AAC.01075-1627401575
29. Yang YQ, Zhang AY, Ma SZ, Kong LH, Li YX, et al. (2016) Co-occurrence of mcr-1 and ESBL on a single plasmid in Salmonella enterica. J Antimicrob Chemother71: 2336–2338. doi: 10.1093/jac/dkw24327330065
30. Sun J, Li XP, Yang RS, Fang LX, Huo W, et al. (2016) Complete nucleotide sequence of an IncI2 plasmid coharboring blaCTX-M-55 and mcr-1. Antimicrob Agents Chemother60: 5014–5017. doi: 10.1128/AAC.00774-1627216063
31. Lv L, Partridge SR, He L, Zeng Z, He D, et al. (2013) Genetic characterization of IncI2 plasmids carrying blaCTX-M-55 spreading in both pets and food animals in China. Antimicrob Agents Chemother57: 2824–2827. doi: 10.1128/AAC.02155-1223478963
32. Doerrler WT, Gibbons HS, Raetz CR, (2004) MsbA-dependent translocation of lipids across the inner membrane of Escherichia coli. J Biol Chem279: 45102–45109. doi: 10.1074/jbc.M40810620015304478
33. Baker D, Sali A, (2001) Protein structure prediction and structural genomics. Science294: 93–96. doi: 10.1126/science.106565911588250
34. Edgar RC, (2004) MUSCLE: a multiple sequence alignment method with reduced time and space complexity. BMC Bioinformatics5: 1–19.
35. Sela I, Ashkenazy H, Katoh K, Pupko T, (2015) GUIDANCE2: accurate detection of unreliable alignment regions accounting for the uncertainty of multiple parameters. Nucleic Acids Res43: W7–W14. doi: 10.1093/nar/gkv31825883146
36. Tamura K, Stecher G, Peterson D, Filipski A, Kumar S, (2013) MEGA6: Molecular Evolutionary Genetics Analysis Version 6.0. Molecular Biology and Evolution30: 2725–2729. doi: 10.1093/molbev/mst19724132122
37. He Z, Kisla D, Zhang L, Yuan C, Green-Church KB, et al. (2007) Isolation and identification of a Paenibacillus polymyxa strain that coproduces a novel lantibiotic and polymyxin. Appl Environ Microbiol73: 168–178. doi: 10.1128/AEM.02023-0617071789
38. Kim JF, Jeong H, Park SY, Kim SB, Park YK, et al. (2010) Genome sequence of the polymyxin-producing plant-probiotic rhizobacterium Paenibacillus polymyxa E681. J Bacteriol192: 6103–6104. doi: 10.1128/JB.00983-1020851896
39. Shaheen M, Li J, Ross AC, Vederas JC, Jensen SE, (2011) Paenibacillus polymyxa PKB1 produces variants of polymyxin B-type antibiotics. Chem Biol18: 1640–1648. doi: 10.1016/j.chembiol.2011.09.01722195566
40. Gadler P, Faber K, (2007) New enzymes for biotransformations: microbial alkyl sulfatases displaying stereo-and enantioselectivity. Trends in Biotechnol25: 83–88.
41. Hanson SR, Best MD, Wong CH, (2004) Sulfatases: structure, mechanism, biological activity, inhibition, and synthetic utility. Angewandte Chemie International Edition43: 5736–5763.
42. Converse SE, Mougous JD, Leavell MD, Leary JA, Bertozzi CR, et al. (2003) MmpL8 is required for sulfolipid-1 biosynthesis and Mycobacterium tuberculosis virulence. Proc Natl Acad Sci U S A100: 6121–6126. doi: 10.1073/pnas.103002410012724526
43. Petrillo Mauro, A-L A, Kreysa Joachim, (2016) Possible genetic events producing colistin resistance gene mcr-1. Lancet Infect Dis16: 280. doi: 10.1016/S1473-3099(16)00005-026774240
44. Delgado-Blas JF, Ovejero CM, Abadia Patino L, Gonzalez-Zorn B, (2016) Coexistence of mcr-1 and blaNDM-1 in Escherichia coli from Venezuela. Antimicrob Agents Chemother60: 6356–6358. doi: 10.1128/AAC.01319-1627431212
45. Li Z, Tan C, Lin J, Feng Y, (2016) Diversified variants of the mcr-1-carrying plasmid reservoir in the swine lung microbiota. Sci China Life Sci, 59: 971–973. doi: 10.1007/s11427-016-5111-927520829
46. Nation RL, Li J, Cars O, Couet W, Dudley MN, et al. (2015) Framework for optimisation of the clinical use of colistin and polymyxin B: the Prato polymyxin consensus. Lancet Infect Dis15: 225–234. doi: 10.1016/S1473-3099(14)70850-325459221
47. Feng Y, Napier BA, Manandhar M, Henke SK, Weiss DS, et al. (2014) A Francisella virulence factor catalyses an essential reaction of biotin synthesis. Mol Microbiol91: 300–314. doi: 10.1111/mmi.1246024313380
48. Feng Y, Cronan JE, (2011) The Vibrio cholerae fatty acid regulatory protein, FadR, represses transcription of plsB, the gene encoding the first enzyme of membrane phospholipid biosynthesis. Mol Microbiol81: 1020–1033. doi: 10.1111/j.1365-2958.2011.07748.x21771112
49. Darling AC, Mau B, Blattner FR, Perna NT, (2004) Mauve: multiple alignment of conserved genomic sequence with rearrangements. Genome Res14: 1394–1403. doi: 10.1101/gr.228970415231754